EKS-LAC-00067
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00067
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK371.13.9E-1117311023293
StatusUnreviewed
Ensembl ProteinENSLACP00000019217
UniProt AccessionH3BBE6;
Protein Name
Protein Synonyms/Alias
Gene NameCDK12
Gene Synonyms/Alias CDK12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000016904ENSLACP00000019217ENSLACT00000019350
ENSLACG00000016904ENSLACP00000019218ENSLACT00000019351
OrganismLatimeria chalumnae
Functional Description
Protein Length1506
Protein Sequence
(FASTA)
MPNTERHGSK KDGGGSGSLQ PSSNSSSSNS KERHRSSSKH KRHKSRHLKE SPVVQDLPVS 60
TIKPLVEYDD ISSDSDTFSD APVLLLEKRE NEEKRRTDKS ERAHRHRHHQ HKRARELHKS 120
KQMEKEKRAE KIREASGKSG ATKDKATVTS SKRQATEYDE QSRKEHVTQS SKNSNKESRS 180
SKAHREKSRK ERESRSAHKE RVKSHRKNRE NPKGYKTTES SKGKSKSPRR KRSASPNRDD 240
SPAGTSYSQD YDVSPPRSHS SSNYESYKRS PAASSRRQSV SPSHKEPAAY QTTTHSPSPY 300
TKRQRSASPY NRWRSSSDER GSGSYSGKSP SPYSRRRSES SYTFKRSSSP SPVARSPAYS 360
RHSQSHSKKQ QRSRSRSRHS SISPPRLPLN SSLGAELNRK KKERAAAAAK VDKKESKQGS 420
PLVQLRKDNN TTEGKSSKTS TKKVTKTIKS EKTVSETEIG NSLSVSTPNK PLVELAKIKT 480
EESPVVSIKD SQPVAVKEEP EIEKEETPPP TLTSPPPLPV LNSPQPPSTP PPQTPPLPPL 540
PPSPATLHQP PPPPPVSPKP VVVPVSTQPP PPSAPVSLPS LPTLPPPTTQ TKTHAVSTPS 600
QANSQTFLQT VVKPQTLVTS SIPQLKTSTL PLLPLPPLLL GDDDLDSPKE SLPPKPVKKE 660
KEQRPRHLLI DLPLPPELLG GDPSPPESPE PKAVTPPQPS FKKRPKICRP RYGERKQSES 720
DWGKRCVDKF DIIGITGEGT YGQVYKARDK DTGALVALKK VRLDNEKEGF PITAIREIKI 780
LRQLNHPSVV NMKEIVTDKQ DALDFKKDKG AFYLVFEYMD HDLMGLLESG LVQFSEDHIK 840
SFMKQLMQGL DYCHKKNFLH RDIKCSNILL NNSGQIKLAD FGLARLYNSE ESRPYTNKVI 900
TLWYRPPELL LGEERYTPAI DVWSCGCILG ELFTKKPIFQ ANQELLQLEL ISRLCGSPCP 960
AVWPDVIKLP YFNSMKPKKQ YRRRLREEFA FVPSAALDLL DHMLTLDPSK RCTAEQTLQS 1020
DFLKDVDPNK MDPPDLPHWQ DCHELWSKKR RRQRQSGIVE ELPANKVPRK DLLSGIGANN 1080
SRSSTPQLAQ AQQIKTQSAA GELGGLGDAA NQLNPNELAV LLNLLQDQTD LSLPQMAQLL 1140
NVNSNPEMQQ QLEVLSQSIA ALTEATNQQQ DSQKQEAAAA AENIKEPVTA AVAATPSQPA 1200
SEEPAPPEVA GGQGDMQNLL TVLLSQLIKP PEASVEPEES NGVKNDGQQQ QQPPLPPPAT 1260
VQQEDTADGV KKSDLPTASR PRILPPEKRP PEPPGPPPSL MDLDFSNSTQ DLNPTVTAAL 1320
LQLMSHHETE QQRSKIQEPD APSSADYSRS HLSRTYSTEE LGTSFGTPEI RDSKHTVIEP 1380
SAQPLEKTRT LSSSVSHLGE TSSYQGTGSV QFPGDQDFRF TRVPISLHLT GGHSATKVDG 1440
SNSTAMQQEA PNQNYSEIGQ GVTAPGSSSG TGHGWGTSSQ GTLYGKGFRG PSRVPPRGGR 1500
GRGVPY 1506
Nucleotide Sequence
(FASTA)
ATGCCAAATA CAGAGAGACA TGGGAGTAAG AAGGATGGAG GAGGGTCAGG TTCTTTGCAG 60
CCAAGCAGCA ACAGCAGCAG TTCTAACAGC AAAGAGAGAC ACAGATCCTC ATCTAAACAC 120
AAGAGACACA AATCTAGGCA CTTAAAAGAA TCACCAGTTG TCCAAGATCT GCCAGTGAGC 180
