EKS-LOA-00162
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00162
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb445.76.0E-134330590261
StatusUnreviewed
Ensembl ProteinENSLAFP00000000100
UniProt AccessionG3UN48;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000000120ENSLAFP00000029257ENSLAFT00000025649
ENSLAFG00000000120ENSLAFP00000000100ENSLAFT00000000121
OrganismLoxodonta africana
Functional Description
Protein Length689
Protein Sequence
(FASTA)
SRTESGLLDV VLVCLFLVGV YFCILTDCAC HLFLDYINGG ELFTHLSQRE RFTEHEVQTY 60
VGEIVLALEH LHKLGIIYRD IKLENILLDS NGHVVLTDFG LSKEFVADEA ERAYSFCGTI 120
EYMAPDIVKG GDSGHDKAVD WWSLGVLMYE LLTGASPFTV DGEKNSQAEI SRRILKSEPP 180
YPQDMSAVAK DLIKRLLMKD PKKRLGCGPR DADEIKEHLF FQKINWDDLA AKKVPAPFKP 240
VIRDELDVSN FAEEFTEMDP TYSPAALPQS SERLFQGYSF VAPSILFKRN AAVIDPLQFH 300
MGVERPGVTN VARSAMMKDS PFYQHYDLDL KDKPLGEGSF SICRKCIHKK SNQAFAVKII 360
SKRMEANTQK EITALKLCEG HPNIVKLHEV FHDQLHTFLV MELLNGGELF ERIKKKKHFS 420
ETEASYIMRK LVSAVSHMHD VGVVHRDLKP ENLLFTDEND NLEIKVIDFG FARLKPPDNQ 480
PLKTPCFTLH YAAPELLNHN GYDESCDLWS LGVILYTMLS GQVPFQSHDK SVTCTSAVEI 540
MKKIKKGDFS FEGEAWKNVS QEAKDLIQGL LTVDPNKRLK MSGLRYNEWL QDGSQLSSNP 600
LMTPDILGSS GAAVHTCVKA TFHAFNKYKR EGFCLQNVDK APLAKRRKMK KTSTSTETRS 660
SSSESSHSSS SHSHGKTTPT KTLQPSNPA 689
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++c+hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 330   LKDKPLGEGSFSICRKCIHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  389
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 390   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  449
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 450   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  508
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    ++ ++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 509   WSLGVILYTMLSGQVPFqshdKSVTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  568
         *****************88888899***********************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 569   GLLTVDPNKRLKMSGLRYNEWL  590
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCIHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD KSVTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00163
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-DAR-00452
EKS-DIO-00087
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-SUS-00143
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 3.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013