EKS-LAC-00175

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00175

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	485.0	5.3E-146	419	677	259

Status

Unreviewed

Ensembl Protein

ENSLACP00000017232

UniProt Accession

H3B5R1;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000015177	ENSLACP00000017232	ENSLACT00000017358

Organism

Latimeria chalumnae

Functional Description

Protein Length

729

Protein Sequence
(FASTA)

MGTLRDLQYA LQEKIEELRQ RDALIDDLEL ELDQKDELIQ KLQNELDKYR SVLRPTSQSQ 60

QEMLESGGQL QEQQRTKRQA ISAEPTGLNI QDISHVTLTC YTKSTESKEL IKEAISENDF 120

MKNLEVSQIQ EIVDCMYPVE YSQGSCIISE GDVGSLVYVI AEGKVEVSKE GVKLCTMAQR 180

KVFGELAILY NCTRTATVKA FLWIIYFSNC KMLTSLNSKS HSGTESVPPT LVMEGPPVSQ 240

AQTHVKLWAI DRQCFQTIMM RTGLIKLAEY MEFLKSVPTF QDLHEDVLSK LADVLEETHY 300

DDGEYIIRQG ASGDTFFIIN KGKVNVTQQK SPNEEPVFLS SLSRGDWFGE EALQGEDVRT 360

VNMIAAGEVS CLVIDRESFR QLIGSLEDIH NKVYENAETK AKFEAEAAFF ASLDFTDFHI 420

VNTLGVGGFG RVELVQLKSN ESKTFAMKIL KKQYIVDTRQ EGHIRSEREI MQEAHCDFIV 480

RLYCTFRNSK YLYMVMEACL GGELWTILRD RGSFDDGTTR FYIACVVQAL AYLHCRGIIY 540

RDLKPENILL DHRGYAKLVD FGFVKKIGFG KKTWTFCGTP EYVAPEIILN KGHDISADYW 600

SLGILVYELL TGSPPFSGSD PMKTYNLILK GIDMVEFPKK ITKNAANFIK KLCRDSPSER 660

LGNQKNGVKD IQKHKWFDGF NWEGIRNGTL NAPITPNVNG PLDTSNFDIF PEDDEDPPPD 720

EESGWDADF 729

Nucleotide Sequence
(FASTA)

