EKS-LAC-00420

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00420

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	530.8	2.0E-159	575	904	330

Status

Unreviewed

Ensembl Protein

ENSLACP00000016266

UniProt Accession

H3B2Z5;

Protein Name

Protein Synonyms/Alias

Gene Name

CSF1R

Gene Synonyms/Alias

CSF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000014332	ENSLACP00000016266	ENSLACT00000016380
ENSLACG00000014332	ENSLACP00000021896	ENSLACT00000025758

Organism

Latimeria chalumnae

Functional Description

Protein Length

968

Protein Sequence
(FASTA)

MKLTLSLLGW HIPKARHMWS APAIFPNVLE LVINVGDPMQ LKCTGNSGVK WIVPLKAKKF 60

VKTTNSGSFV NIPRTNHMQT GTYTCVSEDA KDVKTSLHVF VKDPRNLFYM PLVRVSKNEG 120

EDAVLPCLVT DPQVSELTLW TYEGRPLPKE MKLSSDKKTG VTIQEVIPSY DGEYVCVVKK 180

DGVEQRSQII TLAVRPGEKS PPSLTLSTDM EVRMQGEPFM ISCTAVNPTF DFQVEWNHTA 240

KSYCTNYTVL GNYTVLNEHG TDITAFLNIS AVQLSDTGNY TCVSSNSAGT SKNTTFLQVV 300

DTGYVRLSTK QSTTMEVRLG ENLELSIDIE AYPKLLTWNW ESESLANSTV HLHFLFSPSR 360

YKNTLFLSRL KEHEGGQYTF FASNSQANAS LTFQVFLKQK PKVVVEQYGA YNVLFCLASG 420

YPAPSIVWYK CPGVRNRCDE NRTLILSNSS MQGTEASGKV EVESIVIIDS LKENTTVECL 480

AINVMGNDSD VFSTAVQDSI IRLPNKLFNP VLSIMAGMAV LFLILLAFVS YKYKQKPKYE 540

VRWKIIECSE GNNYTFIDPT QLPYNKKLEF PRDKLRFGKI LGSGAFGKVI EATAYGLGKE 600

DCGTRVAVKM LKPSAHSDEK EALMSELKIM SHLGQHEHIV NLLGACTYGG PILVITEYCC 660

YGDLLNFLRR KAKSFYTCPI EDGLVKNDAD YKNVCLEQKY SRSDSGFSSQ RKDDYIEMRS 720

GSTNGKQASL PAIDQEEDED SLTLNMEDML RFSYQVAQGM AFLAAKNCIH RDVAARNVLL 780

SHRRVAKICD FGLARDIMND SNYVVKGNAR LPVKWMAPES IFDCLYTIQS DVWSYGILLW 840

EIFSLGKSPY PGMLVDSKFY KLIQSGYQMG RPDCASPEMY DIMKKCWNPE PTSRPTFEQI 900

GKLIQNHLGD DPEEQNQTLT SNGDSSLVVQ AIQVMEERTY SSLQCCEETC DPSGTYLPLL 960

RGNNYQFC 968

Nucleotide Sequence
(FASTA)

