EKS-LAC-00176
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00176
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG465.73.9E-140452710259
StatusUnreviewed
Ensembl ProteinENSLACP00000013122
UniProt AccessionH3AU01;
Protein Name
Protein Synonyms/Alias
Gene NamePRKG2
Gene Synonyms/Alias PRKG2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000011556ENSLACP00000013122ENSLACT00000013218
OrganismLatimeria chalumnae
Functional Description
Protein Length761
Protein Sequence
(FASTA)
MGNGTIKASR LEDSCVTSSV KEHSMEVLEK LKNKVLSLEE ALRKKDEELK FKDEKLKRLE 60
KELKAKVSQI DKLQDAIGYN GGPLSPTGNQ SNKLLSIINE GPKRFEQVAA EVHRRLKAKE 120
GVSAEPTSWN YYSHNIQTIS FEKVQVRKDS GTKKLITDAI MNNDFLKKLE AQHMRKMVEC 180
MYKTTYSQSQ LVIQEGEAGN HLYVLAEGLL EVSQNGKLLG HMHPGMVFGE LAILYNCKRT 240
ATVKAVVESR IWVLDRPIFQ NIMMRTAQAQ HEEYFSFLRS VSLLKNLPEE KLAKIIDCLE 300
VDYYDKGDYI IREGEEGNTF FIIAKGKVCV TQTMEGSQEP QEIKTLGAGD YFGEKALISE 360
DVRSANIITA ENDTQCLVID RDTFNQMVGT YEELQTYLRE YVDQLSRNDE KRNAMVEASC 420
SDLKLSKTNY TEAAQLKDKI SQFSYSSPFK YLNIIATLGM GGFGRVELVK LKDEDVAFAL 480
KCIKKKHIVD TRQQEHIYSE KNILQQIDSQ FIVRLYRTFR DAKYVYILLE VCLGGELWSI 540
LRDMYFFEDS TARFCVGCVL EAFDYLHSRG IIYRDLKPEN LLLDADGYVK MVDFGFAKKI 600
GLGKKTWTFC GTPEYVAPEI IMNKGHDFGA DYWSLGILIF ELLTGSPPFM GSDPIKIYNM 660
VLRGIEKMDF PKRIGKRPED LIRRLCKVNP AERLGNKKNG INDIRKNKWF QGFNWEGLRS 720
RKLISPLKRE IRGTTDHSHF DNFPSENEEP PDEFSGWDND F 761
Nucleotide Sequence
(FASTA)
ATGGGAAATG GTACTATCAA AGCCTCAAGA TTGGAGGACA GCTGTGTAAC CTCCTCTGTA 60
AAGGAACATT CAATGGAAGT CTTGGAGAAA CTCAAAAATA AGGTCCTTAG TTTAGAAGAG 120
GCATTAAGAA AGAAAGATGA AGAGCTGAAA TTTAAAGATG AAAAACTTAA AAGACTAGAA 180
AAAGAACTCA AAGCAAAAGT ATCCCAAATA GACAAGCTTC AAGATGCGAT TGGGTACAAT 240
GGTGGTCCTC TGTCACCAAC AGGTAATCAG AGTAATAAAC TGCTCAGTAT TATTAATGAG 300
GGGCCTAAGC GGTTCGAACA GGTGGCAGCA GAGGTGCACA GACGTTTGAA AGCAAAGGAA 360
GGTGTGTCAG CTGAGCCAAC ATCCTGGAAT TATTACTCTC ACAATATCCA AACCATTTCC 420
TTTGAAAAGG TACAGGTTCG CAAGGATTCA GGAACAAAGA AGCTGATAAC AGATGCAATA 480
ATGAATAACG ACTTCCTAAA GAAACTGGAA GCTCAGCACA TGCGGAAGAT GGTGGAGTGC 540
ATGTATAAGA CAACCTACAG CCAATCTCAG CTTGTTATCC AGGAGGGAGA GGCAGGAAAC 600
CATTTGTATG TCTTAGCTGA GGGCTTATTG GAGGTAAGCC AGAATGGCAA ACTGCTGGGA 660
CACATGCATC CTGGGATGGT GTTTGGAGAA TTGGCAATAC TATATAATTG CAAACGGACA 720
GCAACTGTCA AAGCGGTAGT TGAATCTAGG ATCTGGGTTT TGGACCGACC AATTTTCCAA 780
AACATTATGA TGAGGACAGC ACAGGCCCAG CATGAAGAAT ACTTCAGCTT TTTACGCAGT 840
GTTTCTTTAT TAAAGAATTT ACCTGAAGAA AAACTTGCAA AGATAATTGA TTGCCTAGAA 900
GTGGATTATT ATGACAAAGG TGATTACATC ATCCGAGAGG GAGAAGAGGG TAACACCTTC 960
TTTATTATAG CAAAAGGAAA GGTGTGTGTG ACACAGACCA TGGAGGGCTC TCAGGAACCT 1020
CAGGAGATCA AAACACTGGG AGCTGGGGAT TATTTCGGAG AGAAAGCACT AATTAGTGAA 1080
GATGTCCGCT CTGCAAATAT TATCACAGCA GAGAATGACA CCCAGTGCCT TGTAATTGAT 1140
AGAGACACTT TCAACCAGAT GGTGGGCACA TATGAGGAGT TGCAGACCTA TCTAAGAGAG 1200
TATGTGGACC AACTTTCTCG GAATGATGAG AAGAGAAATG CTATGGTTGA GGCTAGCTGC 1260
TCTGACCTGA AGTTAAGTAA AACTAATTAC ACTGAGGCTG CACAACTAAA AGATAAGATC 1320
AGCCAATTCT CCTACTCTTC TCCTTTTAAA TACTTGAATA TAATTGCTAC TCTTGGAATG 1380
GGAGGCTTTG GTCGAGTAGA ACTGGTTAAG CTGAAGGATG AGGATGTAGC TTTTGCTCTT 1440
AAATGTATTA AAAAGAAGCA CATTGTGGAT ACACGGCAAC AAGAGCACAT TTACTCTGAG 1500
AAAAATATTC TTCAGCAGAT AGACTCCCAA TTCATTGTCA GGCTTTATAG AACATTTAGA 1560
