EKS-LAC-00400

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00400

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.5	4.2E-109	625	878	254

Status

Unreviewed

Ensembl Protein

ENSLACP00000012526

UniProt Accession

H3ASA5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000011038	ENSLACP00000012526	ENSLACT00000012620

Organism

Latimeria chalumnae

Functional Description

Protein Length

1289

Protein Sequence
(FASTA)

GSEPGAGEGT AGAGGPECGP CGGGSGSRQR SLRVVYVLND SPKAGVGVSP EAGALQCLQR 60

ACESESALLT TLNFGRLDFG ETSVLDSFYD ADVAVVDMSD VFRQPSLFYQ LGVRESFDMA 120

NNVILYHDTD PDTAQSLKDI VSQKNTASSG NYYFIPYAVT PNNDYVYCES DAQRRASEYM 180

QPSWDNLLGT LCVPLVDRFI SLLKDIHVTS CAYYKETLLN DIRKAREKYQ GDELAKELAR 240

IKLRMDNTEL LTPDIVLNLL LSYRDIQDYD AMVKLVETLE MLPTCDLADQ HNIKFHYAFA 300

LNRRNNPGDR KKALHVMLQV LQSCDHPAPD MFCLCGRIYK DIFLDSNCKD TKNRDSAIEW 360

YRKGFEFQPT LYSGINLAIL LIVAGQQFES SIELRKIGVR LNSLLGRKGS LEKMNNYWDV 420

GQFFTVSMLA NDIGKAVQAA EKLFKLKPPV WYLRSVVQNL LLIQRFKKLN PEHSPKQERL 480

NFWMDIIVEA TNKIANGLRF PVLVLEPTKV YQPSYVSINN EADEKTVSLW HVSPVEKKGI 540

HEWNFTASSI KGISISKFDE RCCFLYVHDN SDDFQIYFST EDQCSRFCRM VKEIITDAVG 600

SAVELEGETD GDTLEYEYDY DENGERVVLG KGTYGVVYAG RDLSNQVRIA IKEIPEKDSR 660

YSQPLHEEIA LHKYLKHRNI VQYLGSISED GYIKIFMEQV PGGSISALLT SKWGPLKEPT 720

IKFYTKQILE GLRYLHENQI VHRDIKGDNV LVNTYSGVLK ISDFGTSKRL AGVNPCTETF 780

TGTLQYMAPE IIDQGPRGYG APADIWSLGC TIIEMATGKP PFYELGEPQA AMFKVGMFKI 840

HPEIPESLSA EAKGFILHCF EPDPNKRTTA AELLRHPLLK LTNKGKKNKI AFKPTAKVAT 900

GCNSVLFPYS SRLVRPSMMF HGSTRREGVA PYNLSHTLSV PDEMSASEDR SVPPSPEERD 960

SGLFLLKKDS ERRAILYKIL NEDQDKVVSN LLECLTQGSE ELKLSVDHIK QINGILRDFV 1020

RSPERRVMAS TISKLKLDLD FDSTSINQIQ LVLFGFQDAV NKVLRNHQIK PHWMFAMDNI 1080

IRRAVQAAVT ILIPELRAHF GPASESEGAD KDADEVEDHD YHQEEQNENE EPIVNSGVST 1140

LSSVVSHESQ NQHHPLSLHL GRLKQETNRL LESLVKKEKE YQDLLRQILQ QRAHDLDLLQ 1200

LKSQPNNIPA TSGSRLSDRQ TGDKELIDWL KEQGANADTI ERFIVEDYTL YDVLNDIDKE 1260

DLRYLRLRGG MLCRIWSAIV KYRNREPRQ 1289

Nucleotide Sequence
(FASTA)

