EKS-LAC-00478

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00478

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	351.6	3.4E-105	4	282	279

Status

Unreviewed

Ensembl Protein

ENSLACP00000020413

UniProt Accession

H3BEU2;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000017941	ENSLACP00000020413	ENSLACT00000020553

Organism

Latimeria chalumnae

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

YNLFGSFRSV TDPRDGKRVA LKKMPNVFQN LVSCKRVFRE LKMLCFFKHD NVLSALDILQ 60

PPHIDYFEEI YVVTELMQSD LHKIIVSPQP LSSDHVKVFL YQILRGLKYL HSAGILHRDI 120

KPGNLLVNSN CVLKICDFGL ARVEELDESR HMTQEVVTQY YRAPEILMGS RHYTNAIDIW 180

SVGCIFAELL GRRILFQAQS PIQQLDLIIE LLGTPSLEAM RTACEGARAH ILKGTPKQLI 240

LKEIYTLNTE SKHEAVHLIT RQLRFEPSKR ISAKDALAHP YLDEGRLRYH TCMCKCCYTT 300

STGRVYTNDF EPITNPKFDD TFEKNLTSVR QVKEIIHQFI LEQQKGNRVP LCINPQSAAF 360

KSFISSTVAQ PSEMPPSPLV WE 382

Nucleotide Sequence
(FASTA)

TATAATCTCT TTGGTTCCTT TAGGTCAGTG ACTGATCCCA GGGATGGAAA GAGAGTTGCA 60

CTTAAAAAGA TGCCCAATGT CTTCCAAAAT CTCGTCTCTT GCAAGCGAGT CTTCCGTGAA 120

TTGAAGATGC TGTGCTTTTT TAAGCATGAC AATGTGCTCT CTGCGCTTGA TATACTCCAA 180

CCACCACACA TTGATTACTT TGAGGAGATC TATGTCGTCA CAGAACTGAT GCAGAGTGAC 240

CTTCATAAGA TCATTGTGTC TCCCCAACCA CTCAGTTCTG ATCACGTCAA AGTATTCCTC 300

TATCAGATTT TGAGAGGTCT GAAGTATCTG CATTCTGCTG GCATTCTGCA TCGAGACATT 360

AAACCAGGGA ACCTCCTTGT CAACAGTAAC TGTGTGCTCA AGATCTGCGA TTTTGGTTTA 420

GCCAGAGTAG AAGAGTTGGA TGAATCGCGC CACATGACTC AGGAAGTTGT CACTCAGTAT 480

TACAGAGCTC CAGAGATCTT GATGGGGAGT CGACACTACA CCAATGCCAT TGATATCTGG 540

TCTGTGGGTT GCATCTTTGC AGAACTGCTA GGGCGCAGAA TACTTTTTCA GGCACAAAGC 600

CCCATACAGC AGTTGGATTT AATCATAGAA CTACTAGGGA CACCATCACT AGAAGCAATG 660

AGGACTGCGT GTGAAGGTGC CAGGGCTCAC ATACTCAAGG GCACTCCTAA ACAGCTAATT 720

CTTAAAGAAA TATATACTTT AAATACAGAA AGCAAGCATG AAGCAGTTCA TTTGATTACT 780

CGTCAGTTGA GATTTGAGCC CTCAAAAAGG ATCTCTGCTA AGGATGCCTT AGCCCACCCC 840

TACCTAGATG AAGGCCGGCT CCGCTACCAC ACCTGCATGT GCAAATGTTG TTATACCACC 900

TCAACTGGAA GGGTTTATAC CAATGACTTT GAGCCCATCA CCAACCCTAA ATTTGATGAT 960

ACTTTTGAAA AGAACCTCAC TTCTGTTAGA CAGGTGAAAG AAATCATTCA TCAGTTCATA 1020

TTGGAACAGC AGAAAGGAAA CAGAGTACCA CTTTGCATCA ACCCTCAGTC TGCTGCTTTT 1080

AAGAGCTTTA TTAGTTCCAC TGTAGCTCAG CCATCCGAGA TGCCTCCATC TCCACTGGTC 1140

TGGGAGTAA 1149

Domain Profile

S: 12    ygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpee  71

         +g   s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++ ld+++p +

Q: 4     FGSFRSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH  63

         677788999**************************************************9

S: 72    eleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsanviHrDlKP  130

          ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+++HrD+KP

Q: 64    -IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKP  122

         .**********************99879********************************

S: 131   sNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeytkavDiWsv  190

         +Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++yt+a+DiWsv

Q: 123   GNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDIWSV  182

         *************************999********************************

S: 191   GCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslp.kkkkk  249

         GCI+aEll +++lf++++ i+ql++i+e+lgtps e +++ ++   ++++k +p +   k

Q: 183   GCIFAELLGRRILFQAQSPIQQLDLIIELLGTPSLEAMRTACEGARAHILKGTPkQLILK  242

         ******************************************986666666666334456

S: 250   dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ +l +++++ea++L+++ L ++p+kRis+++aL+hpYl

Q: 243   EIYTLNTESKHEAVHLITRQLRFEPSKRISAKDALAHPYL  282

         89999999*******************************7

Domain Sequence
(FASTA)

FGSFRSVTDP RDGKRVALKK MPNVFQNLVS CKRVFRELKM LCFFKHDNVL SALDILQPPH 60

IDYFEEIYVV TELMQSDLHK IIVSPQPLSS DHVKVFLYQI LRGLKYLHSA GILHRDIKPG 120

NLLVNSNCVL KICDFGLARV EELDESRHMT QEVVTQYYRA PEILMGSRHY TNAIDIWSVG 180

CIFAELLGRR ILFQAQSPIQ QLDLIIELLG TPSLEAMRTA CEGARAHILK GTPKQLILKE 240

IYTLNTESKH EAVHLITRQL RFEPSKRISA KDALAHPYL 279

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013