EKS-LOA-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	496.0	2.7E-149	722	979	258

Status

Unreviewed

Ensembl Protein

ENSLAFP00000000238

UniProt Accession

G3SLF2;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000000286	ENSLAFP00000000238	ENSLAFT00000000288

Organism

Loxodonta africana

Functional Description

Protein Length

1257

Protein Sequence
(FASTA)

VNTMKLAAWC RWGLLFALLP PGAAGTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ 60

GNLELTYLPA NASLSFLQDI QEVQGYVLVA HNQVRQVPLH RLRIVRGTQL FQDKFALAVL 120

DNRDPLDHAT PATGAVPGGL QELQLRSLTE ILKGGVMIQR NPQLCYQETI LWKDIFHKNN 180

WLSLELVDAN HSRPCKPCSS ACKVPHCWGE SSEDCQSLTR TVCASGCARC KGPLPTDCCH 240

EQCAAGCTGP KHSDCLACLH FNHSGICELH CPPLVVYNTD TFESEINPEG RYTFGASCVV 300

TCPYNYLSTD VGSCTLVCPL NNQEVTAEDG TQKCEKCSKP CARVCYGLGR EHLREVRAVT 360

SANIQEFAGC KKIFGSLAFL PESFEGDPAS STAPLQPEQL RVFETLEEIT GYLYISAWPD 420

NLPDLSVFQN LRVIRGRVLH DGAYSLALQG LGIGWLGLRS LRELSSGLAL IHRNARLCFI 480

HTVPWDQLFR NPHQALLHSA NRPDDECEGK DLACYRLCAH GHCWGPGPTQ CVNCSQYLRG 540

QECVEECRVL QGLPREYVKD RHCLPCHPEC QPQNGSETCF GLEADQCVAC AHYKDAPFCV 600

ARCPSGVKPD LSFMPIWKFP DEEGTCQPCP INCTHSCADL DEKGCPAEQR ASHVTIITTV 660

VGILLFMVVG LVLGIVIKRW RQKIRKYTMR RLLQETELVE PLTPSGALPN QAQMRILKET 720

ELRKVKVLGS GAFGTVYKGI WIPDGENVKI PVAIKVLREN TSPKANKEIL DEAYVMAGVG 780

SPYVSRLLGI CLTSTVQLVT QLMPYGCLLD HVREHRGRLG SQDLLNWCVQ IAKGMSYLED 840

VRLVHRDLAA RNVLVKSPNH VKITDFGLAR LLDIDETEYH ADGGKVPIKW MALESILRRR 900

FTHQSDVWSY GVTVWELMTF GAKPYDGIPA REIPDLLEKG ERLPQPPICT IDVYMIMVKC 960

WMIDSECRPR FRELVAEFSR MARDPQRFVV IQNEDMGPSS PLDSTFYRSL LEDDDMGDLV 1020

DAEEYLVPQQ GFFCPDPAPG TGGTAHRRHR SSSTRSGGGE LTLGLEPSEE EPPRSPLAPS 1080

EGAGSDVFDG DLAMGAAKGL QSLSPHDPSP LQRYSEDPTV SLSPETDGYV APLTCSPQPE 1140

YVNQPEVRPQ PPSPLEVPLP PSCPAGATLE RPKTLSPRKN GVVKDVFAFG SAVENPEYLA 1200

PRGGAAPLPH PPPAFSPAFD NLYYWDQDPS ERGSPPSTFE ETPTAENPEY LGLDMPV 1257

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 722   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  781

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+

Q: 782   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  841

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++

Q: 842   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  901

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw

Q: 902   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  961

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mid+e+rp+f+el++efs

Q: 962   MIDSECRPRFRELVAEFS  979

         ****************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180

THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240

MIDSECRPRF RELVAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0016323	; C:basolateral plasma membrane
GO:0010008	; C:endosome membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507	; P:heart development
GO:0008045	; P:motor neuron axon guidance
GO:0042552	; P:myelination
GO:0033088	; P:negative regulation of immature T cell proliferation in thymus
GO:0007528	; P:neuromuscular junction development
GO:0007422	; P:peripheral nervous system development
GO:0014065	; P:phosphatidylinositol 3-kinase cascade
GO:0045785	; P:positive regulation of cell adhesion
GO:0030307	; P:positive regulation of cell growth
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0032321	; P:positive regulation of Rho GTPase activity
GO:0045943	; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945	; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727	; P:positive regulation of translation
GO:0070372	; P:regulation of ERK1 and ERK2 cascade
GO:0032886	; P:regulation of microtubule-based process
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013