EKS-LOA-00395

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00395

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.5	4.6E-109	529	785	257

Status

Unreviewed

Ensembl Protein

ENSLAFP00000025921

UniProt Accession

G3SM05;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

MAP3K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000000588	ENSLAFP00000025921	ENSLAFT00000026150
ENSLAFG00000000588	ENSLAFP00000000494	ENSLAFT00000000588
ENSLAFG00000000588	ENSLAFP00000022072	ENSLAFT00000028326

Organism

Loxodonta africana

Functional Description

Protein Length

1221

Protein Sequence
(FASTA)

FLFADIAVVE MSDAFRQPSL FYHLGVRESF SMANNIILYC DTNSDSLQSL KMCTGNYTFV 60

PYMITPHNKV YCCDSSFMKG LTELMQPNFE LLLGPICLPL VDRFIQLLKV AQASSSQYFR 120

ESILNDIRKA RNLYTGKELA AELARIRQRV DNIEVLTADI VINLLLSYRD IQDYDSIVKL 180

VETLEKLPTF DLASHHHVKF HYAFALNRRN LPGDRAKALE LMIPLVQSEG QVASDMYCLV 240

GRIYKDMFLD SNFTDTESRD HGAYWFKKAF ESEPTLQSGI NYAVLLLATG QQFESSFELR 300

KVGVKLSSLL GKKGNLEKLQ SYWEVGFFLG ASVLANDHMR VIQASEKLFK LKTPAWYLKS 360

IVETILIYKH FAKLTTEQPV AKQELVDFWM DFLVEATKTD VTVVRFPVLI LEPTKIYQPS 420

YLSINNEVEE KTISIWHVLP DDKKGIHEWN FSASSVRGVS ISKFEERCCF LYVLHNSDDF 480

QIYFCTELHC KKFFEMVNTI TEEKGRGAEE GDCESDSLEY DYEYDENGDR VVLGKGTYGI 540

VYAGRDLSNQ VRIAIKEIPE RDSRYSQPLH EEIALHKHLK HKNIVQYLGS FSENGFIKIF 600

MEQVPGGSLS ALLRSKWGPL KDNEQTIGFY TKQILEGLKY LHDNQIVHRD IKGDNVLINT 660

YSGVLKISDF GTSKRLAGIN PCTETFTGTL QYMAPEIIDK GPRGYGKAAD IWSLGCTIIE 720

MATGKPPFYE LGEPQAAMFK VGMFKVHPEI PESMSAEAKA FILKCFEPDP DKRACANDLL 780

IDEFLKVSSK KKKIQAKLSA LSAGSNEYLR SISLPVPVLV EDTSSSSEYG SVSPDTELKV 840

DPFSFKTRPK SCGEKDVKGI RTLFLGIPDE NFEDHSAPPS PEEKDSGFFL LRKDSERRAT 900

LHRILTEDQD KIVRNLMESL VQGAEEPKLK WEHITTLVAS LREFVRSTDR KIIATTLSKL 960

KLELDFDSHG ISQVQVVLFG FQDAVNKVLR NHNIKPHWMF ALDSIIRKAV QTAITILVPE 1020

LRPHFSLASE SDTADQEDLD VEEDHEEQPS NQTVRRPHAV IEDAVATSGV STLSSTVSHD 1080

SQNAHRSLNV QLGRMKIETN RLLEELVQKE KELQALLHQA IEEKDQEIKH LKLKSQPIDI 1140

PGLSVCHLNS PSTNTEDSEL TDWLRENGAD EDTISRFLAE DYTLVDVLYY VTRDDLKCLR 1200

LSRGGMLCTL WKAIVDFRDK Q 1221

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 529   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  583

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 584   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  643

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 644   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  700

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+

Q: 701   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  760

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ kc+e dp+kr++a++LL +efl

Q: 761   FILKCFEPDPDKRACANDLLIDEFL  785

         *********************9996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180

ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240

DPDKRACAND LLIDEFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008656	; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0000186	; P:activation of MAPKK activity
GO:0070301	; P:cellular response to hydrogen peroxide
GO:0010421	; P:hydrogen peroxide-mediated programmed cell death
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254	; P:JNK cascade
GO:0043065	; P:positive regulation of apoptotic process

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013