EKS-LAC-00084

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00084

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	573.4	1.0E-172	629	909	281

Status

Unreviewed

Ensembl Protein

ENSLACP00000013469

UniProt Accession

H3AUZ8;

Protein Name

Protein Synonyms/Alias

Gene Name

MUSK

Gene Synonyms/Alias

MUSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000011857	ENSLACP00000013469	ENSLACT00000013565

Organism

Latimeria chalumnae

Functional Description

Protein Length

923

Protein Sequence
(FASTA)

APRIINTLET VDALVEEAAT FVCAVESNPQ AEITWTRNNI PIRPFDTRYS MKENGQLLTI 60

LSVEDTDNGV YCCTANNGVG SPAESCGALQ VKMKPRIIRP PTDLTILVGS KAALPCNTMG 120

NPKPSVSWIK DEGVIKESFR VSVLESGSLR IRNTQKDDAG SYRCVAKNSL GLEYSKPVTV 180

EVQVSAGILK PPVSHNVTFG SEVMLQCKAT GIPIPTITWL ENGKTVIGAS VLNSIKNEYI 240

DSRLRVHVTR PGLFTCLATN KHSGGITTVK AAATVSISVL HFDRLYKSDM GYCSTYRGDV 300

CRSLLAKDSL VFFNSSYTDP EQTQEFLVQS AWAELSTVSS FCRPAAESML CHYTFQDCNP 360

TGMGPAPKPL CREHCFAVKD LYCFKEWLSM EENSRRGIYT TGLILTLPDC HRLPSMQEDP 420

KGCTRVPFFA DIKKEHVTTS CYKEKGRFYQ GSVNITSSGI PCQKWSEQAP HFHTRSPEVF 480

PELSKSENYC RNPGGESERP WCYTMDRSVR WEYCNIPRCG NVTLSEVARP NSVTPNLPSS 540

SSSATYSMTV IISIISGFAA SVLLIIFALV CRRRQKEFKT RKREAETPTL AALPSELLLD 600

RLHPNPMYQR LPLLLNPKLL SLEYPRNNIE YVRDIGEGAF GRVFQAKAPG LLLYEPFTMV 660

AVKMLKEEAS ADMQADFQRE AALMAEFDHP NIVKLLGVCA VGKPMCLLFE YMAYGDLNEY 720

LRLRSPTTTC STSHVSLAGR STGSDAEPTP LSCTDQLYIA KQVAAGMAYL SERKFVHRDL 780

ATRNCLVGEN MVVKIADFGL SRNIYSADYY KANENDAIPI RWMPPESIFF NRYTTESDVW 840

AYGVVLWEIF SFGMQPYYGM AHEEVIYYVR DGNILACPDT CPLELYNLMR LCWSKLPSDR 900

PSFASIHRIL ERMHERAIID LQV 923

Nucleotide Sequence
(FASTA)

