EKS-LAC-00393

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00393

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	347.5	5.4E-104	95	352	258

Status

Unreviewed

Ensembl Protein

ENSLACP00000021427

UniProt Accession

H3BHQ6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K10

Gene Synonyms/Alias

MAP3K10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000018827	ENSLACP00000021427	ENSLACT00000021568

Organism

Latimeria chalumnae

Functional Description

Protein Length

998

Protein Sequence
(FASTA)

NHHGQVNTNP FWTAVFDYEA TADEELTLRR GDLVEVLSTD SKVSGDEGWW TGKMKDKVGI 60

FPSNYVTSHP KYTKLQGNVK EYPLPLEISF RELHLEEIIG VGGFGKVYKG VWREQEVAVK 120

AARQDPDEDI SVTTENVRQE AKLFCMLHHP NIIALKGVCL KAPNLCLVME YARGGALNRA 180

LSGKKVPPHV LVNWAVQVAR GMNYLHNETI IPVIHRDLKS SNILILERTE TEDLGDRTLK 240

ITDFGLAREW HKTTKMSAAG TYAWMAPEVI KLSLFSKSSD VWSFGVLLWE LLTGEVPYRE 300

IDALAVAYGV AMNKLTLPIP STCPEPFVRL LEECWNPEPH SRPSFSTILE QLVYIEQSAM 360

FHMPLESFHS LQEDWKLEIQ QMFDDLRTKE KELRSREEEL IRAAQEQKNQ EEMLRRREQE 420

LAEREIDIVE RELNIIMYQM YQEKPKVKKR KGNFKNSRLK LKDGNKISLP SDFQHKITVQ 480

ASPTVDKRKG QGADGTSPPG SPIIIPRLRA IRLTPGDGSK TWGRSAVCKK EEMVGNKKKG 540

RTWGPSSTQQ KERIGGEERL KSLGEGSKQW SSSAPNLGKS PKHVPITVGF ASLTEMEEQG 600

DLDGDSAQSP YLNQSYLSLP THSETESNGT SEDTIQVVSA SSTPTDGLKR SSQRRKSDLA 660

LLGCTAILAS VALGNDLLEL GRQQVLQNEA EGKEEKKRKE GLFQRTGRFR RSTSPPSRSI 720

CRKEDSVLPS TEPSSSVTLL SLSSISDCNS TKSLIQSDSD EANTYEMPCL AESESEAEAP 780

KWASANPLVD LKAESFKKDP KQSLTPTHIT AAMAVSRGHR RIPSDGAIRQ KIQAHQRSPS 840

DGSTQTLTDT GHLKTRSCSK ETTEFPRLPD PASLFPPVLR RKTLDKDSTP ERPKTLEFAP 900

RPRPSGSRPR IDPWKFVSFS RAHSSSPTSS CGAETPSAID SLSSTTEERT GGIYLPTASQ 960

RSRQTLLDMD MEGQSQDGTL PLCSSQRTSV CNTGQEFS 998

Nucleotide Sequence
(FASTA)

