EKS-LAC-00418

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00418

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	550.3	2.3E-165	597	960	364

Status

Unreviewed

Ensembl Protein

ENSLACP00000016550

UniProt Accession

H3B3S9;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000014583	ENSLACP00000016550	ENSLACT00000016664

Organism

Latimeria chalumnae

Functional Description

Protein Length

1103

Protein Sequence
(FASTA)

LLIKGKRPAQ QTRYSYFLSG LLLLVVGSDG IEISPSEPEF VLPLSTNFSL TCTGTEGVAW 60

LNDTFARSSN VEVTNGPLSS TLTIYSVTGH NTGEYVCVHS KSKDESGEKK SVYLFVPDPD 120

VWFVPQEPNE EFVFTLSNEQ STIPCYVTDP QAQVTLYERN DDILIQATYI QQRGFVAHLE 180

DTSYYCKASL NGEERKSEVY YVYKIKVNPQ LEVYVNATQT VVKKGEPITV ICNINGSEMM 240

NISWLYPRRS TGETLEPVTD FSPGPDWHLR SILAIQEGVL ADSGRYTCAV YETTTGRIDQ 300

QSLNISVLEK GFVQLTADIN RTELAELHHS KLFSVGIEAY PRPTIKWLKG NRTMNENSDE 360

ISITNTRISE TSYESTLTVV RVKERDSDSY SLEVFNEDDV QKFTFYLYVN DTVPVRILEL 420

LDHHYDTGGQ RVTCVAEGAP QPDILWYICK NLESCSKDAT WGALNSNVEN IVELKNLSYN 480

ESRKLHRVRS VLKFHSVEES ITLRCVANNT LGQQAQEINL VSKSLQFRVA IISAILVLLV 540

LVIIFLIILI VFWRKKPRYE IRWKVIESVS LDGHEYIYVD PMHLPYDSSW EFPRDRLVLG 600

RTLGSGAFGR VVEATTYGLC NSKSSMKVAV KMLKSTARSS EKQALISELK IMSHLGPHLN 660

IVNLLGACTK GVLGLGPVYI ITEFCRYGDL VDYLHRNKHT FLQYYADKAR REAEIYGNDL 720

SEAKDKSSVT SLSLDSDGGY MDMSKDDLVE YVPMQELKED IKYADIEPSV YETPYQQESY 780

STPGQERTET IVLINESPIL SYTDLIGVSY QVAKGMEFLA SKNCVHRDLA ARNVLICEGK 840

LVKICDFGLA RDIMHDSNYI SKGSTFLPLK WMAPESIFHN LYTTLSDVWS YGILLWEIFT 900

LGGTPYPELP MNEQFYNAIK RGHRMSKPTH ALDEIYEIMQ KCWDEKFEKR PPFSQLVHLL 960

GNMLADSYKK KYNQVEEEFM KSDHPAVKRT KPKCIVVNNG NPSPNYYSEV GLNTPEIKAV 1020

GQAPDNNYII PLPDLQPEEE DSEDYNGGPS SFSSSALNEE NTASTISCDV PLLTPEEGSV 1080

ETEANPSSME QDSRHSDIEE SFV 1103

Nucleotide Sequence
(FASTA)

