EKS-LAC-00457

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00457

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	462.2	6.0E-139	83	345	263

Status

Unreviewed

Ensembl Protein

ENSLACP00000022387

UniProt Accession

H3B7E7;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000015694	ENSLACP00000017818	ENSLACT00000017948
ENSLACG00000015694	ENSLACP00000017819	ENSLACT00000017949
ENSLACG00000015694	ENSLACP00000022387	ENSLACT00000026429

Organism

Latimeria chalumnae

Functional Description

Protein Length

1389

Protein Sequence
(FASTA)

MQANMSAGTV ETSMGNRLKK LEAMITDPRC AVNIESLLDS LKALVQDLDF PALRKNKNIE 60

NFLNRYEKVA AQIRELQMKA EDYDVVKVIG RGAFGEVQLV RHRTSQKVYA MKLLSKFEMI 120

KRSDSAFFWE ERDIMAFANS PWVVQLFCAF QDDRYLYMVM EYMPGGDLVN LMSNYDVPEK 180

WAKFYTAEVV LALNAIHSMG FIHRDVKPDN MLLDKYGHLK LADFGTCMKM DETGMVRCDT 240

AVGTPDYISP EVLKSQGGDG YYGRECDWWS VGVFLFEMLV GDTPFYADSL VGTYSKIMDH 300

KNSLNFPDDV EISKHAKDLI CAFLTDREVR LGRNGVEEIK RHPFFKNDQW TWENMRETAA 360

PVVPELSSDT DSSNFDDIED DKGEVETFPV PKAFVGNQLP FIGFTYYREE KLLSDSPWSC 420

RENEHMPSSK SEDSAESAQL QKKLYKLEEQ LNNEMQAKDE VEQKYRSVSS RLEKLMKELD 480

EEVSSRKNVE SSLRQLEREK ALLQHKHAEY QRKAENEADK KRSLENDVNS LKDQLEDLKR 540

RNQNSQISNE KINQLQRQLD ETNTLLRSES DTATRLRKNQ TEMSKQIQQL DATNRELQDK 600

NCILENTKMK LEKDYINLQS ALESERRDCS HGSEMISDLQ GRISGLEEEV RNVKSSLSKA 660

EMEKRQLQDK LTNLEKEKNN LEIDMTYKLK VLQQSLEQEE AEHKATKARL ADKNKIYESI 720

EGAKSEAMKE MEKKLHEERI SKQKVENNLL EVEKQCSMLD CDLKQSQQKI EELLRQKDKL 780

NEEVKNLTLK IEQETQKRCL TQNDLKVQTQ QVNALKMSEK QLKQEINHLL EFRQSLEKQN 840

NELRKERQDA DGQMKELQDQ LEAEQYFSTL YKTQVREFKE DCEEKSKLCK DIQQKVQELQ 900

DERDSLAAQL EITLTKADSE QLARSIAEEQ YSDLEKEKIM KELEIKEMMA RHKQELAEKD 960

ATIASLEEAN RTLTSDVANL ANEKEELNNK LKETHEQIQK MKDEELNIAV IKTQYDKQLL 1020

NERTLKTQAV NKLAEIMNRK DVRGGVSRRG NDTDVRRKEK ENRKLQLELR SEREKLTQMM 1080

IKYQKEINEM LAQIADENQL RIELQMTLDS KDSDIEQLRS QLQSIHVGLD TTSIGSGPGD 1140

ADADDGFPES RLEGWLSLPV RNNTKKFGWV RKYVVVSSKK ILFYDSEQDK EQSNPYMVLD 1200

IDKLFHVRPV TQTDVYRADA KEIPRIFQIL YANEGESKKE QEFPVEPLPI GEKSSYICHK 1260

GHEFIPTLYH FPTNCEACMK PLWHMFKPPP ALECRRCHIK CHKDHMDKKE EIIAPCRVNY 1320

DVSTAKNLLL LANSTEEQQK WVSRLVKKIP KKPPATDPFP RSSPRASMKV QPNQSIRRPS 1380

RQLPPNKPS 1389

Nucleotide Sequence
(FASTA)

