EKS-LOA-00353

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00353

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	291.5	8.4E-87	544	946	403

Status

Unreviewed

Ensembl Protein

ENSLAFP00000020690

UniProt Accession

G3TYN2;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000001001	ENSLAFP00000020690	ENSLAFT00000026099
ENSLAFG00000001001	ENSLAFP00000000844	ENSLAFT00000001005

Organism

Loxodonta africana

Functional Description

Protein Length

1594

Protein Sequence
(FASTA)

VKEPPEINLV LYPQGLTGEE VYVKVDLRVK CPPTYPDVVP EIELKNAKGL SNESVNLLKS 60

CLEELAKKHC GEVMIFELAY HVQSFLSEHN KPPPKSFHEE MLERRAQEEQ RRLLEAKQKE 120

EQEQREILHE ILCLRFHSVM EKSDPAALEK DKERLEIASL SNQDHTPRKD PGGYRAAAIL 180

HGGSPDFVGN GKHRANSSGR SRRERQYSAC SSEDSPGSCE ILYFSVGSPD QLMVHKGKCI 240

GSDEQLGKSV YNALETAAGS FVLLYEWVLK WQKKMGPFLT SQEKEKIDKC RKQIQGAETE 300

FNSLVKLSHP NVVRYIAMNL KEQDNSIVVD ILVEHITGVS LATHLSHSGP VPLHQLRRYA 360

AQLLAGLEYL HSNSVVHKVL SASNVLVDAK GTIKITDYSI SKRLADICKE DVFEQTRVRF 420

SDNALPYKTG KKGDVWRLGL LLLSLSQGQE CEEYPVTIPS DLPADFQDFL KKCVCLDDKE 480

RWSPQQLLKH SFINPQPKTP LLEQSPEDSG GQDYVETVIP RNQLPSAAFF SETQRQFSRY 540

FIEFEELQLL GKGAFGAVIK VQNKLDGCCY AVKRIPINPA SRQFRRIKGE VTLLSRLHHE 600

NIVRYYNAWI ERHERPAGPG TPPPDSRPQA RNGRSTPGPP AGDTDGTGSV EAAAPPPILS 660

SSVEWSTSCE RSASARFPAA GPGSSSDEDD EEDERHGVFS QSFLPSDSES DIIFDNEDEN 720

SKSQHQEEDI SEKNGCHESE SSVTTEAVHY LYIQMEYCEK STLRDTIDQG LYQDTTRLWR 780

LFREILDGLA YIHEKPCIGG LTKLTNFSTQ KEHYYNHFGF SADGKQDDQA GDHVIKSDPS 840

GHLTGMVGTA LYVSPEVQGS TRSAYNQKVD LFSLGIIFFE MSYHPMVTAS ERIFILNQLR 900

DPTSPKFPED FNDGEHAKQK SVISWLLNHD PAKRPTATEL LKSELLPPPQ MEESELHEVL 960

HHTLANVDGK AYRTMMAHIF SQHIPPAIDY TYDSDILKGN FSIRTAKIQQ HVCETIIRIF 1020

KRHGAVELCT PLLLPRNKQI YEHNEAALFM DHSGMLVMLP FDLRVPFARY VARNNILNLK 1080

RYCIERVFRP RKLDRFHPKE LLECAFDIVT STTSSSLPTA EIIYTIYEII QEFPALQERN 1140

YSIYLNHTTL LKAILLHCGI PEDKLSQVYI ILYDVVTEKL TRREVEAKFC NLSLSSNSLC 1200

RLYKFIEQKG DLQDLTPTIN SLTKQKTGVA QLVKYGLKDL EEVVGLLKKL GIKLQVLINL 1260

GLVYKVQQHN GIIFQFVAFI RRRQRAVPEI LAAGGRYDLL IPRFRGPQAL GPVPTAIGVS 1320

IAIDRISAAV LNMEEPVTIS SCDLLVVSIG QMSMSRAINL TQKLWAAGIT AEIMYDCSQS 1380

QEELQEYCRH HEITCVALVS DKEGSHVKVK SFEKERQTEK RVLESDLVDH VVQKLRTKVS 1440

DERNIREASD NLAVQNLKGS FSNASGLFEI HGATVIPNVS VVAPEKLSAS TRRRYETQVQ 1500

TRLQTSLANL HQKSSEIEIL AVDLPKDTIL QFLSLEWDAD EQTFNATVKQ LLSHLPKQRY 1560

LKLVCDEIYN IKVEKRVSVL FLYSYRDDYY RILF 1594

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a++++++++ ev++L++l+h+niv

Q: 544   FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV  603