TTACTAATAA AAGGTAAGAG GCCAGCTCAA CAGACTAGGT ACTCATATTT TCTTTCAGGA 60

CTTCTTCTCT TGGTGGTTGG CAGTGACGGC ATAGAAATCT CTCCGAGTGA ACCAGAATTT 120

GTTCTGCCTC TCTCCACTAA TTTCTCGCTG ACGTGCACTG GGACGGAAGG TGTTGCTTGG 180

TTGAATGACA CCTTTGCAAG GAGCTCAAAT GTGGAAGTGA CAAACGGACC TCTTTCCAGC 240

ACTCTCACCA TCTACAGTGT GACAGGCCAC AACACAGGAG AGTATGTTTG CGTTCACAGT 300

AAATCCAAGG ACGAGAGTGG CGAGAAAAAG AGTGTGTATC TGTTTGTACC AGACCCTGAC 360

GTGTGGTTTG TCCCACAAGA GCCCAATGAG GAGTTTGTGT TCACACTTTC CAATGAGCAG 420

AGCACCATCC CCTGTTATGT GACCGACCCC CAGGCGCAAG TCACCCTCTA TGAGAGGAAT 480

GACGACATCC TCATCCAAGC TACCTACATC CAACAGCGGG GCTTTGTGGC CCACTTAGAA 540

GACACCTCCT ACTACTGCAA AGCATCACTT AACGGGGAGG AGCGCAAGTC TGAGGTTTAT 600

TATGTTTACA AGATTAAAGT GAACCCACAG CTAGAGGTAT ATGTCAATGC TACACAGACA 660

GTGGTAAAGA AAGGAGAGCC CATCACTGTT ATCTGCAATA TTAACGGAAG TGAGATGATG 720

AACATTAGCT GGCTGTACCC TCGCAGATCT ACTGGAGAGA CACTGGAACC AGTTACAGAC 780

TTCTCCCCTG GGCCGGACTG GCACCTGCGC TCAATTTTGG CAATCCAGGA GGGAGTGCTG 840

GCAGACTCGG GCCGGTACAC CTGTGCAGTT TACGAAACAA CGACAGGCAG AATAGATCAG 900

CAGTCACTCA ACATCTCTGT CCTGGAGAAA GGATTTGTTC AGCTCACAGC AGACATTAAC 960

AGAACTGAGC TGGCAGAGTT ACACCACAGC AAACTGTTCT CTGTGGGCAT CGAGGCCTAT 1020

CCCAGACCGA CCATCAAGTG GCTGAAAGGC AACAGAACTA TGAATGAAAA CAGCGATGAA 1080

ATCTCAATCA CAAACACGAG GATCTCGGAA ACCAGTTATG AAAGCACATT GACTGTAGTA 1140

AGAGTGAAAG AAAGAGACAG TGATAGCTAC AGCCTCGAAG TCTTCAATGA AGATGATGTC 1200

CAAAAGTTTA CCTTTTATCT CTACGTCAAT GACACAGTGC CGGTCAGGAT ACTGGAACTG 1260

TTGGACCATC ATTACGACAC TGGAGGGCAG AGAGTTACTT GTGTGGCTGA GGGAGCTCCC 1320

CAGCCTGACA TACTCTGGTA TATCTGCAAG AACTTAGAAA GTTGCAGTAA AGATGCCACC 1380

TGGGGAGCCC TGAACTCCAA CGTAGAAAAC ATCGTTGAAC TCAAGAACTT GTCGTACAAT 1440

GAGAGCCGGA AACTGCATCG TGTGCGGAGT GTACTCAAGT TTCACAGTGT GGAGGAGTCT 1500

ATAACACTCC GCTGTGTTGC CAACAACACC CTGGGACAGC AGGCTCAGGA AATTAATCTG 1560

GTTTCGAAAT CTTTGCAGTT CCGGGTGGCA ATTATCTCCG CCATCTTGGT TTTGTTGGTT 1620

CTTGTCATCA TCTTCCTGAT TATCCTCATT GTGTTCTGGC GGAAGAAACC TCGTTATGAG 1680

ATCCGATGGA AGGTTATCGA GTCAGTCAGT TTGGACGGGC ACGAGTACAT TTATGTGGAC 1740

CCCATGCATC TCCCCTACGA CTCCAGCTGG GAGTTTCCTA GAGACCGGCT GGTTTTGGGT 1800

CGTACGCTCG GCTCCGGTGC ATTCGGCAGA GTTGTCGAAG CCACGACGTA TGGCTTGTGT 1860

AATTCAAAGT CGTCCATGAA AGTAGCTGTC AAAATGCTGA AGTCAACAGC CAGGAGCAGC 1920

GAGAAACAGG CCCTGATATC AGAGCTGAAG ATTATGAGCC ATTTGGGTCC TCATCTCAAC 1980

ATAGTCAACC TGCTTGGTGC CTGCACAAAA GGAGTTCTCG GCCTAGGCCC TGTTTACATC 2040

ATCACTGAAT TCTGTCGCTA TGGAGACCTG GTGGATTATC TGCACAGGAA CAAGCACACA 2100

TTCCTTCAAT ACTATGCAGA TAAAGCCAGG AGGGAGGCAG AAATATATGG AAACGATCTG 2160

AGCGAGGCCA AGGACAAAAG CAGTGTCACG TCTCTGTCCC TTGACAGTGA CGGTGGCTAT 2220

ATGGACATGA GTAAGGATGA TTTAGTGGAA TATGTGCCCA TGCAGGAGTT AAAGGAAGAT 2280

ATTAAATATG CTGACATTGA ACCCTCGGTC TACGAGACAC CTTATCAACA GGAGAGCTAC 2340

AGCACACCAG GTCAGGAGAG GACAGAAACT ATTGTTCTTA TAAACGAGTC TCCCATCCTC 2400

AGTTACACGG ACCTCATTGG AGTGAGTTAC CAGGTGGCCA AAGGAATGGA ATTTCTGGCC 2460

TCCAAAAATT GTGTGCATCG GGATCTGGCA GCGAGAAACG TCCTGATTTG TGAGGGCAAG 2520

CTGGTGAAGA TCTGTGACTT TGGGCTGGCC AGAGACATCA TGCATGATTC CAACTATATC 2580

TCCAAGGGCA GCACCTTCCT GCCCCTGAAG TGGATGGCCC CCGAGAGTAT CTTCCACAAC 2640

