EKS-LAC-00191

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00191

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	482.3	3.4E-145	44	298	255

Status

Unreviewed

Ensembl Protein

ENSLACP00000014312

UniProt Accession

H3AXE1;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000012597	ENSLACP00000014312	ENSLACT00000014412

Organism

Latimeria chalumnae

Functional Description

Protein Length

351

Protein Sequence
(FASTA)

MGNAATAKKG NEIESVKEFL AKAKEDFLRK WECPPQSTAC LDDFERQKTL GTGSFGRVML 60

VKHKTTEVYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV 120

MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY 180

IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 240

ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RYGNLKNGVN DIKNHKWFAT 300

TDWIAIYQRK VEAPFIPKCR SPGDTSNFDD YEEEDIRVSI TEKCAKEFAE F 351

Nucleotide Sequence
(FASTA)

ATGGGAAACG CTGCTACCGC CAAGAAAGGC AACGAGATCG AGAGTGTGAA AGAGTTCTTA 60

GCCAAAGCCA AAGAAGATTT CTTACGAAAA TGGGAGTGTC CACCACAGAG CACTGCCTGC 120

CTAGATGATT TTGAGCGGCA AAAAACCCTT GGAACAGGTT CTTTTGGGAG GGTCATGCTG 180

GTGAAACATA AAACCACAGA AGTATACTAC GCCATGAAGA TACTGGATAA GCAGAAGGTT 240

GTCAAACTGA AGCAGATAGA GCACACGTTG AACGAAAAGA GAATATTACA AGCAGTGAAC 300

TTTCCATTTC TAGTAAGATT GGAGTATGCA TTTAAGGACA ACTCAAATTT ATATATGGTG 360

ATGGAATATG TTCCTGGTGG TGAAATGTTC TCACATCTTA GAAGAATTGG AAGGTTCAGC 420

GAACCCCATG CACGGTTCTA TGCAGCTCAG ATAGTACTTA CATTTGAGTA CCTCCATTCG 480

TTAGACCTCA TCTACAGAGA CCTGAAGCCT GAAAACCTTT TAATTGATCA ACAAGGGTAC 540

ATCCAGGTCA CAGACTTTGG TTTTGCCAAA AGGGTAAAAG GAAGAACTTG GACATTGTGT 600

GGAACTCCAG AATACTTGGC TCCAGAGATT ATACTCAGTA AGGGTTATAA CAAAGCAGTG 660

GATTGGTGGG CATTAGGTGT TCTAATCTAT GAAATGGCAG CTGGCTACCC CCCATTCTTT 720

GCAGATCAGC CTATTCAGAT TTATGAAAAA ATTGTCTCCG GAAAGGTACG GTTTCCTTCT 780

CACTTCAGTT CAGACTTAAA GGACTTGCTG AGGAATTTGC TCCAAGTGGA CTTGACAAAA 840

CGATATGGAA ACCTCAAGAA TGGTGTGAAT GACATTAAGA ACCACAAGTG GTTTGCTACT 900

ACAGACTGGA TTGCCATCTA TCAGAGAAAG GTTGAAGCTC CATTCATACC AAAGTGTAGA 960

AGCCCTGGAG ACACCAGCAA CTTTGATGAC TATGAAGAGG AAGATATCCG TGTTTCGATT 1020

ACAGAAAAAT GTGCGAAAGA GTTTGCAGAA TTTTAG 1056

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv+lv++k+++ yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 44    FERQKTLGTGSFGRVMLVKHKTTEVYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  103

         7899********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv+l+++fkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 104   LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  163

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 164   IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  223

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 224   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYG  283

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 284   NLKNGVNDIKNHKWF  298

         **************9

Domain Sequence
(FASTA)

FERQKTLGTG SFGRVMLVKH KTTEVYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDQQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRYG 240

NLKNGVNDIK NHKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013