EKS-LAC-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	472.6	3.7E-142	1082	1342	261

Status

Unreviewed

Ensembl Protein

ENSLACP00000015263

UniProt Accession

H3B042;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000013435	ENSLACP00000022430	ENSLACT00000026536
ENSLACG00000013435	ENSLACP00000015263	ENSLACT00000015369

Organism

Latimeria chalumnae

Functional Description

Protein Length

1385

Protein Sequence
(FASTA)

MKHLFLYSIW QLGLLWSLVQ KGHGQCEEAA NGPEMNLNVA YDLFNFLAEE PIQNVVIHNK 60

YVYVGAVNRI YSLTENLEKL FEYKTGPILE GSDCLPCEGC SKHKGNSTVI GVWKDNVNMA 120

LLLETFYEDQ LISCGSANQG VCQRHVLHPD NFANISAHVS CLYSSQVDKS QNYADYVISP 180

LGTKVLAITR DKLVKFFVGN TVNSSLQQSN LHSVSVRTLK EMQNGFEFPS DRSYMDVITT 240

MKNSYPIKYI YAFESNSFVY FLTVQGESPD SQAFHTRIIR VCSSDNEMRS YVEMPFECIF 300

TEKRRKRAIK TDTFNILQAA HVSKPGAALA KEMGIAPDED VLFGVFSQSK LDSPEPTKTS 360

AVCAVGIKTI NELFNKRIEE CNTKHIYHFD NKDSKFCLNK VKLLNQSGRC DEKSEEYRME 420

ITIPFQRLDL FMGMFSNVLL TSVAVFTQGK LTVANLGTSE GRVMQVVISR TVQKKPHVNF 480

QLHLDPVSPQ VAIGRPSEHD GYALVITGKK LTKVPLSGPG CDHFKSCSKC LTAPDFMQCG 540

WCSNQCSRQQ ECVNREWIPN TCPPTVFKLS PSTAPLEGGT RVSICGLDFG FKKTGRFELT 600

QIGVVIGERT CKLETKNCTK NRLICIVGAS NSTSNVSFKV SNGNRSSQMH VFSYKNPEVT 660

SISPAYGPKS GGTILTLTGK YLDIGNLREV SVGRKVCILK RLSDTVIECT TPAQSNLDEY 720

PVKIKIDAAE RKADTLFTYK EDPSVVTIQP TNSFFSGGGT ITVHGRNLNS VSSPQMVITL 780

PQQGKEFKVT CTKRNELQLV CCTTPSLQGL NLVLPFTSKV SFILDGVTTG HFDLSYVGNP 840

MFEPFQKPKV ITKSSNNKLE IEISGVDSEA VKGEVLKVGN KSCENIQLTS SSIICTVPTE 900

LLKSNSELNV EWKQANSSIL IGKVMVVEDQ NFTGLIAGAI CATGLLLLLL GLFIWFRKRK 960

QFKVFHKLGS EIVRYDGKVH TPHLDRLVSA RSVSPTAEMV SSESVDYRTT LPEDQFQTFA 1020

QNGLCRQVQY PHTDLSPILS SGDSDLSSPL LQTNVHIDVS TLNPELLKEV QHVVITSDNL 1080

LVHFTEVIGR GHFGCVYHGT LLDNEGRKVH CAVKSLNRIT DIEEVAQFLK EGIIMKDFSH 1140

PNVLSLLGIC LPSEGSPLVV LPYMKHGDLR NFIRNESHNP TVKDLIGFGL QVAKGMEYLA 1200

SKKFVHRDLA ARNCMLDDKF TVKVADFGLA RDVYEKEYYS VHNKNGAKLP VKWMALESLQ 1260

TQKFTTKSDV WSFGVMLWEL MTRGTPPYPD ISSFDITVFL LQGRRLLQPE YCPDSLYEVM 1320

LKCWHPKPEM RPTFSDLVSR ISTIFSTFIG EHYVLLNATY VNIKCVTPYP PLLSCQDDLG 1380

KDLST 1385

Nucleotide Sequence
(FASTA)

