EKS-LAC-00114
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00114
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec452.83.2E-136367616250
StatusUnreviewed
Ensembl ProteinENSLACP00000016274
UniProt AccessionH3B303;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000014337ENSLACP00000016274ENSLACT00000016388
OrganismLatimeria chalumnae
Functional Description
Protein Length624
Protein Sequence
(FASTA)
MNNNIILEEV LIKKSQQKRR TSPANYKIRV FVLTKSSLAY YESRPGGNRI VRSFINRENI 60
KCAYVMSGTV ELPCCVAHGR YVFQVFHDNY LLYVFAPNKD SRQRWVCALK EETKDNNALV 120
PKYHPSFWTD GRWRCCFQTE KLAAGCAHYD PNRDACKKPL PPTPEDNRKI LPDQEAIVLA 180
LYDFLAQNPQ DLSIRKNEEY YIVDSSDPNW WKLQDKNGHE GYVPSGYVVE KTPNNIQAYD 240
WYNKNIARNK AEQLLLNMGK EGAFMVRDSR TPGTYTVSVF TKALSSENGP VIKHYHIKET 300
SDNPKRYYLA EKHIFDSIPE LIKYHQHNGG VIGLVTRLRH PVSCWKEKAP TTAGFSYGKW 360
EINPSELTFI QELGCGQFGL VHLGTWKDRT NVAIKMIREG AMSEEEFIEE AQVMMKLSHP 420
KLVQLCGVCT KQTPILLAFE FMEYGCLSDY LRNHRGNFSK ETLLGMCQDV CEGMAHLESA 480
YFIHRDLAAR NCLVGESQVV KVSDFGMTRF VLDDQYTSST GTKFPVKWSS PEVFRYSKYS 540
SKSDVWSFGV LMWEVFTEGK MPYENRTNGE VVEDITAGFR LLKPKLASDL VYQLMDWCWK 600
ERPEDRPSFA VLLHELGELA ELGY 624
Nucleotide Sequence
(FASTA)
ATGAACAATA ATATTATTCT CGAAGAGGTG CTGATCAAGA AATCTCAGCA AAAGCGAAGA 60
ACTTCTCCTG CCAACTACAA GATCCGGGTC TTCGTCTTAA CCAAGTCTTC ACTGGCCTAC 120
TATGAAAGTC GTCCTGGGGG AAACAGGATT GTAAGATCTT TCATAAACAG GGAAAATATC 180
AAGTGTGCAT ATGTGATGAG CGGTACTGTA GAGCTTCCCT GTTGTGTTGC TCATGGGAGG 240
TATGTATTTC AGGTGTTCCA CGACAACTAT TTATTGTATG TGTTCGCACC AAATAAAGAC 300
AGCAGACAAA GATGGGTGTG CGCCCTGAAA GAAGAAACAA AAGATAACAA CGCATTGGTG 360
CCAAAATATC ACCCGAGTTT CTGGACGGAT GGAAGGTGGA GGTGTTGTTT CCAGACAGAG 420
AAATTGGCAG CTGGCTGTGC ACATTATGAT CCTAACAGAG ATGCATGCAA AAAGCCCCTT 480
CCTCCTACGC CAGAAGATAA CAGAAAGATT CTACCAGATC AAGAAGCGAT AGTTTTAGCC 540
CTTTACGATT TCCTGGCCCA AAATCCTCAG GACCTGTCCA TAAGAAAGAA TGAAGAGTAC 600
TATATTGTTG ACAGTTCTGA TCCAAACTGG TGGAAGCTGC AAGACAAAAA TGGGCATGAA 660
GGATACGTGC CAAGCGGTTA CGTGGTAGAA AAGACACCAA ACAACATACA AGCATATGAT 720
TGGTATAATA AGAATATAGC CAGAAACAAG GCTGAACAGC TTCTTTTGAA CATGGGTAAA 780
GAGGGAGCAT TTATGGTACG AGACTCTAGG ACGCCTGGAA CATACACAGT CTCTGTTTTT 840
ACCAAGGCTC TCAGCAGTGA GAATGGTCCA GTTATAAAGC ATTACCATAT CAAAGAGACA 900
AGTGACAATC CAAAACGGTA CTACTTGGCA GAAAAGCATA TTTTTGACTC CATACCAGAA 960
