EKS-LAC-00294

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00294

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	413.3	5.9E-124	193	481	289

Status

Unreviewed

Ensembl Protein

ENSLACP00000013694

UniProt Accession

H3AVM3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000012052	ENSLACP00000013694	ENSLACT00000013791

Organism

Latimeria chalumnae

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

IDRGGKLAIY KVCLVSCCPG PGNGEAETRE CIYYNGSWEL DKTNHSGVER CEGEKDKRLH 60

CYASWRNNSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VFFCCCEGNY CNEKFTHLPE 120

VTRPEVTFEP PPPTPSLLNI LVYSLLPIAG FSMAILLAFW MYRHRKPPYG HVDLNEQDPG 180

LPPPSPLVGL KPLQLIEIRA RGRFGCVWKA QLMNEYVAVK IFPIQDKQSW QSEREIFNTP 240

GMKHENLLQF IAAEKRGTNL EMELWLITAF HEKGSLTDFL KGNVINWNEL CHIAETMACG 300

LAYLHEDVPR CKGEGHKPAI AHRDFKSKNV LMKNDLTAVL ADFGLAVRFE PGKPPGDTHG 360

QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELV LRCTASDGPV DEYMLPFEEE 420

IGQHPSLEDL QEVVVHKKMR PSVKEHWLKH PGIAQLCETI EECWDHDAEA RLSAGCVEER 480

ISQIRRLVNG TTSDCLVSVV TSVTNVDLPP KESSI 515

Nucleotide Sequence
(FASTA)

ATTGATCGGG GTGGCAAGCT GGCAATATAC AAGGTATGCT TAGTTTCATG TTGTCCAGGT 60

CCTGGGAATG GGGAGGCGGA GACCAGAGAG TGTATCTATT ACAATGGAAG CTGGGAACTG 120

GACAAGACGA ACCACAGCGG GGTGGAGCGC TGTGAGGGTG AGAAGGACAA ACGGCTCCAC 180

TGCTACGCTT CCTGGCGCAA TAACTCGGGT ACCATTGAGC TGGTTAAGAA GGGATGTTGG 240

CTGGATGACT TCAACTGCTA TGACAGGCAG GAGTGTGTAG CTACAGAAGA GAACCCACAA 300

GTGTTTTTCT GCTGCTGTGA GGGGAATTAC TGCAATGAGA AATTCACTCA TTTACCTGAA 360

GTAACCAGGC CAGAAGTTAC ATTTGAGCCG CCTCCTCCAA CTCCCTCTCT GCTGAACATC 420

CTGGTTTACT CCTTGCTTCC TATTGCTGGC TTCTCCATGG CCATCTTGCT GGCCTTCTGG 480

ATGTACCGGC ATCGCAAGCC TCCGTATGGG CATGTTGACC TGAATGAGCA GGACCCTGGA 540

TTGCCACCTC CATCTCCTCT CGTTGGCCTA AAGCCCTTGC AGTTAATAGA AATCAGGGCC 600

AGGGGGCGCT TTGGTTGTGT CTGGAAGGCC CAGTTGATGA ACGAATACGT AGCTGTGAAA 660

ATATTCCCCA TACAGGATAA ACAGTCCTGG CAGAGTGAGA GAGAGATCTT CAACACCCCT 720

GGGATGAAGC ATGAAAACCT CCTGCAGTTC ATTGCAGCGG AGAAACGAGG CACAAACCTG 780

GAGATGGAAC TGTGGCTCAT TACAGCTTTC CATGAGAAGG GTTCCTTGAC CGATTTCCTG 840

AAGGGGAATG TTATTAACTG GAATGAACTC TGCCACATAG CGGAGACCAT GGCTTGTGGG 900

TTGGCTTACC TGCATGAAGA TGTCCCCAGG TGTAAGGGTG AAGGGCATAA ACCAGCCATA 960

GCGCACAGAG ACTTCAAGAG TAAAAATGTT TTGATGAAAA ATGATCTGAC AGCTGTTTTA 1020

GCAGACTTCG GACTTGCTGT ACGGTTTGAG CCTGGGAAGC CCCCAGGAGA CACTCATGGA 1080

CAGGTGGGCA CACGGAGATA CATGGCTCCA GAGGTACTAG AAGGAGCCAT CAACTTCCAG 1140

CGAGATGCCT TCTTGAGAAT AGACATGTAC GCCATGGGGC TGGTACTGTG GGAGCTGGTG 1200

CTGCGGTGCA CAGCAAGTGA TGGCCCTGTC GATGAGTACA TGTTGCCATT TGAAGAGGAG 1260

ATTGGCCAGC ACCCCTCACT GGAGGATCTA CAGGAAGTGG TTGTCCACAA GAAAATGCGT 1320

CCATCTGTTA AGGAACACTG GCTGAAACAC CCTGGTATCG CACAGTTGTG TGAAACGATT 1380

GAAGAATGCT GGGACCATGA CGCAGAGGCT CGACTCTCAG CGGGCTGTGT GGAGGAGCGC 1440

ATCTCCCAGA TCCGCAGATT GGTGAACGGC ACTACCTCGG ACTGCCTAGT TTCTGTGGTG 1500

ACCTCTGTTA CCAATGTGGA CTTACCACCC AAAGAGTCCA GTATCTGA 1548

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+l+e+ ++Gr+g+Vwka+l++e+vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 193   LQLIEIRARGRFGCVWKAQLMNEYVAVKIFPIQDKQSWQSEREIFNTPGMKHENLLQFIA  252

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++hekgsL+d+Lk ++++++el+++a+++a+Gla+LHe+++ +k

Q: 253   AEKRGTNLEMELWLITAFHEKGSLTDFLKGNVINWNELCHIAETMACGLAYLHEDVPRCK  312

         **********************************************************99

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 313   GeGHKPAIAHRDFKSKNVLMKNDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  370

         989***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++ Rc+++d+ v+ey+lpfee++g++Psle+

Q: 371   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVLRCTASDGPVDEYMLPFEEEIGQHPSLED  429

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++evvv+kk+rP+++e+w k++ +++l++++eecWd+d+eaRl+a +v++r+

Q: 430   LQEVVVHKKMRPSVKEHWLKHPGIAQLCETIEECWDHDAEARLSAGCVEERI  481

         *************************************************985

Domain Sequence
(FASTA)

LQLIEIRARG RFGCVWKAQL MNEYVAVKIF PIQDKQSWQS EREIFNTPGM KHENLLQFIA 60

AEKRGTNLEM ELWLITAFHE KGSLTDFLKG NVINWNELCH IAETMACGLA YLHEDVPRCK 120

GEGHKPAIAH RDFKSKNVLM KNDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVLR CTASDGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPS VKEHWLKHPG IAQLCETIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013