EPS-LAC-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LAC-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	291.3	9.4E-87	23	293	271

Status

Unreviewed

Ensembl Protein

ENSLACP00000013891

UniProt Accession

H3AW71;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000012230	ENSLACP00000013891	ENSLACT00000013988
ENSLACG00000012230	ENSLACP00000013892	ENSLACT00000013989

Organism

Latimeria chalumnae

Functional Description

Protein Length

387

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLLYGLSSMQ GWRVEMEDAH TAVVGIPHGL ENWSFFAVYD 60

GHAGSRVANY CSKHLLEHIT NNEDFRGVKK AGSALEPTVE NVKSGIRSGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVAVMIS PEHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL REEDDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEITDDLEK VCNWVVDTCL HKGSRDNMSI VLVCFPNAPK 300

VSEEGVKKDA ELDKYLESRV EEVMEKSGEE GMPDLGHVMR ILSAENIANL PPGGGLASKR 360

CIIEAVYNRL NPHSDDDGGA GDLEDPW 387

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCAAAAACT GAGAAGCATA ATGCTCATGG TGCAGGAAAT 60

GGTCTGCTTT ATGGCCTCAG CAGTATGCAG GGATGGAGAG TGGAGATGGA AGATGCTCAC 120

ACAGCTGTTG TAGGTATTCC ACATGGCTTA GAAAACTGGT CCTTCTTTGC AGTTTATGAT 180

GGTCATGCAG GCTCTCGAGT AGCAAACTAT TGCTCAAAAC ACTTATTAGA ACACATCACA 240

AACAATGAAG ATTTCAGAGG TGTCAAAAAA GCTGGTTCTG CTCTTGAGCC AACAGTGGAG 300

AATGTGAAGA GCGGTATCAG GAGTGGGTTT TTGAAAATTG ATGAGTACAT GCGCAATTTT 360

TCTGACCTCA GAAATGGTAT GGACAGGAGT GGTTCCACAG CAGTGGCAGT AATGATTTCT 420

CCAGAGCACA TTTACTTTAT CAACTGTGGT GATTCACGGG CAGTTCTGTA CAGGAATGGA 480

CAAGTCTGCT TTTCAACACA AGATCACAAA CCATGCAACC CCAGGGAGAA GGAGCGAATT 540

CAGAATGCAG GAGGAAGTGT AATGATCCAG CGAGTTAATG GGTCACTTGC AGTTTCTCGA 600

GCCTTGGGGG ACTATGATTA TAAATGTGTG GATGGCAAAG GCCCCACAGA GCAGCTGGTT 660

TCTCCTGAGC CTGAGGTCTA TGAAATTTTA AGAGAAGAGG ATGATGAGTT TATTATCCTG 720

GCTTGTGATG GAATATGGGA TGTGATGAGC AATGAGGAGC TCTGCGAGTT TGTTAAATCA 780

AGGCTTGAGA TCACAGATGA TCTGGAGAAA GTATGCAATT GGGTAGTAGA TACCTGTTTA 840

CATAAGGGAA GTCGTGATAA CATGAGCATC GTATTAGTAT GTTTCCCAAA TGCCCCTAAA 900

GTCTCTGAAG AGGGAGTGAA AAAGGATGCA GAGCTGGACA AGTATTTGGA ATCACGTGTT 960

GAAGAAGTTA TGGAAAAGTC TGGTGAGGAG GGTATGCCTG ATCTTGGTCA TGTAATGCGC 1020

ATCCTGTCAG CTGAAAACAT CGCTAATTTA CCCCCTGGAG GAGGCCTGGC TAGCAAGCGC 1080

TGCATTATTG AAGCAGTCTA TAATCGTCTG AATCCACATA GTGATGATGA TGGGGGTGCT 1140

GGTGATCTTG AAGACCCTTG GTAG 1164

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         l+g++s++g+r emeda+t++ ++    e   +++ff+vyDGh+gs+va++cs++l e++

Q: 23    LYGLSSMQGWRVEMEDAHTAVVGIPHGLE---NWSFFAVYDGHAGSRVANYCSKHLLEHI  79

         589***************98655554444...4***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TNNEDfrgvkkagsALEPTVENVKSGIRSGFLKIDEYMRNFSDLRNGMDRSGSTAVAVMI  139

         ***99********999********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPEHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ ++++def+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILREEDDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEITDDLEKVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

LYGLSSMQGW RVEMEDAHTA VVGIPHGLEN WSFFAVYDGH AGSRVANYCS KHLLEHITNN 60

EDFRGVKKAG SALEPTVENV KSGIRSGFLK IDEYMRNFSD LRNGMDRSGS TAVAVMISPE 120

HIYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRE EDDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EITDDLEKVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013