EKS-LAC-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	443.2	6.4E-133	198	526	329

Status

Unreviewed

Ensembl Protein

ENSLACP00000019841

UniProt Accession

H3BD70;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK3

Gene Synonyms/Alias

HIPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000017446	ENSLACP00000019841	ENSLACT00000019979

Organism

Latimeria chalumnae

Functional Description

Protein Length

1204

Protein Sequence
(FASTA)

MASQVLIYPP HVYQTQTSAF CSVKKLKIEP SSCVYHERAY PRTYVNGRTV GIAHPSNLVN 60

SSFQTKNSIG RPRGQNVLLQ ASAVALKNIS GATGVIAARA QQPLTVAPQS ETQGAGLTLL 120

DSYQRCGLKR KSEELDSQDN TMQIVDELSI LPAMLQTNMG NTVTMVTTTT TSKQNSASGD 180

GDYQLVQHEV LCSMKNTYEV LDFLGRGTFG QVVKCWKRGT NEIVAIKILK NHPSYARQGQ 240

IEVSILARLS GENADEFNFV RAHEYFQHRN HTCLVFEMLE QNLYDFLKQN KFSPLPLKVI 300

RAILQQVVTA LKKLKSLGLI HADLKPENIM LVDPVRQPYR VKIIDFGSAS HVSKAVCSTY 360

LQSRYYRAPE IILGLPFCEA IDMWSLGCVI AELFLGWPLY PGALEYDQIR YISQTQGLPG 420

DQLLNVGTKT ARFFCRETDS PYAGWRLKTL EEHEVETGMK SKEARKYIFS CLEDIAHVNM 480

VMDLEGSDLL AEKADRREFV NLLKKMLLID ADKRITPAET LNHPFVTMQH LLDFPHSNHV 540

KSCFHIMDVC RSRPNLYDVN NRNKTTLMRT VISGNAPNMT VGFSKMGTVH SQALAPSGHS 600

VIHHGIPLQA GTAQFGCNDS FQQTLILCPP AIQGIPTNHA KAAGYSVRMD NTVPLVTQAP 660

TIQPLQMRPG VLSQGWSKCT QQILVPAWQQ IATVAPSTTA MASDTVTGPQ RLGDWGKVHP 720

HGNHYNSVIP QRILTNQMAL SAHHQPISVG IAHVVWPQPS AANKRNKPCQ NRSNALQNTN 780

LQNSTPQSPK IPDTIKKVEP ESCKDSQDNH NQEGDVRSCC KASVGQDPDD SAISNKQRQT 840

IVIADSPSPT VSVITISSDT DEEETAQRHS LGECKGSPDC EACQSTLNID RVCSLSSPDS 900

TLSTSSSTSA QSSPSPCKRR NSMSDDEQES GCDTVDGSPA SDSSGQSNSP FIESRFLRDT 960

NQNTENRHSR DTATNKQAVR TVVVPPMRVQ NRSSVSEEQI SNSDATCQPL IKGRSAPGRI 1020

NQPSVGGSRQ QKLTSVFQQQ HINFSQVQHY GSGHQEWNGN YGHRRPQAYI PPTIVSHTFS 1080

LPHGSPNHTT AHAHLAGNTH LGGQPAILPY PPSAPLGTAA PVAHLLASPC TSRPIIQPAA 1140

YSISHPSGIV HQVPVGINPR LLPSPTIHQN QYKPIFPAHS YIAASPAYTG FPLSPNKISQ 1200

YPYI 1204

Nucleotide Sequence
(FASTA)

