EKS-LAC-00306

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00306

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	336.9	8.0E-101	972	1240	269

Status

Unreviewed

Ensembl Protein

ENSLACP00000021843

UniProt Accession

H3BC50;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000017122	ENSLACP00000021843	ENSLACT00000026652
ENSLACG00000017122	ENSLACP00000019471	ENSLACT00000019608

Organism

Latimeria chalumnae

Functional Description

Protein Length

1272

Protein Sequence
(FASTA)

MDFQSCTQIF EEQIKNYTGD DPLNLWDRYV QWAEETLPAE ERGNLAPLLE RLITIFLQDK 60

RYLNDARFIN HCLKFAHFIS DPYEFYSYLQ CQGIGTRTAA FYMAWAQQFE MNGKLQQADA 120

IFQLAIQSQA QPIDTLHYQY RLFQARASQN PFSTQGVARE PLGSSQVLNP VVPPPVTTPE 180

KVSSSCSSKS QDSGLTKPQV SCISQSQCNS YNPESQSVTD ENAADSANTA ASTQQFTQVS 240

MYCKNNLISG DSELSFEEYR AKIYLKKYEQ KQQIQVWEKE KEHFQKKQQE ATEQAMLEQR 300

LEELHIQLKT LKGQQIESNA PAQQPLVVQE MPLGHENALM EGPTASSVPA DRLTLNISAQ 360

SQVWQEVKTS PTQSSSSCSA LATGSSSHSC LGTTAAESCP KLPSASFVLN EQKESKSDWE 420

SRNSQNPVQA LPNFTTSVVA SESVCHTAAD SIHEHSIQNQ CNLEAPHEFK PQQNYGTKDV 480

SHAGNSSGCF GNTSRVTPNT SFGLVQASPS VVQPSPTVHT KEALGFIMNM FQASAVPELQ 540

REDSHALLQQ AEEESDTFCI KNCYQSSGIL ANVQPAPASF CVFEDVNNKE NEGLSKNQKP 600

TELKAFGERL GLRAIGKPRA STQIAESLTE DYTVWGLRNK TLAPSPNSTR DFAAAAHLAS 660

TPFHGPALQS WEILEDQENA VVSNGGHFAF DSVEEKYKQL SKARKLSPIQ EQNLESTKLS 720

LATSFVAPTP DSNQLGAKEL SLTEKITLTE QRLAACKLSS AEEETQHPAC VQGQPDVGEP 780

LFNIHVDELV PAQQSKSTGN ISMSDGGHFA FDSAEGNCNQ LLKLSKPSPV QEQNLESTKP 840

SLATSFVAPT PDSNQLGGKE LSLTEKITLT EQHLAACKLS SAEEETQHPA RVQGQLDVGE 900

PLFNIHVDEE VPAQQSKSTD VIVDNPWDDD LIKCLLSELP KPLSSCPDCY TWKAKLPAVK 960

PKMALSLGNQ SFQVDCLLGE GAFAQVYQAS VLDVKDFKNS QKVILKVQKT ASPWEFYIGS 1020

QLTERLKPSL RHLFINFYSA HFFHTGSILV GELYSFGTLL NTMNLYKKII EKVMPQPLVI 1080

YFAISILYMV EQLHSIGIIH GDIKPDNFIL GERFLDNDPC VVDCSSHGLS LIDLGQSIDL 1140

RLFPAGTAFM AKCETSGFQC VEMLTKKPWT YQVDYYGIAG TVYCMLFGTY MKVHNEKGVW 1200

KPNAVFKRTH HTEMWTDFFH TLLNVPDCQT LPSLGFLREK LLAVFQEHYS SKIKSLRNRL 1260

VVLLLENKRS RK 1272

Nucleotide Sequence
(FASTA)

