EKS-LAC-00250

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00250

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.0	1.9E-116	56	307	252

Status

Unreviewed

Ensembl Protein

ENSLACP00000023113

UniProt Accession

H3ATX2;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000011533	ENSLACP00000013093	ENSLACT00000013189
ENSLACG00000011533	ENSLACP00000023113	ENSLACT00000024998
ENSLACG00000011533	ENSLACP00000013092	ENSLACT00000013188

Organism

Latimeria chalumnae

Functional Description

Protein Length

730

Protein Sequence
(FASTA)

MSTRTPLPTV NERDAEHHIS HGDGRSEVSS RSGRSGARCR NSIASSADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL VMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKYIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGNKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPVKRGTLEQ 300

IMKDRWINAG HDDDELKPFV EPELDISDQK RIDIMVGMGY SREEIQESLS KMKYDEITAT 360

YLLLGRKSSE LDASDSSSSS NLSLAKIRPS SDLSNSTGQS PHHKAQRSIS SSQKQRRYSD 420

HAGPTVPPVV AYPKRSQTST TDNDLKEEGV QSRKSSSSAV GGRGIAPPSP MLGNASNPNK 480

ADIPDRKKTS AISNNNSVAG GMTRRNTYVC SERTTTDRHS VIQNGKENST VPGQRTPVAS 540

THSISSATTP DRLRFPRGTA SRSTFHGGQL RERRTATYNG PPASPTLSHD ATPLSQARSR 600

GSTNLFTKLT SKLTRSRNVS GDQKDENKEA KPRSLRFTWS MKTTSSMDPN DMMREIRKVL 660

DANNCDYEQR ERFLLFCVHG DGHAENLVQW EMEVCKLPRL SLNGVRFKRI SGTSIAFKNI 720

ASKIANELKL 730

Nucleotide Sequence
(FASTA)

ATGTCTACGA GAACGCCGTT GCCTACAGTC AATGAACGTG ATGCAGAACA TCATATATCC 60

CATGGAGATG GACGTTCTGA GGTGTCCTCT CGGTCTGGAC GCTCTGGAGC ACGATGTAGG 120

AACTCAATAG CCTCCAGTGC AGATGAACAA CCCCACATTG GGAATTACAG GCTTCTTAAA 180

ACCATTGGAA AAGGAAATTT TGCAAAAGTA AAGCTTGCTA GGCACATTCT CACAGGAAGA 240

GAGGTTGCAA TAAAAATAAT TGACAAAACC CAGTTAAATC CAACCAGTCT GCAAAAGCTT 300

TTCAGGGAAG TAAGAATAAT GAAGATTTTG AATCATCCAA ATATAGTTAA GTTGTTTGAA 360

GTAATTGAAA CGGAGAAAAC CTTGTACTTA GTGATGGAAT ATGCAAGTGG TGGAGAAGTA 420

TTTGATTACT TGGTTGCTCA TGGAAGAATG AAGGAAAAAG AGGCCAGAGC TAAATTCAGA 480

CAGATAGTAT CTGCAGTGCA GTACTGCCAT CAAAAATATA TTGTACACAG AGATCTGAAG 540

GCAGAGAACC TGTTGTTGGA TGCAGATATG AATATTAAAA TTGCAGACTT TGGCTTCAGC 600

AATGAGTTTA CAGTTGGCAA TAAACTGGAC ACTTTCTGTG GAAGTCCTCC ATATGCTGCT 660

CCAGAACTGT TCCAAGGGAA GAAGTATGAT GGCCCTGAAG TAGATGTTTG GAGTTTAGGT 720

GTCATTCTTT ACACTTTAGT CAGTGGATCG TTACCATTTG ATGGACAGAA CTTGAAGGAA 780

CTAAGGGAAA GGGTGCTAAG AGGAAAATAT AGGATTCCTT TCTACATGTC TACAGACTGT 840

GAAAATCTTT TAAAAAGGTT TCTGGTGCTG AACCCTGTCA AGAGAGGCAC TCTAGAGCAA 900

ATTATGAAGG ATAGATGGAT CAATGCAGGG CATGATGATG ATGAGCTTAA GCCTTTTGTG 960

GAACCAGAAC TGGATATCTC AGACCAAAAG AGAATAGATA TAATGGTGGG GATGGGGTAT 1020

TCCCGAGAAG AAATTCAAGA ATCTCTTAGT AAAATGAAAT ATGATGAAAT CACAGCTACA 1080

TATTTGCTGC TAGGGAGGAA ATCCTCCGAG TTGGATGCAA GTGATTCTAG TTCAAGCAGC 1140

AACCTTTCCC TTGCTAAAAT CAGGCCAAGC AGCGACCTCA GTAATAGCAC TGGACAATCT 1200

CCCCACCATA AAGCGCAAAG AAGCATATCG TCTAGCCAGA AACAGCGACG GTACAGTGAT 1260

CATGCTGGAC CTACTGTCCC TCCAGTTGTG GCTTATCCAA AGAGGAGCCA AACTAGTACT 1320

ACAGACAATG ACTTAAAGGA AGAAGGAGTT CAGTCGAGGA AATCTAGCAG CAGTGCTGTT 1380

GGAGGAAGAG GAATAGCTCC GCCTAGCCCT ATGCTTGGAA ATGCAAGCAA TCCTAACAAA 1440

GCTGATATTC CTGATCGGAA AAAGACTTCT GCCATCTCCA ACAATAATTC TGTGGCTGGC 1500

GGAATGACCA GGCGAAATAC ATATGTGTGT AGTGAAAGAA CCACCACAGA CAGGCATTCA 1560

GTAATACAAA ATGGGAAAGA GAACAGTACT GTCCCTGGTC AAAGAACCCC AGTTGCCTCC 1620

ACCCACAGTA TTAGCAGTGC CACCACACCT GATCGCTTGC GCTTCCCTAG AGGAACAGCC 1680

AGTCGTAGCA CTTTCCATGG TGGTCAGCTT CGAGAACGAC GTACTGCTAC ATACAATGGA 1740

CCCCCTGCAT CACCTACATT ATCACATGAT GCTACACCAC TATCACAGGC CCGAAGCAGA 1800

GGATCCACTA ATCTATTTAC TAAACTAACT TCAAAGCTTA CAAGAAGTCG CAATGTATCT 1860

GGGGATCAGA AAGATGAAAA CAAAGAAGCA AAGCCCCGTT CACTCAGATT CACCTGGAGT 1920

ATGAAAACAA CCAGCTCCAT GGATCCCAAT GATATGATGA GGGAAATTCG TAAAGTTCTA 1980

GATGCTAATA ACTGCGATTA TGAACAACGG GAGCGTTTCT TACTTTTTTG TGTCCATGGT 2040

GATGGGCATG CAGAAAACCT TGTCCAGTGG GAGATGGAGG TCTGCAAGTT ACCAAGACTG 2100

TCACTTAATG GAGTCCGTTT CAAGCGAATA TCAGGAACTT CTATAGCTTT TAAAAACATT 2160

GCTTCTAAAA TTGCCAATGA GTTGAAGCTG TAA 2193

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 116   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKYIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPVKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013