CTCTATACCA CACTGAGTGA TGTCTGGTCA TATGGAATCC TCCTCTGGGA GATCTTCACC 2700

TTGGGAGGGA CACCTTATCC TGAGCTACCA ATGAATGAGC AGTTTTACAA TGCAATAAAA 2760

CGTGGGCATC GCATGTCAAA GCCCACCCAC GCTCTGGACG AAATCTATGA GATCATGCAG 2820

AAGTGCTGGG ATGAAAAGTT TGAGAAGAGG CCTCCTTTCT CCCAGTTAGT TCATCTCCTG 2880

GGAAACATGT TAGCGGACAG CTACAAGAAG AAATACAACC AAGTGGAGGA GGAATTTATG 2940

AAGAGCGACC ACCCAGCGGT CAAGCGGACG AAGCCCAAGT GCATTGTGGT CAATAACGGC 3000

AATCCCAGTC CCAACTACTA CAGTGAAGTT GGGCTGAACA CCCCTGAGAT AAAGGCTGTG 3060

GGGCAGGCCC CCGATAACAA CTACATCATC CCCTTACCTG ATCTGCAGCC AGAGGAAGAA 3120

GACAGTGAGG ATTACAATGG GGGCCCCAGT TCCTTCTCCA GTTCAGCTTT GAATGAAGAG 3180

AATACAGCAT CTACAATCTC CTGTGATGTG CCATTGTTGA CACCAGAAGA AGGGAGCGTG 3240

GAGACTGAGG CAAACCCTTC CTCTATGGAG CAAGACTCCA GGCATTCAGA CATAGAGGAG 3300

AGCTTTGTGT AA 3312

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveat+yGl +s++++kvavkmlkstarssek+al+selki+shlG

Q: 597   LVLGRTLGSGAFGRVVEATTYGLCNSKSSMKVAVKMLKSTARSSEKQALISELKIMSHLG  656

         78**********************************************************

S: 61    ehenivnllGactkg....GpiyviteyccyGdllnylrrkresflkkslekkkekeeel  116

         +h+nivnllGactkg    Gp+y+ite+c+yGdl++yl+r++++fl+ +++k   +e+e+

Q: 657   PHLNIVNLLGACTKGvlglGPVYIITEFCRYGDLVDYLHRNKHTFLQYYADK-ARREAEI  715

         **************888889**************************999999.667899*

S: 117   dskalladkslrsksslssesseeyvdlkkd................vsdvssskadkla  160

         + ++l + k   s +sls +s++ y+d++kd                ++d+++s +++++

Q: 716   YGNDLSEAKDKSSVTSLSLDSDGGYMDMSKDdlveyvpmqelkedikYADIEPSVYETPY  775

         ************************************************************

S: 161   sekkksalerevkaale.eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvl  219

         +++  s+  +e+++++   ++s  l+++dl+  syqvakGmeflaskncvhrdlaarnvl

Q: 776   QQESYSTPGQERTETIVlINESPILSYTDLIGVSYQVAKGMEFLASKNCVHRDLAARNVL  835

         ***99998887776543145599*************************************

S: 220   lteGkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGill  279

         ++eGk+vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvwsyGill

Q: 836   ICEGKLVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILL  895

         ************************************************************

S: 280   weifslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkq  339

         weif+lG+tpyp+l+++++fy++ik+G+rm++p++a +eiyeimqkcw++++ekrp+f+q

Q: 896   WEIFTLGGTPYPELPMNEQFYNAIKRGHRMSKPTHALDEIYEIMQKCWDEKFEKRPPFSQ  955

         ************************************************************

S: 340   lvell  344

         lv+ll

Q: 956   LVHLL  960

         **986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGRVVEATT YGLCNSKSSM KVAVKMLKST ARSSEKQALI SELKIMSHLG 60

PHLNIVNLLG ACTKGVLGLG PVYIITEFCR YGDLVDYLHR NKHTFLQYYA DKARREAEIY 120

GNDLSEAKDK SSVTSLSLDS DGGYMDMSKD DLVEYVPMQE LKEDIKYADI EPSVYETPYQ 180

QESYSTPGQE RTETIVLINE SPILSYTDLI GVSYQVAKGM EFLASKNCVH RDLAARNVLI 240

CEGKLVKICD FGLARDIMHD SNYISKGSTF LPLKWMAPES IFHNLYTTLS DVWSYGILLW 300

EIFTLGGTPY PELPMNEQFY NAIKRGHRMS KPTHALDEIY EIMQKCWDEK FEKRPPFSQL 360

VHLL 364

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013