ATGAAGCACC TTTTCTTATA CTCTATATGG CAGCTTGGAC TACTATGGAG TCTGGTGCAG 60

AAGGGCCATG GACAGTGTGA AGAAGCAGCA AATGGACCAG AGATGAACTT AAATGTAGCA 120

TACGATCTCT TCAACTTTTT AGCAGAAGAA CCTATACAGA ATGTGGTGAT ACACAATAAA 180

TATGTGTATG TTGGAGCAGT AAACAGGATT TATTCTTTGA CCGAAAACCT TGAAAAACTC 240

TTTGAATACA AGACTGGGCC AATTTTGGAA GGCTCTGATT GTTTACCATG TGAAGGTTGT 300

AGTAAACATA AAGGCAATTC AACAGTGATT GGTGTTTGGA AAGATAATGT AAATATGGCT 360

CTGCTTCTTG AGACTTTTTA TGAGGATCAG CTTATTAGCT GTGGAAGTGC AAACCAAGGT 420

GTATGTCAGC GCCATGTTCT CCATCCTGAT AATTTTGCAA ATATAAGTGC TCATGTTTCA 480

TGTTTATATT CTTCACAGGT TGATAAGTCA CAGAATTATG CAGATTATGT AATAAGCCCT 540

TTGGGAACTA AAGTACTTGC CATCACAAGA GATAAATTAG TGAAATTTTT TGTGGGGAAT 600

ACAGTTAACT CTTCGCTGCA GCAGTCTAAT CTACATTCTG TGTCTGTGAG AACTTTAAAA 660

GAAATGCAAA ACGGGTTTGA GTTTCCCTCT GATCGGTCAT ATATGGATGT CATAACAACA 720

ATGAAGAACT CATACCCCAT TAAATACATC TATGCCTTTG AAAGTAATTC TTTTGTATAC 780

TTTCTGACAG TGCAGGGTGA ATCTCCTGAC TCACAGGCTT TCCACACCAG AATTATAAGA 840

GTATGTTCCT CAGATAATGA GATGCGTTCC TATGTAGAAA TGCCATTTGA GTGTATTTTC 900

ACTGAAAAGC GAAGAAAGAG AGCCATAAAA ACAGACACTT TTAACATTTT GCAGGCTGCA 960

CATGTAAGCA AACCAGGTGC AGCTCTTGCA AAGGAAATGG GAATTGCACC TGATGAAGAT 1020

GTGCTATTTG GGGTATTTTC TCAAAGTAAG CTGGATTCCC CTGAGCCAAC AAAAACATCA 1080

GCTGTCTGTG CTGTTGGGAT TAAAACAATC AATGAATTAT TCAATAAGAG GATAGAAGAA 1140

TGCAATACAA AGCATATATA CCACTTTGAC AACAAGGATA GCAAATTTTG TCTTAACAAG 1200

GTAAAATTGT TGAACCAAAG CGGTAGATGT GATGAAAAAA GTGAGGAGTA CCGGATGGAA 1260

ATTACAATAC CTTTTCAACG TCTTGACTTG TTCATGGGCA TGTTCAGTAA TGTTTTGTTG 1320

ACCTCAGTTG CTGTCTTTAC CCAAGGGAAG CTGACAGTTG CCAACCTAGG AACATCTGAA 1380

GGACGTGTAA TGCAGGTGGT CATTTCCCGA ACAGTACAAA AGAAGCCTCA TGTAAATTTT 1440

CAGCTACATT TAGATCCTGT GTCCCCTCAA GTTGCTATTG GAAGACCTTC TGAACATGAT 1500

GGATATGCAC TTGTTATTAC TGGGAAAAAG CTGACAAAAG TCCCTTTATC TGGCCCTGGG 1560

TGTGATCATT TTAAATCCTG CAGCAAATGT CTTACAGCCC CAGACTTCAT GCAGTGTGGG 1620

TGGTGCAGTA ATCAATGTTC CAGACAGCAA GAGTGTGTTA ATAGGGAGTG GATCCCAAAT 1680

ACCTGCCCAC CTACAGTTTT TAAGCTTTCC CCCTCAACTG CTCCTTTAGA GGGTGGAACA 1740