GATGCCAAGT ATGTTTACAT TCTATTGGAA GTGTGCCTTG GAGGGGAGCT CTGGAGCATC 1620
TTAAGGGACA TGTATTTCTT TGAGGACTCC ACTGCCCGCT TCTGTGTTGG CTGTGTTCTA 1680
GAGGCTTTTG ATTACTTACA TAGTCGAGGA ATTATCTACC GTGATCTTAA GCCAGAAAAC 1740
TTACTACTGG ATGCTGATGG TTATGTCAAA ATGGTCGATT TTGGCTTTGC TAAGAAAATT 1800
GGATTAGGTA AAAAAACCTG GACATTTTGT GGAACTCCTG AGTATGTGGC TCCAGAGATA 1860
ATCATGAACA AGGGGCATGA CTTTGGGGCA GATTATTGGT CATTGGGAAT CCTTATCTTT 1920
GAGCTTCTTA CAGGAAGCCC TCCTTTTATG GGTTCTGATC CAATTAAAAT CTACAACATG 1980
GTGTTGAGAG GAATAGAGAA AATGGATTTC CCCAAAAGGA TAGGAAAACG CCCTGAGGAC 2040
CTAATTAGGA GACTCTGCAA GGTCAATCCA GCAGAGAGGC TAGGAAATAA GAAAAATGGA 2100
ATAAACGATA TAAGGAAAAA CAAATGGTTT CAGGGCTTCA ACTGGGAAGG TCTCAGAAGC 2160
AGGAAGCTGA TTTCACCGCT GAAAAGAGAG ATTAGAGGAA CTACAGATCA TAGTCACTTT 2220
GACAACTTCC CTTCAGAGAA TGAAGAGCCA CCAGATGAGT TCTCTGGCTG GGACAATGAT 2280
TTCTGA 2286
Domain Profile
S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60
         l++iatlg+ggfgrvelvk+k+ e  afalk++kkkhivdt+qqeh++sek+il++++s+
Q: 452   LNIIATLGMGGFGRVELVKLKD-EDVAFALKCIKKKHIVDTRQQEHIYSEKNILQQIDSQ  510
         689*****************98.889**********************************
S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120
         fiv+lyrtf+d kyvy+lle+clggelw+ilrd   f+d+ta+f+v+cv+ea++ylhs++
Q: 511   FIVRLYRTFRDAKYVYILLEVCLGGELWSILRDMYFFEDSTARFCVGCVLEAFDYLHSRG  570
         ************************************************************
S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180
         iiyrdlkpenllld++gy+k+vdfgfakk++ gkktwtfcgtpeyvapeii+nkghd+ +
Q: 571   IIYRDLKPENLLLDADGYVKMVDFGFAKKIGLGKKTWTFCGTPEYVAPEIIMNKGHDFGA  630
         ************************************************************
S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240
         dyw+lgil++elltg+ppf g+dp+k+yn++l+gi+k+++p++i+k++edli++lc+ np
Q: 631   DYWSLGILIFELLTGSPPFMGSDPIKIYNMVLRGIEKMDFPKRIGKRPEDLIRRLCKVNP  690
         ************************************************************
S: 241   aerlgylkggikdikkhkwf  260
         aerlg++k+gi+di+k kwf
Q: 691   AERLGNKKNGINDIRKNKWF  710
         *******************8
Domain Sequence
(FASTA)
LNIIATLGMG GFGRVELVKL KDEDVAFALK CIKKKHIVDT RQQEHIYSEK NILQQIDSQF 60
IVRLYRTFRD AKYVYILLEV CLGGELWSIL RDMYFFEDST ARFCVGCVLE AFDYLHSRGI 120
IYRDLKPENL LLDADGYVKM VDFGFAKKIG LGKKTWTFCG TPEYVAPEII MNKGHDFGAD 180
YWSLGILIFE LLTGSPPFMG SDPIKIYNMV LRGIEKMDFP KRIGKRPEDL IRRLCKVNPA 240
ERLGNKKNGI NDIRKNKWF 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00158
EKS-ANC-00160
EKS-BOT-00166
EKS-CAF-00173
EKS-CAP-00165
EKS-DAR-00457
EKS-DRM-00080
EKS-EQC-00165
EKS-FEC-00155
EKS-GAG-00142
EKS-GOG-00165
EKS-ICT-00161
EKS-LOA-00165
EKS-MAM-00164
EKS-MEG-00131
EKS-MOD-00165
EKS-MUM-00171
EKS-MUP-00170
EKS-MYL-00174
EKS-NOL-00159
EKS-ORN-00207
EKS-ORC-00153
EKS-ORL-00192
EKS-OTG-00172
EKS-PAT-00157
EKS-PEM-00088
EKS-POA-00162
EKS-PTV-00148
EKS-RAN-00162
EKS-SAH-00159
EKS-SUS-00145
EKS-TAG-00195
EKS-TAR-00214
EKS-VIP-00079
EKS-XET-00155
EKS-XIM-00202
Gene Ontology
GO:0005524; F:ATP binding
GO:0004692; F:cGMP-dependent protein kinase activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 2.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013