EKS-LAC-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	429.0	1.4E-128	187	483	297

Status

Unreviewed

Ensembl Protein

ENSLACP00000020797

UniProt Accession

H3BFX6;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000018269	ENSLACP00000020797	ENSLACT00000020937

Organism

Latimeria chalumnae

Functional Description

Protein Length

615

Protein Sequence
(FASTA)

SSHTDAYTRS HRLPENNCLA QNKPYQQKFN SNVGTLPHLE PPAKHMLVAN AKSHQHDGSL 60

PQIAMKIQKE TGANDDERHR APQYPPRFGS LESLPEGNSK IHSNKMEKEK ALEGHKLPMT 120

PTDVLKFYKS RLTEYEQEEV LNYAEVWFYG LDAKKINGVP GAQHNSGYDD EQGSYIKVLH 180

DHIAYRYEVQ EVIGKGSFGQ VVKCLDHKNN ELVAVKIIRN KKRFHHQALV ELKILDTLRK 240

KDKDNKHNVV HMKEYFYFRN HLCISFELLG INLYELIKKN NFQGLSLPLI RRFAYALLKC 300

LQMLYRDKII HCDLKPENIL LSSKGQGAIK VIDFGSSCYE HQKVYTYIQS RFYRSPEVIL 360

GHNYTLAIDM WSLGCILAEL YTGYPLFPGE NELEQMACIM EVLGLPPSDF LQTASRKKLF 420

FDSKGSPRNI TNSKGKKRHP SSKDLASVLK TNDSVFLDFL KGCLMWDPVQ RMTPDEAVQH 480

EWIQEVRVIK SNLKLRPARK VTDTTLSTEN NVDIVNKKTS KTKIVTRTYQ ESTDKAKKDS 540

REKGVKDSTS ERLKPIEAST EEAVEEENEK LKDNEELKEQ QEDKCMEIAI QSDQADISKE 600

NKSSGPSIVF ATSCV 615

Nucleotide Sequence
(FASTA)

