EKS-LOA-00421

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00421

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Trk	532.6	2.2E-160	509	778	270

Status

Unreviewed

Ensembl Protein

ENSLAFP00000001109

UniProt Accession

G3SND2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

NTRK1

Gene Synonyms/Alias

NTRK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000001317	ENSLAFP00000001109	ENSLAFT00000001317

Organism

Loxodonta africana

Functional Description

Protein Length

795

Protein Sequence
(FASTA)

MLPGGRRGQL GRYGRATGRG GLLAWLLLAS AGAASCPEAC CPHGTSGLRC AQAGALRNLR 60

YLPGAENLTE LYIENQQHLR RLELDDLRDL GELRNLIIVK SGLHFVAPDA FHFTPRLSRL 120

NLSFNALESL SWKTVQGLSL QELVLSGNPL NCSCALRWLQ RWEEEGLGRV HEQKLQCPGQ 180

GPLALLRNAS CGVPTLKVLM PNASVDVGDS VLLQCQVEGQ ELEQAGWILT DLEESATVMQ 240

SGGLPSLGLT LANVTSNLNR KNVTCWAEND VGRAELSVQV NVSFPASVRL HKAVEQHHWC 300

IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPLANET VRHGCLRLNQ PTHVNNGNYT 360

LLATNPSGRA ADFVMAAFMD NPFEFNPEDP IPVSFSPVDT NSTSRDPVEK KDETPFGVSV 420

AVGLAVFACL FLSTLLLVLN KCGRRNKFGI NREALPDSVL CMGAGVKTLS GVWVLQGEGG 480

SGRTDRSQGM ENPQYFSDAC VHHIKRRDIV LKWELGEGAF GKVFLAECHN LLPEQDKMLV 540

AVKALKEVSE SARQDFQREA ELLTVLQHQH IVRFFGVCTE GRPLLMVFEY MRHGDLNRFL 600

RSHGPDAKLL AGREDVAPGP LGLGQLLAVA SQVAAGMVYL AGLHFVHRDL ATRNCLVGQG 660

LVVKIGDFGM SRDIYSTDYY RVGGRTMLPI RWMPPESILY RKFTTESDVW SFGVVLWEIF 720

TYGKQPWYQL SNTEAIECIT QGRELERPRA CPLEVYAIMR GCWQREPQQR HSIKDVHARL 780

QALAQAPPVY LDVLG 795

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60

         ivlk+elgegafgkvflaec+nllpe+dk+lvavkalk+ se+ar+df+reaellt lqh

Q: 509   IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEVSESARQDFQREAELLTVLQH  568

         89**********************************************************

S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118

         +hiv+++Gvcteg+pll+vfeym+hGdln+flr+hgpdakll++ e+  +g+lgl+qlla

Q: 569   QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGREDvaPGPLGLGQLLA  628

         **********************************************9999**********

S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178

         +a+q+aaG+vyla +hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml

Q: 629   VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  688

         ************************************************************

S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238

         pirw+ppesilyrkfttesdvws+Gvvlwei+tyGkqp+yqlsnte+iecitqGr+lerp

Q: 689   PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERP  748

         ************************************************************

S: 239   racpkevydlmlgcwqrepqkrlnikeiya  268

         racp evy++m+gcwqrepq+r++ik+++a

Q: 749   RACPLEVYAIMRGCWQREPQQRHSIKDVHA  778

         ****************************97

Domain Sequence
(FASTA)

IVLKWELGEG AFGKVFLAEC HNLLPEQDKM LVAVKALKEV SESARQDFQR EAELLTVLQH 60

QHIVRFFGVC TEGRPLLMVF EYMRHGDLNR FLRSHGPDAK LLAGREDVAP GPLGLGQLLA 120

VASQVAAGMV YLAGLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180

PIRWMPPESI LYRKFTTESD VWSFGVVLWE IFTYGKQPWY QLSNTEAIEC ITQGRELERP 240

RACPLEVYAI MRGCWQREPQ QRHSIKDVHA 270

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0010465	; F:nerve growth factor receptor activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0060385	; P:axonogenesis involved in innervation
GO:0030183	; P:B cell differentiation
GO:0042490	; P:mechanoreceptor differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0045766	; P:positive regulation of angiogenesis
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0010976	; P:positive regulation of neuron projection development
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0032320	; P:positive regulation of Ras GTPase activity
GO:0046579	; P:positive regulation of Ras protein signal transduction
GO:0046777	; P:protein autophosphorylation
GO:0048485	; P:sympathetic nervous system development

KEGG

InterPros

IPR000483	; Cys-rich_flank_reg_C.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR020461	; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777	; Tyr_kinase_NGF_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00082	; LRRCT; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR01939	; NTKRECEPTOR.
PR01940	; NTKRECEPTOR1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013