ATGGATTTTC AAAGCTGTAC GCAGATCTTT GAAGAACAAA TCAAAAACTA CACAGGAGAT 60

GATCCACTTA ATCTGTGGGA CAGGTATGTG CAGTGGGCTG AAGAAACACT TCCTGCCGAA 120

GAGAGGGGCA ACTTAGCACC TTTGCTAGAG AGATTGATCA CGATTTTTCT GCAGGACAAG 180

AGGTATCTCA ATGATGCCAG ATTCATTAAC CACTGCCTAA AGTTTGCACA CTTCATTAGT 240

GACCCTTATG AGTTTTACAG TTACCTACAG TGCCAAGGAA TTGGCACAAG GACAGCTGCT 300

TTCTACATGG CTTGGGCGCA ACAGTTTGAA ATGAACGGAA AACTGCAGCA GGCGGATGCC 360

ATTTTTCAGC TGGCCATCCA AAGTCAGGCA CAGCCAATAG ACACATTGCA TTATCAGTAC 420

AGGTTGTTTC AGGCTCGAGC ATCTCAAAAT CCATTTTCAA CACAAGGAGT TGCAAGGGAA 480

CCTCTTGGTA GTTCTCAGGT TTTAAATCCA GTTGTACCAC CTCCAGTGAC CACCCCAGAA 540

AAGGTTAGCT CCAGTTGTTC CTCCAAGTCT CAGGATTCTG GCCTTACAAA ACCTCAGGTT 600

TCCTGCATTA GTCAATCACA GTGCAATTCA TATAACCCAG AATCACAGAG CGTTACAGAT 660

GAAAATGCAG CAGATTCTGC CAACACAGCT GCATCTACGC AACAGTTTAC ACAGGTTTCC 720

ATGTACTGCA AAAACAATCT GATTTCTGGA GACTCCGAAC TGTCATTTGA GGAATACAGA 780

GCTAAGATTT ACCTCAAGAA ATATGAGCAG AAGCAGCAGA TACAAGTGTG GGAAAAAGAA 840

AAGGAACATT TCCAAAAGAA GCAGCAAGAA GCCACGGAGC AAGCGATGTT GGAACAAAGA 900

CTTGAAGAAC TCCATATCCA ACTGAAAACA CTGAAGGGGC AGCAGATAGA GAGCAATGCT 960

CCAGCTCAGC AGCCATTGGT GGTGCAGGAG ATGCCTTTGG GACATGAAAA TGCGCTGATG 1020

GAGGGACCTA CAGCTTCATC TGTTCCAGCT GACAGACTAA CTTTGAACAT CAGTGCCCAG 1080

TCACAAGTTT GGCAAGAGGT GAAGACCAGT CCTACACAGT CTTCCTCGTC TTGTTCTGCT 1140

CTTGCTACAG GGTCCTCTTC TCACAGCTGT TTAGGTACCA CAGCTGCAGA ATCTTGCCCC 1200

AAGCTTCCTT CAGCATCCTT CGTATTGAAT GAACAAAAGG AGAGTAAGTC TGACTGGGAA 1260

AGCAGAAACT CACAGAATCC GGTTCAAGCT CTTCCCAACT TCACTACCTC AGTGGTTGCG 1320

TCAGAGTCTG TGTGCCATAC CGCAGCTGAC AGCATACATG AACACAGTAT CCAAAACCAG 1380

TGTAATCTTG AAGCTCCCCA TGAATTTAAG CCACAGCAAA ACTATGGAAC GAAAGACGTT 1440

TCTCATGCTG GGAATTCTTC AGGCTGTTTT GGTAACACCT CTCGTGTTAC TCCGAACACT 1500

TCCTTTGGCT TGGTTCAGGC ATCTCCTTCA GTAGTGCAGC CTTCTCCCAC TGTTCACACA 1560

AAGGAAGCCT TAGGCTTTAT AATGAACATG TTCCAGGCTT CTGCTGTTCC TGAACTTCAG 1620

AGAGAAGATA GTCATGCTTT GCTTCAGCAA GCAGAGGAGG AGTCCGACAC ATTTTGCATA 1680

AAGAATTGCT ACCAGTCCAG TGGAATTTTG GCCAATGTCC AGCCAGCACC TGCATCATTT 1740