TCATCCCACA CAGATGCATA TACACGATCA CATAGACTGC CAGAGAACAA TTGTCTGGCT 60

CAAAATAAGC CATACCAACA GAAATTCAAT TCCAATGTCG GAACTCTTCC CCATTTGGAG 120

CCCCCTGCCA AGCACATGCT TGTTGCAAAT GCCAAATCTC ATCAACATGA TGGTAGCCTT 180

CCTCAGATAG CCATGAAAAT ACAGAAAGAG ACAGGGGCCA ATGATGATGA AAGGCATCGA 240

GCTCCACAGT ACCCACCCCG ATTTGGCTCA CTGGAGAGTC TGCCAGAAGG AAACAGTAAA 300

ATCCACTCAA ACAAGATGGA AAAGGAGAAG GCACTTGAAG GTCACAAACT GCCAATGACA 360

CCTACAGATG TTCTAAAGTT TTATAAAAGC CGGCTAACAG AGTACGAACA AGAGGAAGTA 420

TTGAACTATG CAGAAGTTTG GTTTTATGGG CTGGATGCCA AAAAGATTAA TGGTGTCCCT 480

GGAGCACAAC ATAACAGTGG TTATGATGAT GAACAGGGCA GTTACATCAA AGTACTACAT 540

GACCATATTG CATATCGATA TGAAGTACAA GAAGTGATAG GCAAAGGATC ATTTGGACAA 600

GTAGTAAAAT GTTTGGATCA TAAAAATAAT GAACTTGTTG CTGTCAAAAT AATAAGGAAC 660

AAAAAAAGAT TTCATCATCA GGCCTTAGTA GAACTGAAAA TTTTAGATAC TCTTCGTAAA 720

AAGGACAAAG ACAACAAACA CAATGTTGTA CACATGAAGG AATATTTTTA CTTCCGCAAT 780

CACCTCTGCA TTTCCTTTGA GCTGTTAGGG ATAAATTTGT ATGAACTTAT CAAGAAGAAC 840

AACTTTCAAG GTCTTAGTTT ACCATTAATC CGCAGATTTG CTTATGCATT GCTGAAATGT 900

TTACAGATGC TATACCGAGA TAAAATTATC CATTGTGATC TTAAGCCTGA GAACATACTA 960

CTCTCCAGTA AAGGGCAAGG AGCAATTAAA GTTATTGATT TTGGATCAAG CTGCTATGAA 1020

CACCAAAAAG TGTACACTTA TATCCAGAGC AGGTTCTATC GCTCTCCTGA AGTGATTCTG 1080

GGCCATAACT ACACCCTGGC CATTGATATG TGGAGTCTGG GCTGTATCTT GGCTGAGCTT 1140

TACACTGGTT ACCCACTGTT TCCTGGGGAA AATGAGTTGG AACAAATGGC CTGCATCATG 1200

GAAGTGTTGG GGCTTCCTCC ATCAGACTTT CTTCAAACAG CATCCAGAAA AAAACTATTT 1260

TTTGACTCTA AAGGTTCTCC AAGAAATATA ACAAACAGTA AGGGGAAGAA AAGACACCCA 1320

AGCTCTAAGG ATCTTGCTAG TGTATTGAAA ACAAATGACT CTGTCTTCTT GGATTTTCTA 1380

AAAGGATGTC TGATGTGGGA TCCTGTCCAG CGCATGACCC CAGATGAAGC AGTACAGCAT 1440

GAATGGATTC AAGAAGTAAG GGTTATCAAA TCAAACCTAA AGTTACGACC AGCAAGGAAA 1500

GTGACAGACA CAACCCTCAG TACAGAAAAC AATGTAGATA TAGTAAACAA AAAGACATCA 1560

AAAACAAAAA TAGTTACCAG GACTTATCAG GAGAGCACTG ATAAAGCAAA GAAAGATTCC 1620

AGAGAGAAAG GTGTAAAGGA TAGTACATCT GAACGTCTAA AACCCATTGA AGCCTCAACA 1680

GAAGAAGCCG TGGAGGAGGA AAATGAGAAA CTCAAAGATA ATGAAGAACT TAAGGAACAA 1740

CAGGAAGACA AATGTATGGA AATTGCCATC CAGTCAGATC AGGCTGACAT TAGTAAAGAG 1800

AACAAGTCTT CAGGACCTTC CATAGTTTTT GCTACTAGTT GTGTA 1845

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yev+evigkGsfgqVvk+ld+k++e va+kii+nkkrf++qa  E++iL++l+kkdk++k

Q: 187   YEVQEVIGKGSFGQVVKCLDHKNNELVAVKIIRNKKRFHHQALVELKILDTLRKKDKDNK  246

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nvv+++e+f+frnhlc+ fell +nLyel+kkn+f+glsl l+r++a  +lk+L++L++

Q: 247   HNVVHMKEYFYFRNHLCISFELLGINLYELIKKNNFQGLSLPLIRRFAYALLKCLQMLYR  306

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

          kiiH+DlKPeNill +k++ ++kviDFGss++++qk +ytyiqsrfYr+PE+ilg++y

Q: 307   DKIIHCDLKPENILLSSKGQGAIKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHNYT  365

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

          aiDmWSlGc+laEl+tG+pLfpGene +q+a+i+evlglpp+ +l++a+++k ff++k+

Q: 366   LAIDMWSLGCILAELYTGYPLFPGENELEQMACIMEVLGLPPSDFLQTASRKKLFFDSKG  425

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+ i+++                + k++ p sk+l+++lk++++  f d+lk +l++dp

Q: 426   SPRNITNS----------------KGKKRHPSSKDLASVLKTNDSV-FLDFLKGCLMWDP  468

         **977743................3345668889999988876655.*************

S: 301   akRitpkealkhpfv  315

          +R+tp+ea++h+++

Q: 469   VQRMTPDEAVQHEWI  483

         **************7

Domain Sequence
(FASTA)

YEVQEVIGKG SFGQVVKCLD HKNNELVAVK IIRNKKRFHH QALVELKILD TLRKKDKDNK 60

HNVVHMKEYF YFRNHLCISF ELLGINLYEL IKKNNFQGLS LPLIRRFAYA LLKCLQMLYR 120

DKIIHCDLKP ENILLSSKGQ GAIKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHNYTL 180

AIDMWSLGCI LAELYTGYPL FPGENELEQM ACIMEVLGLP PSDFLQTASR KKLFFDSKGS 240

PRNITNSKGK KRHPSSKDLA SVLKTNDSVF LDFLKGCLMW DPVQRMTPDE AVQHEWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013