AGAGTGTCAA TTTGTGGATT AGACTTTGGC TTCAAAAAAA CTGGAAGATT TGAGCTAACA 1800

CAAATTGGAG TTGTTATTGG AGAGAGAACT TGCAAACTGG AAACAAAAAA TTGCACAAAA 1860

AACAGGTTGA TATGTATTGT TGGGGCTTCA AACAGCACAA GTAATGTATC CTTTAAGGTT 1920

TCAAATGGGA ATCGTAGCAG TCAAATGCAT GTTTTCTCCT ATAAGAATCC AGAAGTCACA 1980

AGCATCTCTC CAGCTTATGG CCCAAAATCA GGAGGCACAA TATTAACCCT TACTGGAAAA 2040

TACTTAGATA TTGGAAACTT AAGGGAAGTT TCTGTGGGAA GAAAAGTTTG CATCTTAAAA 2100

CGTTTATCTG ACACAGTTAT TGAGTGTACC ACCCCAGCAC AGAGCAATCT CGATGAGTAT 2160

CCAGTTAAAA TAAAAATTGA TGCAGCAGAG CGCAAAGCTG ACACACTCTT TACGTACAAA 2220

GAAGACCCCA GTGTTGTGAC AATTCAACCA ACAAATTCTT TTTTCAGTGG TGGAGGCACC 2280

ATTACAGTTC ATGGCAGAAA CCTGAATTCA GTTTCTTCAC CACAGATGGT GATTACTTTA 2340

CCACAACAGG GAAAAGAATT CAAAGTGACA TGTACAAAGA GGAATGAGCT GCAATTGGTC 2400

TGCTGTACCA CACCCTCACT ACAGGGCCTC AACCTTGTGC TACCTTTTAC ATCAAAGGTT 2460

TCTTTCATTC TTGATGGAGT AACTACAGGC CACTTTGACT TGTCATATGT GGGCAATCCC 2520

ATGTTTGAAC CTTTTCAAAA GCCAAAAGTA ATCACCAAGA GTTCCAATAA TAAACTGGAG 2580

ATAGAGATTA GTGGTGTTGA TTCAGAAGCT GTCAAAGGGG AAGTACTGAA AGTTGGCAAT 2640

AAAAGCTGTG AAAATATCCA GCTAACATCA AGCTCAATTA TCTGTACAGT ACCTACAGAG 2700

CTCTTGAAGA GTAACAGTGA ACTGAATGTA GAGTGGAAGC AAGCTAATTC ATCGATTTTA 2760

ATAGGAAAGG TTATGGTGGT TGAAGATCAG AATTTCACTG GACTTATAGC TGGAGCCATT 2820

TGCGCAACAG GTTTACTTCT TTTACTGCTG GGGCTGTTTA TATGGTTTAG GAAGAGAAAG 2880

CAATTTAAAG TCTTTCATAA ATTAGGCAGC GAAATTGTTA GGTATGATGG AAAAGTACAC 2940

ACTCCCCATT TGGATAGACT TGTAAGTGCA CGGAGTGTTA GTCCAACTGC AGAGATGGTT 3000

TCAAGTGAAT CTGTGGACTA CAGGACAACT CTTCCTGAAG ATCAGTTTCA AACTTTTGCT 3060

CAGAATGGAT TATGTAGACA AGTTCAATAT CCTCATACAG ACTTGTCTCC TATTCTGTCT 3120

AGTGGAGACT CAGACTTATC CAGCCCTTTA CTGCAGACAA ATGTTCATAT TGATGTTAGC 3180

ACCCTGAACC CTGAACTGTT GAAGGAAGTT CAACATGTGG TCATAACCTC TGATAACCTA 3240

CTAGTTCATT TCACAGAGGT GATAGGAAGA GGACATTTTG GGTGTGTATA TCACGGAACA 3300

CTCTTGGATA ATGAGGGCAG GAAAGTACAT TGTGCTGTGA AATCCCTGAA CAGAATCACT 3360

GACATAGAAG AAGTGGCCCA GTTCCTGAAA GAAGGGATCA TCATGAAAGA TTTTAGTCAC 3420

CCTAATGTCC TCTCACTGTT GGGCATCTGT CTCCCCAGTG AAGGTTCCCC TCTGGTAGTG 3480

