EPS-LOA-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	58.6	1.0E-15	56	300	245

Status

Unreviewed

Ensembl Protein

ENSLAFP00000024490

UniProt Accession

G3U9I2;

Protein Name

Protein Synonyms/Alias

Gene Name

TAB1

Gene Synonyms/Alias

TAB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000000210	ENSLAFP00000000170	ENSLAFT00000000210
ENSLAFG00000000210	ENSLAFP00000024490	ENSLAFT00000037538

Organism

Loxodonta africana

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

PSWCPAVLPQ EQQPSWTDDL PLCHLSGVGS ASNRSYSADG KGTESHPPED SWLKFRSENN 60

CFLYGVFNGY DGNRVTNFVA QRLSAELLLG QLSAEHTEAD VRRVLLQAFD VVERSFLESI 120

DDALAEKASL QSQLPEGVPQ HQLPPQYQKI LERLRTLEKE NISTLSMCPV SPYTRSLLSC 180

SNSATGTNRA LLCKSTADGL QVTQLNVAHT TENEDELFRL SQLGLDAGKI KQAGIICGQE 240

STRRIGDYKV KYGYTDIELL SAAKSKPIIA EPEVHGGQPL DGVTGFLVLM SEGLYKALEA 300

AHGPGQPTRE IAAMIDTEFA KQTSLDAVAQ AVVDRVRRIH SDTFASGGER AKFCPRHEDM 360

TLLVRNFGYP LGEMSQSTPT PSPAAGGRVY PVSVPYSSAQ STSKTSVTLS LVMPSQGQMV 420

NGAHSSSTLD EATPTLTNQS PTLTLQSTNT HTQSSSSSSD GGLFRSRPAH SLPPGEDGRV 480

EPYVDFAEFY RLWSVDHGEQ SVMTGP 506

Nucleotide Sequence
(FASTA)