GGGTCGGAGC CTGGAGCCGG GGAGGGCACG GCCGGGGCTG GGGGGCCGGA GTGCGGTCCC 60

TGCGGCGGTG GGAGCGGGTC CAGGCAGCGC TCCCTTCGGG TGGTCTATGT GCTGAATGAC 120

AGCCCCAAGG CCGGCGTCGG GGTGAGCCCG GAGGCGGGCG CCCTGCAGTG TCTCCAGCGA 180

GCCTGCGAGT CGGAGAGCGC CCTTCTCACC ACGCTCAACT TCGGCAGGCT GGACTTCGGG 240

GAGACCTCGG TTCTGGACTC CTTCTATGAT GCAGATGTTG CTGTGGTGGA CATGAGCGAC 300

GTTTTTAGGC AGCCTTCACT GTTTTACCAA CTTGGAGTGA GAGAAAGCTT TGATATGGCG 360

AACAATGTAA TTCTGTATCA CGACACTGAC CCAGACACTG CTCAGTCCCT CAAGGATATA 420

GTTTCTCAGA AGAACACAGC TTCTAGTGGG AATTATTATT TTATTCCTTA TGCAGTAACT 480

CCTAACAATG ATTATGTGTA CTGTGAGAGT GATGCTCAGC GAAGAGCCTC GGAGTACATG 540

CAGCCCAGTT GGGACAACCT GTTGGGGACT TTGTGTGTGC CTTTGGTGGA CAGGTTCATC 600

AGCCTCCTAA AGGATATTCA TGTAACTTCA TGTGCCTATT ATAAGGAAAC TCTACTAAAC 660

GACATCAGAA AAGCCAGAGA GAAGTATCAA GGGGATGAGC TGGCAAAGGA GTTGGCTCGG 720

ATTAAGCTGC GTATGGACAA CACCGAGCTC CTCACCCCAG ACATTGTCCT TAACCTGCTG 780

CTCTCTTATC GAGACATTCA GGACTATGAC GCTATGGTAA AACTGGTGGA GACATTAGAA 840

ATGCTGCCAA CCTGTGATCT GGCTGATCAG CACAACATCA AGTTTCATTA TGCCTTTGCG 900

CTGAATAGGA GGAATAATCC TGGGGACAGA AAGAAGGCCT TGCATGTGAT GTTACAGGTT 960

TTGCAGTCAT GCGATCACCC TGCCCCTGAC ATGTTCTGCT TATGTGGTCG AATTTATAAG 1020

GATATCTTCC TTGATTCCAA CTGTAAAGAT ACAAAAAACC GGGATAGTGC AATTGAATGG 1080

TACCGGAAAG GGTTTGAGTT CCAGCCAACT CTCTATTCTG GAATTAACCT TGCGATTTTA 1140

CTGATTGTAG CTGGGCAGCA ATTTGAAAGC TCAATTGAAC TTAGAAAGAT TGGTGTACGG 1200

TTGAACAGTC TGTTGGGAAG GAAGGGAAGC TTGGAAAAAA TGAACAACTA CTGGGATGTG 1260

GGGCAGTTCT TCACTGTGAG CATGCTCGCT AACGATATCG GCAAAGCTGT ACAAGCAGCT 1320

GAAAAACTCT TTAAACTCAA ACCACCTGTT TGGTATCTGA GGTCAGTAGT CCAAAACTTG 1380

CTGTTGATCC AGCGTTTTAA GAAGCTGAAC CCGGAGCATT CCCCTAAGCA GGAGCGCCTC 1440

AACTTCTGGA TGGATATCAT TGTAGAAGCA ACCAATAAGA TTGCCAATGG ACTAAGATTT 1500

CCAGTTTTGG TTTTGGAGCC AACCAAGGTC TATCAGCCAT CTTATGTCTC AATAAACAAT 1560

GAAGCTGATG AGAAAACTGT CTCATTGTGG CATGTCTCCC CTGTAGAAAA GAAAGGTATT 1620

CATGAGTGGA ATTTTACAGC TTCTTCTATC AAAGGAATAA GCATATCCAA GTTTGATGAG 1680

CGCTGTTGCT TTCTTTACGT CCATGACAAC TCTGATGACT TTCAGATCTA TTTTTCAACA 1740

GAAGATCAAT GCAGCAGGTT TTGCCGAATG GTAAAGGAAA TTATTACAGA TGCAGTGGGC 1800

AGTGCTGTGG AACTTGAAGG AGAGACAGAT GGAGACACAT TGGAGTATGA ATATGACTAT 1860

GATGAGAATG GAGAGAGAGT GGTGCTGGGT AAAGGTACAT ATGGGGTGGT CTATGCTGGA 1920

AGAGATCTCA GCAATCAAGT CCGGATAGCC ATCAAAGAGA TACCCGAGAA GGACTCAAGG 1980

TATTCGCAGC CGCTGCATGA AGAGATAGCA CTGCACAAAT ACCTAAAGCA CCGTAACATT 2040

GTTCAGTATC TTGGATCCAT CTCTGAAGAT GGTTACATTA AGATCTTTAT GGAGCAGGTG 2100

CCAGGAGGTA GCATTTCTGC ACTCCTGACA TCAAAGTGGG GCCCACTGAA AGAGCCCACG 2160

ATTAAATTCT ACACCAAGCA GATCCTAGAA GGACTTAGAT ACCTCCACGA GAACCAGATT 2220

GTCCATAGAG ACATAAAGGG AGACAATGTT CTTGTGAACA CTTACAGTGG AGTGTTAAAG 2280

ATCTCGGATT TTGGTACTTC CAAGCGACTT GCAGGAGTAA ATCCATGTAC TGAGACGTTT 2340

ACTGGAACTT TACAGTACAT GGCTCCAGAG ATCATAGACC AAGGACCCAG GGGATATGGT 2400

GCTCCTGCAG ATATCTGGTC TTTGGGCTGT ACTATTATTG AAATGGCAAC AGGCAAGCCC 2460

