EKS-LAC-00333

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00333

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	315.8	2.5E-94	403	650	248

Status

Unreviewed

Ensembl Protein

ENSLACP00000022619

UniProt Accession

H3BGE6;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK4

Gene Synonyms/Alias

PAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000018422	ENSLACP00000020967	ENSLACT00000021107
ENSLACG00000018422	ENSLACP00000022619	ENSLACT00000025899

Organism

Latimeria chalumnae

Functional Description

Protein Length

669

Protein Sequence
(FASTA)

HRVHTGYDQQ EQKFTGLPRQ WQSLIEESAK RPKPLVDPSC ITTFQLAPRK TIVRGSKIGI 60

DGSLNWLLDE FENVSVTRSN SLRRESPPTQ PRRDLLYQEN GRNEVFPKAR GEGDRSREHR 120

DRSHQGPRDE WDYSRERVRA GDRDREDTRS RHQQQPRGQE PGRTERSNRP GHPSDRVPPP 180

DYPRHSDNRS RPQDRADGRR GGNTKDYSEP ADQVLRRERT ERNDGSDKRP KSTFTGDTSP 240

QSPRDKRPLS GPNIRTPNIP VSEGVVKTAQ QTGRPFNTYP RAETDPARGT SSQVEHRSSK 300

PHEAPHNGPV GGAKSNSSKN HHGQHRPGHP EALRPGLAPH GSDPHLTRPA QPPYPPQAQS 360

SQQQQQHRSP QHEPQRISHE QFRAALQMVV DPGDPRTYLD NFIKIGEGST GIVCISTIRS 420

TGKLVAVKKM DLRKQQRREL LFNEVVIMRD YHHDNVVEMY NSYLVGDELW VVMEFLEGGA 480

LTDIVTHTRM NEEQIATVCL SVLKALSVLH SQGVIHRDIK SDSILLTHDG RVKLSDFGFC 540

AQVSKEVPRR KSLVGTPYWM APELISRLPY GPEVDIWSLG VMVIEMVDGE PPYFNEPPLK 600

AMKMIRDNLP AKLKNIHKVS PLLKGFLDRM LVRDPSQRAT ADELLKHPFL TKTGPPSCIV 660

PLMRQNRMR 669

Nucleotide Sequence
(FASTA)