CCCTCATGGT GTCCTGCTGT CCTTCCCCAG GAGCAGCAGC CGAGCTGGAC GGACGACCTG 60

CCGCTCTGCC ACCTCTCTGG GGTTGGCTCA GCCTCCAACC GCAGCTACTC TGCAGATGGC 120

AAGGGCACCG AGAGCCACCC GCCAGAGGAC AGCTGGCTCA AGTTCAGGAG TGAGAACAAC 180

TGCTTCCTGT ATGGGGTTTT CAACGGCTAC GATGGCAACC GGGTGACCAA CTTCGTGGCC 240

CAGCGGCTGT CGGCGGAGCT CCTGCTGGGT CAGCTCAGCG CCGAGCACAC CGAGGCCGAT 300

GTGCGGCGTG TGCTGCTACA GGCCTTTGAC GTGGTGGAAA GGAGCTTCCT GGAGTCCATT 360

GACGATGCAC TGGCTGAGAA GGCGAGCCTC CAGTCCCAGC TGCCAGAGGG TGTCCCGCAG 420

CACCAGTTGC CTCCTCAGTA TCAGAAGATC CTTGAGAGAC TCAGGACACT GGAGAAGGAG 480

AACATTTCCA CACTTTCAAT GTGTCCTGTT TCTCCTTACA CACGGTCATT GCTCAGCTGC 540

TCAAATTCGG CCACAGGTAC GAACCGCGCG CTGTTGTGCA AATCCACGGC AGATGGGTTA 600

CAGGTGACAC AGCTGAACGT GGCCCACACC ACGGAGAACG AGGACGAGCT CTTCCGCCTT 660

TCGCAGCTGG GTTTGGACGC AGGAAAGATC AAGCAAGCAG GGATCATCTG TGGCCAGGAG 720

AGCACCAGGC GCATTGGGGA TTACAAGGTC AAGTACGGCT ACACTGACAT TGAACTGCTC 780

AGCGCAGCCA AGTCCAAACC GATCATCGCG GAGCCCGAAG TCCACGGTGG GCAGCCACTG 840

GATGGGGTGA CCGGCTTCCT GGTGCTGATG TCCGAGGGGC TCTACAAGGC CCTGGAAGCA 900

GCCCATGGGC CTGGGCAGCC AACCAGGGAG ATTGCAGCGA TGATTGACAC TGAGTTTGCC 960

AAGCAGACCT CCCTGGACGC CGTGGCCCAG GCCGTGGTGG ACCGCGTGAG GCGCATCCAC 1020

AGCGACACCT TTGCCAGTGG CGGGGAGCGT GCCAAGTTCT GCCCACGGCA CGAGGACATG 1080

ACCCTGCTGG TGAGGAACTT TGGCTACCCA CTGGGCGAAA TGAGCCAGTC CACACCGACC 1140

CCATCCCCAG CTGCAGGAGG CCGCGTGTAC CCCGTGTCTG TACCCTACTC GAGCGCTCAG 1200

AGCACCAGCA AGACCAGCGT GACCCTCTCC CTCGTCATGC CCTCCCAGGG CCAGATGGTC 1260

AACGGGGCCC ACAGCTCATC CACCCTGGAT GAAGCCACAC CCACCCTCAC CAACCAGAGC 1320

CCGACCCTGA CCCTACAGTC CACCAACACG CACACCCAGA GCAGCAGCTC CAGCTCGGAC 1380

GGGGGCCTCT TCCGCTCCCG GCCCGCCCAC TCGCTCCCAC CAGGTGAGGA TGGCCGCGTC 1440

GAGCCCTACG TGGATTTTGC TGAGTTTTAC CGCCTCTGGA GTGTGGACCA CGGCGAGCAG 1500

AGCGTGATGA CGGGACCGTA G 1521

Domain Profile

S: 29    pekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstde  88

         +++++   ++gv++G  g++v++f++++l+  l     s e +e++v+++l +aF  +++

Q: 56    RSENN-CFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLSAEHTEADVRRVLLQAFDVVER  114

         44444.589********************976655555599*******************

S: 89    el................................kvleeksldidksGstavvalikds.  115

          +                                k+le+ ++ +++  st +++ +++

Q: 115   SFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLRTLEKENISTLSMCPVSPYt  174

         **********************************77777777777777777777777766

S: 116   ....klyvanvGdSravLcrngk....avelssdHkpsredEleRieeag...gsvilkd  164

             ++  + +G  ra+Lc++      + +l + H++++edEl R+++ g   g++ +

Q: 175   rsllSCSNSATGTNRALLCKSTAdglqVTQLNVAHTTENEDELFRLSQLGldaGKIKQAG  234

         6667777799*********976446779999*******************9877777775

S: 165   gaRvlGvLavsRalGdlylk..............pyvtpePevtshr.ltsedefliLas  209

            ++G  + +R +Gd+++k              + +++ePev+  + l+  + fl+L s

Q: 235   --IICG-QESTRRIGDYKVKygytdiellsaaksKPIIAEPEVHGGQpLDGVTGFLVLMS  291

         ..6777.69************************999*******98651666666******

S: 210   DGlwdvvsn  218

          Gl++ ++

Q: 292   EGLYKALEA  300

         ****98864

Domain Sequence
(FASTA)

RSENNCFLYG VFNGYDGNRV TNFVAQRLSA ELLLGQLSAE HTEADVRRVL LQAFDVVERS 60

FLESIDDALA EKASLQSQLP EGVPQHQLPP QYQKILERLR TLEKENISTL SMCPVSPYTR 120

SLLSCSNSAT GTNRALLCKS TADGLQVTQL NVAHTTENED ELFRLSQLGL DAGKIKQAGI 180

ICGQESTRRI GDYKVKYGYT DIELLSAAKS KPIIAEPEVH GGQPLDGVTG FLVLMSEGLY 240

KALEA 245

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013