AACCACCATG GTCAAGTTAA CACCAATCCT TTTTGGACTG CTGTCTTTGA CTATGAGGCC 60

ACGGCTGATG AGGAACTGAC TTTGAGAAGA GGGGACCTGG TGGAGGTCTT GTCAACAGAT 120

TCCAAGGTTT CTGGGGATGA AGGCTGGTGG ACGGGAAAAA TGAAGGATAA AGTTGGGATC 180

TTTCCCAGCA ACTATGTCAC CAGTCACCCC AAATACACCA AGCTGCAAGG AAATGTGAAG 240

GAATACCCTC TGCCTCTGGA GATAAGTTTC AGGGAACTCC ATCTGGAAGA GATCATAGGG 300

GTTGGTGGGT TTGGGAAGGT CTACAAGGGC GTCTGGAGAG AACAGGAAGT GGCAGTCAAA 360

GCGGCAAGAC AAGACCCTGA TGAAGACATC AGCGTCACCA CAGAGAACGT GAGACAAGAA 420

GCCAAACTCT TCTGTATGCT CCACCATCCC AATATTATTG CCCTCAAGGG AGTTTGTCTT 480

AAAGCGCCGA ACCTGTGTTT GGTGATGGAG TATGCTCGTG GCGGTGCTTT GAACAGAGCC 540

CTGTCAGGGA AGAAAGTGCC GCCTCATGTC CTGGTCAACT GGGCAGTGCA GGTAGCTAGA 600

GGGATGAACT ATCTTCACAA TGAGACCATC ATCCCCGTCA TTCACAGAGA CCTGAAATCC 660

AGCAACATTT TGATTCTGGA GAGAACAGAG ACCGAGGACC TGGGTGATAG GACACTAAAG 720

ATTACCGATT TCGGGCTGGC GAGAGAGTGG CATAAGACGA CGAAAATGAG TGCAGCCGGC 780

ACGTACGCTT GGATGGCGCC CGAAGTGATC AAGCTGTCCC TTTTCTCTAA AAGCAGTGAC 840

GTCTGGAGCT TTGGGGTACT CTTGTGGGAG CTGCTGACGG GGGAGGTGCC GTACCGGGAG 900

ATCGACGCCC TCGCGGTGGC CTACGGCGTC GCAATGAATA AGCTGACGCT GCCAATTCCA 960

TCCACCTGTC CTGAGCCCTT TGTAAGACTT CTAGAAGAAT GCTGGAACCC GGAGCCCCAC 1020

AGCAGGCCTT CCTTCTCAAC TATCCTGGAG CAGTTGGTCT ACATTGAACA GTCCGCCATG 1080

TTCCACATGC CTCTGGAGTC TTTCCATTCT CTGCAGGAGG ACTGGAAACT CGAGATACAG 1140

CAAATGTTCG ATGACCTTAG GACCAAAGAG AAGGAGCTGA GGAGCAGGGA GGAGGAGCTG 1200

ATCCGGGCCG CCCAGGAACA AAAGAACCAG GAAGAGATGC TGAGGCGACG GGAACAGGAG 1260

CTGGCCGAGC GGGAGATCGA CATTGTGGAG AGGGAGCTCA ACATCATCAT GTATCAAATG 1320

TACCAGGAGA AACCAAAGGT CAAGAAACGC AAAGGCAACT TCAAGAACAG CCGGCTTAAG 1380

CTCAAGGATG GGAACAAGAT CAGCCTGCCC TCAGATTTTC AACACAAGAT CACGGTCCAA 1440

GCGTCTCCCA CAGTGGACAA GAGGAAAGGA CAAGGAGCGG ATGGAACCAG CCCTCCAGGG 1500

AGTCCCATCA TCATTCCGAG GCTTAGGGCC ATTCGATTGA CCCCAGGGGA CGGCAGCAAA 1560

ACGTGGGGCC GCAGTGCCGT GTGTAAGAAG GAGGAGATGG TGGGAAACAA GAAAAAAGGA 1620

CGGACCTGGG GACCCAGCTC GACGCAGCAG AAGGAAAGGA TCGGTGGAGA GGAAAGGTTA 1680

AAATCTTTGG GTGAAGGAAG CAAGCAGTGG TCATCCAGTG CTCCAAACCT GGGCAAATCT 1740

CCCAAACACG TGCCGATTAC CGTAGGATTC GCAAGTCTAA CCGAGATGGA AGAACAAGGG 1800

GATCTCGATG GAGACAGTGC ACAATCTCCA TACCTGAATC AGTCCTACCT CAGTCTTCCC 1860

ACGCACAGCG AAACAGAAAG CAACGGGACA TCAGAAGACA CCATCCAGGT GGTCTCGGCC 1920

AGCAGCACTC CCACCGACGG CCTCAAGCGC AGCTCCCAGC GCAGGAAGAG TGACTTGGCG 1980

CTTCTAGGCT GCACGGCCAT CCTGGCCTCG GTCGCCCTGG GAAATGACCT TTTGGAGCTG 2040

GGCCGGCAGC AAGTGCTGCA GAACGAGGCA GAGGGGAAAG AGGAGAAGAA GAGGAAAGAA 2100

GGGCTCTTCC AGCGCACCGG CCGCTTCCGC AGGAGCACCA GCCCTCCGAG CAGAAGCATC 2160

TGCAGGAAAG AAGACTCGGT CCTTCCGTCG ACGGAACCTT CCAGCTCTGT GACGCTGCTC 2220

TCCCTCTCCT CCATCTCGGA CTGCAACTCC ACCAAATCGC TGATCCAGTC AGACAGCGAC 2280

