EKS-LAC-00298

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00298

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	344.9	3.9E-103	198	478	281

Status

Unreviewed

Ensembl Protein

ENSLACP00000021755

UniProt Accession

H3BIN4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000019118	ENSLACP00000021755	ENSLACT00000021896

Organism

Latimeria chalumnae

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

NLSGFCFIEL FGLMFVCVCV CVSPALKCVC SSCTLSNFTC ETNGACLVSI SIVDGMHEVQ 60

TCIPAEKLVP AGKPFYCLSS EDLQNTHCCS DEDFCNQMEK VKPTGDVSPS SGLTPVELAA 120

VIAGPAFLIC VILIVGVFLF QHHQRVYHNR QRLDMEDPSC DLYLSKDKTL QDLIFDLSTS 180

GSGSGLPLFV QRTVARTIVL QEVIGKGRFG EVWRGKWRGG DVAVKIFSSR EERSWFREAE 240

IYQTVMLRHE NILGFIAADN KDNGTWTQLW LVSDYHEYGS LFDYLNRYIV TIEGMIKLAL 300

SAASGLAHLH MEILGTQGKK WGCSEMEMQC FKKNIQDPGT PDQHIRNQQL CDRFPYHCNA 360

VSRYMAPEVL DETLNMKHFD SFKCADIYAL GLVYWEIARR CNAGGVHEEY QLPYYDQVPS 420

DPSIEEMRKV VCDQKLRPNI PNWWQTYEAL RVMGKIMREC WYSNGAARLT ALRIKKTLSQ 480

LGIQEDVKI 489

Nucleotide Sequence
(FASTA)

AATTTGAGTG GTTTTTGTTT CATAGAGTTA TTTGGCTTGA TGTTTGTGTG TGTTTGTGTT 60

TGTGTTTCCC CAGCACTGAA ATGTGTGTGT TCTAGTTGCA CCCTGTCAAA CTTCACATGT 120

GAGACCAATG GAGCCTGTCT GGTATCCATC TCCATTGTAG ATGGGATGCA TGAGGTGCAG 180

ACATGTATTC CTGCTGAGAA ACTGGTCCCA GCTGGAAAGC CTTTCTACTG CCTGAGCTCG 240

GAGGACTTGC AAAATACTCA CTGCTGCTCT GATGAGGACT TCTGTAACCA AATGGAGAAA 300

GTGAAACCTA CGGGAGATGT GTCTCCATCT TCTGGCTTGA CTCCAGTTGA GCTTGCTGCA 360

GTCATTGCTG GTCCCGCCTT CCTCATTTGT GTTATTTTGA TTGTTGGAGT TTTCCTGTTC 420

CAACATCACC AGCGGGTTTA TCATAATCGC CAGCGGCTGG ATATGGAGGA TCCCTCCTGT 480

GACCTCTACC TCTCCAAAGA CAAGACCCTG CAGGACCTCA TATTTGACCT CTCAACCTCG 540

GGGTCTGGCT CAGGTTTACC TCTCTTTGTT CAGCGGACTG TAGCAAGGAC CATTGTTCTG 600

CAGGAAGTGA TCGGAAAGGG TCGCTTTGGA GAGGTTTGGC GTGGCAAGTG GCGAGGGGGT 660

GATGTGGCAG TGAAGATCTT CTCTTCACGG GAAGAACGCT CCTGGTTCAG GGAGGCTGAG 720

ATTTACCAGA CGGTGATGTT ACGACATGAA AATATCCTTG GATTCATAGC AGCTGATAAC 780

AAAGATAATG GTACCTGGAC GCAGCTGTGG CTCGTGTCGG ACTACCATGA ATATGGCTCG 840

CTGTTTGATT ATTTAAACCG CTACATTGTG ACTATTGAGG GGATGATCAA ACTGGCGCTG 900

TCTGCGGCTA GTGGCCTGGC ACATCTTCAT ATGGAGATTC TTGGCACGCA GGGTAAAAAA 960

TGGGGGTGCA GTGAGATGGA GATGCAATGT TTCAAGAAGA ACATCCAGGA CCCCGGGACA 1020

CCTGACCAAC ACATCAGAAA TCAGCAACTG TGTGATAGAT TTCCTTATCA CTGCAATGCA 1080

GTGTCCAGAT ATATGGCACC TGAAGTCTTG GATGAGACGC TAAATATGAA ACACTTTGAT 1140

TCATTCAAGT GCGCTGATAT CTATGCTCTG GGGTTGGTGT ACTGGGAGAT TGCCCGCCGC 1200

TGCAATGCAG GAGGGGTGCA TGAAGAATAC CAGCTTCCAT ACTACGACCA GGTGCCCTCG 1260

GACCCCTCAA TAGAGGAAAT GCGCAAGGTA GTGTGTGACC AGAAGTTGCG TCCAAACATC 1320

CCCAACTGGT GGCAGACCTA CGAGGCTCTG AGAGTGATGG GAAAGATCAT GCGAGAGTGC 1380

TGGTATTCTA ATGGAGCAGC ACGACTTACA GCTCTCCGCA TAAAGAAAAC TCTTTCGCAG 1440

CTTGGCATAC AGGAAGATGT CAAGATTTAA 1470

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++k+rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 198   IVLQEVIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  257

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe gsL+dyL+r+++++e +++lals+asGlahLH+ei gt+

Q: 258   ADNKDNGTWTQLWLVSDYHEYGSLFDYLNRYIVTIEGMIKLALSAASGLAHLHMEILGTQ  317

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g kK   +  +++      kk     i D G   ++ ++++  d    +     RYmaPE

Q: 318   G-KKWGCSEMEMQC----FKK----NIQDPGTPDQHIRNQQLCDRFPYHCNAVSRYMAPE  368

         9.888888877764....344....4889999999999999999888888899*******

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp++++v+sdPs+eem

Q: 369   VLDETLNMKHFDSFKCADIYALGLVYWEIARRCNA-GGVHEEYQLPYYDQVPSDPSIEEM  427

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+++++aRltalr+kk+l

Q: 428   RKVVCDQKLRPNIPNWWQTYEALRVMGKIMRECWYSNGAARLTALRIKKTL  478

         *************************************************97

Domain Sequence
(FASTA)

IVLQEVIGKG RFGEVWRGKW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE YGSLFDYLNR YIVTIEGMIK LALSAASGLA HLHMEILGTQ 120

GKKWGCSEME MQCFKKNIQD PGTPDQHIRN QQLCDRFPYH CNAVSRYMAP EVLDETLNMK 180

HFDSFKCADI YALGLVYWEI ARRCNAGGVH EEYQLPYYDQ VPSDPSIEEM RKVVCDQKLR 240

PNIPNWWQTY EALRVMGKIM RECWYSNGAA RLTALRIKKT L 281

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 2.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013