         89**********************************************************

S: 61    rYfaawleekeesl..........................td.sseveaeaeleesesse  93

         rY++aw+e++e+++                          td + +vea+a++   +ss

Q: 604   RYYNAWIERHERPAgpgtpppdsrpqarngrstpgppagdTDgTGSVEAAAPPPILSSSV  663

         ****************************************55566666666666666666

S: 94    esdtk.......................................................  98

         e++t+

Q: 664   EWSTScersasarfpaagpgsssdeddeederhgvfsqsflpsdsesdiifdnedensks  723

         666666666666666666666666666666666666666666666666666666666666

S: 99    ..........................llyiqmelceketLkdwiderkllesrselvmrl  132

                                   +lyiqme+cek+tL+d+id+  l++++++l+ rl

Q: 724   qhqeedisekngchesessvtteavhYLYIQMEYCEKSTLRDTIDQG-LYQDTTRLW-RL  781

         66666667788888888888888999*********************.9********.**

S: 133   fkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealkedvkqdaqsk  192

         f+++l+gl+y+H+k  i    k +n F   +++     Fg + + +++ ++     ++

Q: 782   FREILDGLAYIHEKPCIGGLTKLTN-FS-TQKEHYYNHFGFSADGKQDDQAGDHVIKSDP  839

         *****************98777777.44.4444457899999998877665444445555

S: 193   eakhtgqvgtklymsPeql..eksqYnkkvDifsLGlilfeLly.pfstemervetltel  249

         +++ tg+vgt+ly+sPe++  ++s+Yn+kvD+fsLG+i+fe++y p+ t++er+ +l++l

Q: 840   SGHLTGMVGTALYVSPEVQgsTRSAYNQKVDLFSLGIIFFEMSYhPMVTASERIFILNQL  899

         579****************999**************************************

S: 250   rd...gkipedfdd.kvpkekkllqkllsrdpkeRpsasellksell  292

         rd    k+pedf+d ++ k+k+++++ll++dp++Rp+a+ellksell

Q: 900   RDptsPKFPEDFNDgEHAKQKSVISWLLNHDPAKRPTATELLKSELL  946

         **9999**************************************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCCYAVK RIPINPASRQ FRRIKGEVTL LSRLHHENIV 60

RYYNAWIERH ERPAGPGTPP PDSRPQARNG RSTPGPPAGD TDGTGSVEAA APPPILSSSV 120

EWSTSCERSA SARFPAAGPG SSSDEDDEED ERHGVFSQSF LPSDSESDII FDNEDENSKS 180

QHQEEDISEK NGCHESESSV TTEAVHYLYI QMEYCEKSTL RDTIDQGLYQ DTTRLWRLFR 240

EILDGLAYIH EKPCIGGLTK LTNFSTQKEH YYNHFGFSAD GKQDDQAGDH VIKSDPSGHL 300

TGMVGTALYV SPEVQGSTRS AYNQKVDLFS LGIIFFEMSY HPMVTASERI FILNQLRDPT 360

SPKFPEDFND GEHAKQKSVI SWLLNHDPAK RPTATELLKS ELL 403

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0009267	; P:cellular response to starvation
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0017148	; P:negative regulation of translation
GO:0043558	; P:regulation of translational initiation in response to stress

KEGG

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013