EKS-LOA-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.2	4.6E-97	1103	1367	265

Status

Unreviewed

Ensembl Protein

ENSLAFP00000022988

UniProt Accession

G3SMR0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000000985	ENSLAFP00000000827	ENSLAFT00000000987
ENSLAFG00000000985	ENSLAFP00000022988	ENSLAFT00000027990

Organism

Loxodonta africana

Functional Description

Protein Length

1372

Protein Sequence
(FASTA)

GSAGQQSQAL REKKAPAGER RPTGQNSSRE MESKETLKGL HKMDDRPEER TIREKLKATC 60

MPAWKHEWLE RRNRRGPVVV KPIPIKGDGS EMNNLAPEPQ AEGQMSAASS APKGRRSPSP 120

GSSPSGRTVK SESPGVRRKR VSPVPFQSGR ITPPRRAPSP DGFSPYSPEE TNRRVNKVMR 180

ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG PQNCSCGRGT FCIHLLFVML RVFQLEPSDP 240

MLWRKTLKNF EVESLFQKYH SRRSSRIKAP SRNTIQKFVS RMSNSHILSS SSTSTSSSEN 300

SIKDEEEQMC PICLLGMLDE ESLTVCDDGC RNKLHHHCMS IWAEECRRNR EPLICPLCRS 360

KWRSHDFYSH ELPSPVDPPS SLRAAQQQTT QQQPLAGSQR RTQESDSNLT HYGAQQVPPA 420

YKDLAEPWIQ VFGMELVGCL FSRNWNVREM ALRRLSHDVS GALLLANGES TGNSGGSGGS 480

SPSVGAASGS SQTSISGDVV EACCNVLSMV CADPVYKVYV AALKTLRAML VYTPCHSLAE 540

RIKLQRLLRP VVDTILVKCA DANSRTSQLS ISTLLELCKG QAGELAVGRE ILKAGSIGIG 600

GVDYVLNCIL GNQTESNNWQ ELLGRLCLID RLLLEFPAEF YPHIVSTDVS QAEPVEVRYK 660

KLLSLLTFAL QSIDNSHSMV GKLSRRIYLS SARMVTTVPH VFSKLLEMLS VSSSTHFTRM 720

RRRLMAIADE VEIAEAIQLG IEDTLNGRHD SFLQASTNSY PETTDDSSLE RTVHLEKTGK 780

GLCASSEDIS DRLAGILVGL PSSTTTEQPK PMVQTKGRPH SQCLNSSPLS HHSQLMFPAL 840

STSSTPSSSA PSVPAGTVTD VSKQRPQGFI PCKIPSASPQ TQRKFSLQFQ RNCSESKDSD 900

KLSPIFTQSR PLPSSNIHRP KPSRPTLGNI SKQGDTSKNS MTLDLNNSSK CDDSFGSSSN 960

SSNAVIPSDE TVFTPVEEKC RLDVNTELNS SIEDLLEASM PSSDTTVTFK SEVAVLSPEK 1020

AENDDTYKDD VNHNQKCKEK MEAEEEEALA IAMAMSASQD ALPIVPQLQV ENGEDIIIIQ 1080

QDTPETLPGH TKAKQPYRED TEWLKGQQIG LGAFSSCYQA QDVGTGTLMA VKQVTYVRNT 1140

SSEQEEVVEA LREEIRMMSH LNHPNIIRML GATCEKSNYN LFIEWMAGGS VAHLLSKYGA 1200

FKESVVINYT EQLLRGLSYL HENQIIHRDV KGANLLIDST GQRLRIADFG AAARLASKGT 1260

GAGEFQGQLL GTIAFMAPEV LRGQQYGRSC DVWSVGCAII EMACAKPPWN AEKHSNHLAL 1320

IFKIASATTA PSIPSHLSPG LRDVALRCLE LQPQDRPPSR ELLKHPVFRT TW 1372

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1103  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1162

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1163  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1222

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1223  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1282

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1283  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1340

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1341  LRDVALRCLELQPQDRPPSRELLKHPV  1367

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013