EKS-LAC-00173

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00173

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	435.6	6.5E-131	349	608	260

Status

Unreviewed

Ensembl Protein

ENSLACP00000013016

UniProt Accession

H3ATP4;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000011467	ENSLACP00000013015	ENSLACT00000013110
ENSLACG00000011467	ENSLACP00000013016	ENSLACT00000013111

Organism

Latimeria chalumnae

Functional Description

Protein Length

722

Protein Sequence
(FASTA)

MKVLKKATII QKAKTAEHTR TERQVLEHIR QSPFLVTLHY AFQTDTKLHL ILDYVNGGEL 60

FTHLSQREKF TESEVRIYSG EIVLALEHLH KLGIIYRDIK LENILLDSSG HVVLTDFGLS 120

KEFLVDENER AYSFCGTIEY MAPEIVRGGD TGHNKAVDWW SLGVLTYELL TGASPFTVDG 180

EKNSQTEISK RILKSDPPFP QEIGPLGRDL IQRLLIKDPK KRLGSGQTGA DEIKNHPFFQ 240

KINWDDLAAK NVPAPFKPVI RDELDVSNFA DEFTEMDPTY SPAALPQNTD RIFQGYSFVA 300

PSILFKRNAV MTDAVQLHLG IERPGVTTIA RSVMMKDSPF YHHYELDLKE SPLGEGSFSI 360

CRKCLHKKSG QEYAVKIISK RLEANTQREI TALKLCEGHP NVVKLSEVYH DQLHTFLVME 420

LLKGGELLER IRKKKHFSET EASRIMRKLV SAVSHMHDVG VVHRDLKPEN LLFTDESENS 480

EMKIIDFGFA RLKPPDNQPL KTPCFTLHYA APELLKHDGY DESCDLWSLG VILYTMLSGQ 540

VPFQCREKML THSSAEEIMR KIKEGDFSFE GEAWKSVSQE AKDLIQGLLT VDPNKRIKMS 600

SLRYNEWLQD SSQLSSNPLM TPDILGSSAA SVHTYVKATF HAFNKCKREG FCLQNVDKAP 660

LAKRRKMKKT STSTETRSSS SESSYSSSSS SQTHGKTSPT KALQPSQPAD SNNPDTIFQF 720

SD 722

Nucleotide Sequence
(FASTA)