TGTGTCTTTG AAGATGTCAA TAATAAAGAG AATGAGGGAC TATCTAAGAA TCAAAAGCCT 1800

ACAGAATTAA AAGCATTTGG AGAGCGTCTT GGATTAAGAG CAATAGGTAA ACCCAGAGCC 1860

AGCACTCAGA TTGCAGAATC TCTGACTGAA GATTACACGG TCTGGGGCCT ACGCAATAAA 1920

ACCTTGGCAC CCAGTCCAAA TAGTACAAGA GACTTTGCAG CTGCTGCACA TCTTGCATCT 1980

ACACCCTTTC ATGGACCAGC ACTGCAGTCT TGGGAAATAT TAGAAGACCA AGAAAACGCT 2040

GTGGTCAGTA ATGGTGGTCA TTTTGCTTTT GACTCGGTGG AAGAGAAGTA CAAGCAGCTG 2100

TCAAAAGCCA GGAAGCTAAG TCCTATTCAG GAGCAAAATC TGGAATCCAC AAAGCTGTCC 2160

TTGGCCACCA GTTTTGTTGC TCCCACGCCT GACTCAAATC AGTTGGGTGC TAAGGAGTTG 2220

TCGCTGACTG AGAAGATCAC TCTCACCGAG CAGCGTCTTG CAGCCTGTAA ACTTTCCAGC 2280

GCAGAAGAGG AGACACAGCA TCCAGCATGT GTTCAGGGGC AACCGGATGT CGGAGAGCCG 2340

CTGTTTAATA TCCATGTAGA CGAATTGGTG CCAGCACAGC AAAGCAAATC AACCGGAAAC 2400

ATTTCCATGA GCGATGGTGG CCATTTTGCT TTTGACTCAG CAGAAGGGAA CTGTAATCAG 2460

CTCTTGAAAC TGAGTAAGCC AAGTCCTGTT CAGGAGCAAA ATTTGGAATC CACAAAGCCA 2520

TCCTTGGCCA CCAGTTTTGT TGCTCCCACG CCTGACTCAA ATCAGTTGGG TGGTAAGGAG 2580

TTGTCGCTGA CTGAGAAGAT CACTCTCACC GAACAGCATC TTGCAGCCTG TAAACTTTCT 2640

AGCGCAGAAG AGGAGACGCA GCATCCAGCA CGTGTTCAGG GGCAACTGGA TGTCGGAGAG 2700

CCGCTGTTTA ATATCCATGT AGACGAAGAG GTGCCAGCAC AGCAAAGCAA ATCAACCGAT 2760

GTAATTGTTG ATAACCCTTG GGATGATGAC CTAATCAAGT GCTTACTGTC TGAATTGCCC 2820

AAACCACTGA GCTCCTGCCC AGACTGCTAT ACCTGGAAGG CCAAACTCCC TGCTGTCAAA 2880

CCCAAAATGG CTCTCTCTCT AGGTAATCAG TCTTTTCAAG TTGATTGTCT GCTTGGAGAA 2940

GGTGCCTTTG CTCAAGTCTA TCAGGCCTCA GTCCTAGATG TGAAAGACTT CAAAAATAGC 3000

CAGAAAGTTA TCTTGAAGGT CCAGAAAACA GCCAGCCCCT GGGAGTTCTA CATTGGATCT 3060

CAACTGACAG AGAGGCTAAA GCCAAGTCTG CGCCATCTTT TTATCAACTT CTATTCTGCC 3120

CATTTCTTCC ACACTGGAAG CATTTTAGTT GGAGAACTTT ATAGCTTTGG AACACTATTG 3180

AATACCATGA ATTTGTACAA AAAAATAATT GAGAAGGTGA TGCCGCAGCC ACTGGTGATC 3240

TACTTTGCTA TCAGCATCCT TTACATGGTG GAACAGCTCC ACAGTATTGG GATCATTCAT 3300

GGAGACATCA AACCGGACAA CTTTATCCTC GGGGAAAGGT TTCTAGACAA TGATCCCTGC 3360

GTTGTGGATT GTTCATCCCA CGGTTTGTCC CTGATCGACT TGGGCCAGAG TATAGATTTG 3420

AGATTATTCC CTGCCGGAAC TGCATTTATG GCCAAATGTG AAACCTCTGG ATTCCAGTGT 3480

GTTGAGATGT TGACAAAGAA GCCGTGGACC TACCAGGTTG ATTATTATGG GATTGCTGGG 3540

