EKS-LAC-00270
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00270
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl550.56.0E-166244495252
StatusUnreviewed
Ensembl ProteinENSLACP00000022036
UniProt AccessionH3B794;
Protein Name
Protein Synonyms/Alias
Gene NameABL1
Gene Synonyms/Alias ABL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000015645ENSLACP00000017766ENSLACT00000017896
ENSLACG00000015645ENSLACP00000017765ENSLACT00000017895
ENSLACG00000015645ENSLACP00000022036ENSLACT00000025798
OrganismLatimeria chalumnae
Functional Description
Protein Length1141
Protein Sequence
(FASTA)
MKMLEICLKL VGCKSKKGLS SASSCYLEEA LQRPIVSDFE PQGLSEAARW NSKENLLAGP 60
SENDPNLFVA LYDFVASGDN TLSITKGEKL RVLGYNHNGE WCEAQTKNGQ GWVPSNYITP 120
VNSLEKHSWY HGPVSRNAAE YLLSSGINGS FLVRESESSP GQRSISLRYE GRVYHYRINT 180
ASDGKLFVSS ESRFNTLAEL VHHHSTVADG LITTLHYPAP KRNKPTIYGV SPNYDKWEIE 240
RTDITMKHKL GGGQYGEVYE GVWKKYNLTV AVKTLKEDTM EVEEFLKEAA VMKEIKHPNL 300
VQLLGVCTRE PPFYIITEFM THGNLLDYLR DCNREEVNAV VLLYMATQIS SAMEYLEKKN 360
FIHRDLAARN CLVGENHLVK VADFGLSRLM TGDTYTAHAG AKFPIKWTAP ESLAYNKFSI 420
KSDVWAFGVL LWEIATYGMS PYPGIDLSQV YELLEKDYRM ERPEGCPEKV YELMRACWKW 480
NPADRHSFAE IHQAFETMFQ ESSISDEVEK ELEKKGGKGA MCNLPQAPEL PTKTRTIRRP 540
TESKEANENL DTPHSKAAGE LDPLDQESAV SPILPGKERV LLDSNLNEDE RLLPKDKKSG 600
LFSALIKKKK KTAPTPPKRS SSFREMDGHL ERRGEAVDEC PSGSRDISNG TFVMPLGETL 660
DPSKFQSTSN GAGVTNGTAS GAVGWFSPHL RKKSSTLASN RAAGNEEEPS SSSSSNISSN 720
KRFLRSCSAS SMPPGTKEME WKSVTLPRDL QSTVRQLDSS TFGCNRSEKP ALPRKRASEN 780
KNDLTPRGTV TPPPRLPRKT EELADEVFKD TESSPGSSPP TSTPKLVRRQ PAVSSINPSL 840
KEEGQKTSAL GSTFHPDQIS TMKQNPIIFT SVVKASGEES RMRRLKQSPD HSVKDKGKLT 900
KPKPAPPPPP PSTGKPGKPS SRSPSHETAG DSTAGAKLKH LTQVVDPVSG DVAKPSQLGE 960
GIKKAILPSI PKPQSSTKPS MVVGTVVSTA PVTSSSSPST LPNSSGDQQS STAFNPLIPT 1020
RVSLRKTRQP PEKIASGTIT KDIVLESTEA LRAAISKNSE QLASHSVVLE AGKNLYTFCV 1080
NYVDSIQQMR NKFAFREAIN KLENNLRELQ ICPASSSSPA AAQDFTKLLS SVKEISDIVQ 1140
R 1141
Nucleotide Sequence
(FASTA)
ATGAAAATGT TGGAGATTTG TCTCAAGTTG GTGGGTTGCA AATCCAAAAA GGGCCTTTCT 60
TCAGCGTCCA GTTGTTATTT GGAAGAAGCC CTCCAGAGGC CGATAGTATC GGATTTTGAG 120
CCCCAAGGCT TAAGCGAAGC TGCCCGTTGG AACTCCAAGG AGAACCTCCT AGCAGGTCCC 180
AGTGAAAATG ACCCCAACCT CTTTGTTGCA CTGTATGATT TTGTTGCCAG CGGCGACAAC 240
ACACTCAGCA TAACCAAAGG TGAGAAGCTC CGTGTCCTGG GTTATAACCA CAATGGGGAG 300
TGGTGTGAAG CACAGACCAA GAACGGGCAG GGCTGGGTTC CTAGTAACTA TATAACCCCA 360
GTAAACAGCT TGGAAAAACA TTCCTGGTAC CACGGGCCAG TGTCACGCAA TGCTGCCGAG 420