ATGAAGGTCC TAAAAAAGGC TACAATAATT CAGAAAGCGA AGACTGCTGA ACATACACGG 60

ACGGAACGAC AGGTGCTGGA ACACATCCGA CAGTCACCAT TTCTCGTCAC ATTACATTAT 120

GCCTTCCAGA CCGACACAAA ACTTCATCTC ATCTTGGACT ATGTGAATGG AGGAGAGTTA 180

TTCACCCACC TGTCCCAGAG AGAGAAGTTC ACGGAGAGTG AAGTCAGGAT TTACAGCGGG 240

GAGATTGTCT TGGCTTTGGA ACATCTACAT AAGCTGGGCA TTATATACCG GGATATTAAA 300

CTTGAAAATA TCCTTCTGGA TTCCAGTGGC CATGTGGTGT TGACAGACTT TGGTCTCAGT 360

AAAGAGTTCC TGGTGGATGA AAATGAAAGA GCATATTCGT TCTGCGGCAC CATTGAGTAT 420

ATGGCTCCAG AGATTGTTCG AGGGGGGGAC ACGGGACACA ACAAGGCAGT TGACTGGTGG 480

AGCCTCGGGG TCTTGACGTA TGAATTATTG ACAGGGGCAT CGCCTTTTAC TGTTGACGGG 540

GAGAAGAATT CCCAAACAGA AATTTCCAAG AGAATATTAA AAAGTGATCC TCCATTCCCC 600

CAAGAGATTG GACCCTTAGG AAGAGATTTA ATCCAGCGCC TTCTAATAAA GGACCCAAAG 660

AAAAGGCTGG GCTCTGGACA GACTGGTGCT GATGAAATAA AGAACCATCC TTTCTTCCAG 720

AAAATAAATT GGGATGATTT AGCTGCCAAG AACGTGCCAG CTCCATTTAA GCCAGTGATC 780

CGGGATGAGC TGGATGTTAG TAATTTTGCT GATGAGTTTA CAGAGATGGA TCCTACCTAC 840

TCCCCTGCAG CCCTGCCACA GAATACAGAC CGGATATTCC AGGGCTACTC CTTCGTGGCT 900

CCCTCCATTT TGTTTAAGCG GAATGCAGTC ATGACGGATG CTGTGCAGCT GCACCTCGGA 960

ATAGAGAGAC CTGGAGTAAC AACCATTGCA AGGAGTGTCA TGATGAAGGA CTCCCCGTTC 1020

TATCATCACT ACGAGCTGGA CTTAAAAGAA AGCCCCCTGG GAGAAGGAAG CTTCTCCATC 1080

TGCAGAAAGT GTTTACATAA GAAAAGTGGC CAGGAATATG CAGTGAAAAT CATCAGCAAA 1140

AGGTTGGAAG CCAACACTCA GAGGGAAATC ACAGCCTTGA AGCTCTGTGA AGGCCATCCC 1200

AATGTGGTGA AACTATCTGA AGTTTATCAT GATCAGTTAC ATACATTTCT GGTGATGGAG 1260

CTGCTGAAGG GAGGGGAGCT GCTGGAGAGA ATTCGGAAGA AGAAACACTT CAGTGAAACG 1320

GAGGCCAGTC GGATTATGCG CAAATTGGTG TCTGCTGTCA GCCACATGCA TGACGTGGGC 1380

GTGGTACACA GAGACCTCAA ACCTGAGAAT TTATTATTTA CTGATGAGAG TGAGAATTCA 1440

GAAATGAAGA TCATTGATTT TGGATTTGCT CGATTGAAGC CCCCCGATAA CCAGCCCCTG 1500

AAGACCCCTT GTTTTACTCT GCATTATGCT GCTCCCGAGC TCCTGAAGCA TGATGGCTAC 1560

GATGAGTCCT GTGACCTCTG GAGCCTCGGT GTCATCCTGT ACACTATGCT GTCAGGACAG 1620

GTACCTTTTC AATGCCGAGA GAAAATGCTA ACTCACAGCA GTGCAGAGGA GATCATGAGG 1680

AAGATTAAAG AAGGTGATTT CTCCTTTGAA GGAGAGGCCT GGAAAAGCGT GTCCCAGGAA 1740

GCCAAGGATT TAATACAAGG ACTCCTAACA GTGGATCCAA ACAAAAGGAT TAAAATGTCA 1800

AGCCTACGCT ACAATGAATG GCTACAAGAT AGCAGTCAGC TCTCATCCAA TCCACTGATG 1860

ACTCCAGACA TTCTGGGCTC CTCTGCAGCA TCTGTGCACA CATATGTCAA GGCAACATTT 1920

CATGCTTTTA ACAAATGCAA GAGAGAAGGG TTCTGTCTCC AGAATGTGGA TAAGGCACCT 1980

TTGGCTAAGA GGAGAAAGAT GAAGAAGACC AGCACGAGCA CAGAGACACG CAGCAGCTCC 2040

AGTGAGAGTT CTTACTCTTC CTCTTCCTCA TCACAGACAC ATGGAAAAAC ATCCCCCACA 2100

AAGGCACTTC AGCCCAGCCA GCCTGCAGAT AGCAATAACC CTGACACCAT CTTCCAGTTC 2160

TCGGACTAG 2169

Domain Profile

S: 3     vkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdv  61

         ++ +lG+Gs+s+c++c+hk+++qe+avkii+k+ +++t++ei++l+++e+hpn+v+l +v

Q: 349   KESPLGEGSFSICRKCLHKKSGQEYAVKIISKRlEANTQREITALKLCEGHPNVVKLSEV  408

         6779********************************************************

S: 62    yddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkp  121

         y+d+++++lv+ellkGGell+ri+kkk+fse+eas i+r+lv+av+++h++Gvvhrdlkp

Q: 409   YHDQLHTFLVMELLKGGELLERIRKKKHFSETEASRIMRKLVSAVSHMHDVGVVHRDLKP  468

         ************************************************************

S: 122   enilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlw  181

         en+l++des+n+e +kiidfGfa+lk+++n++lktpc+tl+++ape+lk++Gyde+cdlw

Q: 469   ENLLFTDESENSE-MKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLKHDGYDESCDLW  527

         *************.**********************************************

S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237

         slGv+lytml+G+vpf    + +++++aeei+ kikeG+fs++Geaw+svs+eakdl+++

Q: 528   SLGVILYTMLSGQVPFqcreKMLTHSSAEEIMRKIKEGDFSFEGEAWKSVSQEAKDLIQG  587

         ****************99877899************************************

S: 238   lltvdpakrlkleqllkhswl  258

         lltvdp+kr+k+++l++++wl

Q: 588   LLTVDPNKRIKMSSLRYNEWL  608

         ********************7

Domain Sequence
(FASTA)

KESPLGEGSF SICRKCLHKK SGQEYAVKII SKRLEANTQR EITALKLCEG HPNVVKLSEV 60

YHDQLHTFLV MELLKGGELL ERIRKKKHFS ETEASRIMRK LVSAVSHMHD VGVVHRDLKP 120

ENLLFTDESE NSEMKIIDFG FARLKPPDNQ PLKTPCFTLH YAAPELLKHD GYDESCDLWS 180

LGVILYTMLS GQVPFQCREK MLTHSSAEEI MRKIKEGDFS FEGEAWKSVS QEAKDLIQGL 240

LTVDPNKRIK MSSLRYNEWL 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013