ACTGTTTACT GCATGCTCTT TGGCACGTAC ATGAAAGTAC ACAATGAGAA GGGAGTCTGG 3600

AAACCAAATG CTGTATTTAA AAGGACCCAC CATACGGAAA TGTGGACTGA TTTCTTTCAT 3660

ACCCTGCTGA ACGTACCAGA TTGCCAGACT CTGCCTTCCC TGGGGTTCTT GCGTGAAAAA 3720

CTGCTGGCTG TGTTTCAAGA ACACTACAGC AGTAAAATCA AATCGCTCCG TAACAGACTT 3780

GTTGTTCTAC TGCTGGAAAA CAAGCGCTCA CGAAAATAA 3819

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeel  56

         ++++ ++geGa+a+vy+a      d k+ ++v+lKv+k a++WefYI +ql+eRlk ++l

Q: 972   FQVDCLLGEGAFAQVYQASVldvkDFKNSQKVILKVQKTASPWEFYIGSQLTERLK-PSL  1030

         578999************999888999*****************************.77*

S: 57    lksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiv  116

          + +i+++sa+ f+++s+lv e++s+gtll+ +n++k++ +kvm++ lv+++++ +l++v

Q: 1031  RHLFINFYSAHFFHTGSILVGELYSFGTLLNTMNLYKKIIEKVMPQPLVIYFAISILYMV  1090

         ************************************************************

S: 117   eklHeveIiHgDlkPdnfllgnrimdkad..kdkeekglkliDfgrsiDmkllpdgtkfk  174

         e+lH+++IiHgD+kPdnf+lg+r+ d+    +d  ++gl liD+g+siD++l+p gt+f

Q: 1091  EQLHSIGIIHGDIKPDNFILGERFLDNDPcvVDCSSHGLSLIDLGQSIDLRLFPAGTAFM  1150

         ************************99876458999*************************

S: 175   gkaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrll  234

         +k++t++f+c+eml+ k+w+YqvD++g+a++++++lfg+y++v +e g wk++  +kr

Q: 1151  AKCETSGFQCVEMLTKKPWTYQVDYYGIAGTVYCMLFGTYMKVHNEKGVWKPNAVFKRTH  1210

         ************************************************************

S: 235   kkelwekiferlLNisdastlpsleelveek  265

         + e+w+++f++lLN++d++tlpsl+ l+e k

Q: 1211  HTEMWTDFFHTLLNVPDCQTLPSLGFLRE-K  1240

         ***************************96.3

Domain Sequence
(FASTA)

FQVDCLLGEG AFAQVYQASV LDVKDFKNSQ KVILKVQKTA SPWEFYIGSQ LTERLKPSLR 60

HLFINFYSAH FFHTGSILVG ELYSFGTLLN TMNLYKKIIE KVMPQPLVIY FAISILYMVE 120

QLHSIGIIHG DIKPDNFILG ERFLDNDPCV VDCSSHGLSL IDLGQSIDLR LFPAGTAFMA 180

KCETSGFQCV EMLTKKPWTY QVDYYGIAGT VYCMLFGTYM KVHNEKGVWK PNAVFKRTHH 240

TEMWTDFFHT LLNVPDCQTL PSLGFLREK 269

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013