EKS-LAC-00315
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00315
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk310.79.3E-93447708262
StatusUnreviewed
Ensembl ProteinENSLACP00000016684
UniProt AccessionH3B463;
Protein Name
Protein Synonyms/Alias
Gene NameALK
Gene Synonyms/Alias ALK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000014697ENSLACP00000016684ENSLACT00000016799
OrganismLatimeria chalumnae
Functional Description
Protein Length978
Protein Sequence
(FASTA)
WLFTTCGASG PHGPTPMQCN DAYRNMNLSV TVGTDGFLKG VQIWRVPSTN KYKISGYGAA 60
GGRGVKSTML RLHGMMVAGF FELQKDELLY ILVGQQGEDA CPHHTNPMIQ KVCVGESNVI 120
EEEIRVNRTV YEWAGGGGGG GGATYIFKIE NGEPVPLIVA AGGGGTAYRG GEMATKPEKL 180
ETNTSIPGLN GLSGAAGGGG GWSDNTFFSW SGKSMLEGAV GGEACPQGIK KWGWQVRGGF 240
GGGGGGCSAG GGAGGYIGGN AVPKNDPKKN GEDGVSFFSP LGVLFSQPLK VMEGHGEVSI 300
QLSLNCSHCE SDECWIDIMT GNITCFCDHG LAMDGVSCES ALTQKPTPSS PEELSLSLVL 360
SVATSALVAV LLLLFSGIMI VYRRKHQELQ AMQMELQSPE YKLSKLRTST IMTDYNPNYC 420
FAGKTTSISD LKEVPRKNIS LISPGPGHAK IGRSQWGQFG GGVNPPLPLQ VFVLTLPEVC 480
SEQDELDFLM EALIIRSFNC RGVSVSESWT LPAGVYLLMV GGGNLKTNQR SAKPKAGQPS 540
ALCMLDLLKV AQDIARGCQY LEENHFIHRD IAARNCLLTC MGPGRVAKIG DFGMARDIYR 600
ASYYRKGGRA MLPVKWMPPE AFMEGIFTSK TDTWWLGGSM SCQAQLLGFI FYPCSKTLDK 660
ILAECTNQMR GEPTWAASGP KYRIMTQCWQ HQPEDRPNFA TILERIDYCT QDPDVINTTI 720
PVEYGPLVEE EEKVPVRPED PDGIPPLLAL PQPEGASEEL QPPPLPTSLC PGEAQANVVT 780
YESPEHTTVG SVKEEGGCVN LAYSQTTPSS GTQSSRGSRN KPTNLWNPTY GSWFAEKHAL 840
QNSATAGQNG QPEDTPTGKE PAYNQSSASA AGNHHIAATV QGSSVLLEPS SLASALKDVP 900
LFRLRHFPCG NINYGYQQQG LPCEPLAPSS SAGISDSSLA CKGGLSQLEP RAHPIVDLPA 960
WDSGLSLADT EDVSVTIL 978
Nucleotide Sequence
(FASTA)
TGGTTATTCA CTACGTGTGG AGCCAGTGGA CCCCATGGAC CGACTCCGAT GCAGTGCAAT 60
GATGCATACC GCAATATGAA CCTGAGCGTG ACAGTCGGCA CTGATGGGTT CCTAAAGGGT 120
GTTCAAATCT GGAGAGTGCC ATCCACCAAC AAATACAAGA TCTCAGGCTA CGGGGCAGCC 180
GGCGGTAGAG GGGTTAAGAG CACTATGCTC AGACTCCACG GCATGATGGT GGCGGGCTTC 240
TTTGAACTCC AGAAAGATGA ACTGCTGTAC ATCTTGGTTG GGCAGCAGGG GGAAGACGCC 300
TGCCCTCATC ACACCAACCC TATGATTCAG AAGGTTTGTG TCGGAGAAAG TAATGTAATA 360
GAAGAGGAGA TCAGAGTGAA TAGAACTGTG TATGAATGGG CAGGCGGTGG AGGAGGAGGA 420
GGAGGTGCCA CCTACATATT TAAGATTGAG AATGGAGAAC CAGTCCCCTT AATCGTTGCG 480
GCAGGAGGCG GTGGGACGGC GTACAGGGGA GGAGAGATGG CCACCAAGCC TGAAAAACTG 540
GAGACCAACA CCTCCATCCC TGGGCTGAAT GGACTCTCTG GAGCTGCTGG TGGTGGAGGG 600
GGCTGGAGTG ATAACACCTT CTTTTCCTGG TCTGGCAAGT CCATGCTGGA AGGAGCTGTA 660
