EKS-LAC-00310
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00310
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR482.53.1E-145373628256
StatusUnreviewed
Ensembl ProteinENSLACP00000023082
UniProt AccessionH3B4Z9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000014945ENSLACP00000023082ENSLACT00000025097
ENSLACG00000014945ENSLACP00000016970ENSLACT00000017090
OrganismLatimeria chalumnae
Functional Description
Protein Length923
Protein Sequence
(FASTA)
MGTLKGVKAV NSSNIDSFTD CTKIFGSLAF LAETFEGDPA ANIPPLDIQK LNVFKKLKEI 60
TGYLYIESWP ENQTDLSVFE NLSVIRGRML YNGVYSLELQ NLSISSLGLR SLNEISGGLV 120
LIHENPSLCF IDKIPWSKIF RGSRQGLIQL ANKSPQQCVS EGQVCYKLCS NQECWGLGPT 180
QCVHCAHFLR GQVCVESCNI LEGEIREYAD GNKCIPCHPE CLPQNNTKTC KGPGAEDCEV 240
CTHYKDGDSC VEKCPTGVKG DGFLHIWKFP DEDSNCQLCP TNCTHMCTVL EENGCPVDQK 300
PSQVTTIVAA VVGVLLFLVL VSVTVYLIMR RKKLNKKHTL KRILQEHELV EPLTPSGALP 360
NQAQMRILKE TELQKVKVLG SGAFGTVYKG IWIPDGEDVK IQVAIKVLRE NTSSKANKEI 420
LDEAYVMAGV GSPYVCRLLG ICLTSTVQLV TQLMPYGCLL DYVRENKDCI GSQHLLNWCV 480
QIAKGMSYLE DVRLVHRDLA ARNVLVKTPN HVKITDFGLA RLLDIDETEY RADGGKVPIK 540
WMALESILHR KFTHQSDVWS YGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPLIC 600
TIDVYMIMVK CWMIDSEQRP RFRELVTEVT QMARDPPRYV VIQNEETMNL QSPVDSKFYR 660
TLLEDEDMRN LVDAEEYLVP HQGFFSAEVS SNYRTRMSSA RSATENTEDV EVPGPTVQNS 720
RLGRSISQQS AGGCSDVFLD GDYAESKAPS IHPLRGNSIA QRYSEDPTNC FNEDFGGELE 780
VDGYIIPGSS TSSPEYVNQA EEIPSTNKCQ TPNSGTRKKF MGQHGKNGLI PDPMYTLLNG 840
NGNIVENPEY ISPNSLPLIN YSGQAFDNPY YFDHCPTTKV PKDNPESQVA GRCQPNGFMT 900
PTVENPEYLG FVEASSGPKN ISV 923
Nucleotide Sequence
(FASTA)
ATGGGCACTC TGAAAGGCGT AAAAGCTGTT AATTCTTCAA ACATCGATTC TTTCACTGAC 60
TGCACTAAAA TCTTCGGCAG TCTAGCGTTC TTAGCTGAGA CTTTTGAAGG TGATCCTGCA 120
GCAAACATCC CCCCTCTGGA CATACAGAAG CTAAATGTCT TTAAAAAGCT GAAGGAGATT 180
ACAGGCTATT TATACATCGA GTCTTGGCCT GAAAACCAGA CAGATCTAAG TGTGTTTGAA 240
AACCTCTCCG TGATACGTGG AAGAATGCTG TATAATGGCG TGTATTCCCT GGAGCTTCAG 300
AACCTTAGTA TCTCTTCACT GGGGTTACGT TCTTTGAATG AGATCAGTGG AGGTTTGGTT 360
CTGATCCATG AAAACCCGAG CCTGTGTTTC ATTGACAAAA TCCCTTGGAG CAAGATTTTC 420
AGAGGCAGCC GTCAGGGGCT GATTCAGTTG GCAAACAAAT CCCCACAGCA ATGCGTGAGT 480
GAAGGCCAGG TATGTTACAA ATTGTGCTCT AATCAGGAAT GCTGGGGACT TGGACCAACA 540
CAATGTGTCC ACTGTGCCCA TTTCTTACGA GGACAAGTGT GTGTGGAATC CTGTAATATA 600
CTTGAAGGGG AAATCCGAGA GTACGCAGAT GGTAACAAGT GCATCCCGTG TCATCCAGAA 660
TGTCTCCCTC AGAACAACAC TAAAACCTGC AAAGGCCCGG GAGCAGAGGA TTGTGAGGTC 720
TGTACCCATT ATAAAGATGG TGATTCCTGC GTGGAGAAGT GCCCCACCGG GGTCAAAGGG 780
GATGGCTTTT TGCACATCTG GAAGTTTCCT GATGAGGACA GTAACTGCCA GCTCTGCCCC 840
ACAAACTGCA CACACATGTG TACAGTTTTG GAAGAAAATG GCTGCCCTGT GGATCAGAAA 900
CCCAGCCAAG TCACAACAAT TGTAGCTGCT GTGGTTGGAG TCCTTCTGTT TCTGGTTTTA 960
GTCTCCGTGA CTGTGTACTT GATTATGCGG CGGAAAAAGC TGAACAAGAA GCACACCCTT 1020
AAGCGCATCC TACAAGAACA TGAGTTGGTT GAGCCTCTGA CTCCCAGTGG AGCATTACCA 1080
AACCAGGCAC AAATGAGAAT CCTTAAAGAA ACAGAATTGC AGAAAGTGAA GGTTCTTGGA 1140
TCTGGTGCCT TTGGTACTGT GTATAAGGGA ATTTGGATTC CTGATGGTGA AGATGTGAAG 1200
ATTCAGGTGG CAATTAAAGT GTTAAGAGAG AACACTTCTT CTAAAGCAAA CAAAGAAATT 1260
CTGGACGAAG CCTATGTAAT GGCAGGGGTG GGTAGCCCCT ATGTCTGCAG GCTGCTCGGA 1320
ATCTGCCTTA CTTCTACTGT GCAGCTGGTA ACTCAACTGA TGCCCTATGG CTGCTTGCTG 1380
GACTATGTTC GAGAAAACAA GGACTGCATT GGTTCCCAGC ACCTCTTAAA CTGGTGTGTC 1440
