EKS-LOA-00167
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00167
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC479.33.9E-144246504259
StatusUnreviewed
Ensembl ProteinENSLAFP00000028240
UniProt AccessionG3SMU4;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000001035ENSLAFP00000000867ENSLAFT00000001034
ENSLAFG00000001035ENSLAFP00000028240ENSLAFT00000037525
OrganismLoxodonta africana
Functional Description
Protein Length575
Protein Sequence
(FASTA)
DPRSKHKFKI HTYSSPTFCD HCGSLLYGLI HQGMKCDTCM MNVHKRCVMN VPSLCGTDHT 60
ERRGRIYIQA HIEREVLIVV VRDAKNLVPM DPNGLSDPYV KLKLIPDPKS ESKQKTKTIK 120
CSLNPEWNET FKFQLKESDK DRRLSVEIWD WDLTSRNDFM GSLSFGISEL QKAGVDGWFK 180
LLSQEEGEYF NVPVPPEGSE ANEELRQKFE RAKINQGTKT PEEKTTNTVS KFDNNGNRDR 240
MKLTDFNFLM VLGKGSFGKV MLSERKGTDE LYAVKILKKD VVIQDDDVEC TMVEKRVLAL 300
PGKPPFLTQL HSCFQTMDRL YFVMEYVNGG DLMYHIQQVG RFKEPHAVFY AAEIAIGLFF 360
LQSKGVIYRD LKLDNVMLDS EGHIKIADFG MCKENIWDGV TTKTFCGTPD YIAPEIIAYQ 420
PYGKSVDWWA FGVLLYEMLA GQAPFEGEDE DELFQSIMEH NVAYPKSMSK EAVAICKGLM 480
TKHPGKRLGC GPEGERDIKE HAFFRYIDWE KLERKEIQPP YKPKARDKRD TSNFDKEFTR 540
QPVELTPTDK LFIMNLDQNE FAGFSYTNPE FVINV 575
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 246   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  305
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 306   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  365
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         +iyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 366   VIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  425
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 426   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  485
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 486   KRLGCGPEGERDIKEHAFF  504
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
VIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-BOT-00168
EKS-CAJ-00172
EKS-CAF-00175
EKS-DRM-00084
EKS-EQC-00173
EKS-FEC-00158
EKS-GAG-00144
EKS-GOG-00171
EKS-ICT-00163
EKS-LAC-00180
EKS-MOD-00167
EKS-MUP-00172
EKS-MYL-00177
EKS-OCP-00107
EKS-ORC-00156
EKS-PAT-00159
EKS-PES-00148
EKS-RAN-00164
EKS-SAH-00162
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005246; F:calcium channel regulator activity
GO:0003682; F:chromatin binding
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0042113; P:B cell activation
GO:0050853; P:B cell receptor signaling pathway
GO:0006816; P:calcium ion transport
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0035556; P:intracellular signal transduction
GO:0010829; P:negative regulation of glucose transport
GO:0045766; P:positive regulation of angiogenesis
GO:0050861; P:positive regulation of B cell receptor signaling pathway
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013