ATGAAACTTA CATTGAGTTT ACTTGGATGG CATATACCAA AAGCCCGCCA TATGTGGAGC 60

GCACCTGCAA TCTTCCCCAA CGTGCTCGAG TTGGTCATCA ACGTAGGAGA TCCCATGCAG 120

CTGAAATGCA CAGGGAACTC GGGTGTGAAG TGGATTGTGC CATTAAAGGC CAAGAAATTT 180

GTGAAGACGA CGAATTCTGG CAGCTTCGTC AACATTCCCA GGACCAATCA CATGCAAACA 240

GGAACCTATA CATGTGTGTC CGAGGATGCA AAGGATGTGA AAACCTCATT ACATGTCTTT 300

GTCAAAGATC CTCGGAACTT ATTCTATATG CCTCTGGTTC GGGTTTCTAA AAACGAGGGA 360

GAAGACGCTG TCCTTCCTTG TCTGGTAACT GATCCCCAAG TATCTGAGCT GACCCTATGG 420

ACATATGAAG GCAGGCCCCT CCCCAAGGAG ATGAAGCTCT CTTCAGATAA GAAAACTGGG 480

GTCACTATCC AGGAAGTGAT TCCCAGCTAT GATGGGGAGT ACGTCTGTGT GGTGAAGAAA 540

GACGGAGTGG AGCAAAGGTC ACAGATAATC ACGCTTGCTG TCCGCCCTGG TGAAAAAAGT 600

CCACCATCAT TGACTCTGAG CACAGACATG GAAGTGCGGA TGCAAGGGGA GCCTTTTATG 660

ATTAGCTGTA CAGCAGTCAA TCCAACCTTT GACTTCCAGG TGGAATGGAA TCATACAGCC 720

AAAAGCTACT GTACTAATTA TACAGTGCTA GGTAATTATA CTGTACTAAA TGAACATGGA 780

ACTGATATCA CAGCCTTCCT GAACATTTCC GCAGTCCAGT TATCAGATAC TGGCAATTAC 840

ACTTGTGTGT CCAGTAACAG CGCTGGAACC AGTAAAAATA CCACCTTTCT ACAGGTTGTA 900

GATACTGGGT ACGTGAGGTT GTCCACCAAG CAGTCCACCA CCATGGAAGT TAGGCTGGGT 960

GAAAACTTAG AATTAAGCAT TGACATCGAG GCTTATCCCA AACTTCTGAC CTGGAACTGG 1020

GAATCGGAAT CCTTGGCCAA TAGCACAGTG CATTTACATT TCTTGTTTTC TCCTTCAAGG 1080

TATAAGAACA CACTCTTCTT GAGCAGACTG AAGGAGCACG AGGGAGGACA ATATACTTTC 1140

TTCGCTTCAA ACTCGCAGGC TAACGCCTCA CTTACTTTCC AAGTCTTTCT GAAGCAAAAG 1200

CCCAAAGTTG TTGTGGAACA GTATGGTGCT TATAATGTCC TGTTCTGTCT TGCCTCCGGC 1260

TACCCTGCCC CCTCGATTGT GTGGTATAAA TGTCCTGGTG TCAGAAATCG CTGTGACGAA 1320

AACAGAACGC TCATTCTGTC CAACTCCAGC ATGCAGGGCA CAGAGGCGTC TGGTAAGGTG 1380

GAGGTGGAAA GCATTGTGAT CATTGACTCG CTGAAGGAGA ACACCACAGT GGAATGCTTG 1440

GCTATCAATG TGATGGGAAA TGATTCTGAC GTCTTTTCAA CTGCCGTTCA AGACAGCATC 1500

ATTCGCCTTC CCAATAAGCT GTTCAACCCA GTTCTGTCCA TCATGGCGGG AATGGCAGTC 1560

CTGTTCCTAA TACTGCTGGC TTTCGTCTCC TACAAGTACA AGCAGAAGCC CAAGTATGAA 1620

GTTCGCTGGA AGATCATTGA ATGCAGTGAA GGGAACAACT ACACCTTTAT TGACCCAACA 1680

CAGCTGCCGT ACAATAAGAA GCTGGAGTTC CCCAGGGACA AGCTGCGGTT TGGTAAGATT 1740

CTGGGATCGG GAGCGTTTGG GAAGGTTATT GAAGCAACTG CTTATGGATT GGGGAAAGAA 1800

GACTGTGGCA CGCGAGTGGC AGTGAAGATG CTAAAACCGA GCGCCCATTC GGATGAGAAG 1860

GAAGCCCTGA TGTCAGAGCT GAAGATCATG AGTCACCTTG GACAACACGA ACACATTGTC 1920

AACCTGCTGG GCGCCTGTAC ATATGGAGGC CCGATCCTCG TTATCACAGA GTACTGTTGC 1980

TATGGTGACC TGCTGAACTT CCTGCGCAGG AAGGCAAAGT CATTTTACAC CTGCCCGATA 2040

GAAGATGGGC TGGTGAAGAA CGATGCAGAT TATAAAAATG TCTGCTTGGA GCAGAAATAC 2100

TCACGGAGTG ACAGTGGATT TTCAAGTCAG CGCAAAGACG ATTATATTGA AATGAGATCC 2160

GGCTCCACTA ACGGAAAACA AGCCAGCCTC CCTGCAATTG ACCAGGAAGA GGACGAAGAC 2220

AGTTTGACCC TCAATATGGA AGACATGCTG AGGTTCTCCT ACCAGGTCGC CCAAGGAATG 2280

