EKS-LOA-00016
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00016
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR446.04.8E-1349401207268
StatusUnreviewed
Ensembl ProteinENSLAFP00000000642
UniProt AccessionG3U1Q3;
Protein Name
Protein Synonyms/Alias
Gene NameINSRR
Gene Synonyms/Alias INSRR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000000759ENSLAFP00000021761ENSLAFT00000030433
ENSLAFG00000000759ENSLAFP00000000642ENSLAFT00000000759
OrganismLoxodonta africana
Functional Description
Protein Length1225
Protein Sequence
(FASTA)
PSLDIRSEVA ELRRLENCSV IEGHLQILLM FTATGEDFHG LSFPRLTQVT DYLLLFRVYG 60
LESLRDLFPN LAVIRGARLF LGYALVIFEM PHLRDVGLPA LGAVLQGAVR VEKNQELCHL 120
STIDWGLLQP APGANHIVGN KLDEECADVC PGMLGRCRRA LCQTTFSGHT DYRCWTSSHC 180
QRVCPCLHGL ACTVKGECCH AECLGGCSRP EDPRACVACR HLYFQGTCHQ ACPPGTYQHE 240
SWRCVTAAHC ASLRSVPGHA STFGIHQGSC LAQCPPGFTR NGSSIFCQKC EGLCPKECKV 300
GTKTIDSVQA AQELVGCTHV EGSLILNLRQ GYNLEPELQR GLGLVETITG FLKIKHSFAL 360
VSLGFFKNLK LIRGDAMVDG NYTLYVLDNQ NLQQLGPWVA DGLTIPVGKI YFAFNPRLCL 420
EHIYRLEEVT GTRGRQNKAE INPRTNGDRA ACQTRTLRFV SNVTEADRIL LRWERYEPLE 480
ARDLLSFIVY YKESPFQNAT EHVGPDACGT QSWNLLDVEL PLSRTQEPGV TLAPLKPWTQ 540
YAVFVRAITL TIAEDSPHQG AQSPIVYLRT LPAAPTVPQD VISTSSSSSH LLVRWKPPIQ 600
RNGNITYYLV LWQRLAEDGD LYLNDYCHRV RLPTSNSDPR FDREDGELEA EVEPGCCPCQ 660
HPPPGQVLPP LEAQEASFQK KFENFLHNAI TIPKCGAAHA DSGRYRRAAE APRLAGNSSD 720
FEIQEDKVPR ERAVLSGLRH FTEYRIDIHA CNHAAHTVGC SAATFVFART MPHREADGIP 780
GKVAWEAASK SSVLLRWLEP PDPNGLILKY EIKYRRSGEE ATVLCVSRLR YAKFGGVHLA 840
LLPPGNYSAR VRATSLAGNG SWTDSVAFYI PGPEEENSGG LHVLLTVTPV GLMLLVILVA 900
LGFFYGKKRN STLYASVNPE YFSASDMYIP DEWEVPREQI SIIRELGQGS FGMVYEGLAR 960
GLEAGEESTP VALKTVNELA SPRECISILG VPDHSQGHNE DQVVRLLGVV SQGQPTLVIM 1020
ELMTRGDLKS HLRSLRPEAE NNPGLPRPAL GDMIQMAGEI ADGMAYLAAN KFVHRDLAAR 1080
NCMVSQDFTV KIGADFGMTR DVYETYYAKG GKGAAAVRWM APESLKDGIF TTHSDVWSFG 1140
VVLWEIVTLA EQPYQGLSNE QVLKFVMDGG VLEELEGCPP QLQELMSRCW QQSPRLRPTF 1200
THILDSIQEE LRPSFRLLSF YYSPE 1225
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as re+i  l   +  +  +
Q: 940   ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECISILGVPDHSQGHN  999
         6799********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
            vvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e
Q: 1000  EDQVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPRPALGDMIQMAGE  1059
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiG.dfGmtrdiyetdyyrkggkgllpvr  179
         iadGmayl+a+kfvhrdlaarncmv++d+tvkiG dfGmtrd+yet yy kggkg   vr
Q: 1060  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGaDFGMTRDVYET-YYAKGGKGAAAVR  1118
         *********************************989********98.99***********
S: 180   wmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpenc  239
         wm+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++e c
Q: 1119  WMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGC  1178
         ************************************************************
S: 240   pelltelmrlcwqynpklrpsfleivell  268
         p +l+elm++cwq +p+lrp+f++i++++
Q: 1179  PPQLQELMSRCWQQSPRLRPTFTHILDSI  1207
         *************************9976
Domain Sequence
(FASTA)
ISIIRELGQG SFGMVYEGLA RGLEAGEEST PVALKTVNEL ASPRECISIL GVPDHSQGHN 60
EDQVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPRPA LGDMIQMAGE 120
IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGADFGMT RDVYETYYAK GGKGAAAVRW 180
MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELEGCP 240
PQLQELMSRC WQQSPRLRPT FTHILDSI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00014
EKS-BOT-00016
EKS-CAJ-00018
EKS-CAF-00018
EKS-CAP-00017
EKS-EQC-00019
EKS-FEC-00017
EKS-GOG-00020
EKS-HOS-00019
EKS-ICT-00018
EKS-MAM-00017
EKS-MOD-00016
EKS-MUM-00016
EKS-MUP-00019
EKS-MYL-00019
EKS-NOL-00017
EKS-ORC-00016
EKS-OTG-00017
EKS-PAT-00018
EKS-PES-00018
EKS-POA-00017
EKS-RAN-00018
EKS-SAH-00015
EKS-SUS-00014
EKS-XET-00017
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0071469; P:cellular response to alkalinity
GO:0030238; P:male sex determination
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013