EKS-LAC-00185

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00185

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	414.8	1.7E-124	393	639	247

Status

Unreviewed

Ensembl Protein

ENSLACP00000020867

UniProt Accession

H3BG46;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCH

Gene Synonyms/Alias

PRKCH;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000018333	ENSLACP00000020867	ENSLACT00000021007

Organism

Latimeria chalumnae

Functional Description

Protein Length

708

Protein Sequence
(FASTA)

MALKFNGYLK VRIGEAVGLK PTSFSRRHSL FNKTTPPMDP YIAINVDECR IGRTRTKQKT 60

NSPTYNEEFC VNVSNGKRLE LAVFHDTSIG YDSFVANCCI RLEDLLRTPG SEEYFEGWMN 120

LEPEGKIYIV VTLTGSFTEG LPSENGKQFQ NFTRQRQRAM RRRIHQVNGH KFMATFLRQP 180

TYCSHCKDFI WGVFGKQGYQ CQVCTCVVHK RCHQLVVTVC PRIKSTATEK KAVSKKFSIN 240

LPHKFSVHNY KVPTFCEHCG SLLWGLMRQG LQCKLCKMNV HIRCEGNVAP NCGVKAVELA 300

KTLAEMGQHA GGFPSELELP LPFPTLSCEI ELEQSNLLAS LTSSRARMKA HNKGELAPPL 360

NAPTVPVDST SKCNKTTFNS IILPPPPKKK KLVMLAQLKD KSDMYAVKVL KKDVILQDDD 420

VECTMTEKRI LSMAGIHPFL TQLFCCFQTR SNLFFVMEFV NGGDLMFHIQ KSRKFDEPRA 480

QFYAAEITSA LMFLHEKGII YRDLKLDNVL LDYEGHCKLA DFGMCKEGIS KGRTTSTFCG 540

TPDYIAPEIL QEMQYGPSVD WWAFGVLLYE MLCGHAPFEA ENEDDLFEAI LKEEVTYPPC 600

LYSNATNFLK ALLMKNPEKR LGSMACYDGE QAILNHPFFK EIDWELLNKR QLEPPFKPRI 660

HSKEDISNFD PEFTKEEPRL TPIDPGLLPM IDQNEFRNFS YTAEALEF 708

Nucleotide Sequence
(FASTA)

