EKS-LOA-00228

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00228

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	336.7	1.2E-100	167	418	252

Status

Unreviewed

Ensembl Protein

ENSLAFP00000001194

UniProt Accession

G3SNJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000001427	ENSLAFP00000028122	ENSLAFT00000028725
ENSLAFG00000001427	ENSLAFP00000001194	ENSLAFT00000001429

Organism

Loxodonta africana

Functional Description

Protein Length

446

Protein Sequence
(FASTA)

MLWLGFGPFH AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLTE PLQIFPRACK PPGERNIHGL 120

KVNTRAGPQH SSPAVSDSLP SNSLKKSSAE LKKILANGQM NEQDIRYRDT LGHGNGGTVY 180

KAYHVPSGKI LAVKVILLDI TLELQKQIMS ELEILYKCDS SYIIGFYGAF FVENRISICT 240

EFMDGGSLDV YRKIPEHVLG RIAVAVVKGL TYLWSLKILH RDVKPSNMLV NTRGQVKLCD 300

FGVSTQLVNS IAKTYVGTNA YMAPERISGE QYGIHSDVWS LGISFMELAL GRFPYPQIQK 360

NQGSLMPLQL LQCIVDEDSP ILPVGEFSEP FVHFITQCMR KQPKERPAPE ELMGHPFIMQ 420

FNDGNAAVVS MWVCRELEER RSQQGP 446

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 167   YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  225

         5679************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+iavavvk+l+yl+ +l

Q: 226   FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-SL  276

         ************************.6876.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 277   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  335

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 336   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPILPVGEFSEPFVHFI  395

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k++keRp  +el+ h+fi

Q: 396   TQCMRKQPKERPAPEELMGHPFI  418

         **********************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPILPVGE FSEPFVHFIT QCMRKQPKER 240

PAPEELMGHP FI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007507	; P:heart development
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013