ATGGGCACTC TCCGGGACCT TCAGTACGCT CTTCAGGAAA AGATTGAGGA ATTACGGCAG 60

AGGGATGCCC TAATTGATGA CCTGGAACTG GAGCTCGACC AGAAGGATGA GTTGATCCAG 120

AAACTTCAAA ATGAACTAGA CAAATACCGG TCAGTTTTGC GGCCTACTAG CCAATCCCAA 180

CAAGAGATGC TGGAGTCAGG GGGGCAGCTT CAGGAGCAGC AGAGAACTAA AAGACAGGCC 240

ATTTCAGCAG AGCCTACAGG ACTGAACATC CAGGATATCA GCCATGTCAC CCTCACCTGC 300

TACACCAAGA GCACAGAGTC AAAGGAACTG ATCAAAGAAG CAATTTCAGA AAATGATTTT 360

ATGAAAAATC TGGAAGTGTC TCAGATTCAG GAGATTGTAG ACTGTATGTA CCCAGTGGAA 420

TACAGCCAGG GAAGCTGCAT AATCAGTGAG GGTGATGTAG GCTCTTTAGT TTATGTCATT 480

GCAGAAGGGA AAGTAGAAGT AAGCAAAGAG GGTGTTAAAT TATGCACAAT GGCACAAAGG 540

AAAGTGTTCG GAGAATTGGC TATTCTATAC AATTGTACTC GAACAGCAAC TGTTAAAGCT 600

TTTTTGTGGA TTATATATTT CAGCAACTGC AAGATGCTGA CAAGCCTGAA TAGTAAGAGC 660

CATTCAGGTA CTGAATCTGT GCCACCCACT TTGGTTATGG AAGGACCACC AGTCAGTCAA 720

GCCCAGACAC ATGTTAAACT TTGGGCAATT GACCGCCAGT GTTTCCAGAC CATCATGATG 780

CGGACAGGAT TGATTAAACT TGCGGAATAT ATGGAATTTT TAAAGAGTGT TCCTACATTC 840

CAAGATCTAC ATGAAGATGT TTTAAGTAAA CTCGCAGATG TGCTGGAAGA GACTCATTAT 900

GATGATGGAG AGTACATTAT TAGACAAGGA GCCAGTGGAG ATACATTCTT TATTATCAAC 960

AAAGGCAAGG TAAACGTCAC CCAACAGAAA TCCCCCAATG AAGAGCCAGT GTTTTTAAGC 1020

AGCCTGTCCA GGGGAGACTG GTTTGGTGAA GAGGCACTAC AAGGAGAAGA TGTAAGGACC 1080

GTGAACATGA TTGCAGCGGG AGAGGTGTCT TGTTTGGTGA TTGACAGAGA GTCATTTAGA 1140

CAGCTGATTG GAAGCTTGGA AGACATCCAT AACAAAGTGT ATGAAAATGC AGAGACAAAA 1200

GCAAAGTTTG AGGCTGAAGC TGCTTTCTTT GCCAGTCTGG ATTTTACAGA TTTCCATATT 1260

GTCAACACGC TGGGAGTTGG AGGGTTTGGA CGAGTGGAAC TGGTACAGCT AAAGAGCAAT 1320

GAATCCAAGA CATTTGCAAT GAAGATCCTG AAGAAACAGT ACATTGTGGA TACCCGACAG 1380

GAGGGGCACA TCCGGTCAGA GCGAGAGATT ATGCAGGAGG CACACTGTGA TTTCATTGTC 1440

AGATTGTACT GTACATTTCG GAACAGTAAG TACCTCTACA TGGTAATGGA GGCTTGCCTG 1500

GGGGGAGAAC TTTGGACCAT CCTGAGAGAC AGGGGCTCCT TTGATGATGG CACCACTCGG 1560

TTCTACATAG CTTGTGTAGT ACAAGCCTTA GCCTATCTGC ACTGCCGAGG GATTATTTAC 1620

CGAGACCTGA AACCAGAGAA CATCCTCCTT GATCATCGTG GCTATGCCAA ATTGGTGGAT 1680

TTTGGCTTTG TGAAGAAGAT TGGATTTGGG AAGAAAACCT GGACCTTCTG TGGTACTCCT 1740

GAGTATGTGG CACCAGAAAT CATCCTGAAT AAAGGTCATG ACATTTCAGC AGACTACTGG 1800

TCCCTGGGGA TCCTCGTGTA CGAGCTGCTG ACTGGGAGCC CTCCATTCTC TGGATCTGAT 1860

CCAATGAAAA CCTATAACCT CATACTCAAG GGAATTGATA TGGTGGAATT TCCCAAAAAG 1920

ATCACTAAAA ATGCAGCAAA CTTCATCAAA AAACTCTGTA GGGACAGCCC ATCTGAAAGG 1980

CTAGGCAACC AAAAAAATGG GGTGAAAGAC ATTCAAAAAC ACAAATGGTT TGATGGTTTT 2040

AACTGGGAAG GAATAAGAAA TGGAACTTTA AATGCTCCTA TCACCCCTAA TGTTAATGGT 2100

CCTCTGGACA CCAGCAACTT TGACATTTTC CCAGAGGATG ATGAGGATCC ACCTCCAGAT 2160

GAGGAATCTG GTTGGGATGC TGACTTCTAA 2190

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++++tlgvggfgrvelv++ks+esk+fa+kilkk+ ivdt+q+ h++se++i++ea++df

Q: 419   HIVNTLGVGGFGRVELVQLKSNESKTFAMKILKKQYIVDTRQEGHIRSEREIMQEAHCDF  478

         689*********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+ly tf+++ky+y+++eaclggelwtilrdrgsfdd t++f++acvv+al+ylh ++i

Q: 479   IVRLYCTFRNSKYLYMVMEACLGGELWTILRDRGSFDDGTTRFYIACVVQALAYLHCRGI  538

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpen+lld++gy+klvdfgf kk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 539   IYRDLKPENILLDHRGYAKLVDFGFVKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  598

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgilvyelltg+ppfsg+dp+ktynlilkgid++e+p+kitk+a+++ikklcrd+p+

Q: 599   YWSLGILVYELLTGSPPFSGSDPMKTYNLILKGIDMVEFPKKITKNAANFIKKLCRDSPS  658

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg++k+g+kdi+khkwf

Q: 659   ERLGNQKNGVKDIQKHKWF  677

         ******************9

Domain Sequence
(FASTA)

HIVNTLGVGG FGRVELVQLK SNESKTFAMK ILKKQYIVDT RQEGHIRSER EIMQEAHCDF 60

IVRLYCTFRN SKYLYMVMEA CLGGELWTIL RDRGSFDDGT TRFYIACVVQ ALAYLHCRGI 120

IYRDLKPENI LLDHRGYAKL VDFGFVKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILVYE LLTGSPPFSG SDPMKTYNLI LKGIDMVEFP KKITKNAANF IKKLCRDSPS 240

ERLGNQKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013