ACAATCAAGC CGCTGGTTGA ATATGATGAT ATAAGTTCTG ATTCAGATAC TTTTTCTGAT 240
GCTCCGGTAC TTCTGTTGGA GAAAAGGGAG AATGAAGAAA AAAGGAGGAC AGACAAAAGC 300
GAAAGGGCAC ACAGACATCG CCATCATCAA CATAAACGGG CCAGGGAGCT ACATAAGTCT 360
AAACAGATGG AAAAGGAAAA GCGAGCAGAG AAAATTCGAG AGGCCTCCGG GAAGTCCGGA 420
GCTACTAAGG ACAAAGCAAC TGTGACTTCT TCAAAAAGGC AAGCGACAGA GTATGATGAA 480
CAAAGTAGAA AAGAGCATGT GACGCAATCC TCTAAAAATA GTAACAAAGA ATCCAGATCA 540
TCGAAAGCAC ACCGTGAGAA ATCCAGAAAA GAGAGAGAGT CTAGATCTGC GCATAAAGAG 600
CGAGTAAAAA GCCATCGAAA GAACAGAGAG AATCCCAAAG GTTACAAAAC AACTGAAAGT 660
TCCAAGGGGA AATCAAAGAG CCCACGTCGA AAGCGATCTG CAAGTCCAAA CCGAGATGAC 720
AGTCCTGCAG GGACGTCATA CAGTCAGGAC TATGACGTCA GCCCACCAAG GTCCCACAGT 780
TCGAGTAACT ATGAGTCCTA TAAGAGAAGT CCCGCTGCTT CATCCAGGAG GCAGTCTGTA 840
AGTCCATCAC ACAAGGAACC TGCTGCCTAC CAAACCACCA CTCACTCTCC AAGTCCATAC 900
ACCAAGAGGC AAAGGTCTGC GAGTCCATAT AACCGATGGC GGTCGTCCAG CGATGAGAGG 960
GGCAGTGGAT CATATAGTGG GAAGTCACCT AGTCCTTATA GTAGGAGACG CTCTGAAAGT 1020
TCATACACCT TTAAACGGTC CTCCAGCCCA AGTCCAGTAG CAAGAAGTCC TGCATACTCG 1080
AGGCATTCCC AATCTCACAG TAAGAAGCAG CAACGGTCTA GATCACGCAG TCGTCATTCA 1140
AGCATTTCGC CCCCCAGATT ACCGTTAAAC TCGAGCCTTG GAGCGGAGCT GAACAGGAAG 1200
AAGAAAGAGC GAGCTGCTGC AGCAGCCAAA GTGGATAAAA AGGAGTCAAA ACAAGGCTCA 1260
CCTCTTGTAC AGCTGAGAAA AGACAATAAT ACTACTGAGG GCAAAAGTTC AAAAACCAGC 1320
ACCAAAAAAG TAACCAAGAC CATTAAATCT GAAAAAACTG TCTCAGAAAC TGAAATTGGC 1380
AACTCATTAA GTGTAAGTAC TCCAAACAAA CCTCTTGTAG AGTTGGCAAA AATAAAGACA 1440
GAAGAAAGTC CTGTAGTTTC TATAAAAGAC TCTCAGCCTG TTGCAGTAAA AGAAGAACCT 1500
GAGATTGAAA AAGAGGAGAC CCCTCCACCG ACTCTTACTT CACCCCCTCC GCTGCCAGTA 1560
CTTAATTCCC CACAACCTCC TTCAACTCCT CCGCCTCAGA CTCCACCCTT GCCTCCCCTC 1620
CCTCCTTCAC CGGCAACTCT ACATCAGCCT CCACCGCCGC CTCCAGTTTC CCCCAAACCT 1680
GTTGTTGTAC CAGTCTCCAC TCAGCCACCG CCTCCTTCAG CGCCAGTGTC GTTGCCGTCG 1740
TTGCCAACAT TGCCGCCGCC TACTACGCAG ACAAAGACAC ATGCAGTGTC GACTCCGTCT 1800
CAGGCTAATT CGCAGACATT TTTGCAAACA GTTGTGAAAC CCCAAACACT GGTAACATCC 1860
TCAATACCAC AACTCAAGAC ATCCACGCTG CCGCTACTCC CGCTCCCACC GCTGCTTTTA 1920
GGAGATGATG ATTTGGATAG TCCAAAAGAG AGCCTCCCTC CAAAGCCAGT GAAGAAGGAG 1980
AAAGAGCAGA GGCCACGGCA TCTGCTGATT GACCTCCCCT TGCCACCTGA GCTTCTTGGA 2040
GGGGATCCAT CACCACCTGA GTCACCTGAA CCAAAAGCAG TGACCCCACC ACAACCTTCC 2100
TTCAAAAAGA GACCAAAAAT ATGTCGTCCT CGTTATGGTG AGAGAAAACA GTCTGAAAGT 2160
GACTGGGGAA AGCGCTGTGT TGATAAGTTT GATATCATTG GGATAACTGG AGAGGGAACA 2220
TATGGACAAG TTTACAAAGC CAGGGACAAA GATACAGGTG CATTGGTTGC TCTGAAAAAG 2280
GTGCGACTGG ATAATGAGAA GGAAGGGTTC CCCATCACTG CCATTCGAGA GATCAAAATT 2340
