EKS-LAC-00112
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00112
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec463.02.4E-139360610251
StatusUnreviewed
Ensembl ProteinENSLACP00000022176
UniProt AccessionH3BCB6;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000017180ENSLACP00000022176ENSLACT00000026314
ENSLACG00000017180ENSLACP00000019537ENSLACT00000019675
OrganismLatimeria chalumnae
Functional Description
Protein Length615
Protein Sequence
(FASTA)
MNMTLNEGKK GSKKGSVDVD KISCVETVAP EENPPPERQI LRKGDDMVEM EQISVIERFP 60
YPFQIIYDEG PLYIFAPTEE LRQRWIKELK NVTRFNKDLA QKYHPCFWID GEWLCCKQIA 120
KTAIGCQILE IRNGSLKAGR AHRKSRKPLP PTPQEEQKIK PLPLVPEHSS PAKTKVIVAL 180
YDYKPMEALD MPLVKGEEYY VIEEANAQWW KARDKNGQEG YIPSNYVTEA TDQLQIFEWY 240
SKHITRSQAE QRLREEGKDG GFIVRDSSRP GKYTVSVFTK ATGEPNGMIR HYVVCSTPQN 300
QYYLAEKYHF ASIPDLIKYH QHNSAGLISR LKHPVSTWSS SAPSTAGLGY GIWEIDPKDL 360
TFLNELGNGQ FGVVKHGKWR GQHDVAIKMI KEGSMSEDDF IDEAKVMMNL SHAKLVQLYG 420
ICTKERPIFI VTEFMANGCL LNYLRENNKR PHTTELLEMC KDVCEAMEYL ESQQFLHRDL 480
AARNCLVDTR GIVKVSDFGL SRYVMDDEYT SSIGSKFPVR WSPPEVLLYN KFSSKSDVWS 540
FGVLMWEIYT LGKMPYERFN NSETADNVTK GLRLYRPQLA TDRIYPIMYS CWHERPEERP 600
SFRVLLSNIL DLLEE 615
Nucleotide Sequence
(FASTA)
ATGAATATGA CTTTGAACGA GGGGAAAAAA GGGAGTAAAA AGGGGTCGGT GGATGTTGAT 60
AAAATCTCCT GTGTGGAGAC AGTTGCTCCA GAAGAGAATC CTCCACCAGA GAGACAGATT 120
CTGAGGAAGG GAGATGACAT GGTCGAGATG GAGCAGATTT CTGTAATTGA AAGATTTCCT 180
TACCCTTTCC AGATTATATA TGATGAAGGA CCACTGTACA TTTTTGCCCC AACAGAAGAG 240
CTTAGACAGC GATGGATCAA GGAGCTAAAG AATGTGACAC GATTCAACAA AGATCTCGCT 300
CAGAAGTATC ACCCTTGTTT TTGGATCGAC GGAGAGTGGC TTTGCTGCAA ACAGATAGCC 360
AAGACTGCCA TAGGCTGTCA GATTCTGGAG ATCAGGAATG GAAGTTTGAA AGCAGGACGA 420
GCTCATCGCA AGTCTCGGAA GCCACTTCCC CCAACTCCCC AGGAGGAGCA GAAGATAAAG 480
CCCTTGCCGC TGGTTCCTGA GCATTCATCG CCCGCAAAGA CGAAGGTGAT TGTTGCGTTG 540
TATGACTACA AGCCAATGGA AGCTCTGGAC ATGCCCCTTG TGAAAGGAGA AGAATATTAT 600
GTGATAGAGG AAGCCAACGC ACAGTGGTGG AAAGCCAGGG ACAAAAATGG GCAAGAAGGG 660
TACATTCCTA GCAACTATGT AACAGAGGCT ACAGACCAAC TGCAGATCTT TGAATGGTAT 720
TCAAAGCACA TCACAAGAAG CCAAGCAGAA CAACGGCTAA GGGAAGAGGG TAAAGACGGA 780
GGATTCATAG TTCGGGACTC CAGCAGACCT GGAAAATACA CCGTCTCTGT ATTCACAAAA 840
GCAACTGGAG AACCAAACGG AATGATCAGA CATTATGTGG TATGCTCTAC ACCTCAGAAT 900
CAGTATTATC TTGCAGAAAA GTACCACTTC GCCTCCATTC CAGATCTTAT AAAGTATCAC 960
