EKS-LAC-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	428.2	8.7E-129	194	437	244

Status

Unreviewed

Ensembl Protein

ENSLACP00000014862

UniProt Accession

H3AYZ1;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000013081	ENSLACP00000014862	ENSLACT00000014966

Organism

Latimeria chalumnae

Functional Description

Protein Length

447

Protein Sequence
(FASTA)

FLQKVWAPGT QCIAKCDHTK PKKQELSFRK GDILTIVCDG ESKGAYKAKH NKTGEEGLVS 60

ASSVREREAI RIDPKLSLMP WFHGKISGQD AVQLLQPPED GLFLVRESIR HPGDYVLCVC 120

FQKEVIHYRV IYQENQLTID EAISFHNLID MIEYYMKNKG AICTILSKPK RKAGTKSAEE 180

ELSKGGWLLD MHLLKLGDAI GEGEFGAVLQ GEYMGQKVAV KNIKCDVTAQ AFLAETTVMT 240

KVQHKNLVRL LGVILNNGLY IVTEFMAKGN LVNHLRTRGR SVITVHHLIQ FAFDVCEGME 300

YLESKKLVHR DLAARNILVS EDNVAKVSDF GLAKVDLKKN DNAKLPVKWT APEALKQNKL 360

SNKSDVWSYG ILLWEIFSYG RTPYPKMSLK DVTEQVEKGY RMASPEECPP SIYVLMKSCW 420

EADPGKRPSF KKLKEKLEKE LRTAGSL 447

Nucleotide Sequence
(FASTA)

TTCCTGCAGA AAGTCTGGGC CCCTGGTACA CAATGTATAG CGAAATGTGA CCACACCAAA 60

CCCAAAAAGC AGGAACTATC ATTTCGGAAG GGAGATATCC TTACTATTGT GTGTGATGGT 120

GAAAGCAAAG GAGCATACAA AGCAAAGCAT AACAAAACTG GAGAAGAGGG CTTGGTATCA 180

GCCAGTTCGG TAAGGGAGCG AGAGGCCATC AGAATAGATC CTAAACTCAG TTTAATGCCC 240

TGGTTTCACG GAAAGATCTC CGGTCAAGAT GCAGTACAAC TTCTCCAGCC TCCTGAAGAC 300

GGCCTCTTCT TGGTCCGAGA GTCCATCCGG CATCCCGGTG ACTACGTCCT GTGTGTCTGT 360

TTCCAAAAGG AGGTTATTCA CTATCGAGTA ATCTACCAAG AGAACCAACT TACCATCGAT 420

GAAGCGATCT CCTTCCACAA CCTCATTGAC ATGATTGAGT ACTACATGAA AAACAAAGGC 480

GCCATCTGTA CGATCCTAAG CAAACCCAAG CGGAAAGCAG GCACTAAGTC AGCAGAAGAA 540

GAGCTGTCCA AAGGTGGCTG GTTACTTGAT ATGCACCTGT TAAAACTGGG GGATGCAATT 600

GGAGAGGGAG AATTTGGAGC CGTGCTGCAA GGTGAATACA TGGGACAGAA AGTTGCGGTA 660

AAAAACATCA AGTGTGATGT CACTGCGCAA GCTTTTCTAG CTGAAACTAC TGTTATGACA 720

AAAGTGCAGC ACAAGAATCT GGTGAGGTTA CTAGGGGTCA TTCTAAATAA CGGCCTGTAC 780

ATCGTGACCG AGTTTATGGC CAAGGGTAAT CTGGTAAACC ACCTCCGGAC TCGTGGGAGA 840

TCGGTCATTA CGGTCCATCA CCTTATCCAG TTCGCTTTTG ATGTCTGTGA AGGCATGGAG 900

TACCTTGAGT CTAAAAAACT AGTGCACAGG GACCTGGCAG CCCGAAACAT CCTGGTTTCT 960

GAGGACAACG TGGCGAAAGT CAGTGACTTT GGGCTGGCCA AAGTGGACCT GAAAAAGAAT 1020

GACAATGCAA AGCTTCCGGT AAAATGGACA GCGCCAGAGG CTCTCAAGCA AAACAAACTC 1080

TCCAACAAGT CCGACGTTTG GAGCTATGGG ATTCTTCTGT GGGAAATCTT CTCTTACGGC 1140

AGGACACCTT ATCCCAAGAT GTCTCTGAAA GATGTGACGG AGCAAGTGGA GAAAGGGTAT 1200

CGCATGGCAT CTCCTGAAGA ATGCCCGCCT TCCATCTACG TTCTCATGAA AAGCTGCTGG 1260

GAGGCTGATC CAGGCAAACG GCCTTCCTTC AAGAAGCTAA AGGAGAAACT GGAGAAGGAG 1320

TTGAGGACTG CTGGGTCTTT ATAG 1344

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lklg++ig+gefg+vl+gey g+kvavk+ik+d+taqafl+e++vmtk++h+nlv+llgv

Q: 194   LKLGDAIGEGEFGAVLQGEYMGQKVAVKNIKCDVTAQAFLAETTVMTKVQHKNLVRLLGV  253

         689*********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+vte++akg+lv++lr+rgr++++ ++l++fa+dv+egmeyleskklvhrdl

Q: 254   ILNN-GLYIVTEFMAKGNLVNHLRTRGRSVITVHHLIQFAFDVCEGMEYLESKKLVHRDL  312

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsed+vakvsdfglak + k++d +klpvkwtapealk++k+s+ksdvws+gil

Q: 313   AARNILVSEDNVAKVSDFGLAKVDLKKNDNAKLPVKWTAPEALKQNKLSNKSDVWSYGIL  372

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lweifs+gr pyp+++lkdv+++vekgy+m +pe cpp++y lmk++we+++ krpsf+k

Q: 373   LWEIFSYGRTPYPKMSLKDVTEQVEKGYRMASPEECPPSIYVLMKSCWEADPGKRPSFKK  432

         ************************************************************

S: 241   lkekl  245

         lkekl

Q: 433   LKEKL  437

         ***97

Domain Sequence
(FASTA)

LKLGDAIGEG EFGAVLQGEY MGQKVAVKNI KCDVTAQAFL AETTVMTKVQ HKNLVRLLGV 60

ILNNGLYIVT EFMAKGNLVN HLRTRGRSVI TVHHLIQFAF DVCEGMEYLE SKKLVHRDLA 120

ARNILVSEDN VAKVSDFGLA KVDLKKNDNA KLPVKWTAPE ALKQNKLSNK SDVWSYGILL 180

WEIFSYGRTP YPKMSLKDVT EQVEKGYRMA SPEECPPSIY VLMKSCWEAD PGKRPSFKKL 240

KEKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013