CTTCGTCAAC TGAATCATCC TAGTGTTGTC AACATGAAGG AGATAGTCAC AGACAAGCAG 2400
GATGCACTGG ACTTCAAAAA GGATAAAGGT GCGTTCTACT TAGTCTTTGA GTACATGGAC 2460
CATGACCTCA TGGGACTGCT CGAATCTGGC TTGGTGCAGT TCTCAGAGGA CCACATCAAA 2520
TCCTTCATGA AACAGTTGAT GCAAGGGCTG GATTACTGTC ACAAAAAGAA CTTCCTACAC 2580
CGTGACATCA AATGTTCAAA CATTCTGCTT AACAACAGTG GGCAGATCAA ACTGGCAGAT 2640
TTTGGACTGG CACGCTTGTA TAACTCTGAA GAAAGTCGTC CCTACACAAA CAAAGTTATA 2700
ACACTGTGGT ATCGACCTCC AGAACTGCTG CTAGGGGAAG AACGCTATAC GCCGGCCATA 2760
GATGTCTGGA GCTGTGGCTG TATCCTAGGA GAGCTCTTTA CGAAGAAGCC CATCTTTCAA 2820
GCAAATCAAG AATTGCTTCA GTTAGAATTA ATCAGTCGGT TGTGTGGCAG CCCGTGTCCG 2880
GCTGTTTGGC CTGATGTTAT TAAACTGCCT TATTTCAACT CCATGAAACC GAAGAAACAG 2940
TATCGGAGAC GGCTGCGGGA AGAGTTTGCT TTTGTTCCTT CTGCTGCCCT GGATCTGTTG 3000
GATCACATGC TCACTCTGGA TCCCAGTAAA CGCTGCACTG CTGAACAGAC ACTTCAGAGT 3060
GACTTTCTGA AGGATGTTGA CCCCAACAAG ATGGATCCTC CTGATCTTCC TCATTGGCAA 3120
GATTGCCATG AGCTTTGGAG TAAGAAACGC CGGCGGCAGA GACAAAGTGG GATTGTGGAA 3180
GAGCTCCCAG CAAATAAAGT TCCCCGAAAG GATCTGTTAT CTGGGATTGG TGCCAACAAT 3240
AGCAGGAGCA GCACCCCCCA GCTCGCACAG GCTCAGCAAA TTAAAACCCA GTCTGCTGCT 3300
GGTGAATTGG GAGGTCTTGG GGATGCAGCA AACCAGCTGA ACCCGAATGA ATTAGCAGTC 3360
TTACTGAACC TGCTCCAGGA CCAGACTGAT CTGAGCCTTC CACAGATGGC TCAGTTACTC 3420
AACGTGAACT CAAATCCTGA AATGCAGCAA CAGCTGGAGG TGCTCAGCCA GTCCATCGCT 3480
GCCCTAACAG AAGCCACTAA TCAACAGCAG GATTCTCAAA AACAGGAAGC GGCAGCAGCG 3540
GCAGAGAACA TAAAAGAGCC AGTCACAGCC GCGGTTGCTG CCACGCCTTC TCAGCCCGCG 3600
TCGGAGGAGC CGGCGCCCCC GGAAGTGGCA GGCGGGCAGG GGGACATGCA GAATCTGCTG 3660
ACTGTGTTGC TGAGTCAGCT GATCAAGCCT CCAGAAGCCT CTGTGGAGCC TGAGGAGAGC 3720
AACGGTGTGA AAAATGATGG GCAGCAACAG CAACAGCCGC CCTTGCCACC ACCAGCTACA 3780
GTACAGCAGG AAGATACTGC AGATGGTGTT AAAAAAAGCG ATCTTCCTAC AGCAAGCCGT 3840
CCCAGAATTC TTCCTCCAGA GAAGAGACCC CCTGAACCTC CTGGGCCGCC ACCTTCTCTA 3900
ATGGACCTGG ACTTTAGTAA TTCCACACAG GACCTGAATC CAACAGTGAC AGCAGCCCTG 3960
TTGCAGCTAA TGTCCCACCA TGAAACGGAG CAACAAAGAT CCAAAATACA AGAGCCTGAT 4020
GCTCCAAGTT CTGCTGATTA CTCTAGATCT CATTTGTCCA GGACTTACAG TACTGAGGAA 4080
CTGGGGACTA GTTTTGGTAC CCCAGAAATC AGAGATTCTA AACATACAGT GATTGAACCA 4140
TCTGCCCAAC CCTTGGAAAA AACCAGGACA CTTTCTAGTT CAGTGAGCCA TCTTGGCGAA 4200
ACGAGCAGCT ATCAGGGAAC AGGCTCTGTG CAGTTTCCAG GGGACCAGGA CTTCAGGTTC 4260
ACCCGTGTTC CTATATCTTT GCATTTGACC GGAGGTCATT CTGCCACTAA AGTTGATGGG 4320
AGCAACAGCA CGGCCATGCA ACAAGAGGCC CCAAATCAAA ACTATAGTGA GATAGGTCAG 4380
GGAGTAACTG CCCCCGGTAG CAGCTCTGGC ACAGGGCATG GATGGGGTAC CTCATCCCAG 4440
