EKS-LAC-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	435.6	5.8E-131	248	497	250

Status

Unreviewed

Ensembl Protein

ENSLACP00000014811

UniProt Accession

H3AYU0;

Protein Name

Protein Synonyms/Alias

Gene Name

LCK

Gene Synonyms/Alias

LCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000013039	ENSLACP00000014811	ENSLACT00000014915

Organism

Latimeria chalumnae

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCNCSSDYD DEWIENIDEI CEHCNCPYPP ESKPQVGVRQ NGTRAEVFDP LVPYERQTPP 60

CSPLPDNLVV ALYNYEPAHD GDLGFQEGEK LQILEESGEW WRALSLTTGN EGFIPYNFVA 120

KFNSLETEPW FFKDIGRKDA ERQLLAPGNM QGSFLVRESE TTKGSFSLSV RDLDQSQGEV 180

VKHYKIRNMD NGGFYISPRI TFKSLTDLVH HYQGGSDGLC SRLSKPCQTQ KPQKPWWQDE 240

WEIPRENLKL IEKLGAGQFG EVWMGFYNGH TKVAIKNLKQ GSMSPSAFLA EANMMKNLQH 300

AKLVRLYAVV TEEPIYIVTE YMEKGSLVDF LKTSEGSRQT TTTLIDMSAQ IAEGMAFIEH 360

KNYIHRDLRA ANILVSESLS CKIADFGLAR LIEDNEYTAR EGAKFPIKWT APEAINYGTF 420

TIKSDVWSFG ILLTEIITYG RIPYPGMSNP EVIQNLERGY RMPQPDNCPE ELYEVMMRCW 480

REKPEERPTF EYLQSVLEDF FTATEAQYQQ EP 512

Nucleotide Sequence
(FASTA)

ATGGGCTGTA ACTGCAGTTC AGACTATGAT GATGAGTGGA TTGAGAATAT TGATGAAATC 60

TGCGAGCATT GTAACTGCCC CTATCCACCA GAAAGCAAAC CACAGGTAGG AGTTAGACAA 120

AATGGGACCA GGGCAGAAGT GTTTGATCCG CTGGTTCCCT ATGAAAGACA GACTCCACCT 180

TGCTCTCCGC TTCCAGATAA CTTGGTGGTT GCTCTCTATA ACTATGAACC TGCTCATGAT 240

GGGGACCTTG GATTTCAGGA AGGGGAAAAA CTCCAGATAC TGGAAGAGAG CGGAGAATGG 300

TGGCGAGCGC TGTCTCTCAC CACGGGAAAT GAGGGCTTCA TCCCTTACAA CTTTGTGGCC 360

AAGTTCAATT CCCTGGAGAC AGAACCGTGG TTCTTTAAAG ACATCGGCCG GAAGGATGCA 420

GAAAGGCAGC TCCTTGCACC GGGTAACATG CAGGGCTCTT TCCTAGTCAG GGAGAGTGAA 480

ACCACTAAAG GTTCTTTCTC GCTATCGGTG AGAGACCTTG ACCAGTCCCA AGGAGAAGTG 540

GTGAAACACT ACAAGATACG AAACATGGAT AATGGAGGCT TCTACATATC ACCAAGAATA 600

ACCTTCAAAA GCCTCACGGA TCTTGTACAC CATTACCAAG GGGGTTCGGA TGGCTTGTGC 660

AGTCGCCTGT CCAAACCCTG CCAGACTCAA AAGCCCCAGA AGCCATGGTG GCAGGATGAG 720

TGGGAGATTC CTCGAGAAAA CCTAAAGCTG ATAGAGAAGT TGGGAGCAGG GCAGTTTGGA 780

GAAGTCTGGA TGGGCTTCTA CAATGGACAC ACCAAAGTGG CGATTAAAAA CCTGAAACAA 840

GGTAGCATGT CTCCGAGTGC CTTCTTGGCC GAGGCGAACA TGATGAAGAA CCTTCAGCAT 900

GCCAAGCTGG TGAGGTTGTA TGCGGTGGTG ACGGAGGAAC CCATCTACAT CGTTACAGAA 960

TACATGGAAA AAGGCAGCCT GGTGGATTTC CTGAAGACTT CAGAAGGATC CAGGCAGACG 1020

ACCACTACAC TCATTGACAT GTCAGCGCAG ATTGCAGAAG GCATGGCTTT TATTGAACAT 1080

AAGAACTATA TTCATCGAGA TCTACGAGCT GCCAACATCC TGGTCTCAGA AAGTCTCAGC 1140

TGTAAGATTG CTGATTTTGG ACTAGCTAGG CTGATTGAAG ACAATGAGTA CACAGCGAGA 1200

GAGGGAGCCA AATTCCCCAT CAAGTGGACA GCGCCCGAGG CAATCAACTA CGGCACCTTC 1260

ACAATAAAAT CGGACGTTTG GTCATTTGGA ATCCTGCTGA CAGAGATCAT CACGTACGGA 1320

AGGATACCAT ATCCAGGGAT GAGTAACCCA GAAGTGATTC AAAACCTGGA GCGTGGTTAC 1380

CGCATGCCGC AACCCGACAA CTGCCCTGAA GAGCTGTATG AGGTGATGAT GCGCTGCTGG 1440

CGGGAAAAGC CGGAGGAACG TCCCACCTTT GAGTATCTGC AGAGTGTCTT GGAGGACTTC 1500

TTTACTGCCA CTGAAGCACA GTACCAGCAG GAGCCCTAA 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl++klG+GqfGevw+g ++g++kva+k lk+g++sp+afl+ea+++k+l+h klv+ly

Q: 248   LKLIEKLGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSPSAFLAEANMMKNLQHAKLVRLY  307

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv+e ePiyivte+m+kGsl+dflk++eg++++ ++l+d++aq+aeGma++e+kn+ihr

Q: 308   AVVTE-EPIYIVTEYMEKGSLVDFLKTSEGSRQTTTTLIDMSAQIAEGMAFIEHKNYIHR  366

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+esl +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANILVSESLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGilltei+t+G++PypGm+n ev++++ergyr+p+p++cpeelye++++cw+++pee

Q: 427   WSFGILLTEIITYGRIPYPGMSNPEVIQNLERGYRMPQPDNCPEELYEVMMRCWREKPEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq+vl

Q: 487   RPTFEYLQSVL  497

         ********986

Domain Sequence
(FASTA)

LKLIEKLGAG QFGEVWMGFY NGHTKVAIKN LKQGSMSPSA FLAEANMMKN LQHAKLVRLY 60

AVVTEEPIYI VTEYMEKGSL VDFLKTSEGS RQTTTTLIDM SAQIAEGMAF IEHKNYIHRD 120

LRAANILVSE SLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180

SFGILLTEII TYGRIPYPGM SNPEVIQNLE RGYRMPQPDN CPEELYEVMM RCWREKPEER 240

PTFEYLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013