EKS-LAC-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	463.8	1.9E-139	548	809	262

Status

Unreviewed

Ensembl Protein

ENSLACP00000018252

UniProt Accession

H3B8N1;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000016078	ENSLACP00000018252	ENSLACT00000018384

Organism

Latimeria chalumnae

Functional Description

Protein Length

956

Protein Sequence
(FASTA)

CFGSTSTVTL PETLLFVSTL DGSLHAVSRR TGSIKWTLKE DPVLQVPTHV AEPAFLPDPN 60

DGSLYTLGGT NNEGLTKLPF TIPELVQASP CRSSDGILYM GKKQDSWHVV DLLTGKKQQT 120

LTSNFAESVC PSASLLYFGR TEYTITMYDT KNKELRWNAT YFDYAATLPD KDTEYRMVHF 180

VSNGDGLVVT VDNKSGDILW YQNYASPVVA MYIWQREGLR KVMHTNIGIE TLRYLAFISG 240

KDGRITNWKY PFPKETETKS KLTQTLYVGK YSASLYASPS LVHEGVAVLP RGSAIPLIEG 300

PKTEGVTIED SGECIITPST DVKFSSGNLE EENKINYLRN HWLLIGHHEV PLGSPMKILE 360

KFPENLPKNS ENVITAGNEK HFFKEVCTKE KKHLNYTPFT SAGFPLEEKL IYRPIVTTKK 420

YFSVVHALFI FCLVNWKIFR LKVYIMKNVQ QQQLQHQQFQ KQLEEKIELL QRQQLILPPP 480

HVSQEADFLD VSRARTESST TSTPTTSPKA SNHSIHSNLS ASEVGSSATE QEDIVDEETA 540

VTVGKISFNP KDMLGHGAEG TIVFRGRFDN RDVAVKRILP ECFSFADREV QLLKESDEHP 600

NVIRYFCTEK DRQFHYIAIE LCTATLQEYV EEKDFERHGL DPISLLQQTM SGLAYLHSLN 660

IVHRDLKPHN ILISKPNAHG RVKAMISDFG LCKKLAMGRH SFSRRSGVPG TEGWIAPEVL 720

NEDCKKNPTY AVDIFSAGCV FYYVLSEGSH PFGKSLQRQA NILLGAYNLD HLNPDKHEDI 780

VAHELIEQML NLNAQKRPSA KSVLKHPFFW SLEKQLQFFQ DVSDRIEKEP LDGPVVKQLE 840

KGGRSVVKMD WKEHVTVPLQ TDLRKFRTYK GASVRDLLRA MRNKKHHYRE LPPEVQETLG 900

SIPDDFVCYF TSRFPHLLIH TYRAMQTCSQ ERLFQPYYQE ATEPRDSAVP ITGDFP 956

Nucleotide Sequence
(FASTA)