GAGGCCAACA CTTACGAGAT GCCGTGCCTC GCCGAGTCCG AGTCCGAAGC GGAGGCGCCC 2340

AAGTGGGCCA GCGCAAATCC GCTGGTGGAC CTCAAGGCGG AGAGCTTCAA AAAGGACCCT 2400

AAGCAGTCGC TCACGCCCAC CCACATCACC GCGGCCATGG CTGTTTCGCG AGGTCACAGG 2460

CGGATCCCCT CGGATGGGGC AATCAGGCAG AAAATCCAGG CACACCAGAG GTCACCATCA 2520

GATGGCAGCA CCCAGACCCT AACAGACACA GGCCACCTGA AAACGAGGTC ATGCTCCAAG 2580

GAGACGACAG AATTCCCTCG TTTACCAGAC CCTGCATCTC TCTTTCCTCC CGTTTTACGC 2640

CGGAAAACGT TGGACAAAGA TTCTACGCCG GAGCGACCAA AGACATTGGA GTTTGCTCCG 2700

AGGCCACGGC CGTCCGGAAG CCGCCCCAGG ATAGACCCGT GGAAGTTTGT CTCTTTCTCA 2760

CGGGCTCACA GTTCCTCTCC GACAAGCAGC TGTGGAGCGG AGACCCCCAG TGCTATAGAC 2820

TCGTTGAGTA GCACCACGGA AGAGAGGACA GGGGGCATCT ATCTTCCCAC AGCGAGCCAA 2880

CGGAGCAGGC AGACTTTGCT GGACATGGAT ATGGAAGGGC AGAGTCAGGA CGGTACCCTT 2940

CCGTTGTGCA GCTCACAAAG AACTTCAGTT TGCAATACAG GGCAAGAATT TTCATAG 2997

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvyk+ wr++evavK++r++  e  + ++e++++eakl+++l+hpnii+

Q: 95    LEEIIGVGGFGKVYKGVWREQEVAVKAARQDPDEdiSVTTENVRQEAKLFCMLHHPNIIA  154

         789****************************99988999*********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l+Gvcl+ pnl+lvmey++gg+L+++l++   ++++++vlv+wa+q+ArGm+YLh+e+ +

Q: 155   LKGVCLKAPNLCLVMEYARGGALNRALSG---KKVPPHVLVNWAVQVARGMNYLHNETII  211

         *****************************...99**************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         ++ihrdLks+n+L+       +  ++tlki+dFG are++k+tkmsaagt+awmaPEv+k

Q: 212   PVIHRDLKSSNILIlerteteDLGDRTLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIK  271

         ******************9988999***********************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

          + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++ +L+

Q: 272   LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFVRLL  331

         ************************************************************

S: 234   kecwnedpekRpsfseivksl  254

         +ecwn +p++Rpsfs+i+++l

Q: 332   EECWNPEPHSRPSFSTILEQL  352

         *****************9986

Domain Sequence
(FASTA)

LEEIIGVGGF GKVYKGVWRE QEVAVKAARQ DPDEDISVTT ENVRQEAKLF CMLHHPNIIA 60

LKGVCLKAPN LCLVMEYARG GALNRALSGK KVPPHVLVNW AVQVARGMNY LHNETIIPVI 120

HRDLKSSNIL ILERTETEDL GDRTLKITDF GLAREWHKTT KMSAAGTYAW MAPEVIKLSL 180

FSKSSDVWSF GVLLWELLTG EVPYREIDAL AVAYGVAMNK LTLPIPSTCP EPFVRLLEEC 240

WNPEPHSRPS FSTILEQL 258

Keyword

Complete proteome; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR016231	; MAPKKK9/10/11.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001452	; SH3_domain.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00326	; SH3; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013