ATGGCCTCAC AAGTCTTGAT CTACCCACCA CATGTTTATC AAACCCAGAC AAGTGCCTTT 60

TGTAGTGTGA AGAAACTCAA AATTGAGCCA AGCAGTTGTG TGTACCATGA GAGAGCCTAT 120

CCACGGACCT ATGTGAATGG TAGAACAGTT GGAATTGCTC ATCCTTCAAA CTTGGTTAAC 180

TCTTCTTTTC AGACAAAGAA CTCAATTGGT AGACCTCGTG GACAGAACGT TCTGTTGCAA 240

GCAAGCGCTG TTGCTTTGAA AAATATATCT GGTGCCACAG GGGTTATAGC AGCGCGGGCG 300

CAGCAACCTC TGACAGTGGC ACCTCAGAGT GAAACGCAAG GAGCTGGGCT GACTTTACTA 360

GACAGTTACC AGCGATGTGG ATTGAAGCGT AAAAGTGAGG AATTGGATAG TCAAGATAAC 420

ACCATGCAGA TTGTTGATGA ACTATCTATA TTGCCTGCAA TGTTGCAAAC AAACATGGGG 480

AACACTGTCA CTATGGTGAC CACTACAACA ACCTCAAAAC AGAACAGTGC CAGTGGGGAT 540

GGGGATTACC AGTTGGTGCA GCATGAAGTG TTGTGTTCCA TGAAAAATAC TTATGAGGTC 600

CTTGATTTTC TTGGGCGTGG GACCTTCGGC CAGGTGGTCA AATGCTGGAA GAGAGGCACA 660

AATGAGATTG TGGCAATTAA AATTTTGAAG AACCACCCCT CCTATGCACG CCAGGGGCAA 720

ATTGAAGTGA GCATATTAGC ACGACTCAGT GGTGAAAATG CAGATGAGTT TAATTTTGTA 780

AGGGCCCATG AATATTTTCA GCATCGTAAC CATACGTGCT TGGTTTTTGA GATGTTGGAA 840

CAGAACTTAT ATGACTTTTT AAAACAAAAC AAATTCAGTC CACTGCCACT GAAAGTAATA 900

AGGGCCATCT TGCAACAGGT GGTCACTGCA CTGAAAAAGC TGAAAAGTCT TGGTTTAATC 960

CATGCAGACC TCAAACCAGA GAATATTATG TTGGTGGATC CTGTTCGACA GCCATACAGG 1020

GTTAAGATAA TAGACTTTGG GTCTGCAAGC CATGTTTCAA AGGCGGTGTG TTCAACTTAT 1080

TTGCAGTCAC GGTACTATAG AGCACCGGAA ATTATTTTAG GTTTGCCGTT TTGTGAAGCC 1140

ATAGATATGT GGTCGTTGGG ATGTGTGATT GCTGAGCTAT TTCTTGGATG GCCGCTGTAC 1200

CCAGGAGCTC TGGAATATGA CCAGATACGT TATATTTCCC AAACCCAAGG GTTGCCTGGT 1260

GATCAGTTGC TGAATGTGGG GACAAAAACA GCAAGATTTT TCTGTAGAGA GACTGATTCC 1320

CCATATGCAG GATGGAGATT GAAGACACTG GAAGAGCATG AGGTCGAGAC AGGGATGAAG 1380

TCTAAGGAAG CTAGAAAGTA TATCTTCAGC TGTTTGGAAG ATATAGCGCA TGTGAACATG 1440

GTGATGGATT TGGAAGGAAG TGACTTGCTG GCAGAGAAGG CGGATAGAAG GGAATTTGTT 1500

AATTTGCTGA AGAAGATGTT ATTGATCGAT GCTGATAAAA GAATCACTCC AGCTGAGACA 1560

TTAAACCATC CTTTTGTTAC CATGCAGCAC CTTTTGGATT TTCCTCACAG CAACCATGTC 1620

AAATCTTGTT TTCATATAAT GGATGTTTGC AGATCACGAC CAAACTTGTA TGATGTAAAT 1680

AATCGCAATA AGACAACACT TATGAGAACT GTCATCTCAG GCAATGCACC CAATATGACT 1740

GTGGGTTTTA GCAAAATGGG CACAGTGCAC AGCCAGGCTT TAGCACCATC TGGCCATTCT 1800

GTTATTCACC ATGGGATACC ACTGCAGGCT GGAACTGCTC AGTTTGGTTG CAATGATTCT 1860

TTTCAACAAA CATTGATCCT TTGCCCTCCA GCTATCCAAG GAATCCCCAC TAACCATGCC 1920

AAGGCTGCTG GCTACTCAGT AAGGATGGAT AACACTGTGC CGTTGGTGAC ACAGGCCCCA 1980

ACTATACAGC CATTACAGAT GAGACCAGGA GTTTTGTCAC AGGGGTGGTC GAAATGTACC 2040

CAGCAGATCC TGGTACCTGC CTGGCAACAG ATAGCAACTG TAGCTCCTTC TACCACAGCA 2100

ATGGCTTCTG ATACTGTTAC TGGCCCACAG AGACTTGGAG ACTGGGGGAA AGTACATCCC 2160

CATGGAAACC ATTACAATTC AGTAATACCA CAGCGTATCT TAACCAATCA AATGGCTTTA 2220

TCAGCCCATC ATCAGCCAAT CAGTGTGGGT ATTGCACATG TTGTCTGGCC TCAACCTTCT 2280

GCTGCTAACA AAAGAAACAA ACCCTGCCAG AACAGGAGTA ATGCATTGCA AAACACCAAC 2340

CTCCAAAATT CAACTCCTCA GTCTCCAAAG ATCCCAGACA CTATTAAAAA AGTTGAACCA 2400

GAAAGTTGTA AAGATTCACA GGACAATCAT AACCAAGAAG GAGATGTAAG AAGCTGCTGT 2460

AAAGCATCAG TCGGGCAGGA CCCTGACGAT TCAGCTATCT CTAACAAACA ACGTCAAACA 2520