TGTTTTGGAA GCACCAGCAC AGTGACCCTG CCAGAGACAT TGCTATTTGT ATCAACTCTG 60

GATGGAAGTT TGCACGCTGT TAGCAGAAGA ACAGGGTCTA TTAAGTGGAC CTTAAAAGAA 120

GATCCAGTGC TTCAGGTCCC AACACACGTA GCAGAGCCGG CATTTCTTCC TGATCCAAAT 180

GACGGCAGTC TTTATACTCT TGGAGGCACA AATAACGAAG GCTTAACAAA ACTTCCATTT 240

ACAATCCCTG AGCTGGTTCA AGCGTCCCCA TGTCGGAGTT CTGATGGCAT ACTATACATG 300

GGGAAAAAGC AGGATAGCTG GCACGTTGTG GACCTTTTGA CTGGAAAAAA ACAGCAAACA 360

TTAACTTCTA ATTTTGCAGA AAGTGTGTGC CCATCAGCCT CTCTCTTGTA CTTTGGGCGG 420

ACAGAATACA CCATCACCAT GTACGATACA AAGAACAAAG AGCTGAGATG GAATGCTACT 480

TACTTTGATT ATGCAGCCAC CCTACCCGAC AAAGACACAG AATATAGAAT GGTCCATTTT 540

GTTTCTAATG GAGATGGATT GGTTGTCACT GTGGATAATA AATCTGGGGA CATCCTTTGG 600

TATCAGAACT ATGCGTCTCC TGTGGTGGCT ATGTACATCT GGCAACGCGA GGGACTAAGA 660

AAAGTAATGC ACACCAACAT TGGCATAGAG ACACTTCGCT ACCTTGCCTT TATCTCCGGA 720

AAGGATGGGC GGATCACAAA TTGGAAGTAT CCTTTTCCAA AAGAAACGGA GACTAAAAGC 780

AAACTGACGC AAACCCTTTA TGTAGGGAAG TACTCAGCTA GCTTGTATGC TTCCCCATCA 840

CTGGTGCATG AAGGAGTGGC TGTTTTGCCA CGAGGAAGTG CAATCCCATT AATAGAGGGC 900

CCTAAAACAG AAGGCGTTAC TATTGAAGAC AGCGGAGAGT GCATCATCAC TCCTAGTACT 960

GATGTGAAAT TCTCATCTGG AAACCTTGAG GAGGAGAATA AAATCAACTA CCTAAGAAAC 1020

CACTGGCTTC TGATAGGACA TCATGAAGTA CCTTTAGGAT CTCCTATGAA GATCTTGGAA 1080

AAGTTTCCAG AGAACCTGCC GAAGAATTCT GAAAATGTCA TTACTGCTGG CAATGAGAAG 1140

CACTTTTTTA AAGAGGTTTG TACAAAAGAA AAGAAGCATT TAAATTATAC GCCTTTCACA 1200

AGCGCTGGGT TCCCTCTGGA AGAAAAATTA ATCTATAGAC CGATAGTTAC AACAAAAAAA 1260

TATTTCTCAG TAGTTCACGC ACTTTTTATT TTCTGTCTGG TAAATTGGAA AATTTTTAGG 1320

TTAAAGGTGT ACATCATGAA GAATGTGCAA CAGCAACAGC TCCAGCATCA GCAGTTCCAG 1380

AAGCAGTTGG AGGAGAAGAT TGAGCTGCTC CAGAGACAGC AGCTCATTCT CCCTCCTCCT 1440

CACGTGAGCC AGGAGGCTGA TTTCCTAGAC GTGTCTCGAG CGAGGACTGA GAGCTCAACC 1500

ACCAGCACTC CCACCACATC CCCTAAAGCG TCTAATCATT CCATTCACTC CAACTTGTCT 1560

GCGTCAGAAG TGGGCAGCTC TGCAACAGAG CAAGAAGATA TAGTAGATGA GGAAACTGCT 1620

GTTACAGTTG GAAAGATTTC ATTTAATCCA AAGGATATGT TGGGCCATGG TGCTGAGGGT 1680

ACCATTGTAT TCAGGGGAAG ATTTGATAAC AGAGATGTTG CAGTCAAACG AATTCTCCCA 1740

GAATGCTTCA GTTTTGCTGA CCGGGAAGTG CAACTGCTCA AAGAGTCTGA TGAACATCCC 1800

AATGTGATTC GCTACTTCTG CACAGAGAAA GACAGACAGT TTCATTATAT AGCAATTGAG 1860

CTTTGTACTG CTACTCTACA GGAGTATGTG GAAGAAAAGG ACTTTGAACG ACATGGTTTG 1920

GACCCGATTT CTTTACTACA GCAGACAATG TCAGGGCTTG CTTACCTTCA CTCTCTCAAT 1980

ATTGTTCACA GGGACCTAAA GCCACATAAC ATTCTCATCT CAAAGCCAAA TGCCCATGGC 2040