GGAGGGGAGG CCTGTCCCCA GGGAATAAAG AAGTGGGGGT GGCAAGTAAG AGGGGGTTTC 720
GGAGGAGGCG GGGGTGGATG CTCTGCCGGC GGAGGAGCAG GCGGATACAT AGGAGGCAAT 780
GCTGTGCCGA AGAACGACCC TAAGAAAAAC GGGGAGGATG GAGTATCGTT TTTTAGTCCA 840
CTGGGTGTCC TCTTTAGCCA GCCTCTCAAA GTGATGGAGG GCCACGGTGA AGTCTCCATC 900
CAGCTCAGCC TGAACTGCAG CCACTGTGAG TCGGACGAGT GCTGGATCGA CATCATGACT 960
GGGAACATCA CCTGCTTCTG CGATCACGGC TTGGCAATGG ACGGCGTCTC CTGCGAAAGC 1020
GCTCTGACTC AGAAGCCGAC TCCAAGCAGC CCGGAAGAAC TGTCCCTCTC TCTGGTCCTG 1080
TCTGTGGCCA CCTCTGCTCT CGTGGCGGTT CTCCTTCTCC TCTTCTCCGG GATTATGATC 1140
GTATACCGCC GGAAACACCA GGAACTGCAG GCCATGCAGA TGGAGCTTCA GAGTCCCGAG 1200
TACAAGCTGA GCAAACTCCG AACCTCCACC ATCATGACGG ACTACAACCC CAACTATTGC 1260
TTTGCTGGAA AGACCACCTC CATCAGCGAC CTGAAGGAAG TGCCCCGCAA AAACATCTCC 1320
CTCATCAGTC CAGGGCCAGG GCATGCCAAG ATTGGGAGGA GCCAATGGGG CCAGTTTGGG 1380
GGTGGTGTCA ACCCACCCCT CCCCCTCCAA GTTTTTGTTT TGACGTTGCC TGAGGTGTGC 1440
TCCGAGCAAG ATGAGCTGGA TTTCCTCATG GAAGCTCTCA TAATCAGATC CTTCAACTGC 1500
CGGGGTGTAT CTGTTAGTGA GAGTTGGACC CTTCCTGCCG GGGTGTATCT GTTAATGGTG 1560
GGGGGGGGCA ACTTGAAAAC AAACCAAAGA AGTGCCAAGC CTAAAGCCGG CCAGCCCTCC 1620
GCTCTGTGTA TGTTGGACCT GCTGAAGGTG GCTCAGGACA TTGCCCGTGG CTGTCAGTAC 1680
CTAGAGGAGA ACCACTTTAT CCACAGGGAC ATTGCTGCCA GGAACTGCCT GCTCACCTGT 1740
ATGGGGCCTG GAAGGGTGGC TAAGATTGGC GATTTTGGAA TGGCTCGAGA TATCTACAGA 1800
GCAAGTTACT ACAGGAAGGG GGGGCGAGCA ATGCTCCCGG TCAAGTGGAT GCCTCCGGAG 1860
GCCTTTATGG AAGGAATATT TACATCCAAG ACAGACACTT GGTGGTTGGG GGGCAGCATG 1920
AGCTGTCAAG CACAACTATT AGGCTTCATT TTCTACCCAT GTAGCAAAAC CCTTGACAAA 1980
ATTTTAGCAG AATGCACAAA CCAGATGAGA GGGGAACCAA CCTGGGCAGC TAGTGGTCCA 2040
AAATATCGGA TCATGACACA GTGCTGGCAG CACCAACCAG AGGACAGGCC CAACTTTGCC 2100
ACCATACTGG AACGTATTGA CTACTGCACT CAGGACCCTG ATGTGATAAA TACTACCATC 2160
CCTGTGGAAT ATGGCCCCCT GGTGGAAGAG GAAGAAAAAG TCCCAGTGCG TCCAGAAGAT 2220
CCTGATGGAA TTCCACCCTT GTTGGCCTTG CCGCAGCCAG AAGGGGCGAG CGAGGAATTG 2280
CAGCCGCCCC CTCTCCCCAC CAGCCTCTGC CCAGGAGAGG CACAAGCCAA CGTGGTGACA 2340
TACGAGTCGC CAGAGCACAC GACGGTTGGG TCCGTGAAGG AGGAGGGAGG CTGTGTGAAC 2400
CTGGCGTACT CACAGACCAC CCCATCGTCG GGGACTCAGA GCAGCCGAGG CTCCCGGAAC 2460
AAGCCTACAA ACCTGTGGAA CCCCACCTAC GGCTCTTGGT TTGCAGAAAA GCACGCCCTG 2520
CAGAACAGCG CCACGGCCGG CCAAAACGGG CAGCCGGAGG ACACGCCCAC TGGAAAGGAG 2580
CCGGCATACA ACCAGAGCAG CGCAAGTGCG GCCGGCAACC ACCACATAGC TGCCACGGTG 2640
CAGGGCTCCT CCGTGCTTTT AGAGCCTTCT TCGCTGGCCT CTGCGCTGAA GGACGTGCCT 2700
