EKS-LAC-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	368.3	2.4E-110	13	265	253

Status

Unreviewed

Ensembl Protein

ENSLACP00000018364

UniProt Accession

H3B8Z3;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000016174	ENSLACP00000018364	ENSLACT00000018497

Organism

Latimeria chalumnae

Functional Description

Protein Length

982

Protein Sequence
(FASTA)

MTASIGEKVK DFNVLNLLGK GSFACVYRAK SIHSGLEVAI KMIDKKAMHK VGMVQRVRNE 60

VEIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMSRY LKNKKKGFSE EEARHFMHQI 120

VKGILYLHSH GILHRDLTLS NLLLTSNMNI KIADFGLATQ LKMPNEKHFT MCGTPNYIAP 180

EIATRSAHGL ESDVWSLGCM FYSFLVGCPP FDTDTVKNTL NKVMLADFEM PTFVSREAQN 240

LIYQLLRKNP ADRISLSSVL DHPFMTGSFS ARNKEPGTVE DSMDSGNATL STAITVATGS 300

SLASTNSRLQ QKGRHLIRQP LPNKMAVLAS HEKYYTETSS VGGSSCFSER GGNGEESDRA 360

GRGRTAQLTG EERPHSRYLR RAHSSDRSGA SHSQTQGKPN SILERCLSVE VLSNPSRPGV 420

KENVDTFSVY SCGELPQAFS GNGSLERRFS PPVKQKSNSD YLYPSKAGIE PRFQSETIQQ 480

WVGSAQAQLG QFRKPADISS ISSASESFRN RQHPLSVHAD FLQNAWNDQE VKRKPDQSFE 540

DVQSGKQVGS RRCAGAAPSA AETVQAGAVF GCAHVSEQSE ATQREPTPLC YEPQTLRSIV 600

APLSAHRLKP IRQKTKNAVV SVLDRGEVCM EFLKGHGSQE QVREVLRISC DGLKIAAYHP 660

NEGRGLPLDD RPPSPPEECF VYSFDNLPEK YWKKYQYACK FIQLVRSKTP KVTLYTKHAK 720

CMLMENSPDA DVEVCFYDGA KIHKTSEFLR IIEPSGKSYT LKGESAVGGL NEGVRMYLEH 780

VNESRRTCLA LESAIAAEEK KSEKHTSFFP IIIGRKPAST DSLQVLPQPP SSAGPKQAEP 840

EHPSQSKTVL ASCASPLEAP NSTPLMSAYG GSVFTTATSV AKSSSSPPGQ KETAVNSPQV 900

LKSVFVQNVG WASQLTSGAV WVQFNDGSQL VVQAGVPSIV YISPDGKKAR YDGDVKLPVY 960

VTEKLQCLSS ILSQFASPSS HH 982

Nucleotide Sequence
(FASTA)