GCCTTCCTCG CCGCCAAGAA CTGCATTCAC AGAGATGTTG CCGCCCGGAA CGTTTTACTG 2340

TCACACCGTC GAGTTGCTAA AATCTGTGAC TTCGGACTGG CCCGGGACAT CATGAATGAC 2400

TCCAACTACG TTGTGAAGGG CAACGCCCGA CTTCCTGTGA AATGGATGGC CCCGGAGAGC 2460

ATTTTTGACT GCCTGTACAC CATCCAGAGC GATGTCTGGT CTTACGGGAT TCTGCTTTGG 2520

GAAATCTTCT CACTGGGTAA AAGTCCTTAC CCTGGCATGT TGGTGGATAG TAAGTTCTAC 2580

AAGCTGATCC AGAGCGGGTA CCAGATGGGT CGCCCCGACT GCGCCTCTCC CGAAATGTAT 2640

GACATCATGA AGAAGTGCTG GAACCCAGAA CCCACCAGCC GGCCAACATT TGAGCAGATT 2700

GGAAAATTGA TTCAGAACCA TCTGGGTGAC GACCCAGAAG AGCAAAACCA AACCCTGACT 2760

TCTAATGGTG ACTCTTCTCT TGTTGTTCAA GCCATACAAG TGATGGAAGA ACGCACGTAC 2820

AGCAGCCTCC AGTGCTGTGA AGAGACCTGT GACCCCAGCG GGACCTACCT GCCGCTCCTG 2880

AGGGGCAACA ACTACCAGTT CTGCTAA 2907

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l++Gk+lGsGafGkv+eatayGl+k+d   +vavkmlk++a+s+ekealmselki+shlG

Q: 575   LRFGKILGSGAFGKVIEATAYGLGKEDCGTRVAVKMLKPSAHSDEKEALMSELKIMSHLG  634

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +he ivnllGact gGpi+viteyccyGdlln+lrrk++sf +  +e     ++++d+k+

Q: 635   QHEHIVNLLGACTYGGPILVITEYCCYGDLLNFLRRKAKSFYTCPIEDGL-VKNDADYKN  693

         ******************************************88888755.566677777

S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179

         + l++k+ rs+s +ss+ +++y++++ ++++       k+as     a+     +++e+e

Q: 694   VcLEQKYSRSDSGFSSQRKDDYIEMRSGSTN------GKQASLP---AI-----DQEEDE  739

         76999*********************94332......2222222...22.....235689

S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239

         ds +l++ed+l fsyqva+Gm+fla+knc+hrd+aarnvll++ +v+kicdfGlardim+

Q: 740   DSLTLNMEDMLRFSYQVAQGMAFLAAKNCIHRDVAARNVLLSHRRVAKICDFGLARDIMN  799

         9***********************************************************

S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299

         dsnyvvkGnarlpvkwmapesifd+lyt++sdvwsyGillweifslG +pypg+lvdskf

Q: 800   DSNYVVKGNARLPVKWMAPESIFDCLYTIQSDVWSYGILLWEIFSLGKSPYPGMLVDSKF  859

         ************************************************************

S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         ykli++Gy+m +p+ a+ e+y+im+kcw+ ep+ rp+f+q+ +l+

Q: 860   YKLIQSGYQMGRPDCASPEMYDIMKKCWNPEPTSRPTFEQIGKLI  904

         *****************************************9886

Domain Sequence
(FASTA)

LRFGKILGSG AFGKVIEATA YGLGKEDCGT RVAVKMLKPS AHSDEKEALM SELKIMSHLG 60

QHEHIVNLLG ACTYGGPILV ITEYCCYGDL LNFLRRKAKS FYTCPIEDGL VKNDADYKNV 120

CLEQKYSRSD SGFSSQRKDD YIEMRSGSTN GKQASLPAID QEEDEDSLTL NMEDMLRFSY 180

QVAQGMAFLA AKNCIHRDVA ARNVLLSHRR VAKICDFGLA RDIMNDSNYV VKGNARLPVK 240

WMAPESIFDC LYTIQSDVWS YGILLWEIFS LGKSPYPGML VDSKFYKLIQ SGYQMGRPDC 300

ASPEMYDIMK KCWNPEPTSR PTFEQIGKLI 330

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013