AGAGTCAAAG CGATGATCTC AGATTTTGGT CTTTGTAAAA AGCTAGCAAT GGGTAGGCAT 2100

AGCTTTAGCC GACGGTCCGG GGTACCAGGA ACTGAAGGAT GGATTGCCCC AGAAGTGCTA 2160

AACGAAGATT GCAAAAAGAA TCCTACCTAC GCAGTTGATA TTTTCTCAGC GGGTTGCGTC 2220

TTCTATTATG TGTTATCTGA AGGAAGCCAT CCCTTTGGCA AGTCCCTGCA ACGGCAAGCC 2280

AATATCCTGT TGGGTGCTTA CAACCTTGAT CATTTAAACC CTGATAAGCA TGAGGACATT 2340

GTTGCTCATG AACTTATTGA GCAGATGCTT AATCTGAACG CCCAAAAACG TCCATCAGCT 2400

AAATCTGTAC TGAAACATCC ATTCTTCTGG AGTCTTGAAA AACAGCTTCA GTTTTTCCAG 2460

GATGTGAGCG ACCGAATAGA GAAGGAGCCT CTAGATGGTC CAGTTGTTAA ACAGTTGGAG 2520

AAAGGAGGGA GAAGTGTGGT AAAAATGGAT TGGAAAGAAC ATGTTACCGT TCCTCTCCAG 2580

ACAGATCTCA GGAAATTCAG AACGTACAAA GGAGCATCTG TAAGAGATCT TCTGAGGGCA 2640

ATGAGAAATA AGAAACATCA CTACAGAGAG CTGCCTCCAG AAGTCCAGGA GACACTAGGG 2700

TCTATCCCAG ATGACTTTGT ATGCTATTTC ACATCTCGTT TCCCTCATCT TTTAATTCAC 2760

ACATATCGTG CCATGCAAAC CTGCAGCCAA GAAAGACTAT TTCAGCCTTA TTACCAAGAA 2820

GCTACCGAGC CAAGGGACTC GGCTGTGCCA ATTACTGGTG ATTTTCCTTG A 2871

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkd+lG+GaeGt+vfrG f++r+vavkr+l+e++++a+rev+ll+esdehpnviryfc

Q: 548   FNPKDMLGHGAEGTIVFRGRFDNRDVAVKRILPECFSFADREVQLLKESDEHPNVIRYFC  607

         799*********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         tekdrqf+yia+elc+a+lq+yve+kd+e +++l+pisll+q++sGla+lhsl+ivhrdl

Q: 608   TEKDRQFHYIAIELCTATLQEYVEEKDFE-RHGLDPISLLQQTMSGLAYLHSLNIVHRDL  666

         *****************************.99****************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nilis p+a+g+++++isdfGlckkl++G++sfsrrsgv+GteGwiape+l+e++k+

Q: 667   KPHNILISKPNAHGRVKAMISDFGLCKKLAMGRHSFSRRSGVPGTEGWIAPEVLNEDCKK  726

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t+avdifs+Gcvfyyvls+G+hpfG+sl+rqanil g+++ld+l+++k+e+++a++li

Q: 727   NPTYAVDIFSAGCVFYYVLSEGSHPFGKSLQRQANILLGAYNLDHLNPDKHEDIVAHELI  786

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         ++m++ + +krpsak vlkhp+f

Q: 787   EQMLNLNAQKRPSAKSVLKHPFF  809

         **********************9

Domain Sequence
(FASTA)

FNPKDMLGHG AEGTIVFRGR FDNRDVAVKR ILPECFSFAD REVQLLKESD EHPNVIRYFC 60

TEKDRQFHYI AIELCTATLQ EYVEEKDFER HGLDPISLLQ QTMSGLAYLH SLNIVHRDLK 120

PHNILISKPN AHGRVKAMIS DFGLCKKLAM GRHSFSRRSG VPGTEGWIAP EVLNEDCKKN 180

PTYAVDIFSA GCVFYYVLSE GSHPFGKSLQ RQANILLGAY NLDHLNPDKH EDIVAHELIE 240

QMLNLNAQKR PSAKSVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013