TACCTGCTAA GCAGTGGGAT TAACGGCAGC TTCCTAGTGC GGGAGAGCGA GAGCAGTCCG 480
GGACAGCGGT CCATCTCACT ACGATACGAA GGAAGGGTAT ACCACTACAG AATCAACACT 540
GCTTCTGATG GAAAGCTGTT TGTTTCCTCT GAGAGCCGCT TTAACACACT GGCAGAGTTG 600
GTGCATCACC ACTCGACTGT GGCTGATGGA CTGATCACCA CCCTGCACTA CCCGGCCCCC 660
AAGCGGAACA AGCCCACCAT CTATGGTGTG TCTCCCAACT ATGACAAGTG GGAGATCGAA 720
CGGACTGACA TTACCATGAA ACACAAGCTG GGAGGGGGCC AGTATGGCGA AGTGTATGAA 780
GGCGTGTGGA AGAAGTACAA CCTCACTGTA GCTGTGAAGA CTTTAAAGGA GGACACAATG 840
GAGGTGGAAG AGTTCTTGAA AGAGGCTGCA GTTATGAAGG AAATTAAACA TCCCAATCTG 900
GTTCAGCTGC TGGGGGTGTG TACACGGGAA CCACCGTTTT ACATCATCAC GGAGTTTATG 960
ACTCATGGGA ACCTCCTGGA TTACCTGCGC GATTGTAACC GTGAGGAAGT GAACGCGGTT 1020
GTGCTGCTGT ACATGGCCAC ACAAATCTCA TCTGCCATGG AATACCTAGA AAAAAAAAAC 1080
TTTATTCACA GGGATCTTGC TGCCAGGAAC TGCTTAGTAG GGGAGAACCA CTTAGTGAAG 1140
GTGGCGGATT TTGGACTGAG CAGGCTAATG ACGGGGGACA CGTACACGGC ACATGCTGGC 1200
GCCAAATTTC CCATTAAGTG GACGGCACCG GAGAGCTTGG CATACAACAA GTTTTCAATT 1260
AAATCTGATG TCTGGGCCTT CGGAGTCCTG CTGTGGGAGA TTGCTACTTA TGGCATGTCC 1320
CCTTATCCTG GGATCGACCT GTCGCAGGTG TACGAGCTGC TGGAGAAAGA TTACCGAATG 1380
GAGCGCCCTG AGGGCTGTCC CGAGAAGGTC TATGAGCTCA TGAGAGCATG CTGGAAGTGG 1440
AATCCTGCAG ACCGACACTC ATTTGCTGAA ATCCACCAAG CTTTTGAGAC CATGTTTCAG 1500
GAATCCAGTA TATCGGATGA GGTTGAGAAG GAGCTGGAGA AGAAAGGAGG AAAAGGGGCA 1560
ATGTGTAACC TTCCACAGGC CCCCGAGCTG CCAACCAAAA CACGCACCAT CAGGAGACCA 1620
ACTGAGAGCA AAGAGGCCAA TGAGAACCTG GACACGCCTC ATTCCAAAGC AGCAGGGGAA 1680
CTGGATCCCC TGGACCAGGA GTCTGCTGTT TCTCCAATAC TTCCTGGAAA GGAGCGGGTG 1740
CTTCTGGATA GTAACTTGAA TGAAGATGAG CGCCTGCTCC CGAAGGATAA GAAGTCAGGC 1800
CTGTTCAGCG CTCTGATTAA AAAGAAAAAG AAGACAGCCC CGACGCCCCC CAAGCGCAGC 1860
AGCTCTTTCC GTGAAATGGA TGGCCATTTG GAGAGGCGAG GGGAGGCTGT AGACGAGTGC 1920
CCCTCAGGCA GTAGGGACAT CAGCAATGGA ACCTTTGTGA TGCCACTTGG CGAGACCCTC 1980
GATCCATCCA AGTTTCAGAG CACCAGCAAT GGGGCAGGGG TGACAAACGG CACGGCTTCA 2040
GGGGCAGTTG GGTGGTTCTC CCCCCATCTC CGGAAAAAGT CCAGCACATT AGCAAGTAAT 2100
AGGGCAGCAG GGAATGAGGA GGAGCCCAGC TCCAGCTCCA GCTCCAACAT CAGCTCCAAT 2160
AAGCGATTTC TCAGGTCATG TTCAGCTTCC AGCATGCCTC CTGGGACCAA GGAGATGGAG 2220
TGGAAATCGG TGACTCTACC TCGAGATCTG CAGTCCACGG TGAGGCAGTT AGACTCTTCC 2280
ACATTTGGTT GCAACAGAAG CGAGAAGCCA GCACTGCCTC GGAAAAGGGC TAGCGAAAAT 2340
AAAAATGACC TCACCCCTAG GGGAACTGTG ACTCCCCCTC CCCGTCTGCC CAGAAAAACT 2400
GAGGAGTTAG CCGATGAGGT TTTTAAAGAC ACAGAATCCA GTCCTGGCTC CAGCCCACCA 2460
ACGTCCACAC CAAAATTGGT CCGCAGGCAA CCTGCGGTCT CTTCAATAAA CCCATCCCTC 2520
AAGGAAGAGG GGCAGAAAAC TAGTGCCTTA GGTTCCACTT TTCATCCAGA CCAAATTTCC 2580