ATGCAGGCAA ACATGTCGGC TGGCACAGTG GAAACTAGCA TGGGTAACCG GCTGAAGAAA 60

CTGGAAGCCA TGATAACGGA TCCTAGGTGT GCAGTCAATA TTGAAAGTTT GCTGGATAGC 120

TTGAAGGCTT TGGTTCAAGA TTTAGACTTT CCTGCCCTTC GGAAAAATAA GAACATAGAA 180

AACTTCTTAA ATAGATATGA AAAGGTAGCA GCACAAATTC GAGAATTACA GATGAAAGCT 240

GAAGACTATG ATGTAGTGAA GGTCATTGGC AGAGGTGCTT TTGGAGAAGT TCAGTTGGTT 300

CGACACAGAA CATCACAGAA AGTGTATGCA ATGAAGCTGC TAAGTAAGTT TGAAATGATC 360

AAACGGTCAG ACTCTGCTTT TTTCTGGGAA GAAAGAGATA TCATGGCTTT TGCTAACAGT 420

CCCTGGGTAG TTCAGCTGTT TTGTGCCTTC CAAGATGACC GATATCTTTA CATGGTAATG 480

GAGTACATGC CAGGCGGGGA TCTTGTAAAC CTCATGAGCA ACTATGATGT ACCGGAAAAA 540

TGGGCCAAAT TCTACACAGC TGAAGTAGTG CTTGCCCTCA ATGCTATCCA CTCAATGGGT 600

TTTATACATA GGGATGTGAA ACCTGATAAT ATGCTGTTAG ATAAATACGG ACACTTAAAG 660

TTAGCAGATT TTGGCACCTG CATGAAAATG GATGAGACAG GAATGGTGCG ATGTGACACA 720

GCAGTAGGAA CTCCTGACTA TATATCTCCA GAAGTACTAA AATCGCAAGG AGGTGATGGT 780

TACTATGGCC GCGAGTGTGA TTGGTGGTCT GTTGGAGTTT TCCTTTTTGA AATGCTGGTT 840

GGTGATACTC CATTTTATGC AGACTCTTTA GTGGGAACAT ACAGTAAAAT TATGGATCAC 900

AAGAACTCAC TCAACTTTCC TGATGATGTT GAAATTTCAA AACATGCCAA AGACCTCATT 960

TGTGCCTTCT TGACTGACAG GGAAGTACGG CTGGGGAGAA ATGGAGTTGA AGAGATTAAA 1020

CGGCACCCTT TCTTTAAGAA TGATCAGTGG ACATGGGAAA ATATGCGCGA GACTGCTGCT 1080

CCTGTTGTGC CTGAACTAAG TAGTGATACA GACAGCAGTA ATTTTGATGA TATTGAGGAT 1140

GACAAGGGAG AAGTAGAAAC ATTCCCTGTT CCCAAAGCTT TTGTGGGGAA CCAGCTGCCC 1200

TTTATAGGAT TCACATATTA TAGAGAAGAA AAGTTGCTAA GTGATTCTCC CTGGTCCTGT 1260

AGAGAGAATG AGCACATGCC ATCGAGTAAA AGTGAGGACA GTGCAGAGTC TGCACAGTTA 1320

CAAAAGAAGT TGTATAAGCT AGAAGAGCAA TTGAATAATG AAATGCAAGC CAAAGATGAA 1380

GTAGAACAGA AATACAGGTC GGTCAGTAGT CGTCTTGAGA AGCTAATGAA AGAACTGGAT 1440

GAAGAGGTAA GCTCTAGGAA GAATGTTGAA TCTTCTTTAA GACAGTTGGA AAGAGAAAAA 1500

GCACTGCTTC AGCACAAGCA TGCTGAATAT CAACGAAAAG CTGAAAACGA GGCAGATAAG 1560

AAACGAAGTC TTGAAAATGA TGTTAACAGT TTAAAAGATC AACTCGAAGA TTTGAAAAGG 1620

CGGAACCAAA ACTCCCAAAT ATCAAATGAG AAGATTAATC AATTACAAAG GCAGCTGGAT 1680

GAAACCAACA CCCTTCTGCG GTCAGAGTCT GATACAGCAA CGAGGCTGAG AAAAAACCAG 1740

ACTGAAATGT CAAAGCAGAT TCAGCAGTTG GATGCTACCA ATAGGGAACT GCAGGACAAA 1800

AACTGTATAC TAGAAAATAC CAAAATGAAA CTTGAGAAGG ACTATATAAA TTTGCAGTCA 1860

GCACTTGAAT CTGAACGAAG GGACTGTAGC CATGGTTCGG AGATGATTAG TGATTTACAA 1920

GGTAGAATTT CTGGCCTGGA AGAAGAAGTT AGAAATGTAA AGAGCTCTTT GTCAAAAGCT 1980

GAGATGGAGA AAAGGCAGCT ACAAGACAAG TTGACAAACT TGGAAAAGGA GAAGAATAAT 2040

CTGGAGATAG ACATGACGTA TAAACTAAAA GTACTGCAGC AAAGCCTGGA GCAGGAAGAA 2100

GCAGAGCATA AGGCTACTAA AGCACGGCTA GCAGACAAGA ACAAGATATA TGAGTCTATT 2160

GAGGGAGCAA AATCTGAGGC AATGAAAGAG ATGGAAAAGA AGCTTCATGA AGAGAGAATT 2220

TCAAAGCAGA AAGTTGAAAA CAACTTGCTA GAGGTTGAAA AACAATGTTC TATGCTAGAC 2280

TGTGACCTTA AACAGTCACA ACAGAAAATA GAAGAACTGC TGAGGCAAAA AGACAAACTA 2340

AACGAGGAGG TTAAAAATTT AACACTGAAG ATAGAACAGG AAACACAGAA GCGTTGCCTT 2400

ACCCAGAATG ACCTGAAGGT ACAAACACAG CAGGTCAATG CATTGAAAAT GTCTGAGAAG 2460

CAGCTAAAGC AAGAAATAAA TCATCTCTTA GAGTTCAGAC AGAGCCTGGA GAAGCAGAAT 2520

AATGAATTAC GAAAAGAGCG CCAAGATGCA GATGGACAGA TGAAAGAACT TCAGGACCAG 2580

CTTGAAGCCG AACAGTATTT CTCAACTCTA TACAAGACAC AAGTTCGGGA ATTCAAAGAG 2640

