EKS-LAC-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	548.8	2.1E-165	386	662	277

Status

Unreviewed

Ensembl Protein

ENSLACP00000015391

UniProt Accession

H3B0H1;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000013549	ENSLACP00000015392	ENSLACT00000015498
ENSLACG00000013549	ENSLACP00000015391	ENSLACT00000015497

Organism

Latimeria chalumnae

Functional Description

Protein Length

730

Protein Sequence
(FASTA)

MFIWTNFIFW AVLVTVSLSA ARPALTLPED ALPSAEDDDD DDSSSEEKEE ASSNQEQYPV 60

PPFWAQPEKM EKKLHAVPAA KTVKFRCPAS GTPMPTLRWL KNGREFKPDQ RIGGYKVRYQ 120

TWSIIMDSVV PSDKGNYTCI VENKYGSINH TYQLDVVERS PHRPILQAGL PANKTVVLGS 180

NVEFSCRVYS DPQPHIQWLK HIEVNGSKID SSGQPYVQIL KNAGINTTDK EMEVLHLRNV 240

SFEDAGEYTC LAGNSIGISY HSAWLTVLQA TEKPGVASSP FYLEIVIYCV GAFIISIMIV 300

IVIIFKMKNT TKKPDFNSQL AVHKLAKSIP LRRQVTVSVN SNSSMNSGAM LVRPSRLSSS 360

GTPMLSGVSD NELPEDPRWE FPRDRLVLGK PLGEGCFGQV VMAEAIGLDK EKPNRVTKVA 420

VKMLKADATE KDLSDLISEM EMMKMMGKHK NIINLLGACT QDGPLYVIVE YAAKGNLREY 480

LRERRPPGME YCYNPNHVAE ELLSFKDLVS CAFQVARGME YLASKKCIHR DLAARNVLVT 540

EDNVMKIADF GLARDIHHID YYKKTTNGRL PVKWMAPEAL FDRIYTHQSD VWSFGVLLWE 600

IFTLGGSPYP GVPVEELFKL LKEGHRMDKP TNCTNELYMM MRDCWHAMPS HRPTFKQLVE 660

DLDRILAMSS NQEYLDLSMP VDQYSPSFPD TRSSTCSSGE DSVFSHDPLP DEPCLPKYPP 720

QHANGGFKKR 730

Nucleotide Sequence
(FASTA)

