EPS-LAC-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LAC-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	287.6	1.3E-85	24	289	266

Status

Unreviewed

Ensembl Protein

ENSLACP00000021185

UniProt Accession

H3BH13;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000018611	ENSLACP00000021185	ENSLACT00000021325
ENSLACG00000018611	ENSLACP00000021184	ENSLACT00000021324

Organism

Latimeria chalumnae

Functional Description

Protein Length

380

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAHGDGN DLHYGLSSMQ GWRVEMEDAH TAVIGLPNGL DLWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT SNSDFNGSDG QPTVESVKNG IRTGFLQIDE HMRVISEKKH 120

GADRSGSTAV GVMISPQHIY FINCGDSRGL LCRNKKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VYEIERSEDE DQFIILACDG 240

IWDVMGNEEL CDFVKSRLEV TDDLEKVCNE IVDTCLYKGS RDNMSVILIC FPSAPKVSPE 300

AVKRETELDK YLENRVEEII KKQGEEGVPD LVQVMRTLAT ESIPNLPPGG ELASKRSVIE 360

AVYNKLNPYR SDDTVLLPSD 380

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA ACCAAAGATG GAAAAACATA ATGCTCATGG AGATGGTAAT 60

GACCTGCACT ATGGTTTAAG CAGCATGCAA GGCTGGCGAG TTGAAATGGA AGATGCACAT 120

ACGGCTGTGA TTGGTCTACC AAATGGACTT GACCTGTGGT CTTTCTTTGC AGTGTATGAT 180

GGGCATGCTG GATCCCAGGT TGCAAAGTAC TGCTGTGAGC ACTTGCTGGA TCACATCACA 240

AGCAATTCAG ATTTTAATGG CTCAGATGGA CAACCTACTG TTGAAAGTGT AAAGAACGGA 300

ATTAGAACAG GCTTTTTACA GATTGATGAA CACATGAGAG TAATTTCTGA GAAGAAACAT 360

GGGGCAGACA GAAGTGGGTC AACAGCTGTG GGTGTCATGA TTTCCCCCCA GCATATTTAC 420

TTCATCAACT GTGGAGACTC AAGAGGTTTG CTTTGTAGGA ACAAGAAAGT CCATTTTTTT 480

ACCCAAGATC ACAAACCAAG CAATCCTTTG GAGAAAGAAC GCATTCAGAA TGCAGGTGGC 540

TCTGTAATGA TTCAACGTGT CAACGGTTCT CTTGCAGTGT CCAGAGCCCT TGGAGACTTT 600

GATTATAAGT GTGTACATGG TAAGGGTCCT ACAGAGCAGC TAGTTTCCCC AGAACCTGAA 660

GTTTATGAAA TTGAGAGGTC TGAAGATGAA GATCAGTTTA TTATCCTTGC ATGTGATGGC 720

ATATGGGATG TCATGGGCAA CGAGGAGCTT TGTGACTTTG TCAAGTCAAG GCTGGAAGTC 780

ACAGATGACC TTGAAAAAGT TTGCAATGAG ATTGTTGACA CTTGTCTATA CAAGGGTAGT 840

CGAGATAACA TGAGTGTGAT ACTCATTTGT TTTCCAAGTG CACCAAAAGT GTCCCCAGAA 900

GCAGTGAAGA GAGAGACAGA GCTGGACAAG TATTTGGAAA ACAGAGTAGA AGAGATCATT 960

AAGAAGCAGG GCGAAGAAGG AGTGCCAGAC TTAGTCCAAG TGATGCGCAC ATTAGCGACG 1020

GAGAGCATCC CAAACCTCCC ACCAGGGGGT GAACTGGCCA GCAAACGGAG TGTGATTGAA 1080

GCAGTTTACA ACAAGCTGAA TCCCTATAGG AGTGATGATA CTGTCCTGCT GCCTAGTGAC 1140

TGA 1143

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         +g++s++g+r emeda+t+   ++  p+  d ++ff+vyDGh+gs+vak+c e+l ++++

Q: 24    YGLSSMQGWRVEMEDAHTA---VIGLPNGLDLWSFFAVYDGHAGSQVAKYCCEHLLDHIT  80

         89***************97...6666777778****************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

          + +    +++++ + vk+ ++++Fl++de+++v++ek++  d+sGstav ++i+++++y

Q: 81    SNSDfngsDGQPTVESVKNGIRTGFLQIDEHMRVISEKKHGADRSGSTAVGVMISPQHIY  140

         **999999999999**********************************************

S: 119   vanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRal  178

         ++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRal

Q: 141   FINCGDSRGLLCRNKKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRAL  197

         *********************************************...************

S: 179   Gdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdv  228

         Gd+++k         ++v+pePev++++++++++ f+iLa+DG+wdv+ nee++++v+++

Q: 198   GDFDYKcvhgkgpteQLVSPEPEVYEIERSEDEDqFIILACDGIWDVMGNEELCDFVKSR  257

         *****************************877777*************************

S: 229   lekkeaeqeaakkLvklalargskdnvsaivv  260

         le +++++++++++v+++l +gs+dn+s+i++

Q: 258   LEVTDDLEKVCNEIVDTCLYKGSRDNMSVILI  289

         ***************************99976

Domain Sequence
(FASTA)

YGLSSMQGWR VEMEDAHTAV IGLPNGLDLW SFFAVYDGHA GSQVAKYCCE HLLDHITSNS 60

DFNGSDGQPT VESVKNGIRT GFLQIDEHMR VISEKKHGAD RSGSTAVGVM ISPQHIYFIN 120

CGDSRGLLCR NKKVHFFTQD HKPSNPLEKE RIQNAGGSVM IQRVNGSLAV SRALGDFDYK 180

CVHGKGPTEQ LVSPEPEVYE IERSEDEDQF IILACDGIWD VMGNEELCDF VKSRLEVTDD 240

LEKVCNEIVD TCLYKGSRDN MSVILI 266

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013