EKS-LAC-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	376.0	1.3E-112	56	354	299

Status

Unreviewed

Ensembl Protein

ENSLACP00000017145

UniProt Accession

H3B5H3;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000015107	ENSLACP00000017145	ENSLACT00000017271
ENSLACG00000015107	ENSLACP00000017144	ENSLACT00000017270

Organism

Latimeria chalumnae

Functional Description

Protein Length

875

Protein Sequence
(FASTA)

EEITVIALAS VSVVAVVTVA LIFGYRMLTG DRKQGLHSMN MMEAAASEPS LDLDSLKLLE 60

LIGRGRYGAV YKGSLDERPV AVKVFSYSNR QNFVNEKSIY RLPLMDHDNI ARFMVGDERF 120

TADGRMEYVL VMEYYPHGSL CKYLSLHTSD WVGSCRLAHS VTKGLAVLHT ELLRGDQYKP 180

AVSHRDLNSR NVLVKNDGTC VISDFGLSMK LTGNRLVRPG EEDNAAISEV GTIRYMAPEV 240

LEGAVNLRDC ESALKQVDMY ALGLIYWEIF MRCTDLFPGE TVPEYQMVFQ AEVGNHPTFE 300

DMQVLVSREK QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD AEARLTAQCA EERMSELMVI 360

WDRNKSVSPT VNPMSTAVQN ERNLSHSQRV PKIGPYPDYS SSSYIEGPIH HADGMVKNIC 420

TEHSSSGTPS TTGEKNRNSI NYERQQAQAR VPSPETSVTS LSTNTTTTNT TGLTPSTGMT 480

TISEMPYSDD TSSHNANVLQ PTGPSPVFLH LTEEDLETNK LDPKEVDKNL KESSDENLME 540

HSLKQFSGPD PLSSSSSSLL YPLIKLAAEV TGQQDFAQPG GSQACLIPDV PPVQVYPLPK 600

QQNLPKRPTS LPLNTKNATK ESRLKFGKHK SNLKQVETGV AKMNTINAAE PQLVTVTMNG 660

VAGRGHSGNT NAVTMQYANG VVPSSQSSNV AIHRGQDMLQ SQFSGEDSRL NINSSPDEHE 720

PLLRREQQAE RRDRSLDAGR TNSNNNNSNH CPVVEEVARA SLGNTEENLQ QGRRVERPTS 780

LDLSAMNSLD SYSMQCETTQ DSKPGSGEKI KKRVKTPYSL KRWRPSTWVI STEALDCEVN 840

NNQGAGRSKS STAVYLVGGG TATATISKDS GMSCL 875

Nucleotide Sequence
(FASTA)