CCTTTCTATG AATTAGGAGA ACCTCAAGCA GCCATGTTTA AGGTAGGGAT GTTTAAAATC 2520

CATCCTGAGA TCCCAGAATC ACTATCAGCT GAAGCAAAGG GCTTCATTCT TCACTGCTTT 2580

GAGCCAGATC CCAATAAGCG AACCACAGCA GCAGAGCTGC TTAGACACCC CTTGCTTAAA 2640

CTGACCAACA AGGGCAAAAA GAATAAAATT GCCTTTAAGC CAACAGCAAA AGTAGCAACT 2700

GGATGCAACA GTGTGCTTTT CCCATATAGT TCAAGGCTTG TGAGACCCAG TATGATGTTT 2760

CATGGGTCAA CACGAAGAGA AGGGGTGGCA CCATACAATC TCTCACATAC TTTAAGTGTT 2820

CCAGATGAGA TGTCTGCTTC AGAAGATCGT AGCGTTCCTC CTTCCCCTGA GGAGAGAGAC 2880

TCTGGCCTCT TCTTGCTCAA GAAGGACAGT GAGCGCAGAG CCATCCTCTA CAAAATCTTA 2940

AATGAAGACC AAGATAAAGT TGTCTCAAAC CTGTTGGAAT GTTTAACACA GGGCTCTGAA 3000

GAGCTGAAGC TCTCTGTCGA CCACATCAAG CAGATCAATG GTATCTTGAG GGATTTTGTC 3060

CGCTCCCCTG AACGCAGAGT TATGGCGTCT ACCATATCTA AACTCAAACT GGATTTGGAC 3120

TTCGACAGTA CTTCTATAAA CCAAATTCAG TTGGTGTTGT TTGGATTTCA GGATGCAGTA 3180

AATAAAGTTC TGAGAAACCA CCAAATTAAA CCTCACTGGA TGTTTGCTAT GGATAATATT 3240

ATTCGCCGTG CAGTCCAGGC AGCAGTGACA ATTCTCATTC CTGAGTTGCG AGCTCACTTT 3300

GGTCCAGCTT CAGAGAGCGA AGGGGCAGAT AAGGATGCAG ATGAAGTAGA AGACCATGAC 3360

TACCACCAAG AGGAACAAAA TGAAAATGAA GAGCCAATAG TTAATTCTGG AGTGAGCACC 3420

CTCAGCTCAG TTGTTTCCCA TGAGTCACAG AACCAGCACC ATCCACTTAG CTTGCATTTG 3480

GGCAGGCTGA AACAGGAAAC CAACAGATTA CTGGAAAGCC TTGTTAAGAA AGAGAAAGAG 3540

TACCAGGACC TGCTAAGACA AATCCTACAG CAGAGAGCCC ATGATCTGGA CCTTCTTCAA 3600

TTAAAATCCC AGCCTAATAA TATTCCAGCA ACTTCTGGAT CACGTTTATC TGACCGGCAG 3660

ACCGGGGACA AAGAGCTAAT TGATTGGTTA AAAGAACAAG GAGCTAATGC AGATACCATA 3720

GAAAGGTTCA TTGTAGAAGA TTACACCCTA TATGATGTTC TTAATGACAT TGATAAAGAG 3780

GATTTAAGAT ATTTAAGGCT CAGAGGTGGA ATGCTTTGCA GAATATGGAG TGCCATAGTA 3840

AAGTACAGAA ATAGAGAACC AAGGCAATGA 3870

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pek+s+  ++++l+eEi+l+k lkH+n

Q: 625   ERVVLGKGTYGVVYAGRDLSNQVRIAIKEI---PEKDSR--YSQPLHEEIALHKYLKHRN  679

         6899**************************...787775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGs+s+ll+ k+g+l+e +ik+ytkqilegl+yLHe++

Q: 680   IVQYLGSISEDGYIKIFMEQVPGGSISALLTsKWGPLKEPTIKFYTKQILEGLRYLHENQ  739

         ******************************99****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++

Q: 740   IVHRDIKGDNVLVNTySGVLKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDQGP  796

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe+ls+e+k f+

Q: 797   RGYGAPADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESLSAEAKGFI  856

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhef  262

          +c+e dp+kr++a+eLL+h+

Q: 857   LHCFEPDPNKRTTAAELLRHPL  878

         ********************86

Domain Sequence
(FASTA)

ERVVLGKGTY GVVYAGRDLS NQVRIAIKEI PEKDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSISEDGYIK IFMEQVPGGS ISALLTSKWG PLKEPTIKFY TKQILEGLRY LHENQIVHRD 120

IKGDNVLVNT YSGVLKISDF GTSKRLAGVN PCTETFTGTL QYMAPEIIDQ GPRGYGAPAD 180

IWSLGCTIIE MATGKPPFYE LGEPQAAMFK VGMFKIHPEI PESLSAEAKG FILHCFEPDP 240

NKRTTAAELL RHPL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013