GACTGTGAGG AAAAGAGCAA ATTGTGCAAG GATATACAAC AGAAAGTGCA AGAGCTGCAA 2700

GATGAAAGAG ACTCACTGGC AGCACAGTTA GAGATTACTC TGACAAAGGC AGACTCAGAG 2760

CAGCTTGCTC GCTCTATTGC TGAGGAGCAG TACTCGGACT TGGAGAAAGA GAAGATCATG 2820

AAAGAGCTAG AGATCAAAGA GATGATGGCC AGGCACAAAC AAGAGTTAGC AGAAAAAGAT 2880

GCTACAATAG CGTCTTTGGA GGAAGCAAAC AGAACACTAA CTAGCGATGT TGCAAACCTT 2940

GCTAATGAGA AGGAAGAGCT GAACAACAAA CTGAAAGAAA CCCATGAACA AATACAGAAA 3000

ATGAAGGACG AAGAACTAAA TATAGCAGTT ATCAAAACAC AATATGATAA ACAACTACTG 3060

AATGAGAGAA CACTCAAAAC ACAGGCTGTG AATAAACTGG CTGAGATCAT GAATCGTAAG 3120

GATGTGAGAG GTGGTGTTAG TAGACGTGGT AATGACACAG ATGTGCGGAG AAAGGAAAAA 3180

GAAAACAGGA AACTCCAGTT GGAGTTGAGA TCGGAACGTG AGAAGCTGAC GCAGATGATG 3240

ATCAAATATC AAAAGGAGAT TAATGAGATG CTGGCGCAAA TAGCAGATGA AAACCAGTTA 3300

CGGATTGAAC TGCAGATGAC ACTAGACAGC AAAGATAGTG ACATTGAACA GCTTCGGTCA 3360

CAACTGCAAT CAATACATGT TGGCCTTGAC ACCACCAGCA TTGGCAGTGG ACCAGGAGAT 3420

GCTGATGCAG ATGATGGATT CCCTGAGTCA AGGCTAGAAG GCTGGTTATC GCTGCCTGTT 3480

AGGAACAACA CGAAAAAATT TGGTTGGGTT AGAAAGTATG TAGTTGTAAG CAGCAAGAAG 3540

ATCCTGTTTT ATGACAGTGA ACAAGATAAA GAACAATCAA ATCCTTACAT GGTTTTGGAT 3600

ATAGACAAAT TGTTCCATGT TCGACCGGTC ACACAAACAG ATGTATACAG AGCGGATGCC 3660

AAAGAAATTC CAAGAATATT CCAGATTTTG TACGCTAACG AAGGAGAAAG CAAGAAGGAA 3720

CAAGAATTCC CTGTAGAGCC TCTTCCTATT GGAGAGAAAT CCAGTTACAT TTGTCATAAA 3780

GGACATGAGT TTATTCCAAC ACTATATCAT TTCCCTACAA ACTGTGAGGC TTGTATGAAG 3840

CCACTGTGGC ACATGTTTAA ACCCCCACCT GCCCTTGAGT GTCGTCGCTG CCATATCAAA 3900

TGTCATAAAG ATCACATGGA CAAAAAGGAG GAGATCATAG CACCTTGCAG AGTGAACTAT 3960

GATGTTTCAA CGGCAAAAAA CCTACTCCTG TTAGCTAATT CAACAGAAGA ACAGCAAAAA 4020

TGGGTGAGTC GACTGGTGAA AAAGATTCCA AAGAAGCCTC CAGCGACTGA TCCCTTTCCC 4080

AGGTCATCTC CTAGAGCTTC CATGAAGGTA CAACCAAACC AATCTATAAG ACGGCCGAGC 4140

CGACAGCTTC CTCCAAACAA GCCCAGCTAA 4170

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         ++++kviGrGafgev++vr+++++kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 83    YDVVKVIGRGAFGEVQLVRHRTSQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  142

         799*********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql++afqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlal+++h++g

Q: 143   VVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALNAIHSMG  200

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+

Q: 201   FIHRDVKPDNMLLDKYGHLKLADFGTCMKMDETGMVRCDTAVGTPDYISPEVLKSQG-GD  259

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fp+d+++s++akdl

Q: 260   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISKHAKDL  319

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+hpff

Q: 320   ICAFLTDREVRLGRNGVEEIKRHPFF  345

         *************************9

Domain Sequence
(FASTA)

YDVVKVIGRG AFGEVQLVRH RTSQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFCAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LNAIHSMGFI 120

HRDVKPDNML LDKYGHLKLA DFGTCMKMDE TGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLNFPDDVEI SKHAKDLICA 240

FLTDREVRLG RNGVEEIKRH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013