EKS-LAC-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	387.1	4.3E-116	7	290	284

Status

Unreviewed

Ensembl Protein

ENSLACP00000017338

UniProt Accession

H3B617;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000015271	ENSLACP00000017338	ENSLACT00000017465

Organism

Latimeria chalumnae

Functional Description

Protein Length

390

Protein Sequence
(FASTA)

LADLYTLTDE LLGEGAYARV QGCVSLLNGK EYAVKIIEKK VGHSRSRVFR EVETLYQCQG 60

NRNILELIEF CEDETKFYLV FEKLCGGSIL THIQRRKHFN EREASRVVRD IASALDFLHN 120

KGIAHRDLKP ENILCEFVDQ VSPVKICDFD LGSGMKLSSA CTPITTPELT TPCGSAEYMA 180

PEVVEVFTEE ASFYDKRCDL WSLGVVLYIL LSGYPPFVGN CGTNCGWDRG EVCRACQNIL 240

FESIQEGNYE FPEKDWSHIS QGAKDLISKL LVRDAKKRLG ASQVLQHPWV QGNAPERGLP 300

TPQVLRRNSS TKDLTQFAAE AIAFNRQLSQ HDEQLREEQD KMIQTIRSMK LSPPSNSRLA 360

KRRAKAHASK EGGFQPAGDP VQRGSSAGTS 390

Nucleotide Sequence
(FASTA)

TTGGCAGATC TTTACACGTT GACTGATGAG CTCTTAGGGG AAGGAGCCTA TGCCAGGGTC 60

CAAGGCTGTG TCAGTCTGCT GAATGGAAAA GAGTATGCAG TGAAGATCAT TGAGAAAAAA 120

GTAGGACACA GTCGCAGTAG AGTATTTCGG GAGGTGGAGA CATTATATCA GTGTCAAGGC 180

AACAGGAACA TTTTGGAGCT TATAGAATTT TGTGAAGATG AAACGAAGTT TTATTTGGTT 240

TTTGAAAAAC TGTGTGGAGG TTCAATCCTG ACTCATATTC AGAGGCGGAA GCACTTTAAC 300

GAGAGAGAAG CCAGCAGGGT CGTGAGAGAC ATTGCCTCGG CTTTGGATTT TCTGCACAAT 360

AAAGGTATTG CACATAGAGA CCTGAAACCA GAGAACATCC TCTGTGAGTT CGTAGATCAG 420

GTGTCGCCAG TGAAGATTTG TGACTTTGAC CTTGGCAGTG GAATGAAACT AAGCAGTGCC 480

TGCACTCCAA TAACCACCCC CGAGCTGACC ACTCCTTGTG GCTCCGCGGA GTACATGGCT 540

CCGGAGGTGG TTGAAGTATT CACAGAAGAG GCCTCTTTCT ACGACAAGCG CTGTGACCTG 600

TGGAGCCTGG GGGTGGTTCT CTACATCCTT CTGAGCGGAT ACCCACCTTT TGTGGGGAAC 660

TGTGGAACAA ACTGTGGCTG GGACAGGGGG GAGGTCTGCA GAGCCTGCCA GAACATTCTG 720

TTTGAGAGTA TCCAAGAAGG TAATTATGAA TTTCCTGAGA AGGACTGGTC CCACATCTCA 780

CAAGGCGCTA AAGATCTGAT TTCAAAGCTG CTGGTTCGAG ATGCCAAGAA GAGGCTTGGG 840

GCTTCCCAGG TCTTACAACA TCCCTGGGTA CAGGGGAATG CTCCTGAGAG GGGTTTGCCT 900

ACACCACAAG TTCTTCGGAG AAACAGCAGC ACGAAGGACC TGACGCAGTT TGCAGCGGAA 960

GCCATCGCCT TTAACCGCCA GCTCTCCCAA CACGACGAGC AGCTGAGGGA GGAGCAGGAC 1020

AAGATGATTC AAACCATCCG CTCGATGAAG CTCTCCCCGC CTTCCAACTC CCGCCTGGCC 1080

AAGCGCAGAG CCAAGGCCCA TGCCAGCAAA GAGGGCGGCT TCCAGCCAGC CGGAGACCCC 1140

GTGCAACGAG GAAGTAGTGC TGGTACCTCC TGA 1173

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         lt+e+lGeG++++v+ cv+  +g++ya+ki+     ++r++v+reve+++q++g++ni+e

Q: 7     LTDELLGEGAYARVQGCVSLLNGKEYAVKIIekkvgHSRSRVFREVETLYQCQGNRNILE  66

         6899********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         li++ e    de++++lv+ekl GG++l++iq+rk+f+e+eas+vv+diasal+flh+k+

Q: 67    LIEFCE----DETKFYLVFEKLCGGSILTHIQRRKHFNEREASRVVRDIASALDFLHNKG  122

         ******....**************************************************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaPe  168

         iahrDlkpen+L+e  ++++pvk+cDf+l+++++ +        +el+tpc++aey+aPe

Q: 123   IAHRDLKPENILCEFVDQVSPVKICDFDLGSGMKLSsactpittPELTTPCGSAEYMAPE  182

         ********************************954456888888****************

S: 169   vleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklke  217

         v+e+++eea++ydk+CDlWslGv+lyill+GypPf++++g           ra+++ l+e

Q: 183   VVEVFTEEASFYDKRCDLWSLGVVLYILLSGYPPFVGNCGtncgwdrgevcRACQNILFE  242

         ***************************************99*******************

S: 218   riqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +iqeg+yefPe++Ws++s+ akdli+klL+rd+k+rl +++vl+hpwv

Q: 243   SIQEGNYEFPEKDWSHISQGAKDLISKLLVRDAKKRLGASQVLQHPWV  290

         ***********************************************8

Domain Sequence
(FASTA)

LTDELLGEGA YARVQGCVSL LNGKEYAVKI IEKKVGHSRS RVFREVETLY QCQGNRNILE 60

LIEFCEDETK FYLVFEKLCG GSILTHIQRR KHFNEREASR VVRDIASALD FLHNKGIAHR 120

DLKPENILCE FVDQVSPVKI CDFDLGSGMK LSSACTPITT PELTTPCGSA EYMAPEVVEV 180

FTEEASFYDK RCDLWSLGVV LYILLSGYPP FVGNCGTNCG WDRGEVCRAC QNILFESIQE 240

GNYEFPEKDW SHISQGAKDL ISKLLVRDAK KRLGASQVLQ HPWV 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013