TTGCCATACA TGAAACATGG AGACCTGCGG AACTTCATCA GGAATGAGAG TCATAACCCA 3540

ACAGTAAAGG ATCTGATAGG ATTTGGGCTT CAAGTGGCAA AGGGAATGGA ATATCTAGCA 3600

AGTAAAAAGT TTGTTCATAG AGACCTGGCT GCACGAAACT GCATGTTAGA TGATAAATTT 3660

ACTGTGAAGG TTGCTGATTT TGGCCTTGCT AGGGATGTCT ATGAGAAAGA GTACTACAGT 3720

GTCCATAATA AAAATGGAGC AAAACTGCCA GTGAAATGGA TGGCCCTTGA GAGTTTACAG 3780

ACACAGAAGT TCACTACAAA GTCTGATGTG TGGTCCTTTG GAGTAATGCT TTGGGAATTA 3840

ATGACAAGAG GGACACCCCC TTATCCTGAT ATCAGTTCAT TTGATATAAC TGTGTTTTTA 3900

CTGCAAGGAC GAAGGCTGCT ACAGCCAGAA TACTGCCCAG ACTCACTGTA TGAAGTAATG 3960

TTGAAGTGCT GGCACCCTAA ACCTGAAATG CGACCAACAT TTTCTGATCT GGTTTCAAGA 4020

ATATCAACAA TTTTTTCCAC TTTTATTGGC GAGCACTATG TTCTCCTTAA TGCAACGTAT 4080

GTTAATATAA AATGCGTTAC TCCCTATCCA CCCCTTCTGT CATGTCAAGA TGATCTAGGC 4140

AAGGATCTAA GTACGTGA 4158

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v++ eviG+GhfG+vy+g+l+d++++k+++avksl+ritdie+v +fl+eg++mk+++hp

Q: 1082  VHFTEVIGRGHFGCVYHGTLLDNEGRKVHCAVKSLNRITDIEEVAQFLKEGIIMKDFSHP  1141

         7999********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgmeylas

Q: 1142  NVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRNESHNPTVKDLIGFGLQVAKGMEYLAS  1201

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ld+k+tvkvadfGlardv++ke+y+v+++++a+lpvkw+aleslqt

Q: 1202  KKFVHRDLAARNCMLDDKFTVKVADFGLARDVYEKEYYSVHNKNGAKLPVKWMALESLQT  1261

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGv+lwel+trg++py++++sfd+t++l +grrl +peycpd+ly+vm

Q: 1262  QK-FTTKSDVWSFGVMLWELMTRGTPPYPDISSFDITVFLLQGRRLLQPEYCPDSLYEVM  1320

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++kp++rp+fsdlvs+is

Q: 1321  LKCWHPKPEMRPTFSDLVSRIS  1342

         ********************98

Domain Sequence
(FASTA)

VHFTEVIGRG HFGCVYHGTL LDNEGRKVHC AVKSLNRITD IEEVAQFLKE GIIMKDFSHP 60

NVLSLLGICL PSEGSPLVVL PYMKHGDLRN FIRNESHNPT VKDLIGFGLQ VAKGMEYLAS 120

KKFVHRDLAA RNCMLDDKFT VKVADFGLAR DVYEKEYYSV HNKNGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVMLWELM TRGTPPYPDI SSFDITVFLL QGRRLLQPEY CPDSLYEVML 240

KCWHPKPEMR PTFSDLVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013