EKS-LAC-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	367.5	5.1E-110	83	344	262

Status

Unreviewed

Ensembl Protein

ENSLACP00000013485

UniProt Accession

H3AV14;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1

Gene Synonyms/Alias

RPS6KB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000011872	ENSLACP00000013485	ENSLACT00000013581

Organism

Latimeria chalumnae

Functional Description

Protein Length

443

Protein Sequence
(FASTA)

KTRRFRPTEK RRGFEAMAGV FDIDLDQPEE TVSDDEVEDG AQLSEYMDHG GGSCELDMEH 60

CEKFEISENS VNKGPEKIRP ECFELLRVLG KGGYGKVFQV RKVTGANTGK IFAMKVLKKA 120

MIVRNAKDTA HTKAERNILE EVKHSFIVDL IYAFQTGGKL YLILEYLSGG ELFMQLEREG 180

IFMEDTACFY LAEISMALGH LHQNGIIYRD LKPENIMLNH QGHVKLTDFG LCKESIHDGT 240

VTHTFCGTIE YMAPEILMRS GHNRAVDWWS LGALMYDMLT GAPPFTGENR KKTIDKILKC 300

KLNLPPYLTQ EARDLLKKLL KRNAASRLGA GPGDAEEVKA HPFFRHINWE ELLARKVEPP 360

FRPYLQSDDD VSQFDSKFTR QTPVDSPDDS TLSESANQVF LGFTYVAPSV LESVKEKFSF 420

EPKIRSPRRF IGSPRTPVRS KSC 443

Nucleotide Sequence
(FASTA)

AAAACAAGGC GATTCCGGCC GACTGAAAAG CGACGAGGGT TCGAGGCCAT GGCGGGGGTG 60

TTCGATATTG ACTTGGATCA ACCGGAGGAG ACTGTCTCCG ATGATGAAGT GGAGGATGGG 120

GCTCAATTAA GTGAATATAT GGACCATGGA GGGGGATCTT GTGAGCTTGA TATGGAGCAC 180

TGTGAAAAGT TTGAAATCTC AGAAAACAGT GTAAACAAAG GTCCAGAAAA AATCCGACCA 240

GAATGCTTTG AGCTGTTGCG TGTGCTTGGG AAAGGTGGCT ATGGGAAGGT ATTCCAAGTA 300

CGAAAAGTAA CAGGAGCAAA CACAGGAAAA ATATTTGCTA TGAAGGTTCT CAAAAAGGCA 360

ATGATAGTAA GGAATGCAAA GGACACGGCT CACACAAAAG CAGAACGTAA CATCCTGGAA 420

GAAGTGAAGC ACTCTTTCAT TGTAGATCTG ATCTATGCTT TTCAAACTGG AGGAAAACTC 480

TACCTCATCC TTGAGTATCT CAGTGGAGGA GAACTGTTTA TGCAGTTGGA GAGGGAAGGA 540

ATCTTCATGG AAGACACTGC ATGCTTTTAT TTAGCAGAAA TCTCAATGGC ATTGGGACAT 600

TTACATCAGA ATGGGATCAT CTATCGAGAT TTGAAGCCAG AGAATATTAT GCTTAATCAT 660

CAAGGTCATG TAAAACTGAC AGATTTTGGA CTGTGTAAGG AATCTATTCA TGATGGGACA 720

GTTACACACA CATTCTGTGG TACAATAGAA TACATGGCCC CTGAAATCTT GATGAGAAGT 780

GGACATAACC GTGCTGTGGA CTGGTGGAGC TTAGGGGCAT TGATGTACGA TATGCTGACT 840

GGAGCGCCTC CTTTTACTGG TGAGAACAGA AAGAAAACTA TTGATAAGAT CTTAAAATGT 900

AAATTGAACC TGCCACCCTA CCTCACACAA GAAGCCAGAG ACCTGCTTAA AAAGCTGCTA 960

AAACGGAATG CTGCTTCGCG GCTGGGAGCT GGCCCTGGAG ATGCAGAAGA AGTTAAGGCT 1020

CATCCTTTCT TTAGACATAT AAACTGGGAA GAGCTTCTGG CACGGAAAGT GGAGCCCCCT 1080

TTCAGGCCAT ATCTGCAATC TGATGATGAT GTGAGCCAGT TTGATTCAAA GTTTACGCGT 1140

CAGACACCTG TTGACAGCCC AGATGATTCA ACACTTAGTG AAAGTGCCAA CCAGGTCTTT 1200

CTGGGTTTTA CATATGTTGC CCCTTCTGTA CTTGAGAGCG TCAAGGAAAA GTTTTCATTC 1260

GAGCCAAAAA TTCGATCACC TCGCAGATTC ATTGGCAGCC CGAGGACACC TGTTAGGAGC 1320

AAAAGTTGT 1329

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 83    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  142

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +h fiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 143   KHSFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  202

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         ++g++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 203   QNGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  261

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 262   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  317

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk++ a+Rlga   +aee+k+h+f+

Q: 318   KLLKRNAASRLGAgpgDAEEVKAHPFF  344

         *************************97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHSFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QNGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240

NAASRLGAGP GDAEEVKAHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013