EKS-LAC-00476

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00476

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	411.8	1.5E-123	36	331	296

Status

Unreviewed

Ensembl Protein

ENSLACP00000021152

UniProt Accession

H3BGY1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK8

Gene Synonyms/Alias

MAPK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000018583	ENSLACP00000021152	ENSLACT00000021292
ENSLACG00000018583	ENSLACP00000021153	ENSLACT00000021293

Organism

Latimeria chalumnae

Functional Description

Protein Length

437

Protein Sequence
(FASTA)

MKSTILQHIV MSRNKRDNHF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAMLDR 60

NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYLVMEL 120

MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF 180

GLARTAGTSF LMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIR GGVLFPGTDH 240

IDQWNKVIET LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDNLF PSESEHQKLK 300

ASQARDLLSK MLVVDATKRI SVDEALQHPY INVWYDPAEV EAPSPKIPDK QLDERDHTVE 360

EWKELIYKEV LEWEERTKNG VIRGQPAPLG AAVINNSQHP SSSSSVNDVS SMSTGPTLPS 420

DTDSSLETSA GPLGCCR 437

Nucleotide Sequence
(FASTA)

ATGAAAAGCA CCATCCTACA ACATATAGTG ATGAGCAGAA ATAAACGTGA CAACCACTTC 60

TACAGTGTGG AGGTTGGAGA CTCGACATTC ACAGTGCTAA AACGCTATCA GAATTTGAAA 120

CCTATAGGCT CGGGGGCTCA GGGAATTGTA TGTGCAGCCT ATGATGCTAT GCTTGACAGG 180

AATGTTGCAA TTAAGAAGCT CAGTCGTCCC TTTCAGAACC AGACCCATGC AAAAAGGGCT 240

TACCGGGAGC TGGTCTTAAT GAAATGTGTA AACCACAAAA ATATTATTGG CCTTCTAAAT 300

GTCTTCACCC CTCAGAAATC ACTGGAGGAA TTTCAGGACG TTTACTTGGT GATGGAGCTG 360

ATGGATGCCA ATCTGTGTCA GGTGATTCAG ATGGAGTTGG ACCATGAGCG CATGTCCTAC 420

TTGCTGTACC AGATGCTCTG TGGAATCAAA CACCTTCACT CGGCTGGGAT CATACACAGG 480

GACTTAAAGC CCAGTAATAT TGTGGTCAAA TCTGATTGCA CGCTGAAAAT CCTTGACTTT 540

GGATTGGCTA GGACAGCAGG AACAAGTTTT TTGATGACCC CTTACGTAGT GACACGGTAC 600

TACAGAGCAC CTGAGGTCAT CCTGGGGATG GGATACAAAG AAAACGTTGA TATCTGGTCA 660

GTTGGGTGTA TCATGGGAGA AATGATCAGA GGTGGTGTTT TGTTTCCTGG TACAGATCAT 720

ATTGATCAGT GGAACAAAGT TATTGAAACG TTAGGGACAC CATGTCCTGA ATTCATGAAG 780

AAGTTACAAC CTACAGTCAG GACCTATGTG GAGAACAGAC CCAAGTATGC AGGCTACAGT 840

TTCGAGAAGC TTTTCCCCGA TAATCTTTTT CCATCAGAGT CTGAACACCA GAAGTTGAAA 900

GCAAGCCAAG CAAGAGATTT GCTGTCCAAA ATGCTGGTTG TAGACGCCAC TAAGCGGATC 960

TCAGTGGATG AAGCTCTCCA ACATCCATAC ATAAATGTCT GGTATGATCC AGCTGAAGTA 1020

GAGGCACCTT CCCCGAAGAT TCCAGACAAG CAGCTTGATG AAAGAGATCA CACCGTGGAG 1080

GAATGGAAAG AATTGATATA TAAGGAAGTC CTTGAATGGG AAGAGAGAAC GAAGAATGGA 1140

GTTATACGAG GGCAGCCAGC TCCTTTAGGT GCAGCAGTGA TCAACAACTC TCAGCACCCA 1200

TCCTCATCCT CATCTGTCAA CGATGTGTCC TCCATGTCAA CAGGCCCAAC ATTGCCCTCC 1260

GACACAGACA GCAGTTTGGA GACGTCAGCA GGACCCCTGG GCTGTTGTAG ATGA 1314

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 36    YQNLKPIGSGAQGIVCAAYDAMLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  95

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 96    IGLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  154

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++    +t+yv+tr+YraPe++l  +

Q: 155   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFL--MTPYVVTRYYRAPEVILG-MG  211

         *********************************9965..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+

Q: 212   YKENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKVIETLGTPCPEFMKKLQP-TVRTYV  270

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY

Q: 271   ENRPKYAGYSFEKLFPDnlfpsesehqklKASQARDLLSKMLVVDATKRISVDEALQHPY  330

         *****************************99*****************************

S: 289   l  289

Q: 331   I  331

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AMLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

IGLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFLMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMIRGGVLF PGTDHIDQWN KVIETLGTPC PEFMKKLQPT VRTYVENRPK 240

YAGYSFEKLF PDNLFPSESE HQKLKASQAR DLLSKMLVVD ATKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013