CACCGGGTCC ACACGGGCTA CGATCAACAG GAGCAGAAGT TCACGGGCCT CCCGCGCCAG 60

TGGCAAAGCC TCATTGAGGA GTCGGCGAAG CGTCCCAAAC CTCTCGTGGA TCCCTCCTGC 120

ATCACCACTT TCCAACTCGC ACCAAGAAAG ACAATCGTAA GAGGGAGTAA AATCGGGATT 180

GACGGTTCGC TGAACTGGCT TCTGGATGAG TTTGAAAATG TTTCTGTAAC TCGGTCCAAC 240

TCGCTACGAC GAGAAAGTCC CCCCACCCAG CCCAGGAGGG ACTTGCTGTA CCAGGAGAAT 300

GGGAGGAACG AGGTCTTCCC AAAAGCTAGA GGGGAAGGAG ACCGGAGCAG GGAGCACAGA 360

GACAGGAGCC ATCAGGGACC CAGGGATGAG TGGGACTACA GCAGGGAGCG AGTCCGAGCC 420

GGAGATCGAG ACAGGGAGGA TACCCGGAGC CGCCATCAGC AACAGCCGAG GGGACAGGAG 480

CCCGGCAGGA CGGAACGGAG TAACCGACCA GGCCATCCCA GCGACAGAGT GCCGCCTCCA 540

GATTACCCCA GACACTCGGA CAACAGATCC AGGCCCCAAG ACAGGGCGGA CGGCAGAAGG 600

GGCGGGAACA CGAAGGATTA CAGTGAGCCG GCTGACCAGG TGCTCCGAAG GGAAAGGACT 660

GAGAGGAATG ATGGCTCGGA CAAGAGGCCG AAGTCCACGT TTACAGGAGA CACTAGTCCC 720

CAGTCCCCCA GGGATAAACG CCCCTTATCA GGTCCCAATA TCCGAACACC AAATATTCCG 780

GTTTCCGAAG GGGTCGTAAA GACTGCACAG CAAACTGGAA GACCCTTTAA CACATACCCA 840

CGAGCTGAAA CGGACCCAGC CAGAGGCACA TCCAGTCAGG TTGAGCACCG TTCCAGCAAA 900

CCCCACGAGG CCCCGCACAA CGGTCCAGTG GGCGGGGCAA AGAGCAACTC CTCTAAAAAC 960

CATCATGGCC AGCACCGACC CGGCCACCCC GAAGCGTTGC GCCCAGGCCT GGCACCACAT 1020

GGCTCGGACC CTCATTTAAC ACGTCCAGCG CAGCCCCCTT ACCCGCCCCA GGCGCAGAGC 1080

TCGCAACAGC AGCAGCAGCA CCGGTCACCT CAACACGAGC CGCAGCGCAT CTCCCACGAA 1140

CAGTTCAGGG CCGCCCTGCA GATGGTGGTG GACCCTGGCG ACCCCAGGAC CTACCTGGAC 1200

AACTTTATAA AGATCGGCGA AGGCTCAACT GGCATCGTCT GCATCTCCAC CATCAGAAGC 1260

ACGGGCAAGC TGGTGGCCGT GAAGAAAATG GACCTCCGGA AACAGCAACG GCGAGAGCTG 1320

CTCTTCAACG AGGTGGTGAT AATGCGGGAT TACCACCACG ACAATGTGGT TGAGATGTAC 1380

AACAGTTACC TGGTGGGCGA TGAACTCTGG GTCGTCATGG AATTCCTTGA GGGTGGAGCC 1440

CTGACAGACA TAGTAACCCA CACAAGAATG AACGAGGAGC AGATCGCGAC CGTCTGCCTG 1500

TCGGTGTTGA AGGCGCTGAG CGTGCTCCAC TCACAGGGCG TCATTCACAG GGATATCAAG 1560

AGCGACTCCA TTCTTCTCAC TCACGACGGC CGGGTAAAGC TTTCCGACTT TGGATTTTGT 1620

GCTCAGGTCT CCAAAGAGGT GCCGAGGCGC AAGTCTCTGG TAGGAACCCC CTATTGGATG 1680

GCACCGGAGC TGATTTCGAG ATTACCGTAT GGACCGGAGG TGGATATCTG GTCACTGGGC 1740

GTGATGGTGA TCGAAATGGT TGACGGCGAG CCCCCTTATT TCAACGAACC GCCTCTGAAG 1800

GCTATGAAGA TGATTCGGGA CAATCTACCA GCCAAACTGA AAAACATTCA CAAGGTTTCT 1860

CCGTTACTGA AGGGCTTTCT GGACCGCATG TTGGTGAGGG ATCCCAGCCA AAGAGCCACC 1920

GCCGATGAAC TGTTAAAGCA CCCCTTCCTG ACTAAAACCG GGCCACCCTC CTGTATCGTC 1980

CCCCTCATGA GGCAGAACAG AATGAGATGA 2010

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++++ ++tg+lva+kk++l+kq++ e+l++e+ ++++++h n+ve+++s

Q: 403   IKIGEGSTGIVCISTIRSTGKLVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVEMYNS  462

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vlkaL+ lHs++viHrdi

Q: 463   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLKALSVLHSQGVIHRDI  519

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g+VkLsdfg++aq++k++ +rk++vgtpywmAPE+i+  +  Y  ++Diw

Q: 520   KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS--RLPYGPEVDIW  577

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slG+++ie+++gepP+++++plka+ +i +n p klk+ +k+s+ +k f++++l ++p++

Q: 578   SLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPAKLKNIHKVSPLLKGFLDRMLVRDPSQ  637

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ellkh+Fl

Q: 638   RATADELLKHPFL  650

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCISTIRSTG KLVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVEMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LKALSVLHSQ GVIHRDIKSD 120

SILLTHDGRV KLSDFGFCAQ VSKEVPRRKS LVGTPYWMAP ELISRLPYGP EVDIWSLGVM 180

VIEMVDGEPP YFNEPPLKAM KMIRDNLPAK LKNIHKVSPL LKGFLDRMLV RDPSQRATAD 240

ELLKHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013