EKS-LAC-00473

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00473

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	430.3	3.5E-129	30	318	289

Status

Unreviewed

Ensembl Protein

ENSLACP00000015867

UniProt Accession

H3B1U6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK1

Gene Synonyms/Alias

MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000013972	ENSLACP00000015867	ENSLACT00000015977

Organism

Latimeria chalumnae

Functional Description

Protein Length

365

Protein Sequence
(FASTA)

MAAAAPGGSS NPTGTPETVR GQVFDVGPRY TNLSYIGEGA YGMVCSAHDN VNKVRVAIKK 60

ISPFEHQTYC QRTLREIKIL LRFKHENIIG INDIIRAPTI DQMKDVYIVQ DLMETDLYKL 120

LKTQHLSNDH ICYFLYQILR GLKYIHSANV LHRDLKPSNL LLNTTCDLKI CDFGLARVAD 180

PDHDHTGFLT EYVATRWYRA PEIMLNSKGY TKSIDIWSVG CILAEMLSNR PIFPGKHYLD 240

QLNHILGILG SPSQEDLNCI INVKARNYLL SLPHKNKVPW NKLFPNADLK ALDLLDKMLT 300

FNPHKRIEVE EALAHPYLEQ YYDPTDEPVA EEPFKFNMEL DDLPKEKLKE LIFEETARFQ 360

PGYQP 365

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CAGCTCCAGG CGGCTCTTCC AACCCCACCG GCACCCCGGA GACGGTGCGC 60

GGGCAGGTCT TCGACGTTGG TCCCCGCTAC ACCAACCTGT CGTACATCGG GGAGGGGGCC 120

TACGGCATGG TGTGTTCTGC CCATGACAAC GTGAATAAGG TTCGAGTAGC CATCAAAAAA 180

ATTAGTCCTT TTGAGCACCA GACGTATTGC CAGAGGACTT TGAGAGAGAT CAAAATCCTA 240

CTTCGCTTCA AGCATGAGAA CATCATTGGA ATCAATGACA TCATCAGAGC TCCCACTATT 300

GATCAGATGA AGGATGTCTA CATCGTACAG GACCTCATGG AAACAGATCT TTACAAGCTG 360

CTAAAGACAC AGCATCTCAG CAATGACCAT ATCTGCTATT TCCTCTACCA GATCTTGAGA 420

GGGTTGAAAT ATATCCATTC AGCTAATGTC CTGCATCGTG ACCTCAAACC CTCCAACCTG 480

CTTCTCAACA CCACTTGTGA TCTTAAGATC TGTGATTTCG GACTGGCTCG TGTGGCAGAC 540

CCGGACCACG ATCACACAGG GTTTCTGACG GAGTACGTAG CCACACGTTG GTACAGGGCC 600

CCAGAGATTA TGTTGAATTC CAAGGGTTAC ACAAAGTCGA TTGATATCTG GTCAGTAGGC 660

TGTATTCTGG CAGAGATGCT GTCAAACAGA CCCATATTCC CAGGCAAACA CTACCTGGAC 720

CAGCTTAACC ACATCCTGGG TATTCTCGGG TCACCTTCAC AGGAAGATCT AAATTGCATT 780

ATTAATGTGA AAGCCAGAAA CTATCTGTTA TCACTCCCAC ACAAGAACAA GGTGCCTTGG 840

AACAAACTTT TCCCAAATGC TGATCTCAAA GCTTTGGATT TGCTGGATAA AATGTTGACC 900

TTTAACCCTC ACAAGAGAAT TGAGGTTGAA GAAGCTCTGG CCCACCCTTA CCTGGAGCAG 960

TATTATGACC CCACTGATGA GCCTGTGGCA GAAGAACCAT TTAAATTTAA CATGGAGCTG 1020

GATGACTTGC CCAAGGAAAA ACTGAAGGAA CTAATTTTTG AGGAAACAGC CCGTTTTCAG 1080

CCAGGATACC AACCATAA 1098

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+sa d+ ++ rvaikk+s pf+++t ++rtlRE+k+l ++kheNi

Q: 30    YTNLSYIGEGAYGMVCSAHDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFKHENI  88

         78999***************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + ++++kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs

Q: 89    IGINDIIRAPT-IDQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  147

         ********999.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++

Q: 148   ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNS  207

         ***********************************999999*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 208   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINVKARN  267

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y+ slp+k+k ++++lfp+a+ +aldLl+k+L+++p+kRi+veeaL+hpYl

Q: 268   YLLSLPHKNKVPWNKLFPNADLKALDLLDKMLTFNPHKRIEVEEALAHPYL  318

         **************************************************7

Domain Sequence
(FASTA)

YTNLSYIGEG AYGMVCSAHD NVNKVRVAIK KISPFEHQTY CQRTLREIKI LLRFKHENII 60

GINDIIRAPT IDQMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLLNTTCDLK ICDFGLARVA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINVKARNYL 240

LSLPHKNKVP WNKLFPNADL KALDLLDKML TFNPHKRIEV EEALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013