ATTGTTATTG CTGACTCACC AAGTCCCACA GTCAGTGTAA TCACCATCAG CAGTGATACA 2580

GATGAAGAGG AAACAGCCCA GAGACACTCG CTTGGAGAAT GTAAAGGAAG CCCAGACTGT 2640

GAAGCCTGTC AGAGTACGTT AAATATTGAC CGTGTGTGTT CACTTAGCAG CCCTGATAGC 2700

ACCCTGAGTA CAAGTTCATC AACTTCAGCA CAGTCTAGCC CTTCTCCTTG CAAGAGGCGT 2760

AACAGCATGT CAGATGACGA GCAAGAAAGT GGCTGTGATA CTGTAGATGG CTCTCCAGCA 2820

TCGGACTCTT CGGGACAAAG CAACAGTCCA TTCATTGAGA GCAGGTTTCT GAGAGACACC 2880

AACCAAAACA CAGAAAACAG GCACTCACGT GACACAGCGA CCAACAAGCA AGCTGTCCGC 2940

ACTGTGGTAG TGCCACCAAT GAGAGTACAG AACAGAAGCT CAGTCTCTGA AGAACAGATT 3000

TCAAATTCAG ATGCCACATG TCAGCCTTTA ATAAAGGGAC GATCTGCCCC TGGAAGAATA 3060

AACCAGCCTT CAGTTGGGGG TAGCCGCCAA CAGAAACTAA CATCAGTATT CCAGCAGCAG 3120

CATATAAACT TCAGTCAGGT TCAGCATTAC GGATCTGGGC ATCAGGAGTG GAACGGAAAT 3180

TATGGACACA GAAGACCGCA GGCATACATC CCACCTACAA TTGTTAGCCA TACGTTTTCT 3240

CTTCCGCATG GGAGCCCTAA TCACACTACA GCGCATGCTC ACCTGGCTGG GAATACACAT 3300

CTAGGAGGGC AGCCTGCTAT TCTACCTTAC CCACCATCTG CACCTCTTGG CACTGCAGCT 3360

CCTGTAGCAC ATCTCCTGGC CTCTCCGTGT ACGTCAAGAC CTATAATACA GCCTGCAGCC 3420

TACAGTATCT CTCATCCCAG TGGTATTGTT CACCAGGTTC CTGTAGGCAT AAATCCTCGC 3480

CTTTTGCCTT CTCCAACTAT CCATCAGAAC CAGTATAAAC CAATTTTTCC TGCACATTCT 3540

TACATAGCAG CATCACCTGC TTACACAGGG TTTCCATTAA GTCCAAACAA AATCAGCCAG 3600

TACCCATACA TTTGA 3615

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l+  +++++

Q: 198   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSG-ENADE  256

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +n+vr+ e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+

Q: 257   FNFVRAHEYFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRAILQQVVTALKKLKS  316

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vk+iDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 317   LGLIHADLKPENIMLVDPVRQPyrVKIIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  376

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp ++ll+ ++k+ +ff

Q: 377   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGDQLLNVGTKTARFFcr  436

         **********************************************************99

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

          t++ +  ++lkt          ks++++k+++++ ++++++++ ++ e ++ l+ek+d+

Q: 437   eTDSPYAGWRLKTLeehevetgmKSKEARKYIFSCLEDIAHVNMVMDLEGSDLLAEKADR  496

         8888999999999999*******************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + f++llk+ml +d++kRitp+e+l+hpfv

Q: 497   ReFVNLLKKMLLIDADKRITPAETLNHPFV  526

         99***************************7

Domain Sequence
(FASTA)

YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSGENADEF 60

NFVRAHEYFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRAILQQV VTALKKLKSL 120

GLIHADLKPE NIMLVDPVRQ PYRVKIIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGDQLLNVG TKTARFFCRE 240

TDSPYAGWRL KTLEEHEVET GMKSKEARKY IFSCLEDIAH VNMVMDLEGS DLLAEKADRR 300

EFVNLLKKML LIDADKRITP AETLNHPFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013