ATGGCCCTGA AGTTTAATGG CTATTTAAAA GTAAGAATCG GGGAGGCGGT AGGGCTGAAA 60

CCTACCAGCT TCTCCCGGCG GCATTCTTTA TTCAACAAAA CGACTCCTCC GATGGATCCC 120

TACATCGCGA TCAACGTGGA TGAATGCCGA ATCGGCCGGA CCCGCACCAA GCAGAAAACC 180

AACAGTCCCA CCTACAACGA GGAGTTTTGT GTCAATGTCA GTAATGGCAA AAGGCTGGAG 240

CTGGCCGTTT TCCACGATAC CTCCATCGGA TATGATAGTT TTGTGGCCAA CTGCTGCATT 300

CGGCTTGAGG ATCTGCTGCG AACTCCTGGA TCAGAGGAAT ACTTTGAAGG CTGGATGAAT 360

TTGGAACCCG AAGGAAAAAT TTACATTGTG GTAACTCTGA CAGGAAGCTT TACTGAAGGA 420

TTACCCTCAG AAAATGGAAA GCAGTTTCAG AACTTTACTC GGCAACGGCA ACGTGCAATG 480

CGACGCCGAA TTCACCAGGT CAACGGCCAC AAGTTCATGG CCACGTTCCT ACGGCAGCCA 540

ACTTACTGCT CGCACTGCAA AGATTTCATA TGGGGGGTGT TTGGAAAACA GGGATACCAA 600

TGTCAAGTGT GTACCTGTGT TGTTCACAAG CGTTGTCATC AGCTGGTTGT CACAGTGTGC 660

CCTCGGATAA AAAGCACCGC CACTGAAAAG AAAGCAGTCT CTAAGAAATT TAGCATCAAC 720

CTTCCTCACA AATTCAGTGT TCATAACTAC AAGGTTCCGA CGTTCTGTGA ACACTGTGGC 780

TCTCTGCTGT GGGGACTGAT GAGACAAGGA CTACAATGTA AACTGTGCAA AATGAACGTT 840

CACATTCGAT GCGAAGGGAA CGTGGCACCA AACTGTGGGG TCAAAGCCGT GGAGTTGGCC 900

AAAACGCTGG CTGAGATGGG ACAGCACGCA GGAGGGTTCC CCTCGGAGTT GGAGCTGCCA 960

CTGCCTTTTC CAACTCTCTC CTGTGAGATT GAACTGGAGC AATCGAATTT ACTTGCCTCA 1020

CTCACTAGCA GCAGAGCAAG AATGAAAGCA CACAACAAAG GAGAGCTAGC ACCGCCCCTG 1080

AATGCTCCCA CCGTGCCAGT AGACAGTACT TCTAAATGCA ATAAAACCAC ATTTAACAGC 1140

ATCATCTTAC CCCCCCCCCC AAAAAAAAAA AAACTTGTGA TGCTTGCACA ACTCAAAGAT 1200

AAAAGTGATA TGTACGCAGT GAAAGTCTTG AAGAAGGATG TCATTCTCCA GGATGATGAT 1260

GTGGAATGCA CCATGACTGA AAAACGGATT CTATCAATGG CAGGAATACA TCCCTTCCTC 1320

ACCCAGCTCT TCTGCTGCTT TCAGACACGA AGTAATCTGT TTTTTGTGAT GGAATTTGTA 1380

AACGGTGGGG ATTTGATGTT CCACATTCAG AAATCAAGGA AATTCGATGA GCCTCGAGCC 1440

CAGTTCTATG CTGCGGAGAT TACCTCTGCT CTTATGTTTC TTCACGAGAA GGGAATCATT 1500

TACAGGGATC TGAAGCTAGA TAATGTATTA TTAGACTATG AGGGACATTG CAAATTGGCA 1560

GACTTTGGAA TGTGTAAAGA GGGGATCTCT AAAGGAAGAA CAACTTCAAC TTTTTGTGGT 1620

ACACCGGACT ACATCGCTCC AGAGATACTG CAAGAGATGC AGTATGGGCC TTCTGTAGAC 1680

TGGTGGGCCT TTGGGGTTTT ACTGTATGAA ATGCTCTGTG GTCACGCACC CTTTGAGGCA 1740

GAAAATGAAG ATGATCTGTT TGAAGCTATA TTAAAGGAAG AAGTCACCTA TCCACCTTGT 1800

CTGTACAGTA ATGCAACTAA TTTCCTGAAA GCTCTGTTGA TGAAAAATCC AGAGAAACGT 1860

TTGGGAAGCA TGGCGTGCTA TGATGGAGAA CAGGCCATTC TTAACCATCC ATTCTTTAAA 1920

GAAATTGACT GGGAGTTGCT TAATAAGAGA CAACTTGAGC CACCATTTAA ACCTAGAATC 1980

CACTCAAAAG AGGACATTAG TAATTTTGAC CCAGAGTTCA CAAAAGAAGA GCCGAGACTG 2040

ACGCCCATTG ACCCAGGACT GCTTCCTATG ATAGATCAGA ATGAATTCAG AAACTTTTCA 2100

TACACAGCAG AAGCACTGGA GTTCTAA 2127

Domain Profile

S: 15    vllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkpflvqlfscfqtedr  74

         v+la+lk+++++ya+kvlkkdv+lqdddve+t++ekr+l++a  +pfl+qlf+cfqt+++

Q: 393   VMLAQLKDKSDMYAVKVLKKDVILQDDDVECTMTEKRILSMAGIHPFLTQLFCCFQTRSN  452

         9***********************************************************

S: 75    lffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekgiiyrdlkldnvlld  134

         lffv+e+vnGGdlmfhiqk+rk++e+ra+fyaaei++al+flhekgiiyrdlkldnvlld

Q: 453   LFFVMEFVNGGDLMFHIQKSRKFDEPRAQFYAAEITSALMFLHEKGIIYRDLKLDNVLLD  512

         ************************************************************

S: 135   aeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygksvdwwalGvllyeml  194

          eGh+kladfG+cke+i +g+ttstfcGtPdyiaPeil+e++yg svdwwa+Gvllyeml

Q: 513   YEGHCKLADFGMCKEGISKGRTTSTFCGTPDYIAPEILQEMQYGPSVDWWAFGVLLYEML  572

         ************************************************************

S: 195   agqsPfegededelfesilekevlyPkslskeaveilkglltkdpekrlGvk..eegeed  252

         +g++Pfe+e+ed+lfe+il++ev+yP  l  +a++ lk+ll k+pekrlG+    +ge++

Q: 573   CGHAPFEAENEDDLFEAILKEEVTYPPCLYSNATNFLKALLMKNPEKRLGSMacYDGEQA  632

         **************************************************944599****

S: 253   ikehaff  259

         i +h+ff

Q: 633   ILNHPFF  639

         ******9

Domain Sequence
(FASTA)

VMLAQLKDKS DMYAVKVLKK DVILQDDDVE CTMTEKRILS MAGIHPFLTQ LFCCFQTRSN 60

LFFVMEFVNG GDLMFHIQKS RKFDEPRAQF YAAEITSALM FLHEKGIIYR DLKLDNVLLD 120

YEGHCKLADF GMCKEGISKG RTTSTFCGTP DYIAPEILQE MQYGPSVDWW AFGVLLYEML 180

CGHAPFEAEN EDDLFEAILK EEVTYPPCLY SNATNFLKAL LMKNPEKRLG SMACYDGEQA 240

ILNHPFF 247

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013