GAGGAAATTA CAGTGATCGC CCTGGCTTCA GTCTCCGTGG TGGCTGTCGT GACTGTTGCA 60

CTTATCTTTG GATACAGGAT GCTTACAGGT GATCGTAAGC AGGGCCTTCA CAGTATGAAC 120

ATGATGGAGG CAGCAGCATC AGAGCCTTCC TTAGACCTGG ACAGCCTGAA ACTGCTAGAG 180

CTAATTGGTC GTGGTCGGTA TGGAGCAGTT TATAAAGGAT CCCTGGATGA GCGCCCGGTG 240

GCCGTGAAGG TGTTCTCCTA CTCCAACAGG CAGAACTTTG TTAATGAGAA AAGCATTTAC 300

CGTCTCCCGC TGATGGATCA TGACAACATA GCTCGCTTTA TGGTTGGGGA CGAACGATTC 360

ACTGCAGATG GGCGGATGGA GTATGTGTTG GTTATGGAGT ACTATCCACA TGGCTCGCTA 420

TGCAAGTATC TGAGCCTTCA CACCAGTGAC TGGGTAGGCT CCTGCAGGCT GGCCCATTCT 480

GTCACAAAAG GTTTGGCGGT TCTTCACACG GAGCTACTCA GAGGAGATCA ATACAAGCCT 540

GCAGTTTCTC ATCGGGACCT CAACAGCCGT AATGTCTTGG TGAAGAACGA TGGAACCTGC 600

GTAATTAGTG ATTTTGGACT CTCCATGAAA CTGACTGGGA ACAGACTTGT CCGGCCAGGG 660

GAAGAGGACA ATGCAGCCAT CAGTGAGGTG GGTACAATTC GCTACATGGC ACCAGAAGTT 720

CTAGAGGGGG CAGTGAACCT TCGAGACTGC GAGTCAGCAC TTAAACAGGT GGATATGTAC 780

GCACTGGGTC TCATCTACTG GGAGATCTTT ATGAGATGCA CAGACCTCTT TCCAGGAGAG 840

ACTGTACCAG AGTACCAAAT GGTGTTCCAA GCAGAAGTTG GCAACCATCC CACCTTTGAG 900

GATATGCAAG TGTTGGTTTC CAGGGAGAAG CAGAGGCCTA AGTTCCCAGA AGCCTGGAAA 960

GAGAATAGTC TGGCTGTAAG GTCTCTGAAA GAGACAATTG AAGATTGCTG GGACCAGGAT 1020

GCTGAGGCTC GGCTGACAGC CCAGTGCGCA GAGGAGCGAA TGTCGGAGTT GATGGTGATC 1080

TGGGACAGGA ACAAGTCAGT CAGCCCCACT GTCAACCCTA TGTCAACTGC GGTGCAGAAC 1140

GAAAGAAACC TTTCTCATAG TCAGCGAGTG CCAAAGATTG GACCGTACCC GGATTATTCT 1200

TCCTCTTCCT ACATAGAAGG TCCCATCCAC CACGCAGATG GAATGGTCAA GAACATTTGC 1260

ACAGAACATT CTTCTTCTGG AACTCCCTCG ACAACAGGCG AAAAGAACCG CAACTCCATC 1320

AACTACGAGA GGCAGCAAGC CCAGGCTCGG GTCCCGAGTC CTGAGACCAG TGTTACCAGC 1380

TTATCCACCA ACACCACCAC CACAAACACT ACAGGTCTTA CCCCCAGCAC TGGCATGACC 1440

ACAATATCTG AAATGCCATA TTCAGATGAC ACCAGCTCCC ACAATGCCAA TGTCCTGCAA 1500

CCTACAGGTC CGAGTCCTGT CTTCCTGCAT CTTACAGAAG AAGACCTGGA GACCAATAAG 1560

CTAGACCCTA AAGAGGTGGA CAAAAACCTT AAGGAAAGCT CTGATGAAAA CCTAATGGAA 1620

CACTCACTCA AGCAGTTCAG TGGACCTGAC CCTCTTAGCA GCAGCAGTTC CAGTTTGCTA 1680

TACCCTTTGA TAAAGCTTGC TGCAGAGGTC ACAGGACAGC AAGATTTTGC ACAGCCTGGC 1740

GGTAGCCAGG CTTGCTTGAT TCCTGATGTC CCCCCTGTCC AGGTGTACCC GCTACCTAAG 1800

CAGCAGAATC TGCCTAAGCG TCCCACCAGC CTGCCACTCA ACACCAAAAA TGCCACTAAG 1860

GAGTCACGGC TGAAATTTGG CAAGCACAAG TCAAACCTAA AGCAGGTTGA AACTGGGGTA 1920

GCGAAGATGA ACACAATCAA TGCAGCAGAG CCCCAGCTAG TGACAGTCAC GATGAACGGA 1980

GTTGCGGGCA GAGGCCATAG TGGAAACACC AACGCCGTGA CAATGCAGTA TGCCAATGGT 2040

GTTGTGCCAT CCAGTCAGTC ATCAAATGTG GCCATCCACA GGGGCCAGGA CATGTTGCAG 2100

TCCCAGTTCA GCGGAGAAGA CAGCAGGCTA AACATCAACT CCAGTCCCGA TGAACATGAG 2160

CCACTGCTGA GACGAGAGCA GCAAGCAGAG AGGAGAGACC GATCGTTGGA TGCTGGGCGA 2220

ACAAACTCCA ACAACAACAA CAGCAATCAC TGTCCTGTGG TGGAGGAAGT GGCGAGGGCT 2280

AGCTTAGGCA ACACAGAAGA AAACCTCCAG CAAGGGAGAA GAGTAGAGAG ACCGACCTCT 2340

TTGGATCTAT CTGCTATGAA CAGTCTGGAC AGCTATAGCA TGCAGTGTGA AACAACACAA 2400

GACAGTAAAC CGGGCTCTGG GGAGAAGATC AAGAAACGGG TGAAGACGCC TTACTCCCTC 2460

AAACGGTGGC GCCCCTCAAC GTGGGTCATC TCAACGGAAG CACTAGACTG CGAAGTGAAC 2520

AACAACCAGG GGGCTGGTCG CTCCAAGTCT AGCACTGCTG TTTATCTGGT GGGAGGAGGC 2580

ACTGCCACAG CAACCATTTC CAAGGATTCA GGAATGAGCT GCCTGTAG 2628

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs+++++++++Ek iy+++l+ h+ni +f++

Q: 56    LKLLELIGRGRYGAVYKGSLDERPVAVKVFSYSNRQNFVNEKSIYRLPLMDHDNIARFMV  115

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e++lv+ey+++gsL++yL+ +t+d+  ++rla+s+++Gla LH+e+

Q: 116   GDErFTADGRMEYVLVMEYYPHGSLCKYLSLHTSDWVGSCRLAHSVTKGLAVLHTELLRG  175

         **98999*************************************************8655

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpa++HRDl+s+N+lvk+d+tc+i+D+GL++kl+ ++ +    +d+aa+s+vGt R

Q: 176   -DQYKPAVSHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVrpgeEDNAAISEVGTIR  234

         .579*********************************9999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey++ f+++vg

Q: 235   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGETVPEYQMVFQAEVG  294

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 295   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  354

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SYSNRQNFVN EKSIYRLPLM DHDNIARFMV 60

GDERFTADGR MEYVLVMEYY PHGSLCKYLS LHTSDWVGSC RLAHSVTKGL AVLHTELLRG 120

DQYKPAVSHR DLNSRNVLVK NDGTCVISDF GLSMKLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGETVPEY QMVFQAEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013