ACCATGAAGC AGAACCCCAT AATTTTTACA AGCGTTGTGA AGGCTTCAGG CGAGGAGTCC 2640
AGAATGCGAA GGCTAAAGCA ATCCCCTGAT CACTCAGTGA AAGATAAGGG GAAACTGACT 2700
AAGCCCAAAC CAGCCCCACC TCCCCCACCG CCATCTACTG GGAAGCCTGG AAAGCCATCA 2760
TCGCGTAGCC CCAGCCATGA AACAGCAGGG GACTCAACAG CAGGCGCTAA ACTTAAACAT 2820
TTAACTCAGG TTGTAGACCC TGTGAGTGGT GACGTTGCCA AGCCAAGCCA GCTGGGGGAA 2880
GGCATCAAAA AGGCCATCCT TCCTTCCATA CCAAAGCCCC AGTCCTCCAC AAAGCCATCC 2940
ATGGTGGTTG GGACAGTGGT CAGCACAGCA CCAGTCACTT CTTCCTCCTC ACCGTCCACT 3000
TTGCCGAACT CTAGCGGTGA CCAGCAGTCT TCAACAGCCT TCAACCCTCT TATACCAACA 3060
AGAGTTTCCC TGCGTAAGAC GCGGCAGCCT CCAGAAAAGA TCGCCAGTGG CACCATTACC 3120
AAGGACATTG TCTTGGAAAG CACTGAGGCA CTGCGTGCTG CTATTAGCAA GAACTCAGAG 3180
CAGTTGGCAA GCCACAGCGT GGTCCTAGAA GCTGGGAAAA ATCTCTACAC GTTCTGCGTG 3240
AACTACGTGG ACTCCATCCA GCAGATGAGG AACAAGTTTG CCTTCCGGGA AGCTATTAAC 3300
AAGTTAGAGA ACAATCTTCG GGAGCTCCAG ATCTGCCCAG CCAGCTCCAG CAGCCCTGCA 3360
GCTGCCCAGG ACTTTACCAA GCTGCTCTCT TCTGTGAAAG AAATCAGTGA CATTGTCCAG 3420
AGGTAG 3426
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkky+ltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 244   ITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  303
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm++gnlldylr+++reev+avvllymatqissameylekknfih
Q: 304   LGVCTREPPFYIITEFMTHGNLLDYLRDCNREEVNAVVLLYMATQISSAMEYLEKKNFIH  363
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 364   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  423
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracwkw+p+
Q: 424   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWKWNPA  483
         ************************************************************
S: 241   drpsfaeihqal  252
         dr sfaeihqa+
Q: 484   DRHSFAEIHQAF  495
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYNLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTHG NLLDYLRDCN REEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWKWNPA 240
DRHSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00218
EKS-ANC-00228
EKS-BOT-00257
EKS-CAE-00214
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LOA-00268
EKS-MAM-00261
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00244
EKS-ORL-00286
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00230
EKS-PTV-00011
EKS-RAN-00271
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00297
EKS-TUT-00026
EKS-XET-00314
EKS-XIM-00328
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013