CAGATTGCAA AGGGAATGAG CTACCTGGAA GATGTGAGGT TAGTGCACCG AGATCTTGCA 1500
GCACGAAATG TTTTGGTGAA GACTCCCAAT CATGTGAAGA TCACTGATTT TGGGCTGGCT 1560
AGACTCCTGG ATATTGATGA AACTGAGTAC CGTGCCGATG GAGGAAAGGT TCCAATCAAA 1620
TGGATGGCTC TGGAATCAAT TCTGCACAGA AAATTCACAC ACCAGAGTGA TGTATGGAGT 1680
TATGGTGTAA CAGTTTGGGA ACTAATGACT TTTGGAGCGA AGCCATATGA CGGAATTCCA 1740
GCACGAGAGA TTCCCGACCT CTTGGAGAAG GGCGAGAGGT TACCACAGCC TCTGATCTGT 1800
ACCATTGACG TCTATATGAT CATGGTGAAA TGTTGGATGA TTGATTCAGA ACAACGACCC 1860
AGGTTCCGTG AACTGGTCAC AGAAGTCACC CAGATGGCAA GGGATCCCCC GCGTTATGTT 1920
GTAATCCAGA ATGAGGAAAC GATGAACCTG CAGAGTCCCG TTGACAGTAA GTTCTACCGT 1980
ACCCTGCTGG AAGATGAGGA TATGCGGAAC CTGGTGGATG CTGAGGAGTA CCTGGTACCA 2040
CACCAAGGGT TTTTCAGCGC CGAGGTCTCC TCCAACTACA GGACTAGGAT GTCATCAGCC 2100
AGGAGTGCCA CAGAAAACAC AGAAGACGTG GAAGTGCCGG GCCCCACCGT ACAGAATTCC 2160
CGACTGGGAC GGAGCATTTC CCAACAGTCT GCTGGAGGGT GTTCAGATGT GTTCCTTGAC 2220
GGAGACTATG CAGAAAGTAA GGCACCATCC ATCCATCCTT TGCGAGGAAA CAGCATTGCC 2280
CAGAGATATA GCGAGGATCC CACCAACTGT TTTAATGAAG ACTTTGGGGG CGAGTTGGAA 2340
GTGGATGGGT ATATCATACC TGGCTCCAGC ACCTCTTCAC CAGAATATGT AAACCAAGCA 2400
GAAGAGATAC CATCTACAAA CAAATGTCAG ACGCCCAATA GTGGAACTCG TAAAAAATTC 2460
ATGGGCCAAC ACGGCAAAAA TGGACTAATT CCAGATCCAA TGTACACTCT TCTAAATGGG 2520
AATGGCAATA TAGTGGAGAA TCCAGAGTAC ATATCACCAA ACAGCCTCCC TTTGATAAAT 2580
TACAGTGGAC AGGCCTTCGA CAACCCCTAC TATTTTGACC ACTGCCCCAC CACCAAGGTG 2640
CCCAAGGATA ACCCTGAAAG CCAAGTAGCT GGTCGATGCC AGCCCAATGG ATTTATGACA 2700
CCAACGGTTG AAAATCCAGA ATACCTGGGA TTTGTAGAGG CGAGCAGTGG ACCAAAAAAC 2760
ATCTCCGTGT GA 2772
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+ge+vki vaikvl+e+t++kanke+ldea+v+a + +
Q: 373   LQKVKVLGSGAFGTVYKGIWIPDGEDVKIQVAIKVLRENTSSKANKEILDEAYVMAGVGS  432
         689*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd +Gsq+llnwcvqiakGmsyle+ 
Q: 433   PYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDCIGSQHLLNWCVQIAKGMSYLEDV  492
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+rk+
Q: 493   RLVHRDLAARNVLVKTPNHVKITDFGLARLLDIDETEYRADGGKVPIKWMALESILHRKF  552
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qp ictidvym++vkcw
Q: 553   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPLICTIDVYMIMVKCW  612
         ************************************************************
S: 241   midaesrpkfkelaee  256
         mid+e rp+f+el++e
Q: 613   MIDSEQRPRFRELVTE  628
         *************987
Domain Sequence
(FASTA)
LQKVKVLGSG AFGTVYKGIW IPDGEDVKIQ VAIKVLRENT SSKANKEILD EAYVMAGVGS 60
PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDCIGS QHLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKTPNHV KITDFGLARL LDIDETEYRA DGGKVPIKWM ALESILHRKF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPLICTI DVYMIMVKCW 240
MIDSEQRPRF RELVTE 256
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-CII-00175
EKS-CIS-00072
EKS-DAR-00646
EKS-DRM-00152
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LOA-00309
EKS-MAM-00302
EKS-MEG-00239
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORA-00262
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-PES-00267
EKS-POA-00289
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAG-00314
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013