ATGTTCATCT GGACTAACTT CATCTTTTGG GCAGTGCTGG TCACAGTCTC ACTCTCCGCT 60

GCCCGGCCAG CACTCACCCT ACCTGAAGAT GCACTTCCTT CAGCTGAAGA CGACGATGAT 120

GATGATTCCT CCTCAGAAGA GAAAGAGGAA GCTTCAAGTA ACCAGGAGCA GTATCCAGTT 180

CCTCCATTTT GGGCTCAGCC AGAGAAGATG GAAAAGAAAC TCCATGCAGT TCCAGCAGCC 240

AAAACTGTCA AATTTCGTTG TCCTGCCAGT GGGACCCCGA TGCCAACACT GCGCTGGCTC 300

AAGAATGGCA GAGAGTTCAA ACCTGATCAG CGAATAGGGG GATACAAGGT TCGCTATCAA 360

ACATGGAGTA TCATTATGGA CTCGGTGGTA CCATCTGATA AGGGCAATTA CACTTGCATT 420

GTGGAGAACA AATATGGCAG CATCAACCAT ACCTACCAGC TTGATGTAGT TGAGCGTTCC 480

CCACATCGGC CCATTTTGCA AGCAGGGCTC CCCGCTAACA AAACTGTGGT GCTGGGCAGC 540

AATGTTGAAT TTTCCTGTCG GGTCTACAGT GACCCCCAGC CCCACATCCA GTGGCTAAAG 600

CATATTGAGG TGAATGGGAG CAAGATTGAC TCTAGCGGGC AACCATATGT CCAAATTCTT 660

AAGAATGCCG GAATTAACAC TACAGACAAG GAAATGGAAG TCCTCCACTT GAGGAATGTC 720

TCTTTTGAGG ACGCTGGGGA GTATACATGC TTGGCGGGTA ACTCTATTGG GATCTCCTAT 780

CACTCTGCAT GGTTGACAGT TCTTCAAGCT ACTGAGAAGC CAGGGGTTGC ATCCTCGCCC 840

TTCTACCTGG AGATTGTTAT TTACTGCGTG GGTGCCTTCA TCATCTCCAT CATGATTGTC 900

ATTGTTATCA TCTTCAAGAT GAAGAATACT ACCAAGAAAC CAGACTTCAA CAGCCAGCTG 960

GCTGTCCATA AACTGGCTAA GAGCATCCCC TTGCGCAGAC AGGTAACAGT GTCGGTGAAC 1020

TCCAACTCTT CCATGAATTC GGGGGCAATG CTTGTTAGAC CCTCACGGCT GTCTTCCAGT 1080

GGTACCCCAA TGTTATCTGG GGTGTCAGAT AATGAACTTC CAGAAGATCC AAGATGGGAA 1140

TTTCCTCGAG ACAGGCTGGT GCTGGGCAAG CCTCTTGGAG AGGGTTGCTT TGGTCAGGTT 1200

GTCATGGCAG AAGCAATTGG GTTAGACAAG GAGAAACCCA ACAGGGTAAC CAAAGTTGCT 1260

GTGAAAATGC TGAAAGCGGA TGCCACAGAA AAGGACTTAT CTGACCTGAT CTCTGAGATG 1320

GAGATGATGA AAATGATGGG GAAACACAAA AACATTATTA ATCTTCTGGG AGCTTGTACC 1380

CAAGATGGTC CCCTTTATGT GATTGTGGAG TATGCAGCCA AAGGAAACTT ACGGGAGTAC 1440

TTAAGAGAAC GACGCCCTCC AGGGATGGAA TATTGTTATA ACCCTAATCA TGTGGCTGAA 1500

GAACTGCTCT CTTTTAAAGA TCTTGTGTCA TGTGCTTTCC AGGTAGCAAG GGGAATGGAG 1560

TACCTGGCCT CAAAGAAGTG TATCCATAGA GATCTGGCTG CAAGAAATGT CTTGGTTACA 1620

GAAGACAATG TGATGAAGAT TGCTGATTTT GGTCTGGCCC GTGACATCCA CCACATAGAT 1680

TACTACAAAA AGACAACCAA TGGTCGATTA CCAGTGAAAT GGATGGCACC AGAAGCTTTG 1740

TTTGACAGAA TCTACACTCA CCAGAGTGAT GTTTGGTCCT TTGGAGTGTT GCTGTGGGAG 1800

ATCTTCACAC TGGGTGGATC TCCTTATCCT GGAGTGCCAG TAGAAGAGCT GTTTAAATTG 1860

CTGAAGGAGG GGCATAGAAT GGACAAACCC ACTAATTGTA CCAATGAACT GTACATGATG 1920

ATGAGGGATT GCTGGCATGC CATGCCATCC CATAGACCCA CTTTCAAACA GCTGGTGGAG 1980

GACCTGGACA GAATCCTTGC CATGTCATCA AATCAGGAAT ACCTGGATCT CTCCATGCCA 2040

GTGGACCAGT ATTCTCCCAG CTTTCCTGAT ACTCGCAGCT CCACCTGCTC CTCTGGAGAA 2100

GATTCTGTAT TTTCCCATGA TCCACTACCA GATGAGCCCT GTCTTCCCAA GTACCCACCA 2160

CAGCATGCCA ATGGTGGATT TAAAAAACGC TGA 2193

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+aeaigldk+k+++ ++vavkmlk dat+kdl+dl+seme++k+

Q: 386   LVLGKPLGEGCFGQVVMAEAIGLDKEKPNRVTKVAVKMLKADATEKDLSDLISEMEMMKM  445

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         +GkhkniinllGactq+GplyviveyaakGnlre+lr+rrp+g+e+++++++++ee l++

Q: 446   MGKHKNIINLLGACTQDGPLYVIVEYAAKGNLREYLRERRPPGMEYCYNPNHVAEELLSF  505

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+a+qvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 506   KDLVSCAFQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  565

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 566   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  625

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha +s+rptfkqlvedl

Q: 626   RMDKPTNCTNELYMMMRDCWHAMPSHRPTFKQLVEDL  662

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVMAEA IGLDKEKPNR VTKVAVKMLK ADATEKDLSD LISEMEMMKM 60

MGKHKNIINL LGACTQDGPL YVIVEYAAKG NLREYLRERR PPGMEYCYNP NHVAEELLSF 120

KDLVSCAFQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPTNCTN ELYMMMRDCW HAMPSHRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013