CTCATAAAAT ATCACCAGCA CAATGGAGGA GTTATAGGGC TTGTGACACG GCTACGGCAC 1020
CCTGTTTCAT GCTGGAAGGA AAAGGCACCA ACGACAGCTG GCTTCAGCTA CGGTAAATGG 1080
GAGATCAACC CTTCTGAGCT AACCTTTATA CAAGAACTAG GGTGCGGACA ATTTGGGCTG 1140
GTTCATCTGG GCACTTGGAA AGACAGAACT AATGTAGCAA TAAAGATGAT CCGGGAAGGC 1200
GCCATGTCTG AGGAGGAGTT TATTGAAGAG GCTCAAGTTA TGATGAAATT GTCTCACCCT 1260
AAATTAGTAC AGCTGTGTGG CGTCTGCACA AAACAAACAC CAATCTTGCT GGCGTTTGAG 1320
TTCATGGAAT ATGGTTGCCT CTCTGACTAC CTGCGAAACC ACCGGGGCAA TTTCTCCAAG 1380
GAGACTCTTC TGGGCATGTG CCAGGACGTG TGTGAGGGCA TGGCCCATCT GGAGAGTGCC 1440
TACTTCATTC ACAGAGACCT GGCTGCAAGG AACTGCTTGG TTGGAGAGTC TCAAGTGGTG 1500
AAGGTGTCCG ATTTTGGAAT GACCAGGTTT GTCTTGGATG ATCAGTACAC CAGTTCTACA 1560
GGAACCAAGT TTCCCGTGAA GTGGTCATCC CCAGAGGTTT TCCGTTACTC CAAATATAGC 1620
AGCAAATCAG ACGTCTGGTC ATTTGGAGTG CTAATGTGGG AGGTGTTCAC GGAGGGGAAA 1680
ATGCCTTATG AGAACAGGAC AAATGGAGAG GTGGTTGAAG ATATCACAGC AGGATTCAGG 1740
TTACTGAAAC CTAAGCTGGC ATCGGACCTA GTCTACCAGC TTATGGACTG GTGTTGGAAA 1800
GAGAGACCAG AAGACAGACC TTCCTTTGCT GTGCTGTTAC ATGAACTTGG TGAACTTGCC 1860
GAACTTGGAT ATTAA 1875
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++elg gqfg+v+lg w+ +++vaik+i+egamsee+fieea+vmmklshpklvql 
Q: 367   LTFIQELGCGQFGLVHLGTWKDRTNVAIKMIREGAMSEEEFIEEAQVMMKLSHPKLVQLC  426
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi++ +e++e gcl++ylr+++++++ke+ll mc+dvcegm++le++ fihrd
Q: 427   GVCTKQTPILLAFEFMEYGCLSDYLRNHRGNFSKETLLGMCQDVCEGMAHLESAYFIHRD  486
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++vvkvsdfg++r+vlddqy+ss+g+kfpvkws+pev++yskyssksdvw
Q: 487   LAARNCLVGESQVVKVSDFGMTRFVLDDQYTSSTGTKFPVKWSSPEVFRYSKYSSKSDVW  546
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+pye+++n evve+++ g+rl +pklas+ vy++m  cwke+pe+r
Q: 547   SFGVLMWEVFTEGKMPYENRTNGEVVEDITAGFRLLKPKLASDLVYQLMDWCWKERPEDR  606
         ************************************************************
S: 241   ptfkellsal  250
         p+f+ ll++l
Q: 607   PSFAVLLHEL  616
         *******987
Domain Sequence
(FASTA)
LTFIQELGCG QFGLVHLGTW KDRTNVAIKM IREGAMSEEE FIEEAQVMMK LSHPKLVQLC 60
GVCTKQTPIL LAFEFMEYGC LSDYLRNHRG NFSKETLLGM CQDVCEGMAH LESAYFIHRD 120
LAARNCLVGE SQVVKVSDFG MTRFVLDDQY TSSTGTKFPV KWSSPEVFRY SKYSSKSDVW 180
SFGVLMWEVF TEGKMPYENR TNGEVVEDIT AGFRLLKPKL ASDLVYQLMD WCWKERPEDR 240
PSFAVLLHEL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013