EKS-LAC-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	505.1	4.6E-152	96	353	258

Status

Unreviewed

Ensembl Protein

ENSLACP00000017359

UniProt Accession

H3B638;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000015290	ENSLACP00000022625	ENSLACT00000025512
ENSLACG00000015290	ENSLACP00000017359	ENSLACT00000017486

Organism

Latimeria chalumnae

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

FYRAECQLMK TERPKPNTFI IRCLQWTTVI ERTFHVDTPE EREEWTEAIQ AVADRLQKQE 60

EERMNCSPTS HIDNLCEEEM DTSTSHHKRK ITMNDFDYLK LLGKGTFGKV ILVREKASGK 120

YYAMKILKKE VIIAKDEVAH TLTESRVLKN TRHPFLTSLK YSFQTKDRLC FVMEYVNGGE 180

LFFHLSRERV FSEDRTRFYG AEIVSALDYL HSGKIVYRDL KLENLMLDKD GHIKITDFGL 240

CKEGITDAAT MKTFCGTPEY LAPEVLEDND YGRAVDWWGL GVVMYEMMCG RLPFYNQDHE 300

KLFELILMEE IKFPRTLSSD AKSLLSGLLI KDPNKRLGGG PDDAKEIMRH SFFVGVNWQD 360

VYDKKLVPPF KPQVSSETDT RYFDEEFTAQ TITITPPEKY DDDGMDCMDN ERRPHFPQFS 420

YSASGRE 427

Nucleotide Sequence
(FASTA)

TTCTATCGTG CAGAATGCCA ACTAATGAAA ACTGAACGAC CAAAGCCCAA CACGTTTATT 60

ATCAGATGCT TGCAGTGGAC CACTGTCATA GAGAGGACAT TTCATGTAGA CACTCCTGAA 120

GAAAGGGAAG AGTGGACGGA GGCTATCCAG GCAGTAGCAG ACAGACTTCA GAAGCAGGAA 180

GAAGAGAGGA TGAACTGTAG CCCTACCTCT CACATAGATA ACTTATGCGA GGAAGAAATG 240

GATACTTCAA CTAGCCATCA TAAACGAAAG ATCACCATGA ATGACTTTGA CTATTTGAAA 300

CTACTGGGTA AAGGCACTTT TGGCAAAGTC ATTCTAGTCC GAGAGAAAGC AAGTGGGAAG 360

TATTATGCAA TGAAGATTTT GAAGAAAGAA GTTATTATTG CAAAGGACGA GGTGGCACAT 420

ACACTTACAG AAAGCAGAGT GCTAAAAAAC ACTAGGCATC CATTTTTAAC GTCTTTGAAG 480

TATTCATTCC AGACAAAGGA CCGGTTGTGT TTTGTGATGG AATATGTAAA CGGCGGAGAG 540

CTGTTTTTCC ATTTGTCGAG AGAGCGGGTG TTCTCGGAGG ACCGCACGCG CTTCTACGGT 600

GCAGAAATTG TCTCGGCTCT GGACTATCTG CATTCCGGCA AGATTGTGTA CCGCGATCTC 660

AAGTTAGAGA ATCTAATGTT GGATAAAGAT GGCCACATTA AAATTACAGA TTTTGGACTT 720

TGCAAAGAAG GAATCACAGA CGCTGCTACA ATGAAAACAT TCTGTGGTAC ACCAGAATAC 780

CTAGCTCCCG AGGTTTTGGA AGATAATGAC TATGGCCGAG CTGTAGACTG GTGGGGTCTT 840

GGAGTGGTTA TGTATGAGAT GATGTGCGGC AGACTACCGT TCTATAACCA GGACCACGAG 900

AAATTGTTTG AGCTAATTCT TATGGAGGAG ATCAAATTCC CAAGAACACT TTCTTCGGAT 960

GCAAAATCAC TGCTTTCAGG ACTACTTATA AAAGATCCAA ACAAACGACT AGGCGGGGGC 1020

CCTGATGATG CGAAGGAGAT TATGCGACAC AGCTTCTTTG TTGGAGTGAA CTGGCAGGAT 1080

GTATATGATA AAAAGCTTGT ACCTCCCTTT AAGCCTCAGG TGTCGTCTGA AACAGATACA 1140

AGGTATTTTG ATGAAGAATT TACAGCTCAA ACCATTACAA TAACGCCACC TGAAAAATAT 1200

GATGACGATG GTATGGACTG CATGGACAAT GAGAGGCGAC CGCACTTCCC CCAGTTTTCC 1260

TACTCCGCCA GTGGCCGAGA ATAG 1284

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 96    FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  155

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 156   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  215

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 216   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  275

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+ee+kfpr+ls++aksllsGll kdp+k

Q: 276   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIKFPRTLSSDAKSLLSGLLIKDPNK  335

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 336   RLGGGPDDAKEIMRHSFF  353

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013