ATGACGGCTT CAATCGGGGA GAAAGTGAAG GATTTCAATG TTTTGAACCT CCTTGGGAAG 60

GGATCGTTTG CTTGTGTTTA CAGAGCAAAA TCTATTCATT CAGGCTTGGA GGTTGCTATA 120

AAAATGATAG ATAAAAAGGC TATGCACAAA GTTGGAATGG TGCAGAGAGT CCGAAATGAA 180

GTGGAAATTC ATTGTCAGTT AAAACATCCC TCTATACTGG AGCTTTATAA TTATTTTGAA 240

GATAGCAACT ATGTGTATCT GGTATTAGAG ATGTGTCATA ATGGAGAAAT GAGCAGGTAC 300

CTAAAGAACA AAAAGAAAGG CTTCAGTGAA GAGGAAGCTC GACACTTCAT GCATCAGATT 360

GTCAAAGGGA TACTGTATCT ACATTCGCAT GGCATATTAC ATCGGGACCT CACACTTTCC 420

AACCTTTTGC TCACCAGCAA CATGAACATT AAGATTGCAG ACTTTGGACT GGCGACGCAG 480

TTAAAAATGC CAAATGAAAA GCACTTCACA ATGTGTGGAA CCCCAAACTA TATTGCTCCA 540

GAGATTGCTA CCCGCAGCGC TCATGGACTT GAATCTGATG TCTGGTCTCT GGGTTGCATG 600

TTTTACAGCT TTCTTGTTGG CTGTCCGCCT TTTGACACTG ACACGGTCAA AAACACCTTA 660

AATAAGGTAA TGCTGGCAGA CTTTGAAATG CCAACCTTTG TGTCCAGGGA GGCTCAGAAC 720

CTCATCTATC AACTGCTTCG TAAGAACCCT GCAGATCGCA TTAGCCTTTC ATCCGTGTTG 780

GATCACCCAT TCATGACAGG CAGTTTTTCA GCACGAAATA AGGAACCTGG TACAGTGGAA 840

GATTCTATGG ACAGTGGAAA CGCCACACTC TCGACGGCCA TTACTGTTGC AACAGGCTCA 900

TCCCTTGCCA GCACGAATAG TCGCTTGCAG CAGAAAGGCA GACATCTGAT AAGACAGCCC 960

CTCCCAAACA AAATGGCTGT GCTGGCTTCC CATGAAAAGT ACTATACTGA GACGTCCTCT 1020

GTGGGTGGAA GCTCCTGCTT TAGTGAAAGA GGTGGAAATG GGGAGGAAAG TGACAGGGCT 1080

GGAAGGGGAA GGACAGCACA GCTTACTGGG GAGGAAAGAC CTCACTCTCG CTACCTCCGG 1140

AGGGCTCACT CCTCAGACAG GTCTGGTGCC TCCCACAGCC AAACTCAGGG TAAACCAAAC 1200

AGTATTCTAG AGAGATGTCT CTCAGTGGAA GTGCTTTCCA ATCCCAGCAG GCCTGGAGTG 1260

AAGGAAAATG TAGACACTTT TTCTGTTTAT AGTTGTGGAG AGCTTCCACA AGCGTTCAGT 1320

GGTAATGGGT CACTTGAGAG ACGGTTCTCT CCTCCGGTGA AACAAAAATC AAACTCTGAT 1380

TATCTATACC CCAGTAAAGC AGGAATAGAA CCGAGATTCC AGTCTGAAAC AATACAGCAG 1440

TGGGTTGGAA GTGCACAAGC ACAGCTAGGC CAGTTCAGAA AGCCCGCAGA CATCAGCTCA 1500

ATTAGTAGTG CAAGTGAAAG TTTTCGTAAC AGGCAACATC CTCTGTCTGT GCATGCTGAT 1560

TTCCTGCAGA ATGCATGGAA TGATCAAGAG GTGAAAAGGA AGCCCGATCA GTCCTTTGAG 1620

GATGTTCAGT CTGGGAAACA GGTGGGCTCA AGGAGATGTG CTGGTGCAGC TCCATCTGCA 1680

GCAGAAACTG TACAGGCAGG TGCTGTGTTT GGCTGTGCTC ATGTGTCTGA GCAAAGCGAG 1740

GCCACACAGA GGGAGCCAAC ACCTTTGTGT TACGAACCGC AGACTCTGAG AAGCATTGTT 1800

GCTCCACTGA GTGCCCACCG ACTCAAACCC ATCCGGCAGA AAACAAAAAA TGCTGTGGTG 1860

AGCGTCCTGG ACAGAGGAGA AGTTTGCATG GAGTTTCTTA AGGGGCACGG CTCTCAAGAG 1920

CAAGTGCGAG AAGTTCTCAG GATCTCCTGT GACGGATTGA AGATAGCGGC CTATCATCCT 1980

AATGAAGGCA GAGGTCTTCC CCTTGATGAC AGACCACCAT CTCCACCTGA AGAATGTTTT 2040

GTTTATAGTT TTGATAATTT ACCAGAAAAA TACTGGAAGA AATACCAGTA TGCATGCAAA 2100