CTGTTCAGGC TCCGGCACTT CCCCTGTGGG AACATCAACT ACGGCTACCA GCAGCAAGGG 2760
CTGCCCTGTG AGCCGCTGGC CCCATCTTCC TCTGCCGGCA TCAGTGACTC CAGCCTCGCC 2820
TGCAAGGGTG GTCTCTCCCA GCTGGAACCC CGAGCCCACC CTATTGTTGA CCTACCAGCT 2880
TGGGACTCAG GACTTTCCCT TGCAGACACG GAGGATGTTA GTGTTACTAT ACTATAA 2937
Domain Profile
S: 8     GkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfnhenivrl  67
         G+  +G    g++ g  + + +l+v v tlpe++seqdeldfl+ealii  fn + +   
Q: 447   GHAKIGRSQWGQFGGGVNPPLPLQVFVLTLPEVCSEQDELDFLMEALIIRSFNCRGV---  503
         88899999999999999***********************************96554...
S: 68    iGvsle.klprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvakGckyle  126
           vs + +lp  + l ++ GG+lk+  r ++pk  q+s+l+m dllkva+d+a+Gc+yle
Q: 504   -SVSESwTLPAGVYLLMVGGGNLKTNQRSAKPKAGQPSALCMLDLLKVAQDIARGCQYLE  562
         .33322257899999999******************************************
S: 127   enkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkwmppeaf  186
         en+fihrdiaarn+ll++ Gp+rvaki+dfGmardiyra+yyrkggra+lpvkwmppeaf
Q: 563   ENHFIHRDIAARNCLLTCMGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAF  622
         ************************************************************
S: 187   leGiftsktdvwsfG.vllwevfslGvvpyp.gksnqevlelvveGgrldspkeipgsvy  244
         +eGiftsktd+w +G  +  +   lG++ yp +k+ +++l   ++  r ++     g+ y
Q: 623   MEGIFTSKTDTWWLGgSMSCQAQLLGFIFYPcSKTLDKILAECTNQMRGEPTWAASGPKY  682
         ***********9986267789999*******45677999*********************
S: 245   rimtdcwkhepedrpkfvsilerlqa  270
         rimt+cw+h+pedrp+f++iler+++
Q: 683   RIMTQCWQHQPEDRPNFATILERIDY  708
         ***********************986
Domain Sequence
(FASTA)
GHAKIGRSQW GQFGGGVNPP LPLQVFVLTL PEVCSEQDEL DFLMEALIIR SFNCRGVSVS 60
ESWTLPAGVY LLMVGGGNLK TNQRSAKPKA GQPSALCMLD LLKVAQDIAR GCQYLEENHF 120
IHRDIAARNC LLTCMGPGRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW MPPEAFMEGI 180
FTSKTDTWWL GGSMSCQAQL LGFIFYPCSK TLDKILAECT NQMRGEPTWA ASGPKYRIMT 240
QCWQHQPEDR PNFATILERI DY 262
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>
EKS-ANC-00292
EKS-CAJ-00312
EKS-CAF-00313
EKS-CAP-00341
EKS-FEC-00287
EKS-GAG-00253
EKS-GOG-00304
EKS-HOS-00307
EKS-ICT-00290
EKS-LOA-00317
EKS-MAM-00304
EKS-MEG-00248
EKS-MOD-00295
EKS-MUM-00338
EKS-MUP-00298
EKS-MYL-00306
EKS-NOL-00278
EKS-ORA-00265
EKS-OTG-00308
EKS-PES-00268
EKS-POA-00292
EKS-RAN-00317
EKS-TAG-00316
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013