EKS-LOA-00273
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00273
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK388.91.4E-11612265254
StatusUnreviewed
Ensembl ProteinENSLAFP00000000350
UniProt AccessionG3SLN8;
Protein Name
Protein Synonyms/Alias
Gene NamePLK4
Gene Synonyms/Alias PLK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000000411ENSLAFP00000000350ENSLAFT00000000411
ENSLAFG00000000411ENSLAFP00000024890ENSLAFT00000029624
OrganismLoxodonta africana
Functional Description
Protein Length938
Protein Sequence
(FASTA)
MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60
VKIHCQLKHP SVLELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMHQI 120
ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180
EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSREAKD 240
LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 300
SISGSLFDRR RLLIGQPLPN KMTVFPKNKN SSDFSSLGDG SSFYTQWGNQ EQETANGGRG 360
RIIQDAEERP HSRYLRRAHS SDRSGTSHSQ SRAKTYTMER CHSAEMLPKP TRSGVDEHEM 420
FSSDHLCPRK AHFPFSDQPS HTEMVQQWFG NMQLNAHLRD PTEHHGISPS RDFQGHPDLQ 480
KDTSRNAWTE KRTRKNPDPS DNAHSVKQQN PMKYVPALHS KPEIIQQESV FGYDPLSEQT 540
KTRSMEPPSG YQKHTLRSIT SPLTAHRLKP IRQKTKKAVV SILDSEEVCV ELLKEYTSQE 600
YVKEVLQISS DGNTITVYYP HDGRGFPLAD RPPSPTDNIS RYSFDNLPEK YWKKYQYASR 660
FVQLVRSKSP KITYFTKYAK CILMENSPGA DFEVWFYDGA KIHKTEDLIQ VIEKTGKSYT 720
LKGESEVNSL KEKMKVYMDH ANEGHRICLA LESVISEEEK KSGSAPFFPI IIGRKPGSTS 780
SPKPLSPPPV DPDYPIRDTP SLNTVIRNSA ASLKQAPILT PSMVTNEELG LTATASKTNI 840
SSSSLKDCLP KSAQLLKSVF VKDVGWATQL TSGAVWVQFN DGSQLVVQAG VSSISYTSPN 900
GQTTRYGENE KLPEYIKQKL QCLSSILLMF SNPTPSFH 938
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++
Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71
         6899********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119
         +++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++ 
Q: 72    VLELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMHQIITGMLYLHSHG  131
         ********************************99**************************
S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179
         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le
Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191
         ************************************************************
S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239
         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+
Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPA  251
         ************************************************************
S: 240   erpsleevlkdefl  253
         +r+sl++vl+++f+
Q: 252   DRLSLSSVLDHPFM  265
         ************98
Domain Sequence
(FASTA)
FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60
VLELYNYFED SNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMHQII TGMLYLHSHG 120
ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180
SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSREAKDL IHQLLRRNPA 240
DRLSLSSVLD HPFM 254
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00246
EKS-ANC-00252
EKS-BOT-00263
EKS-CAJ-00269
EKS-CAF-00270
EKS-CAP-00299
EKS-CII-00156
EKS-CIS-00036
EKS-DAR-00599
EKS-DIO-00019
EKS-DRM-00135
EKS-EQC-00254
EKS-FEC-00249
EKS-GAG-00221
EKS-GAA-00324
EKS-GOG-00261
EKS-HOS-00270
EKS-ICT-00248
EKS-LAC-00275
EKS-MAM-00265
EKS-MEG-00207
EKS-MOD-00260
EKS-MUM-00294
EKS-MUP-00260
EKS-MYL-00264
EKS-NOL-00242
EKS-ORN-00341
EKS-ORA-00230
EKS-ORC-00249
EKS-ORL-00318
EKS-OTG-00269
EKS-PES-00233
EKS-PEM-00138
EKS-POA-00255
EKS-RAN-00278
EKS-SAH-00245
EKS-SUS-00228
EKS-TAG-00278
EKS-TAR-00337
EKS-TEN-00332
EKS-VIP-00010
EKS-XET-00338
EKS-XIM-00333
Gene Ontology
GO:0005814; C:centriole
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007099; P:centriole replication
GO:0046601; P:positive regulation of centriole replication
GO:0060707; P:trophoblast giant cell differentiation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008266; Tyr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
Created Date20-Feb-2013