CAGCACAATT CTGCAGGCCT CATTTCTCGA CTGAAGCATC CCGTATCAAC CTGGAGCAGC 1020
AGTGCCCCCT CCACGGCCGG ATTAGGCTAC GGGATATGGG AAATAGATCC TAAAGATCTG 1080
ACCTTCTTGA ATGAGCTGGG AAATGGACAG TTTGGAGTGG TGAAGCATGG GAAGTGGAGA 1140
GGCCAGCACG ATGTGGCCAT TAAAATGATT AAAGAAGGCT CCATGTCTGA GGATGACTTT 1200
ATTGATGAAG CCAAAGTCAT GATGAACCTA TCGCATGCCA AACTGGTCCA GCTTTACGGA 1260
ATTTGCACCA AGGAGCGGCC CATCTTTATT GTGACAGAGT TCATGGCAAA TGGCTGCCTC 1320
CTGAACTACC TGAGGGAAAA CAACAAGCGC CCTCATACCA CTGAGCTCCT GGAGATGTGC 1380
AAGGATGTCT GCGAGGCCAT GGAATACCTG GAATCCCAAC AGTTCCTGCA CAGAGATTTG 1440
GCTGCTCGGA ACTGCTTAGT TGACACACGT GGCATAGTGA AGGTGTCAGA CTTTGGCTTA 1500
TCAAGGTACG TCATGGACGA TGAATATACC AGTTCAATAG GGTCTAAGTT TCCCGTCCGT 1560
TGGTCCCCTC CAGAGGTTCT TCTCTATAAC AAGTTTAGCA GCAAATCTGA CGTTTGGTCC 1620
TTTGGGGTCC TCATGTGGGA GATATATACT TTGGGGAAAA TGCCTTATGA AAGATTTAAT 1680
AACAGTGAGA CTGCAGATAA TGTGACCAAG GGACTTCGCT TGTATCGACC TCAACTTGCT 1740
ACAGACAGGA TCTACCCCAT CATGTATAGC TGCTGGCACG AGAGACCTGA AGAACGTCCA 1800
AGTTTTCGAG TGCTTCTTTC CAACATTTTA GATCTTCTGG AGGAATAG 1848
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+l+elg+gqfgvvk gkwr+++dvaik+ikeg+mse+dfi+eakvmm+lsh klvqly
Q: 360   LTFLNELGNGQFGVVKHGKWRGQHDVAIKMIKEGSMSEDDFIDEAKVMMNLSHAKLVQLY  419
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         g+c+k++pi+ivte+++ngcllnylre++k+ +++ llemckdvce+meyle+++f+hrd
Q: 420   GICTKERPIFIVTEFMANGCLLNYLRENNKRPHTTELLEMCKDVCEAMEYLESQQFLHRD  479
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclvd   +vkvsdfgl+ryv+dd+y+ss g+kfpv+wsppevl y+k+ssksdvw
Q: 480   LAARNCLVDTRGIVKVSDFGLSRYVMDDEYTSSIGSKFPVRWSPPEVLLYNKFSSKSDVW  539
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwe++++gk+pye+++nse++++v++glrlyrp+la++++y +m+scw+e+peer
Q: 540   SFGVLMWEIYTLGKMPYERFNNSETADNVTKGLRLYRPQLATDRIYPIMYSCWHERPEER  599
         ************************************************************
S: 241   ptfkellsale  251
         p+f+ lls++ 
Q: 600   PSFRVLLSNIL  610
         ********996
Domain Sequence
(FASTA)
LTFLNELGNG QFGVVKHGKW RGQHDVAIKM IKEGSMSEDD FIDEAKVMMN LSHAKLVQLY 60
GICTKERPIF IVTEFMANGC LLNYLRENNK RPHTTELLEM CKDVCEAMEY LESQQFLHRD 120
LAARNCLVDT RGIVKVSDFG LSRYVMDDEY TSSIGSKFPV RWSPPEVLLY NKFSSKSDVW 180
SFGVLMWEIY TLGKMPYERF NNSETADNVT KGLRLYRPQL ATDRIYPIMY SCWHERPEER 240
PSFRVLLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013