GGAACTCTGT ATGGAAAGGG CTTCAGGGGG CCTAGCAGGG TGCCCCCAAG AGGAGGAAGA 4500
GGGAGGGGTG TTCCATATTG A 4521
Domain Profile
S: 2     eklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkniv  61
         + +   geGtyg+vyka+dk+tg +vAlKk+rl++ekeg+pita+rEi++l++l+h+ +v
Q: 731   DIIGITGEGTYGQVYKARDKDTGALVALKKVRLDNEKEGFPITAIREIKILRQLNHPSVV  790
         5667789*****************************************************
S: 62    kLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112
         +++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql++g
Q: 791   NMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-QFSEDHIKSFMKQLMQG  849
         ***************8899********************999.*****************
S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPel  171
         l+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pel
Q: 850   LDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPEL  909
         **************************************7766527***************
S: 172   LlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevskl  231
         Llg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++l+g+p  +vwp+v kl
Q: 910   LLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAVWPDVIKL  969
         ************************************************************
S: 232   peykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         p +++  pkk+++ +l+e++  + ++aldll+++l+ldp+kR++a+++lq++++
Q: 970   PYFNSMKPKKQYRrRLREEFAFVPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1023
         ****6666666666******999999************************9985
Domain Sequence
(FASTA)
DIIGITGEGT YGQVYKARDK DTGALVALKK VRLDNEKEGF PITAIREIKI LRQLNHPSVV 60
NMKEIVTDKQ DALDFKKDKG AFYLVFEYMD HDLMGLLESG LVQFSEDHIK SFMKQLMQGL 120
DYCHKKNFLH RDIKCSNILL NNSGQIKLAD FGLARLYNSE ESRPYTNKVI TLWYRPPELL 180
LGEERYTPAI DVWSCGCILG ELFTKKPIFQ ANQELLQLEL ISRLCGSPCP AVWPDVIKLP 240
YFNSMKPKKQ YRRRLREEFA FVPSAALDLL DHMLTLDPSK RCTAEQTLQS DFL 293
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00061
EKS-BOT-00067
EKS-CAJ-00060
EKS-CAF-00064
EKS-CAP-00063
EKS-CII-00024
EKS-CIS-00070
EKS-DAR-00080
EKS-EQC-00064
EKS-FEC-00063
EKS-GAM-00035
EKS-GOG-00064
EKS-HOS-00066
EKS-LOA-00063
EKS-MAM-00063
EKS-MOD-00061
EKS-MUM-00065
EKS-MUP-00067
EKS-MYL-00064
EKS-NOL-00058
EKS-ORN-00085
EKS-ORA-00051
EKS-ORC-00061
EKS-ORL-00076
EKS-OTG-00068
EKS-PAT-00067
EKS-PES-00056
EKS-PEM-00035
EKS-POA-00060
EKS-RAN-00061
EKS-SAH-00058
EKS-SUS-00057
EKS-TEN-00089
EKS-TUT-00059
EKS-VIP-00026
EKS-XET-00059
EKS-XIM-00084
EKS-SAC-00066
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013