GCCCCACGGA TCATCAACAC ACTTGAGACT GTGGATGCAT TAGTAGAAGA GGCAGCCACT 60

TTTGTCTGTG CAGTGGAATC AAACCCACAG GCAGAGATCA CCTGGACTCG TAATAACATT 120

CCCATCAGAC CATTTGATAC AAGATACAGT ATGAAAGAAA ATGGGCAGCT GCTGACCATT 180

CTGAGTGTAG AAGACACAGA TAACGGAGTG TACTGCTGCA CTGCTAACAA TGGGGTTGGA 240

AGTCCTGCTG AAAGTTGTGG AGCTTTACAA GTAAAAATGA AACCTAGGAT CATTCGCCCA 300

CCCACCGATC TAACAATATT AGTGGGATCA AAGGCAGCTC TACCATGTAA TACAATGGGA 360

AATCCTAAAC CTTCTGTTTC CTGGATCAAA GATGAGGGTG TGATAAAGGA AAGTTTTCGT 420

GTGTCCGTAC TGGAATCTGG AAGCTTACGG ATACGCAACA CTCAAAAGGA TGATGCAGGC 480

TCGTACCGTT GTGTGGCAAA GAACAGCCTA GGCCTTGAGT ATTCTAAGCC TGTCACAGTA 540

GAAGTGCAAG TTTCTGCTGG GATTTTGAAA CCTCCTGTCT CCCATAACGT CACGTTTGGT 600

TCTGAAGTGA TGCTGCAGTG CAAGGCAACA GGCATTCCTA TTCCCACCAT AACCTGGCTA 660

GAAAATGGGA AAACAGTAAT AGGGGCTTCT GTACTGAACA GCATCAAGAA TGAGTATATT 720

GACTCCAGAC TGCGGGTGCA CGTCACTAGG CCAGGCCTGT TCACCTGCCT CGCCACCAAC 780

AAACACAGCG GAGGGATCAC AACAGTAAAG GCTGCGGCAA CAGTCAGTAT TTCAGTTTTA 840

CATTTTGACA GATTGTACAA GAGTGACATG GGCTACTGCA GCACATACAG GGGTGATGTT 900

TGCAGAAGCC TCTTGGCAAA GGATTCTCTG GTTTTCTTCA ATTCTTCTTA CACGGACCCC 960

GAGCAGACCC AGGAGTTCCT TGTCCAGAGT GCCTGGGCTG AGTTGAGCAC AGTGAGTTCT 1020

TTCTGCCGTC CAGCCGCTGA GTCCATGCTG TGTCATTACA CCTTCCAAGA CTGCAATCCC 1080

ACTGGAATGG GACCAGCCCC TAAACCTCTG TGTAGAGAGC ACTGTTTTGC TGTGAAGGAT 1140

CTCTACTGCT TCAAAGAATG GCTCTCAATG GAGGAGAACT CCCGCAGAGG GATCTATACC 1200

ACAGGCCTGA TACTGACACT ACCTGACTGC CACAGGCTTC CCAGCATGCA GGAGGATCCC 1260

AAGGGCTGTA CTAGAGTCCC ATTCTTTGCA GACATTAAAA AAGAACATGT TACTACATCT 1320

TGTTATAAAG AGAAAGGAAG GTTTTACCAA GGTTCTGTCA ACATCACCTC CTCTGGTATT 1380

CCTTGTCAGA AATGGAGTGA ACAGGCGCCG CATTTTCACA CGAGGTCCCC AGAGGTTTTC 1440

CCCGAGCTGT CAAAGTCTGA GAATTACTGT CGTAATCCAG GAGGAGAGAG TGAGCGACCA 1500

TGGTGTTACA CGATGGACCG ATCAGTGAGA TGGGAATATT GCAACATACC TCGTTGTGGA 1560

AATGTCACCC TATCAGAGGT TGCCAGGCCA AACTCTGTGA CTCCCAATTT ACCTTCTTCA 1620

TCTTCCTCTG CAACTTATTC CATGACAGTC ATCATTTCGA TTATCTCAGG CTTTGCAGCT 1680

TCAGTGCTGC TCATCATTTT TGCCCTTGTC TGCCGCAGGC GGCAAAAGGA ATTTAAGACC 1740

AGAAAAAGAG AGGCAGAAAC ACCCACACTT GCAGCCCTTC CTTCAGAGCT TCTGCTGGAC 1800

AGACTCCATC CAAATCCTAT GTACCAGCGC CTGCCACTGC TCCTCAACCC CAAACTGCTC 1860

AGCCTGGAGT ATCCCAGAAA CAACATTGAG TATGTAAGAG ACATCGGAGA AGGAGCCTTT 1920

GGAAGGGTCT TTCAAGCAAA GGCTCCTGGT CTGCTCCTAT ACGAACCGTT CACGATGGTG 1980

GCTGTAAAAA TGCTGAAAGA AGAGGCTTCT GCTGACATGC AGGCAGACTT CCAGAGAGAA 2040

GCGGCACTCA TGGCCGAGTT TGATCACCCA AATATTGTCA AACTACTAGG GGTATGTGCA 2100

GTGGGGAAGC CAATGTGCCT ACTTTTTGAG TACATGGCCT ATGGGGATCT CAATGAATAT 2160

TTGCGACTAC GATCTCCTAC CACCACATGT AGCACGAGCC ATGTGAGTCT TGCAGGAAGA 2220

AGCACTGGGT CAGATGCAGA GCCAACTCCT CTCAGCTGCA CAGATCAGCT TTACATTGCT 2280

AAGCAGGTTG CTGCTGGAAT GGCCTATCTT TCAGAGCGCA AGTTTGTCCA TCGTGACCTG 2340

GCCACCAGAA ACTGTTTAGT TGGAGAAAAC ATGGTTGTGA AGATTGCTGA CTTTGGCCTT 2400

TCCAGAAACA TCTACTCTGC AGACTATTAC AAAGCCAATG AAAATGATGC CATTCCAATC 2460

AGGTGGATGC CACCTGAGTC CATCTTCTTT AACCGCTACA CAACGGAGTC AGACGTCTGG 2520

GCTTATGGGG TGGTTCTGTG GGAGATTTTT TCATTTGGCA TGCAACCATA TTATGGCATG 2580

GCCCACGAAG AGGTGATTTA CTATGTGAGA GATGGGAACA TTCTTGCCTG TCCTGACACC 2640

TGCCCTTTGG AGCTATACAA CTTGATGCGT CTATGCTGGA GTAAACTACC TTCTGATAGA 2700

CCCAGCTTTG CTAGCATTCA TCGCATTCTT GAACGTATGC ATGAGCGAGC GATAATTGAC 2760

CTTCAAGTCT AA 2772

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqa+apgll ye+f++vavkmlkeeasadmqadf+reaal+aefd

Q: 629   IEYVRDIGEGAFGRVFQAKAPGLLLYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  688

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         +pnivkllgvcavgkpmcllfeymaygdlne+lr  sp t+cs sh  l+ r+  s  ++

Q: 689   HPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEYLRLRSPTTTCSTSHVSLAGRSTGSDAEP  748

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

          pls++++l ia+qvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad

Q: 749   TPLSCTDQLYIAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  808

         ************************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yyka+endaipirwmp+esi++nryt+esdvwaygvvlweifs+++qpyyg+aheevi+y

Q: 809   YYKANENDAIPIRWMPPESIFFNRYTTESDVWAYGVVLWEIFSFGMQPYYGMAHEEVIYY  868

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdgnilacp+ +plely+lmrlcwsklp+drpsfasihri

Q: 869   VRDGNILACPDTCPLELYNLMRLCWSKLPSDRPSFASIHRI  909

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQAKA PGLLLYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

HPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EYLRLRSPTT TCSTSHVSLA GRSTGSDAEP 120

TPLSCTDQLY IAKQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180

YYKANENDAI PIRWMPPESI FFNRYTTESD VWAYGVVLWE IFSFGMQPYY GMAHEEVIYY 240

VRDGNILACP DTCPLELYNL MRLCWSKLPS DRPSFASIHR I 281

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Kringle; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000001	; Kringle.
IPR013806	; Kringle-like.
IPR018056	; Kringle_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 2.
PF00051	; Kringle; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00130	; KR; 1.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00021	; KRINGLE_1; 1.
PS50070	; KRINGLE_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013