TTTATTCAGT TGGTGAGGTC CAAGACCCCG AAGGTTACTC TCTATACTAA ACACGCTAAG 2160

TGCATGCTAA TGGAAAACTC ACCAGATGCA GATGTTGAAG TCTGTTTTTA TGACGGGGCA 2220

AAAATTCACA AGACTTCTGA ATTCCTTCGA ATAATAGAGC CATCAGGGAA ATCCTACACT 2280

TTGAAAGGGG AAAGTGCAGT GGGTGGTCTA AATGAAGGAG TCAGAATGTA TTTGGAACAT 2340

GTAAATGAGA GCCGTCGAAC ATGCCTTGCA CTTGAATCTG CCATCGCGGC AGAAGAGAAA 2400

AAGAGTGAAA AACACACTTC ATTTTTTCCA ATTATCATTG GAAGGAAGCC AGCCAGCACA 2460

GATTCTCTAC AGGTTTTACC ACAGCCACCC TCTTCTGCAG GCCCAAAACA GGCAGAACCA 2520

GAGCATCCAT CCCAAAGTAA AACTGTGCTG GCTAGCTGTG CATCACCTCT TGAAGCTCCT 2580

AACAGTACTC CTCTGATGAG TGCTTATGGA GGATCTGTGT TTACCACAGC CACCAGTGTT 2640

GCCAAAAGTA GTTCTTCCCC ACCTGGTCAA AAGGAAACCG CTGTAAATTC ACCACAGGTG 2700

CTGAAATCTG TCTTTGTGCA AAATGTTGGC TGGGCATCCC AGCTGACCAG CGGAGCAGTG 2760

TGGGTGCAGT TTAACGATGG ATCTCAGTTG GTAGTTCAAG CAGGTGTCCC ATCTATCGTC 2820

TATATATCTC CTGATGGTAA AAAAGCACGG TATGATGGTG ATGTAAAGTT GCCTGTATAT 2880

GTTACGGAAA AGCTGCAGTG TTTGTCTTCC ATCCTTAGTC AGTTTGCCAG TCCATCAAGC 2940

CACCACTGA 2949

Domain Profile

S: 2     ergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkni  61

         ++ +llGkG+fa +y++k+++++ ++a+k+++k++++k  + ++v++e+eih++lkh++i

Q: 13    NVLNLLGKGSFACVYRAKSIHSGLEVAIKMIDKKAMHKVGMVQRVRNEVEIHCQLKHPSI  72

         5679********************************************************

S: 62    vklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekri  120

         ++ly++fed+++vylvle+c+++++ ++lk++ k ++e+e+r++++qiv+g++ylh++ i

Q: 73    LELYNYFEDSNYVYLVLEMCHNGEMSRYLKNKkKGFSEEEARHFMHQIVKGILYLHSHGI  132

         *****************************998689*************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdl+l+nl+l++++++ki+dfGlat+l++++e++ t+cGtPnyiaPe++++++h+le+

Q: 133   LHRDLTLSNLLLTSNMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLES  192

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++y +lvG PPf+t+++k+t++k+  a++++P+ +s+ea++li +ll+k+P++

Q: 193   DVWSLGCMFYSFLVGCPPFDTDTVKNTLNKVMLADFEMPTFVSREAQNLIYQLLRKNPAD  252

         ************************************************************

S: 241   rpsleevlkdefl  253

         r+sl++vl+++f+

Q: 253   RISLSSVLDHPFM  265

         ***********98

Domain Sequence
(FASTA)

NVLNLLGKGS FACVYRAKSI HSGLEVAIKM IDKKAMHKVG MVQRVRNEVE IHCQLKHPSI 60

LELYNYFEDS NYVYLVLEMC HNGEMSRYLK NKKKGFSEEE ARHFMHQIVK GILYLHSHGI 120

LHRDLTLSNL LLTSNMNIKI ADFGLATQLK MPNEKHFTMC GTPNYIAPEI ATRSAHGLES 180

DVWSLGCMFY SFLVGCPPFD TDTVKNTLNK VMLADFEMPT FVSREAQNLI YQLLRKNPAD 240

RISLSSVLDH PFM 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013